Article
Environmental Sciences
Sailo Lalrinzuali, Maurya Khushboo, Roy Dinata, Baishya Bhanushree, Nisekhoto Nisa, Rema Momin Bidanchi, Saeed-Ahmed Laskar, Bose Manikandan, Giri Abinash, Buragohain Pori, Vikas Kumar Roy, Guruswami Gurusubramanian
Summary: Long-term consumption of fermented pork fat (FPF) food with excessive calories, high fat content, and high FAME levels induces oxidative stress, inflammation, and apoptosis, resulting in metabolic syndrome and hampering male reproductive system and functions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Penny A. F. Whiley, Benedict Nathaniel, Peter G. Stanton, Robin M. Hobbs, Kate L. Loveland
Summary: Adult male fertility depends on spermatogonial stem cells (SSCs) which undergo self-renewal or differentiation in response to microenvironmental signals. This study reveals that chronically elevated activin A affects SSC fate in vivo and suggests that it promotes a microenvironment supporting SSC self-renewal. Testis stromal tumours in Inha KO mice create a microenvironment that supports SSC self-renewal, offering a potential strategy for improving spermatogonial propagation in vitro.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Andrology
Anupam Yadav, Kiran Yadav, Arti Rajpoot, Bechan Lal, Raghav Kumar Mishra
Summary: Psychological stress is recognized as a major risk factor for male fertility. In this rat study, researchers found that psychological stress adversely affected testicular germ cell dynamics, testosterone biosynthesis, and oxidative balance.
Article
Biochemical Research Methods
P. Prathima, K. Venkaiah, R. Pavani, K. V. L. Shrikanya Rao, Gopi Krishna Pitchika, B. Kishori, Vijaya R. Dirisala, Jangampalli Adi Pradeepkiran, S. B. Sainath
Summary: The study aimed to investigate the changes in the testis transcriptome in adult rats of the F1 generation exposed to carbimazole prenatally. Transcriptomic analysis using NGS platform identified 187 differentially expressed genes in carbimazole exposed rats, which were involved in apoptotic pathways, solute carriers, nuclear receptors/zinc family members, steroidogenic pathway, cholesterol synthesis, growth factors, and protein kinases. The findings suggest that prenatal exposure to carbimazole affects key regulatory events associated with testicular functions, spermatogenesis, and steroidogenesis. The results provide valuable information for future studies addressing the developmental toxic effects of carbimazole on male reproductive health.
JOURNAL OF PROTEOMICS
(2023)
Article
Agriculture, Dairy & Animal Science
Megumi Shimazaki, Manita Wittayarat, Rentsenkhand Sambuu, Asami Sugita, Masaki Kawaguchi, Maki Hirata, Fuminori Tanihara, Mitsuhiro Takagi, Masayasu Taniguchi, Takeshige Otoi, Yoko Sato
Summary: This study investigated the proliferation and apoptosis status in the development of yaks and crossbred cattle-yaks. The results showed that proliferation and apoptosis only occurred in spermatogenic cells in yak testes, while crossbred cattle-yak testes had a higher proliferation ability and lower apoptosis ability in spermatogenic cells, suggesting disrupted balance between proliferation and apoptosis in sperm cell fate control.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Medicine, Research & Experimental
Samah M. Elaidy, Mohamed M. Tawfik, Angie M. Ameen, Wael Abdou Hassan, Iman El Sherif, Mona Karem Amin, Shereen E. Elkholy
Summary: Most of the published experiments about carbimazole-induced testicular injury are constructed in normal healthy animals, lacking translational identification. This study used a levothyroxine/carbimazole (LT4/CMZ) model in Wistar rats and found that metformin (MET) showed a dose-dependent ameliorative effect on LT4/CMZ-induced testicular toxicity without significant harmful effects on thyroid functions. These findings suggest that MET may have a protective role on the testicles of diabetic patients with thyroidal diseases.
Article
Reproductive Biology
Yao Ma, Xu-dong Jiang, Da-wei Zhang, Xiang-dong Zi
Summary: In this study, the yak TGIF1 gene was cloned and its functions in yak granulosa cells (GCs) were investigated. The results showed that TGIF1 regulates the proliferation, apoptosis, cell cycle progression, and steroidogenesis in yak GCs.
Article
Endocrinology & Metabolism
Weiguo He, Huiqing Liu, Linlin Hu, Yaohui Wang, Lane Huang, Aihong Liang, Xuan Wang, Qing Zhang, Yi Chen, Yi Cao, Suyun Li, Junli Wang, Xiaocan Lei
Summary: ICA effectively improves male reproductive dysfunction in diabetic rats by increasing cell proliferation and decreasing cell apoptosis in the testis. This suggests that ICA could be a novel therapeutic strategy against DM-induced testicular damages.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Qiqi Zhu, Shanshan Zhu, Qiyao Li, Yun Wang, Dongxu Zheng, Chunjiang Chen, Naqi Ruan, Haiqiong Chen, Haoni Yan, Han Lin, Ren-Shan Ge
Summary: Exposure to MTBE during late puberty compromises the development of Leydig cells in male rats by inhibiting cell proliferation, inducing mitochondrial autophagy and apoptosis, and indirectly stimulating Sertoli cells to secrete anti-Mullerian hormones, resulting in a reduced number of Leydig cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Obstetrics & Gynecology
Rashid A. Aldahhan, Peter G. Stanton, Helen Ludlow, David M. de Kretser, Mark P. Hedger
Summary: Experimental cryptorchidism in adult rats leads to complete spermatogenic failure, chronic testicular inflammation, edema, and fibrosis, impacting Sertoli and Leydig cell function at the molecular level.
REPRODUCTIVE SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Vanrohlu Nicy, Milirani Das, Guruswami Gurusubramanian, Pradip Mondal, Vikas Kumar Roy
Summary: CuNPs have adverse effects on the testis, impairing spermatogenesis through oxidative stress-mediated DNA damage and germ cell apoptosis.
Article
Biochemistry & Molecular Biology
Anandha R. Ravula, Suresh Yenugu
Summary: The study reveals that long-term exposure to a mixture of pyrethroids can lead to abnormalities in the transcriptome of factors involved in sperm production and development in rats.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Sara Falvo, Sergio Minucci, Alessandra Santillo, Rosalba Senese, Gabriella Chieffi Baccari, Massimo Venditti
Summary: This study investigates the impact of a short-term high-fat diet on testicular activity, specifically focusing on steroidogenesis and spermatogenesis in rats. The findings demonstrate that the high-fat diet leads to reduced steroid synthesis, increased apoptosis of spermatogenic cells, and altered spermatogenesis. The study also reveals the involvement of mitochondrial dynamics, blood-testis barrier integrity, and SIRT1/NRF2/MAPKs pathways in the observed effects.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Kai O. Skaftnesmo, Diego Crespo, Lene Kleppe, Eva Andersson, Rolf B. Edvardsen, Birgitta Norberg, Per Gunnar Fjelldal, Tom J. Hansen, Rudiger W. Schulz, Anna Wargelius
Summary: The study showed that the function of the stra8 gene in Atlantic salmon plays a crucial role in the development of germ cells in the testis, with its loss leading to increased germ cell apoptosis. However, most mutants were still able to produce functional sperm.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Farima Rahimi Mansour, Mohammad Nabiuni, Elaheh Amini
Summary: Aluminum, a widely used metal, can affect the ovaries and granulosa cells by up-regulating steroidogenic and proliferative genes. Additionally, aluminum may induce issues such as apoptosis and autophagy.