Article
Rheumatology
Reuven Mader, Nicola Pappone, Xenofon Baraliakos, Iris Eshed, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Amir Bieber, Irina Novofastovski, David Kiefer, Jorrit-Jan Verlaan, Pasquale Ambrosino, Dan Buskila, Jacome Bruges Armas, Muhammad Asim Khan
Summary: Diffuse Idiopathic Skeletal Hyperostosis (DISH) is considered a metabolic condition with possible involvement of inflammation as a non-metabolic mechanism. Inflammation may play a role in promoting new bone formation in DISH, and further research is needed to better understand the mechanisms for early detection and management.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Medicine, General & Internal
Teresa Clavaguera, Patricia Reyner, Maria Buxo, Marta Valls, Eulalia Armengol, Xavier Juanola
Summary: This study examined different phenotypes of DISH patients based on clinicoradiological features, identifying peripheral, axial, and mixed patterns. The results indicated distinct clinical characteristics and disease progression among DISH patients, with the peripheral pattern standing out. Suggestions were made to include extravertebral manifestations in new classification criteria to cover the entire spectrum of the disease.
MEDICINA-LITHUANIA
(2021)
Article
Clinical Neurology
Scott McCarty, Jacob J. Bruckner, Jael E. Camacho, Julio J. Jauregui, Alexandra E. Thomson, Ivan Ye, Daniel L. Cavanaugh, Eugene Y. Koh, Steven C. Ludwig, Daniel E. Gelb
Summary: This study analyzed the outcomes and complications of patients with thoracic and lumbar fractures in the setting of ankylosing spinal disorders treated with minimally invasive surgery. The study found that DISH patients experienced more post-operative complications compared to AS and advanced spondylosis patients.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Maximilian Schwendner, Martin Seule, Bernhard Meyer, Sandro M. Krieg
Summary: This study evaluated patient characteristics and procedures in patients with ankylosing spinal disorders (ASDs), finding that timely preoperative imaging and surgical treatment procedures are crucial for patient outcomes.
NEUROSURGICAL FOCUS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riku M. Vierunen, Ville V. Haapamaki, Mika P. Koivikko, Frank V. Bensch
Summary: This study retrospectively reviewed MRI findings of 70 patients with spinal ankylosis from DISH, revealing that 49% had spinal epidural hematoma and 4% had spinal subdural hematoma. It was found that spinal epidural hematoma can cause spinal cord impingement and progress to spinal cord injury.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Yuji Tsuchikawa, Naosuke Kamei, Kiyotaka Yamada, Toshio Nakamae, Nobuo Adachi, Yoshinori Fujimoto
Summary: The aim of the study was to determine the poor prognostic factors of balloon kyphoplasty for fractures of the distal vertebrae in ankylosing spines with diffuse idiopathic skeletal hyperostosis. The change in wedge angle was significantly associated with delayed bone healing, suggesting that balloon kyphoplasty alone should be avoided in patients with a difference of ≥10° in the wedge angle.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Medicine, General & Internal
Hisanori Ikuma, Tomohiko Hirose, Dai Nakamura, Kazutaka Yamashita, Masataka Ueda, Kazuhiro Sasaki, Keisuke Kawasaki
Summary: This study conducted a cross-sectional survey on DISH patients and found that DISH is most prevalent at the thoracolumbar junction. Age and hyperostosis around the costovertebral joint were identified as related factors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacopo Ciaffi, Elena Borlandelli, Gaia Visani, Giancarlo Facchini, Marco Miceli, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Ursini
Summary: The purpose of this study was to provide updated information on the prevalence of DISH in Italy and describe the clinical and radiographic characteristics associated with the disorder. The results showed that the prevalence of DISH was higher in men and was significantly associated with factors such as age, BMI, diabetes, hypertension, and enthesopathies.
Article
Chemistry, Multidisciplinary
Norihiro Nishida, Fei Jiang, Junji Ohgi, Masahiro Fuchida, Rei Kitazumi, Yuto Yamamura, Rui Tome, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Xian Chen, Takashi Sakai
Summary: Patients with DISH are more prone to stress on vertebrae, and stresses on vertebrae and intervertebral discs differ depending on the morphology of ossification, even with similar loads. Examining ossification geometry may help surgeons determine the elevated position of stress in the thoracolumbar spine of patients with DISH, contributing to an understanding of the pathogenesis of pain.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Ryosuke Hirota, Atsushi Teramoto, Mitsunori Yoshimoto, Hiroyuki Takashima, Naomi Yasuda, Arihiko Tsukamoto, Noriyuki Iesato, Makoto Emori, Kousuke Iba, Nobuyoshi Kawaharada, Toshihiko Yamashita
Summary: This study investigated the association between the incidence and severity of DISH with vascular calcification and the occurrence of cardiovascular events in heart failure patients. The results showed a higher incidence of DISH in the cardiovascular events group, and DISH patients had more calcification of the coronary arteries and aorta. These findings suggest a correlation between DISH and cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Geoffrey O. Littlejohn
Summary: Diffuse idiopathic skeletal hyperostosis (DISH) is a common disorder in human history with diverse distribution in ancient populations. Metabolic factors play an important role in ancient populations affected by DISH.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Marie Wetterslev, Mikkel Ostergaard, Inge J. Sorensen, Ulrich Weber, Anne G. Loft, Gina Kollerup, Lars Juul, Gorm Thamsborg, Ole R. Madsen, Jakob M. Moller, Susanne J. Pedersen
Summary: This study aimed to combine the SPARCC SIJ structural score into three versions of a novel axSpA MRI SIJ Composite Structural Damage Score (CSDS) and test these in patients with axSpA. The results showed that CSDS stepwise and CSDS hierarchical demonstrated good construct validity and responsiveness, supporting further validation in larger clinical trials. The potential clinical implication is the assessment of SIJ damage progression by a composite score.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Lauren K. Ridley, Mark C. Hwang, John D. Reveille, Lianne S. Gensler, Mariko L. Ishimori, Matthew A. Brown, Mohammad H. Rahbar, Amirali Tahanan, Michael M. Ward, Michael H. Weisman, Thomas J. Learch
Summary: This study investigated a subgroup of patients with ankylosing spondylitis (AS) who had long-standing disease and fused sacroiliac (SI) joints and found that females and males with early symptom onset had less radiographic damage in the SI joints. All 23 patients without syndesmophytes were HLA-B27 positive.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Jean W. Liew, S. Reza Jafarzadeh, Maureen Dubreuil, Susan R. Heckbert, Stephen J. Mooney, Matthew A. Brown, Mariko L. Ishimori, John D. Reveille, Michael M. Ward, Michael H. Weisman, Lianne S. Gensler
Summary: This study found no significant association between TNFi use and incident hypertension in a longitudinal cohort of patients with ankylosing spondylitis.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Georg Schett, Xenofon Baraliakos, Filip Van den Bosch, Atul Deodhar, Mikkel Ostergaard, Ayan Das Gupta, Shephard Mpofu, Todd Fox, Adam Winseck, Brian Porter, Abhijit Shete, Lianne S. Gensler
Summary: The study demonstrated that Secukinumab has significant efficacy in improving enthesitis in patients with ankylosing spondylitis, particularly in the axial and overall MASES scores, showing substantial improvements in patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Surgery
H. Pelet, S. Tunon de Lara, C. Pfirrmann, P. Meynard, L. Harper, A. Angelliaume, X. Berard, Y. Lefevre
Summary: An 11-year-old boy presented with pain in the right knee, intermittent reverse ischemia of the right foot, and paraesthesia of the right toes. Imaging revealed a false aneurysm in the right superior popliteal artery and a singular osteochondroma in the posterior aspect of the distal femur. Two-stage surgeries were performed to excise the aneurysm and osteochondroma. At a 1-year follow-up, the patient was clinically well.
ACTA CHIRURGICA BELGICA
(2022)
Article
Orthopedics
Martin C. Berli, Kai Higashigaito, Tobias Gotschi, Christian W. A. Pfirrmann, Reto Sutter, Andrea B. Rosskopf
Summary: A new MRI scoring system (Balgrist Score) was developed for assessment of active Charcot foot with excellent interreader agreement. The Balgrist Score can help to identify patients requiring off-loading treatment for >= 90 days.
SKELETAL RADIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Christian W. A. Pfirrmann
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim Fischer, Christoph Stern, Benjamin Fritz, Patrick O. Zingg, Christian W. A. Pfirrmann, Reto Sutter
Summary: The study found that increased postoperative FA after THA was associated with MRI findings of acute as well as acute and chronic IFI. Findings of IFI were commonly seen in women.
Article
Orthopedics
Kai Higashigaito, Christian W. A. Pfirrmann, Sarah Koch, Dimitri Graf, Andreas Schweizer, Daniel Nanz, Andrea B. Rosskopf
Summary: The study evaluated the MRI anatomy of the STT ligament complex in asymptomatic and symptomatic individuals, showing that increased signal intensity of rpSTL is more frequent in patients with radial-sided wrist pain.
SKELETAL RADIOLOGY
(2022)
Article
Orthopedics
Julien Galley, Reto Sutter, Christoph Germann, Christian W. A. Pfirrmann
Summary: The presence of the Vulcan salute sign on conventional radiographs is specific for Morton's neuroma. The study also found significant differences in interphalangeal angles between patients with Morton's neuroma and controls, while there was no significant difference in intermetatarsal angle I/V between the groups. Interobserver agreement was substantial for the V-sign, and excellent for angle measurements.
SKELETAL RADIOLOGY
(2022)
Article
Orthopedics
B. Fritz, J. Fritz, S. F. Fucentese, C. W. A. Pfirrmann, R. Sutter
Summary: This study compared the quantification of femorotibial joint space using different imaging techniques, and found that weight-bearing cone beam CT combined with 3D-analysis allows for more detailed assessment of the joint space, demonstrating significantly more bone-on-bone appositions compared to weight-bearing conventional radiographs.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Ophthalmology
Livia Faes, Kathrin Golla, Meriam Islam, Kenny R. Lienhard, Martin K. Schmid, Dawn A. Sim, Lucas M. Bachmann
Summary: This study evaluates the usability and long-term adherence to the mobile hyperacuity app Alleye in patients with retinal pathology. The majority of patients showed satisfaction with the usability and had a positive attitude towards its trustworthiness and usefulness.
Article
Ophthalmology
Frantisek Sanak, Philipp Baenninger, Katja Iselin, Claude Kaufmann, Lucas Bachmann, Daniela Buhl, Michael Thiel
Summary: This study measured the concentration of VEGF-A in SED and PRGF eye drops, and found that the VEGF concentration was significantly higher in SED compared to PRGF. This is an important finding for the potential treatment of dry eye disease in patients with neuropathic eye disease.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Ophthalmology
Frantisek Sanak, Livia Faes, Leila Eppenberger, Philipp Baenninger, Claude Kaufmann, Kathrin Golla, Lucas Bachmann, Daniela Buhl, Martin K. Schmid, Michael Thiel
Summary: This study evaluates the effectiveness of protective measures on the risk of SARS-CoV-2 infection among employees in a large public eye hospital. The results show that these measures are effective in preventing the transmission of SARS-CoV-2 and there is no significantly higher risk of infection for physicians compared to other staff members.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Orthopedics
Tina Passon, Christoph Germann, Benjamin Fritz, Christian Pfirrmann, Reto Sutter
Summary: The purpose of this study was to investigate the predictive value of talar head edema in acute ankle sprain for the presence of concomitant ligament injuries. The results showed that patients with talar head edema had more severe ligament injuries compared to patients without talar head edema. Talar head edema was associated with medial and lateral collateral ligament complex injuries, indicating severe ankle trauma.
SKELETAL RADIOLOGY
(2022)
Article
Orthopedics
Thorsten Jentzsch, Yann K. Meyer, Ines Unterfrauner, Andrea B. Rosskopf, Christian W. Pfirrmann, Patrick O. Zingg
Summary: This retrospective cohort study aimed to investigate the correlation between pain relief after injection and arthroplasty. The study included 88 patients who received intra-articular hip injection before primary total hip arthroplasty. Pain scores were compared at different stages, and it was found that the response to injection could predict pain relief after arthroplasty. The response to local anaesthetic in the diagnostic phase might be a better predictor than corticosteroids. Majority of patients with osteoarthritis can expect better pain relief after arthroplasty compared to the therapeutic phase after injection.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Ophthalmology
Livia Faes, Peter M. Maloca, Katja Hatz, Thomas J. Wolfensberger, Marion R. Munk, Dawn A. Sim, Lucas M. Bachmann, Martin K. Schmid
Summary: Ophthalmology faces challenges in providing eye care to an increasing group of people. Health systems will be pushed to their limits due to the quantitative patient increase and new treatment availability. Better networking and patient involvement can lead to efficiency gains, and digitalization has shown potential during the pandemic.
Article
Urology & Nephrology
Stephanie A. Stalder, Oliver Gross, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Veronika Birkhauser, Mirjam Bywater, Giulio del Popolo, Daniel S. Engeler, Enrico Finazzi Agro, Susanne Friedl, Nuno Grilo, Stephan Kiss, Miriam Koschorke, Lorenz Leitner, Martina D. Liechti, Ulrich Mehnert, Stefania Musco, Helen Sadri, Lara Stachele, Jure Tornic, Stephanie van Der Lely, Stephen Wyler, Thomas M. Kessler
Summary: This study protocol describes a randomized controlled trial investigating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). The primary outcome is improvement in bladder diary variables at study end compared to baseline values. Secondary outcomes include urodynamic, neurophysiological, and bowel function measures, as well as safety assessments.
Article
Orthopedics
Martin C. Berli, Nicolas Azaiez, Tobias Gotschi, Christian W. A. Pfirrmann, Ilker Uckay, Reto Sutter, Felix W. A. Waibel, Andrea B. Rosskopf
Summary: This study evaluated the distribution and severity of muscle atrophy in diabetic patients with active Charcot foot (CF) compared to those without CF, and correlated the muscle atrophy with the severity of CF disease.
SKELETAL RADIOLOGY
(2023)