Article
Food Science & Technology
Kuankuan Xiong, Lei Tan, Siliang Yi, Yingxin Wu, Yi Hu, Aibing Wang, Lingchen Yang
Summary: The study revealed that a low concentration of T2 can inhibit the replication of PRV in PK15 cells, alleviate cell injury, reduce the number of infected cells, and decrease the copy number of PRV. T2 inhibits PRV replication by regulating oxidative stress- and apoptosis-related genes.
Review
Environmental Sciences
Wenxi Song, Youshuang Wang, Tingyu Huang, Yu Liu, Fengjuan Chen, Yunhe Chen, Yibao Jiang, Cong Zhang, Xu Yang
Summary: T-2 toxin, a type A trichothecene produced by various Fusarium species, is highly toxic and causes severe damage to the liver and other organs. Its contamination is widespread in plants globally, posing a great threat to human and animal health due to its chemical stability and difficulty to remove completely from food and feed. This review summarizes the recent research on the hepatotoxicity of T-2 toxin and discusses its metabolic characteristics, hepatotoxic mechanisms, and potential detoxification strategies.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Xuliang Zhang, Yucong Wang, Xu Yang, Menglin Liu, Wanyue Huang, Jian Zhang, Miao Song, Bing Shao, Yanfei Li
Summary: The study showed that T-2 toxin induced renal damage and dysfunction in mice through oxidative stress-mediated apoptosis, potentially involving the Nrf2 pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Xingyao Pei, Haiyang Jiang, Xinyu Liu, Liuan Li, Cun Li, Xilong Xiao, Daowen Li, Shusheng Tang
Summary: T-2 toxin induces toxicity in PC12 cells, including oxidative stress, mitochondrial damage, and neuroinflammation, with HMGB1 playing a critical role in these processes.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Si Yang, Jie Chen, Bingchun Ma, Jinglei Wang, Jiaxiang Chen
Summary: LPC has been found to inhibit cell viability and induce apoptosis and autophagy in mouse ovarian granulosa cells, with the involvement of oxidative stress and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Dongmei Jiang, Xin Wang, Xuemin Zhou, Zelong Wang, Shuo Li, Qian Sun, Yilong Jiang, Chengweng Ji, Weikang Ling, Xiaoguang An, Bo Kang
Summary: This study investigated the effects of spermidine on oxidative stress and apoptosis in goose granulosa cells (GCs), and found that spermidine alleviated these effects by inducing autophagy. The results showed that spermidine could inhibit oxidative stress and apoptosis by regulating the expression of autophagy-related proteins.
Article
Agriculture, Multidisciplinary
Xuan Zhang, Yuanyuan Chen, Hongmin Li, Baobao Chen, Zhaojun Liu, Gang Wu, Chengyu Li, Rongyang Li, Yan Cao, Jiaqi Zhou, Ming Shen, Honglin Liu, Jingli Tao
Summary: The study found that Sulforaphane can alleviate the adverse effects of hypoxia on porcine granulosa cells by activating antioxidant defenses and mitophagy through nuclear factor erythroid 2-related factor 2 (NFE2L2).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Fisheries
Chunling Wang, Jingyu Pan, Xiaodan Wang, Xinyu Cai, Zhideng Lin, Qingchao Shi, Erchao Li, Jian G. Qin, Liqiao Chen
Summary: The research showed that dietary N-acetylcysteine (NAC) improved growth performance and survival of Chinese mitten crab fed T-2 toxin. A dosage of 0.1% NAC effectively alleviated oxidative stress, immunodepression, and apoptosis induced by T-2 toxin.
Review
Environmental Sciences
Youshuang Wang, Yu Liu, Tingyu Huang, Yunhe Chen, Wenxi Song, Fengjuan Chen, Yibao Jiang, Cong Zhang, Xu Yang
Summary: T-2 toxin, a highly toxic mycotoxin produced by Fusarium, is commonly found in contaminated feed and grains. It is difficult to remove this toxin from food, leading to unavoidable contamination and posing a major threat to human and animal health. Oxidative stress is the main cause of T-2 toxin poisoning, and Nrf2 plays a crucial role in this process. This review discusses the major ideas and emerging trends in future research, along with the molecular mechanism of Nrf2's involvement in T-2 toxin toxicity.
Article
Genetics & Heredity
Bo Zhai, Xu Li, Zhongli Zhao, Yang Cao, Xinxin Liu, Zheng Liu, Huihai Ma, Wenfa Lu
Summary: Melatonin is a potent scavenger of active oxygen and also functions as a reproductive hormone with regulatory effects on animal reproduction, particularly in the ovaries. The protective mechanisms of melatonin against oxidative damage in granulosa cells, especially in sheep, remain unclear. Our study explored the mechanisms of melatonin in alleviating apoptosis in sheep granulosa cells induced by H2O2 through the MAP3K8-FOS pathway.
Article
Biochemistry & Molecular Biology
Gaoqing Xu, Yangyunyi Dong, Zhe Wang, He Ding, Jun Wang, Jing Zhao, Hongyu Liu, Wenfa Lv
Summary: The study found that melatonin can promote mitophagy and inhibit oxidative-stress-induced apoptosis and mitochondrial injury in bovine ovarian granulosa cells through the SIRT1/FoxO1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Jia-Qing Zhang, Qiao-Ling Ren, Jun-Feng Chen, Bin-Wen Gao, Xian-Wei Wang, Zi-Jing Zhang, Jing Wang, Ze-Jun Xu, Bao-Song Xing
Summary: In pig granulosa cells under oxidative stress, early induction of autophagic flux contributes to oxidative stress-induced apoptosis in the cells.
REPRODUCTIVE SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li
Summary: This study investigated the therapeutic effect of isorhamnetin on ZEA-induced damage in porcine ovarian granulosa cells and elucidated its molecular mechanism. The results showed that isorhamnetin protected ovarian granulosa cells from ZEA-induced damage, promoting proliferation and alleviating apoptosis, endoplasmic reticulum stress, oxidative stress, and steroidogenesis disorder.
Article
Pharmacology & Pharmacy
Jieyu Cui, Yankun Li, Wenqiang Zhang, Hongrun Qian, Zhiying Zhang, Kun Xu
Summary: This study investigated the impact of alginic acid (AA) on the ovary and its cellular mechanism. The results showed that AA down-regulated the levels of estradiol and progesterone, induced oxidative stress, mitochondrial-mediated apoptosis, and autophagy. The animal experiments also confirmed the toxicity of AA on the ovary, resulting in a shortened estrus period in mice. These findings provide scientific basis for controlling the increasing use of AA.
Article
Biochemistry & Molecular Biology
IrantzuADD F. B. Perez-Ruiz, Jose-Ignacio Ruiz-Sanz, Maria-Luisa Hernandez, Rosaura Navarro, Marcos Ferrando, Zaloa Larreategui, Maria-Begona Ruiz-Larrea
Summary: This study provided the first evidence of the presence of mRNAs and proteins of the three members of the PON family in human ovarian granulosa cells, with active secretion of PON1 and PON3 by the cells. Additionally, it was discovered that PON2 mainly localized with mitochondria and the subcellular nucleo-cytoplasmic distribution of PON1 was associated with the cell cycle.