Article
Marine & Freshwater Biology
Jiangong Jiang, Bingying He, Yimu Wei, Jingna Cui, Qiang Zhang, Xueke Liu, Donghui Liu, Peng Wang, Zhiqiang Zhou
Summary: This study investigated the potential toxic interactions of chlorpyrifos and p,p'-DDE on zebrafish. The results showed that the co-exposure of these pesticides resulted in significant additive acute toxic effects on adult zebrafish, as well as altered activity of antioxidant enzymes and decreased activity of certain enzymes related to detoxification. The bioaccumulation of these pesticides in co-exposure was significantly different from single exposure.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Chengxi Li, Bo Wang, Xue Lu, Yichao Huang, Hua Wang, Dexiang Xu, Jun Zhang
Summary: The research found that maternal cadmium exposure can result in reproductive developmental issues in female offspring on PND21, including delayed vaginal opening, irregular estrous cycle, and inhibited follicular development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, Research & Experimental
Simone Forcato, Ana Beatriz de Oliveira Aquino, Nathaly de Moura Camparoto, Hannah Hamada Mendonca Lens, Flavia Alessandra Guarnier, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin
Summary: The study showed that SAS treatment decreased maternal motivation in dams and induced reproductive alterations in F1 females, with an increase in lordosis behavior and lipid peroxidation in ovarian tissues at different life stages.
Article
Biochemistry & Molecular Biology
Ming-Kuei Shih, You-Lin Tain, Yu-Wei Chen, Wei-Hsuan Hsu, Yao-Tsung Yeh, Sam K. C. Chang, Jin-Xian Liao, Chih-Yao Hou
Summary: The study showed that Resveratrol butyrate esters (RBE) can suppress obesity and lipid accumulation caused by Bisphenol A (BPA) exposure in female offspring rats, optimize blood lipids, and modulate intestinal microbiota. RBE demonstrated excellent potential for perinatological research due to its regulatory effects on body weight, blood lipids, and gut microbiota in the offspring rats exposed to BPA.
Article
Environmental Sciences
Rui Sha, Yangsheng Chen, Yijing Wang, Yali Luo, Yiyun Liu, Yongchao Ma, Yunping Li, Li Xu, Heidi Qunhui Xie, Bin Zhao
Summary: The study found that maternal exposure to TCDD, especially at a low dose, increased movement ability, novelty-exploration, and certain anxiety-related behaviors in the offspring. These hyperactivity-like behaviors were accompanied by the upregulation of certain genes associated with cholinergic neurotransmission or synaptogenesis in the offspring brain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Shuwen He, Ping Li, Ling Liu, Zhi-Hua Li
Summary: The study found that TBT had the greatest impact on plasma metabolism in aquatic organisms, followed by MIX and Cd. Exposure to Cd and TBT can lead to metabolic abnormalities in TCA cycle-related pathways and interfere with energy metabolism.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xiu-Wen Li, Feng Qiu, Yi Liu, Li-Jian Chen, Jia-Hao Li, Jia-Li Liu, Jian-Zheng Yang, Clare Hsu, Long Chen, Jia-Hao Zeng, Xiao-Li Xie, Qi Wang
Summary: This study aimed to investigate the neuroinflammatory effects of 2-ethylhexyl diphenyl phosphate (EHDPHP) and the potential mitigating role of inulin. The results showed that EHDPHP significantly increased serum levels of IL-1β, IL-6, and MDA in both mothers and offspring, but decreased SOD levels, which were reversed by inulin supplementation. RNA-sequencing revealed that EHDPHP induced inflammation and oxidative stress through the TLR4/NF-κB pathway, which was mitigated by inulin. In conclusion, inulin ameliorated EHDPHP-induced neuroinflammation and oxidative stress in both mothers and offspring, highlighting its potential therapeutic role.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Bi-gui Lin, Cai-rong Chen, Xi-chao Chen, Jing Qiao, Qiu-xia Yan, Pan Yang, Wan-le Chen, Liang-zhong Li, Pei-chang Qiu, Cheng Ding, Dao-jian Huang, Yun-jiang Yu
Summary: Several studies have shown that organochlorine exposure can impact male reproductive functions, such as semen quality and thyroid hormones. This study found significant associations between PCB levels in seminal plasma and human semen quality, as well as thyroid hormones. Additionally, correlations were observed between serum pollutants levels and semen quality, reproductive hormones, and thyroid hormones.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Hongya Gan, Bingqi Zhu, Fangmei Zhou, Zhishan Ding, Jing Liu, Xiaoqing Ye
Summary: This study found that perinatal exposure to low doses of cypermethrin (CP) can promote the onset of puberty and regulate puberty-related hormones through the hypothalamic-pituitary-ovarian axis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Nair C. F. Castro, Izabelle S. Silva, Sabrina C. Cartagenes, Luanna M. P. Fernandes, Paula C. Ribera, Mayara A. Barros, Rui D. Prediger, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: This study evaluated the long-lasting neurobehavioral and nociceptive consequences in adult rats and mice exposed to morphine during pregnancy and lactation periods. The results showed that both male and female rats exhibited anxiety- and depressive-like behaviors, while mice displayed alterations in nociceptive responses. These findings suggest that intrauterine and lactation exposure to morphine can have long-lasting effects on psychological and pain responses in adulthood.
Article
Pharmacology & Pharmacy
Carla Elise Heinz Rieg, Daiane Cattani, Nathalia Ferrazzo Naspolini, Vitoria Hayduck Cenci, Vera Lucia de Liz Oliveira Cavalli, Amanda Virtuoso Jacques, Marcus Vinicius Pereira Dos Santos Nascimento, Eduardo Monguilhott Dalmarco, Ana Carolina Rabello De Moraes, Maria Claudia Santos-Silva, Fatima Regina Mena Barreto Silva, Eduardo Benedetti Parisotto, Ariane Zamoner
Summary: The present study investigated the effects of perinatal exposure to glyphosate-based herbicide (GBH) in offspring's liver. The results showed that perinatal exposure to GBH increased Ca2+ influx, oxidative damage and inflammation in the liver of offspring. Additionally, the study found that GBH exposure led to increased levels of iron in the liver, blood and bone marrow, which might contribute to iron-driven hepatotoxicity. These findings indicate the potential harmful effects of GBH on liver function in offspring.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Reproductive Biology
Jordana F. Zanol, Oscar M. S. Nin, Charles S. da Costa, Leandro C. Freitas-Lima, Leandro Miranda-Alves, Jones B. Graceli
Summary: The study revealed that exposure to TBT and HCD together can result in metabolic and reproductive abnormalities, exacerbating features of premature ovary failure in female rats.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Environmental Sciences
Zengjing Liu, Adam A. Szpiro, Tsegaselassie Workalemahu, Michael T. Young, Joel D. Kaufman, Daniel A. Enquobahrie
Summary: This study found associations between PM2.5 exposure and gestational weight gain and birth weight, which may be affected by exposure window and pre-pregnancy BMI. Further exploration of these associations is needed to better understand their impact on maternal and child health outcomes.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Feng Zhan, Ye-Cheng Wang, Quan-Mei Liu, Meng-Juan Guo, Hui-Min Zhu, Chi Zhang, De-Xiang Xu, Xiu-Hong Meng
Summary: The study found that paternal exposure to fenvalerate may transgenerationally affect spatial cognition in offspring, with gender differences in the effects. The signaling pathway of thyroid hormone receptor in the hippocampus may partially contribute to the cognitive impairment induced by paternal fenvalerate exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Sulagna Dutta, Bapi Gorain, Hira Choudhury, Shubhadeep Roychoudhury, Pallav Sengupta
Summary: Untainted environment promotes health, but environmental contaminants from human activities can have detrimental effects on female reproductive health, potentially leading to reproductive issues, infertility, and serious illnesses. Therefore, further research and management efforts are necessary to reduce the negative impacts of heavy metal exposure on female fertility.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)