Article
Environmental Sciences
Sumitra Arora, Anu Kumar
Summary: This study investigated the response of AChE in the brain of silver perch fingerlings exposed to OP and CB insecticides, and evaluated the toxicological interaction of these chemicals. The study found the inhibitory effects of various insecticides on AChE, as well as observed synergistic and antagonistic effects between different insecticide combinations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Agronomy
Christian Ritz, Jens C. Streibig, Andrew Kniss
Summary: This article reviews statistical approaches for analyzing pesticide mixture experiment data, discussing different dose designs and antagonistic and synergistic effects. Factorial designs should be analyzed using two-way analysis of variance, while fixed-ratio designs should be analyzed using non-linear dose-response analysis. Dose addition and independent action serve as references for the lack of antagonistic and synergistic effects, with fixed-ratio designs being more suitable for validating dose-response relationships.
PEST MANAGEMENT SCIENCE
(2021)
Article
Ecology
Yuxuan Zhang, Peiyong Guo, Meixian Wang, Yanmei Wu, Yinshi Sun, Haitao Su, Jun Deng
Summary: The acute toxicities of chloramphenicol, thiamphenicol, florfenicol, and their mixtures on Daphnia magna vary under different temperatures, with toxicity significantly increasing at 25 degrees Celsius. The phenicol antibiotic mixtures generally exhibit a dual synergism-antagonism effect, and the Combination Index equation appears to be more suitable for predicting their toxicity values compared to other models. Overall, phenicol antibiotic mixtures with temperature variation may pose greater hazards and risks to aquatic organisms and the environment.
Article
Geochemistry & Geophysics
Wenshuai Li, Xiao-Ming Liu
Summary: This study investigated the dissolution of ferrihydrite in the presence of phosphorus and siderophores, revealing the formation of complex Fe-P precipitates under different pH conditions. Phosphorus was found to promote initial Fe release from minerals but subsequently prevent further attacks from protons and siderophores. Overall, there is an antagonistic relationship between phosphorus compounds and siderophores on ferrihydrite dissolution, providing insights into biologically-mediated Fe cycling in natural systems.
APPLIED GEOCHEMISTRY
(2021)
Article
Environmental Sciences
Li-Tang Qin, Min Liu, Xin Zhang, Ling-Yun Mo, Hong-Hu Zeng, Yan-Peng Liang
Summary: The study investigated the toxicological interactions of HAA mixtures in green algae and predicted DBP mixture toxicities based on different models. Results showed that mixture effects were synergistic in 47.1% and antagonistic in 25%, while additive effects were only observed in 27.9% of experiments. Predictive models failed to accurately predict mixture toxicity.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Environmental Sciences
Samuel J. Macaulay, Kimberly J. Hageman, Jeremy J. Piggott, Christoph D. Matthaei
Summary: The global intensification of agriculture has led to pesticides playing an increasingly important role in environmental change. This study investigates the combined effects of the widely used insecticide imidacloprid, heatwaves, and food limitation on freshwater organisms. The results show that heatwaves have drastic negative effects on mayflies, while imidacloprid exhibits cumulative toxicity over time.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Microbiology
Eva Armengol, Kasper Norskov Kragh, Tim Tolker-Nielsen, Josep M. Sierra, Doaa Higazy, Oana Ciofu, Miguel Vinas, Niels Hoiby
Summary: The combination of colistin and rifampicin has been found to effectively kill colistin-resistant Pseudomonas aeruginosa, suggesting it as a promising treatment for infections caused by this strain.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Horticulture
Zhengyu Huang, Kimberly Ann Falco
Summary: Calculating the predicted biological efficacy and determining the significance of the difference between the predicted and measured efficacy are essential in assessing the synergy of mixtures. An appropriate method for evaluating synergy of growth-affecting mixtures is needed within the scientific community.
Article
Environmental Sciences
Juanjuan Zhou, Ningning Du, Dongqin Li, Junhao Qin, Huashou Li, Guikui Chen
Summary: The study showed that Cr(VI) was more toxic to Daphnia carinata than perchlorate as a single contaminant. In terms of combined effects, the interactions between perchlorate and Cr(VI) displayed additivity, antagonism, and synergism on survival, growth, and reproduction endpoints.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Marine & Freshwater Biology
Thandy Junio da Silva Pinto, Juliane Silberschmidt Freitas, Raquel Aparecida Moreira, Lais Conceicao Menezes da Silva, Maria Paula Cardoso Yoshii, Lais Fernanda de Palma Lopes, Bianca Veloso Goulart, Marina Reghini Vanderlei, Danillo Badolato Athayde, Priscille Dreux Fraga, Allan Pretti Ogura, Luis Schiesari, Cassiana Carolina Montagner, Michiel Adriaan Daam, Evaldo Luiz Gaeta Espindola
Summary: The study examined the effects of pesticides and vinasse on the survival, behavior, and reproduction of indigenous aquatic invertebrates, finding that at higher concentrations, these chemicals lead to decreased survival rates and negatively impact reproduction.
AQUATIC TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Sarita Rani, Rakesh K. Sahoo, Vinay Kumar, Akash Chaurasiya, Onkar Kulkarni, Ashutosh Mahale, Sumeet Katke, Kaushik Kuche, Vivek Yadav, Sanyog Jain, Kartik T. Nakhate, Ajazuddin, Umesh Gupta
Summary: Breast cancer is the deadliest disease among women, and multidrug therapy has shown greater efficacy compared to monodrug therapy. Caffeic acid and bortezomib have potential anticancer and antioxidant properties. A HP-PCL PMCs system was developed for simultaneous delivery of bortezomib and caffeic acid in breast cancer treatment. In vitro and in vivo experiments demonstrated that the designed PMCs system exhibited enhanced therapeutic efficiency against breast cancer.
MOLECULAR PHARMACEUTICS
(2023)
Article
Environmental Sciences
Anastasios A. Malandrakis, Nektarios Kavroulakis, Constantinos V. Chrysikopoulos
Summary: The antifungal potential of ZnO-NPs against Alternaria alternata isolates with reduced sensitivity to the succinate dehydrogenase inhibitor (SDHI) boscalid was evaluated. ZnO-NPs effectively inhibited mycelial growth, especially when combined with boscalid. The study found that zinc ion release and nanoparticle properties interfering with cellular ion homeostasis mechanisms may contribute to the fungitoxic effect of ZnO-NPs, and ROS production may also play a role.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Yan Pei, Xun Liu, Mengbo Cao, Zijun Wang, Hongbing Yang
Summary: Heteroatom doping can reconfigure the electronic structure of heterogeneous catalysts, leading to the development of advanced oxidation water purification materials with superior performance and stability. In this study, a series of catalysts with different elemental doping were prepared using a simple and environmentally friendly method. The S-doped NiCo2O4 catalyst showed excellent catalytic performance for the removal of Tetracycline, with significantly increased kinetic constant and high oxidation and mineralization efficiency in a wide pH range. The degradation process was dominated by non-radical oxidation pathway after S doping, and the overall process moved towards low toxicity.
ENVIRONMENTAL RESEARCH
(2024)
Article
Multidisciplinary Sciences
Wenhong Li, Lu Lv, Yanhua Wang, Yu-Cheng Zhu
Summary: This study investigated the toxic effects of pesticide mixtures on honey bees in the field. Results showed that thiamethoxam had the highest toxicity, followed by methomyl and dimethoate, while pyrethroids and tetraconazole had relatively low toxicities. Some combinations of pesticides exhibited synergistic effects on honey bees, while others showed antagonistic effects. Pesticide combinations containing thiamethoxam and tetraconazole displayed synergistic toxicities to the bees.
SCIENTIFIC REPORTS
(2023)
Review
Medical Laboratory Technology
Mohsen Heidary, Ahmad Ebrahimi Samangani, Abolfazl Kargari, Aliakbar Kiani Nejad, Ilya Yashmi, Moloudsadat Motahar, Elahe Taki, Saeed Khoshnood
Summary: This review examines the clinical and biochemical aspects of azithromycin and highlights its benefits and drawbacks. The study finds that azithromycin has a wide range of antimicrobial effects and can be used to treat various diseases, but there is an increasing global prevalence of azithromycin resistance. The review recommends using combination therapy with other drugs to address different pathogens.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Environmental Sciences
Alice A. Horton, Richard K. Cross, Daniel S. Read, Monika D. Juergens, Hollie L. Ball, Claus Svendsen, Jes Vollertsen, Andrew C. Johnson
Summary: Analysis of samples from wastewater treatment works in the UK showed high removal rates of various types of microplastics during the treatment process, with sludge samples revealing higher concentrations than previously reported. The most common polymers identified were polyethylene, polypropylene, and polyethylene terephthalate.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
E. Lahive, C. L. Schultz, C. A. M. Van Gestel, A. Robinson, A. A. Horton, D. J. Spurgeon, C. Svendsen, M. Busquets-Fite, M. Matzke, A. Green Etxabe
Summary: The study revealed that different types of nanosilver accumulate differently in crop plants, with Ag-0 NMs showing the highest uptake and Ag2S NMs exhibiting lower accumulation, unaffected by size variations.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Engineering, Environmental
Carolin L. Schultz, Sylvain Bart, Elma Lahive, David J. Spurgeon
Summary: Surface functionalization and eco-corona formation can modulate the toxicity of nanoplastics, altering the potency and order of toxicity. The effects of surface charges on nanoplastic toxicity are primarily linked to differences in effect thresholds and dose-associated damage parameters, rather than toxicokinetic parameters. Eco-corona interactions between particles can reduce toxicity, but the order of potency of charged forms remains consistent.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Janeck James Scott-Fordsmand, Monica Joao de Barros Amorim, Camille de Garidel-Thoron, Vincent Castranova, Barry Hardy, Igor Linkov, Ilise Feitshans, Gregory Nichols, Elijah Joel Petersen, David Spurgeon, Sally Tinkle, Ulla Vogel, Paul Westerhoff, Mark Robert Wiesner, Christine Ogilvie Hendren
Summary: Assessing the risk of nanomaterials is crucial for society, and effective cross-Atlantic collaboration is needed to solve essential issues related to their use.
NATURE NANOTECHNOLOGY
(2021)
Article
Ecology
Henny O. Omosigho, Elmer Swart, Tom P. Sizmur, Dave J. Spurgeon, Claus Svendsen, Liz J. Shaw
Summary: Earthworms play a crucial role in soil ecosystems, particularly in functions like organic matter decomposition and nutrient cycling. Antibiotic treatment successfully suppressed the earthworm-associated microbiome, providing a valuable tool for future ecological studies on earthworm microbial interactions affecting host health and function.
EUROPEAN JOURNAL OF SOIL BIOLOGY
(2022)
Article
Environmental Sciences
Elma Lahive, Richard Cross, Aafke Saarloos, Alice A. Horton, Claus Svendsen, Rudolf Hufenus, Denise M. Mitrano
Summary: Microplastic fibres and nanoplastics have the potential to harm soil organisms. This study used inorganic tracers to quantify the uptake of these particles in earthworms. The results showed that both types of particles can be retained in the earthworms for extended periods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
R. D. Handy, N. J. Clark, D. Boyle, J. Vassallo, C. Green, F. Nasser, T. L. Botha, V Wepener, N. W. van den Brink, C. Svendsen
Summary: This study aimed to predict the bioaccumulation potential of manufactured nanomaterials (MNs) in fish using alternative methods. It explored the physico-chemical properties of MNs, measured metal uptake through the ex vivo gut sac technique, and simulated bioaccessible metal through an in chemico digestibility assay. The results showed that the liver's nano biomagnification factor (nBMF) had the best correlation with the physico-chemical parameters, and the in chemico digestibility assay could predict bioaccumulation potential. The ex vivo gut sac technique also correlated well with in vivo results.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Environmental Sciences
Nina Jeliazkova, Eric Bleeker, Richard Cross, Andrea Haase, Gemma Janer, Willie Peijnenburg, Mario Pink, Hubert Rauscher, Claus Svendsen, Georgia Tsiliki, Alex Zabeo, Danail Hristozov, Vicki Stone, Wendel Wohlleben
Summary: This paper discusses methods for grouping nanoforms and evaluating data similarity, emphasizing the property-by-property evaluation of the data matrix to support grouping. Multidimensional approaches were found to offer unexpected insights from a scientific perspective, but were deemed difficult to use in a regulatory context.
Article
Environmental Sciences
Frederic Loosli, Kirsten Rasmussen, Hubert Rauscher, Richard K. Cross, Nathan Bossa, Willie Peijnenburg, Josje Arts, Marianne Matzke, Claus Svendsen, David Spurgeon, Per Axel Clausen, Emmanuel Ruggiero, Wendel Wohlleben, Frank von der Kammer
Summary: Before introducing a new nanoform on the market, it is important to evaluate its potential adverse effects through hazard and risk assessment. Grouping and read-across of nanoforms can help reduce resource consumption and maximize the use of existing data for assessment. The impact of nanoforms on human health and the environment depends greatly on their concentration and physicochemical properties, making knowledge of these properties essential for assessing similarity.
Article
Ecology
Willem Proesmans, Christopher Andrews, Alan Gray, Rob Griffiths, Aidan Keith, Uffe N. Nielsen, David Spurgeon, Richard Pywell, Bridget Emmett, Adam J. Vanbergen
Summary: Cattle grazing has profound effects on the abiotic and biotic characteristics of forest ecosystems, including modifications to soil environment and changes in microbial and invertebrate communities.
ECOLOGY AND EVOLUTION
(2022)
Article
Engineering, Environmental
David Spurgeon, Helen Wilkinson, Wayne Civil, Lorraine Hutt, Elena Armenise, Natalie Kieboom, Kerry Sims, Tim Besien
Summary: Semi-quantitative GC-MS and LC-MS measurements were used to assess the overall magnitude and contribution of organic chemicals to mixture hazard in groundwater and surface waters. The analysis showed that the hazard from a mixture of substances was higher than that from any single chemical, but the contribution of the most important chemical to the overall mixture effect was not large.
Article
Environmental Sciences
Claire Badder, Sylvain Bart, Alex Robinson, Helen Hesketh, Peter Kille, David J. Spurgeon
Summary: In this study, a new bioassay method was developed to assess the sensitivity of lepidopteran larvae to pesticides through dietary exposure. The study demonstrated the repeatability and reliability of the method, as well as its potential to observe sub-lethal effects. The findings have important implications for chemical risk assessments and other scenarios.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Chemistry, Analytical
Alex Billings, Kevin C. Jones, M. Gloria Pereira, David J. Spurgeon
Summary: Modern society heavily relies on plastics, leading to widespread macro- and microplastic pollution in every environmental compartment on Earth. Plasticisers, chemicals added to plastics for flexibility, are also prevalent in the environment and can contaminate remote areas through long-range transport. The persistence and potential risks of plasticisers in soil, as well as the need for research on emerging alternatives, highlight the ongoing environmental impact and management challenges posed by these chemicals in the broader plastics debate.
ENVIRONMENTAL CHEMISTRY
(2021)