Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 32, Issue 3, Pages 406-416Publisher
ELSEVIER
DOI: 10.1016/j.etap.2011.08.007
Keywords
Antioxidant; Antiulcerogenic; Opuntia; Flowers; Ethanol; DNA
Funding
- Tunisian Ministry higher education, Scientific Research and Technology through the Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa
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The Opuntia ficus indica f. inermis methanolic flowers extract (OMFE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, linoleic acid peroxidation assays and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The OMFE was rich in polysaccharide, phenolics and flavonoids contents and exhibited a moderate in vitro antioxidant activity when compared with (+)-catechin and ascorbic acid. Pre-treatment with OMFE at oral doses 250, 500 and 1000 mg/kg body weight was found to provide a dose-dependent protection against ethanol-induced gastric ulcer by averting the deep necrotic lesions of the gastric epithelium, by preserving normal antioxidant enzymes activities, by inhibiting the lipid peroxidation, the oxidation of protein and the DNA fragmentation in gastric mucosa. The antiulcerogenic activity of OMFE might be due to a possible synergistic antioxidant and antihistaminic-like effects. (C) 2011 Elsevier B.V. All rights reserved.
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