Journal
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 28, Issue 3, Pages 603-608Publisher
WILEY
DOI: 10.1897/08-317.1
Keywords
2,4,6-Trichlorophenol; Zebrafish; p53 Gene; Point mutation; Genotoxicity
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Funding
- National Natural Science Foundation of China [20577022]
- Ministry of Science and Technology of China [2008CB418102]
- Natural Science Foundation of Jiangsu Province, China [BK2007141]
- Funds for Distinguished Scholars in Six Scientific Fields of Jiangsu Province, China
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Trichlorophenol (2,4,6-trichlorophenol [TCP]), a probable human carcinogen, is widely present in the environment. Employing denaturing high-performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10-d exposure of zebrafish to TCP at 5 mu g/L resulted in elevated point mutations of p53 gene in the liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in the somatic genome.
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