Article
Biotechnology & Applied Microbiology
Yong Sub Shin, Kwan Joong Kim, Hyein Park, Mi-Gi Lee, Sueungmok Cho, Soo-Im Choi, Ho Jin Heo, Dae-Ok Kim, Gun-Hee Kim
Summary: The study showed that the Ecklonia cava phlorotannin-rich extract (ECPE) has antioxidative, neuroprotective, and anti-apoptotic effects on neuronal PC-12 cells, suggesting its potential for the development of functional materials to improve cognition and memory.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yoshimasa Sugiura, Yoichi Kinoshita, Shouta Misumi, Hiroaki Yamatani, Hirotaka Katsuzaki, Yuichi Hayashi, Noboru Murase
Summary: The study investigated the antiallergic effects of brown algae harvested in Japan and found seasonal variations in the active components, which correlated with changes in antiallergic effects. Monthly measurements revealed higher levels of phlorotannins and stronger antiallergic effects in summer-autumn, indicating a correlation between seasonal variation and effectiveness. Removing phlorotannins from the extracts eliminated the antiallergic effects, demonstrating their role as active components.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Chemistry, Medicinal
Hye Ju Han, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Seul Ki Yoo, Dae-Ok Kim, Gun-Hee Kim, Ho Jin Heo
Summary: The mixture P4F6 showed a potential anti-amnesic effect on A beta-induced cognitive deficit mice by reducing oxidative stress, enhancing mitochondrial function, regulating tau hyperphosphorylation, promoting BDNF expression, and improving cholinergic system function.
Article
Chemistry, Medicinal
Hui Li, Seung Ha Oh, Hyeon-Cheol Shin, Myung-Whan Suh
Summary: The study suggests that intratympanic delivery of dieckol may be a safe and effective method to prevent ototoxic hearing loss.
Article
Biochemistry & Molecular Biology
Chi-Heung Cho, Guijae Yoo, Mingyeong Kim, Ulfah Dwi Kurniawati, In-Wook Choi, Sang-Hoon Lee
Summary: The study found that dieckol (DK) isolated from Ecklonia cava has therapeutic potential in improving renal damage in patients with diabetic nephropathy induced by methylglyoxal (MGO). DK exhibits antiglycation properties by inhibiting AGE production, cross-linking formation, and breaking of cross-links. DK also protects renal cells by suppressing intracellular reactive oxygen species (ROS) formation, MGO and AGE accumulation, apoptosis cascade activation, apoptosis-related protein expression, RAGE protein expression, and glyoxalase system suppression. The stronger binding affinity of DK to RAGE than AGE suggests its competitive inhibitory effect on the AGE-RAGE interaction. Thus, DK can be utilized as a potential natural AGE inhibitor for the prevention and treatment of AGE-induced diabetic nephropathy.
Article
Chemistry, Medicinal
Jun-Geon Je, Yunfei Jiang, Jun-Ho Heo, Xining Li, You-Jin Jeon, Bo-Mi Ryu
Summary: This study evaluated the anti-melanogenic effects of PFF-A derived from Ecklonia cava, showing that low doses of PFF-A can suppress pigmentation in vivo and melanogenesis in vitro. This suggests the potential use of PFF-A as a new anti-melanogenic agent in the cosmeceutical industries.
Article
Chemistry, Medicinal
Lei Wang, Jun-Geon Je, Hyun-Soo Kim, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, You-Jin Jeon
Summary: EME-EA showed strong anti-melanogenesis and photoprotective activities, indicating its potential use in the pharmaceutical and cosmeceutical industries.
Article
Biochemistry & Molecular Biology
Muhammad Aleem Abbas, Naila Boby, Eon-Bee Lee, Joo-Heon Hong, Seung-Chun Park
Summary: The study investigates the anti-obesity properties of E. cava and finds that it can suppress pre-adipocyte differentiation, reduce body weight and organ weight in obese rats, and lower the risk of liver injury and fatty liver. This suggests that E. cava could be a potential candidate for preventing obesity induced by a high-fat diet.
Article
Biochemistry & Molecular Biology
Yu-An Lu, Jun-Geon Je, Jin Hwang, You-Jin Jeon, BoMi Ryu
Summary: The study found that dieckol extracted from Ecklonia cava can enhance vasodilation by modulating NO production in endothelial cells and influencing calcium transients. Experimental results showed that dieckol enlarged the dorsal aorta diameter in zebrafish, regulating blood flow velocity, making it a potential natural vasodilator.
Article
Endocrinology & Metabolism
Hao Wang, Leigang Yang, Junwei Chao
Summary: The study found that dieckol has anti-osteoporotic effects in rats with GC-induced osteoporosis. It significantly improves bone density and metabolism, and has antioxidant and anti-inflammatory effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Seyeon Oh, Myeongjoo Son, Kyung-A Byun, Ji Tae Jang, Chang Hu Choi, Kuk Hui Son, Kyunghee Byun
Summary: The study showed that ECE or DK attenuated NAFLD by reducing the NLRP3 inflammasome and pyroptosis. High-fat diet induced activation of NLRP3 inflammasome in the liver, which was significantly reduced with the administration of ECE or DK.
Article
Nutrition & Dietetics
Seong-Lae Jo, Hyun Yang, Kang-Joo Jeong, Hye-Won Lee, Eui-Ju Hong
Summary: Inflammation is a natural defense mechanism, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system is important in the development of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava, have anti-inflammatory and antioxidant properties and can be used to control neuroinflammation in the treatment of neurodegenerative diseases. In this study, we found that Ecklonia cava extract can reduce the levels of pro-inflammatory cytokines and markers of inflammation and neurodegeneration in mice with chronic inflammation induced by lipopolysaccharide.
Article
Chemistry, Medicinal
Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Hyun-Jin Kim, Ho Jin Heo
Summary: The study found that water extract from Ecklonia cava has significant preventive effects on neurotoxicity induced by PM2.5, improving cognitive dysfunction by inhibiting inflammatory responses and oxidative damage.
Article
Biochemistry & Molecular Biology
Jong Jin Park, Won Young Lee
Summary: The study examined the anti-glycation effects of polysaccharides extracted from Ecklonia cava using different methods such as hot buffer, ultrasound, enzyme, or a combination of ultrasound and enzyme. Results showed that the polysaccharides with higher fucose and galactose compositions, as well as higher sulfate contents, had better inhibition effects on AGE formation. Specifically, the combination of ultrasound and enzyme extraction method showed the highest extraction yield and lowest protein and uronic acid contents, making it a suitable method for obtaining anti-glycation agents from E. cava.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Chi-Heung Cho, Chang-Jun Lee, Min-Gyeong Kim, Bomi Ryu, Jun-Geon Je, Yoonsook Kim, Sang-Hoon Lee
Summary: The study highlights the potential therapeutic effects of phlorotannin-rich Ecklonia cava extract (ECE) on MGO-induced diabetic nephropathy, showing its ability to break AGEs-collagen cross-links and inhibit AGEs formation and AGE-collagen cross-linking formation. Furthermore, ECE was found to have renoprotective effects by reducing intracellular ROS production and MGO accumulation, as well as activating the Nrf-2/ARE signaling pathway to alleviate dicarbonyl stress. Collectively, the results suggest that ECE may have preventive properties against MGO-induced renal damage and could be beneficial for managing AGE-related diabetic nephropathy.
Article
Food Science & Technology
Chan Seo, Hyun Woo An, Won Han, Joo Won Lee, Krishna K. Shrestha, Won-Kyo Jung, Joong Ho Shin, Sang Gil Lee
Summary: Exposure to pollutants from industrial development leads to oxidative stress in the human body. Consuming antioxidants through diet has a protective effect against oxidative damage caused by oxidative stress. This study measured the antioxidant activities of certain Nepali medicinal plants and found a strong correlation between the singlet oxygen scavenging capacity assay and other antioxidant assays. Additionally, the antioxidant capacities of the plant extracts, including the singlet oxygen scavenging assay, were highly correlated with their total phenolic contents. The study identified Persicaria capitata, Elaphoglossum marginatum, and Eurya acuminata as having the highest antioxidant capacities among the selected extracts.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ryeon Heo, Minji Kang, Seo-Yeong Mun, Minju Park, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Hongzoo Park, Won-Kyo Jung, Il-Whan Choi, Won Sun Park
Summary: Omarigliptin induces vasodilation in rabbit aortic smooth muscle by activating voltage-dependent K+ channels and the SERCA pump independently of other K+ channels, cAMP/PKA- and cGMP/PKG-related signaling pathways, and the endothelium.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Plant Sciences
Su-Hyeon Cho, Hoibin Jeong, SeonJu Park, Hyun-Tak Shin, Hyung-Min Lee, Kil-Nam Kim
Summary: The study demonstrated the inhibitory effects of E. koreensis Nakai root extract (EKRE) on inflammatory responses both in vitro and in vivo. The extract effectively reduced the production of nitric oxide, interleukin-6, and inducible nitric oxide synthase in cells. It also suppressed the activation of nuclear factor kappa-B and mitogen-activated protein kinase. In a mouse model, EKRE significantly inhibited carrageenan-induced paw edema.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Shantanu Kundu, Tanoy Mukherjee, Ah Ran Kim, Soo-Rin Lee, Abhishek Mukherjee, Won-Kyo Jung, Hyun-Woo Kim
Summary: This study reveals lower genetic diversity and more fragmented habitats in India compared to Sri Lanka for the star tortoise, Geochelone elegans. The findings highlight the need for genetic screening, strict measures against wildlife trafficking, and urgent habitat restoration to protect this highly-threatened species.
Article
Materials Science, Multidisciplinary
Seungyun Han, Hyun-Woo Lee, Kyoung-Whan Kim
Summary: In this work, the authors investigate the microscopic origins and strength of orbital textures, which are k-dependent orbital states. They derive the orbital texture Hamiltonians from microscopic tight-binding models and reveal two microscopic mechanisms for the hybridization of orbital states. By considering the orbital hybridization, they not only reproduce the orbital Hamiltonian obtained by symmetry analysis but also discover previously unreported orbital textures. These orbital Hamiltonians are valuable for analyzing orbital physics and designing materials for spin-orbitronic applications.
CURRENT APPLIED PHYSICS
(2023)
Article
Physics, Multidisciplinary
Dongwook Go, Daegeun Jo, Kyoung-Whan Kim, Soogil Lee, Min-Gu Kang, Byong-Guk Park, Stefan Bluegel, Hyun-Woo Lee, Yuriy Mokrousov
Summary: Contrary to the common assumption, the orbital response in ferromagnets can exhibit remarkable long-ranged behavior, even in the presence of strong crystal field potential and orbital quenching. By studying a bilayer structure composed of a nonmagnet and a ferromagnet, it is found that induced orbital angular momentum can extend far beyond the spin dephasing length, even when an external electric field is applied only on the nonmagnet. This behavior is attributed to nearly degenerate orbital characters imposed by crystal symmetry, which form hotspots for the intrinsic orbital response. The findings suggest the potential use of long-range orbital response in orbitronic device applications.
PHYSICAL REVIEW LETTERS
(2023)
Article
Multidisciplinary Sciences
Jeong-Mok Kim, Seok-Jong Kim, Min-Gu Kang, Jong-Guk Choi, Soogil Lee, Jaehyeon Park, Cao Van Phuoc, Kyoung-Whan Kim, Kab-Jin Kim, Jong-Ryul Jeong, Kyung-Jin Lee, Byong-Guk Park
Summary: The Spin Seebeck effect (SSE) refers to the generation of electric voltage perpendicular to a temperature gradient using a magnon current. SSE has the potential for efficient thermoelectric devices because of its transverse geometry which simplifies the device structure for utilizing waste heat. However, SSE has low conversion efficiency that needs improvement for widespread application. In this study, we demonstrate a substantial enhancement of SSE by oxidizing a ferromagnet in normal metal/ferromagnet/oxide structures. The enhancement is attributed to the reduced exchange interaction in the oxidized region, which increases the temperature difference between magnons in the ferromagnet and electrons in the normal metal, or the gradient of magnon chemical potential in the ferromagnet. This result provides a promising method for improving SSE efficiency and invigorating research on thermoelectric conversion.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Woo Seung Ham, Thi Huynh Ho, Yoichi Shiota, Tatsuya Iino, Fuyuki Ando, Tetsuya Ikebuchi, Yoshinori Kotani, Tetsuya Nakamura, Daisuke Kan, Yuichi Shimakawa, Takahiro Moriyma, Eunji Im, Nyun-Jong Lee, Kyoung-Whan Kim, Soon Cheol Hong, Sonny H. H. Rhim, Teruo Ono, Sanghoon Kim
Summary: Spin current, converted from charge current via spin Hall or Rashba effects, can transfer its angular momentum to local moments in a ferromagnetic layer. A high charge-to-spin conversion efficiency is required for developing future memory or logic devices, and here it is demonstrated in an artificial superlattice without centrosymmetry. The observed field-like torque efficiency in the [Pt/Co/W] superlattice with sub-nm scale thickness is about 0.6 when the W thickness becomes 0.6 nm, which is significantly higher than other metallic heterostructures.
Article
Infectious Diseases
Fazlurrahman Khan, Nazia Tabassum, Geum-Jae Jeong, Won-Kyo Jung, Young-Mog Kim
Summary: Synthesized β-caryophyllene gold nanoparticles have the potential to inhibit polymicrobial biofilms and can be used as a therapeutic approach for controlling polymicrobial infections.
Review
Multidisciplinary Sciences
Pipuni Tennakoon, Pathum Chandika, Myunggi Yi, Won-Kyo Jung
Summary: The manufacturing and consumption of plastic products have caused depletion of petroleum resources and increased environmental pollution. Biobased plastics, while introduced as an alternative, have negative impacts on the environment and livelihoods. Marine-derived bioplastics offer a promising and cost-effective solution, but further research is needed. This review summarizes the raw materials, extraction processes, and properties of marine-derived bioplastics to accelerate their production.
Article
Engineering, Biomedical
Dong Uk Lee, Se-Chang Kim, Dong Yun Choi, Won-Kyo Jung, Myung Jun Moon
Summary: In this study, a biocompatible and pH-monitorable wound healing dressing with antimicrobial activity was developed through basic amino acid-mediated surface modification, creating cationic amphiphilic surfaces. The basic amino acid-modified polyimide displayed excellent bactericidal, antifouling, and biofilm inhibition performance, as well as wound healing efficacy and biocompatibility. The findings are significant for wound management and potential applications in wearable healthcare devices.
BIOMATERIALS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tae-Hee Kim, Seong-Yeong Heo, Ji Sung Han, Won-Kyo Jung
Summary: This study extracted PDRN from Porphyra sp. and compared it with commercial products. The results showed that Ps-PDRN has anti-inflammatory and cell proliferative effects, indicating its potential as a bioactive drug for tissue engineering.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Pharmacology & Pharmacy
Wenwen Zhuang, Seo-Yeong Mun, Minju Park, Junsu Jeong, Hongzoo Park, Sunghun Na, Se Jin Lee, Won-Kyo Jung, Il-Whan Choi, Hongliang Li, Won Sun Park
Summary: Lurasidone, a second-generation antipsychotic drug, inhibits vascular Kv channels in a concentration- and use (state)-dependent manner by affecting the voltage sensors and the steady-state inactivation curve of the channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Entomology
Chol-Nam Yun, Il-Song Maeng, Son-Hui Yang, Un-Jo Hwang, Kil-Nam Kim, Kyong-Chol Kim, Kum-Chol Ho, Chung -Song Ri, Hyon-Son Yang, Song-Hun Jang
Summary: The study aimed to evaluate the phototactic behavior responses of diamondback moths (P. xylostella) to different wavelengths and photon flux densities of LED lights under laboratory and field conditions. The results showed that the moths exhibited the highest phototactic behavior responses to UV (380 nm) LED light under certain intensity conditions. The findings from the laboratory and field experiments were consistent, indicating the high sensitivity of P. xylostella moths to 380 nm LED light. The study suggests the potential use of a 380 nm LED light trap for monitoring and controlling diamondback moths.
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Se-Chang Kim, Seong-Yeong Heo, Gun-Woo Oh, Pathum Chandika, Won Sun Park, Il- Whan Choi, Won-Kyo Jung
Summary: This study evaluated the effects of Spirulina maxima-derived phycocyanin (PC) on bone cells and developed a hierarchically structured fibrous membrane loaded with PC. The results showed that the fibrous membrane exhibited excellent biocompatibility and enhanced bone tissue regeneration.
MATERIALS TODAY COMMUNICATIONS
(2023)
