Article
Immunology
Yohei Maki, Toshihiro Kushibiki, Tomoya Sano, Takunori Ogawa, Eri Komai, Shusaku Takahashi, Etsuko Kitagami, Yusuke Serizawa, Ryosuke Nagaoka, Shinya Yokomizo, Takeshi Ono, Miya Ishihara, Yasushi Miyahira, Satoshi Kashiwagi, Akihiko Kawana, Yoshifumi Kimizuka
Summary: This study investigates the effect of 1270 and 1064 nm wavelengths on laser adjuvant effects and demonstrates that 1270 nm can achieve the same effect as 1064 nm at lower energy levels, with medium-to-long-lasting antibody titers. The findings also suggest that the effects of laser adjuvants vary depending on the wavelength.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dhivya Venkatesan, Mahalaxmi Iyer, Neethu Raj, Abilash Valsala Gopalakrishnan, Arul Narayanasamy, Nachimuthu Senthil Kumar, Balachandar Vellingiri
Summary: Parkinson's disease is caused by genetic and environmental factors, with the mitochondrial impact being one of the contributing reasons. High ROS levels, decreased MMP and ATP, as well as tRNA alterations, were found in late-onset PD patients. Early-onset PD patients had significant mutations in tRNAThr and tRNAGln. These findings suggest that aging disrupts tRNA metabolism, affecting ATP synthesis and MMP, leading to oxidative stress in PD patients.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Jiancheng Yang, Shaojie Zhou, Min Wei, Yanwen Fang, Peng Shang
Summary: Moderate-intensity static magnetic fields (SMFs) have been shown to effectively alleviate menopause-induced bone loss in animal models. SMF prevented the reduction of BMD and BMC, improved bone microarchitecture, mitigated mechanical property reduction, and had significant effects on bone cell formation.
IEEE TRANSACTIONS ON MAGNETICS
(2021)
Article
Cell Biology
Desiree Forstner, Jacqueline Guettler, Beatrice A. Brugger, Freya Lyssy, Lena Neuper, Christine Daxboeck, Gerhard Cvirn, Julia Fuchs, Kristin Kraeker, Alina Frolova, Daniela S. Valdes, Christina Stern, Birgit Hirschmugl, Herbert Fluhr, Christian Wadsack, Berthold Huppertz, Olivia Nonn, Florian Herse, Martin Gauster
Summary: Tissue insults in response to inflammation, hypoxia and ischemia cause the release of ATP, which modulates various pathological processes. CD39 and CD73 are two major enzymes that convert extracellular ATP into adenosine. This study investigated the expression of CD39 and CD73 in placental tissue and their regulation in response to platelet-derived factors and oxygen conditions. The results showed that placental CD39 expression increased in preeclampsia and platelet-derived factors led to deregulated CD39 expression. CD39 overexpression decreased extracellular ATP levels and abolished the upregulation of pro-inflammatory cytokine interleukin-1 beta. These findings suggest that increased placental CD39 could be an important anti-coagulant defense mechanism of the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Nadine Mundt, Lina Kenzler, Marc Spehr
Summary: Adenosine triphosphate (ATP) is not only the essential source of cellular energy, but also functions as an extracellular signal that activates purinergic receptors. Purinergic signaling plays a crucial role in male reproductive system functions, particularly in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Estefaniia Delgado-Pinar, Matilde Medeiros, Telma Costa, J. Sergio Seixas de Melo
Summary: Chemical derivatives of PEI with either TPA or Cou can form stable complexes with adenine and guanine nucleotides in water based on noncovalent interactions such as pi-pi stacking and hydrogen bonding. PEI-TPA acts as a chemosensor with recognition based on AIE and pi-pi interaction, while the Cou derivative relies on electrostatic interaction. The study provides valuable insights into designing receptors for selective recognition of nucleotides in water.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Cell & Tissue Engineering
Zhaoyuan Guo, Jiahao Zhu, Guanyu Qin, Yumei Jia, Zheng Liu, Na Yang, Renpeng Guo
Summary: Static magnetic fields (SMFs) have significant effects on the proliferation and differentiation of adult stem cells, but their role in pluripotent embryonic stem cells (ESCs) is not well understood. This study demonstrates that SMFs promote the expression of pluripotent markers and enhance the differentiation of ESCs into muscle cells. Transcriptome analysis further confirms the strengthening of muscle lineage differentiation in ESCs under SMF stimuli. In addition, SMFs also improve the proliferation, expression of muscle markers, and myogenic differentiation capacity of C2C12 myoblasts. This research highlights the potential of SMFs in promoting muscle cell generation for regenerative medicine and cultured meat production.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Luiz Eduardo Baggio Savio, Raissa Leite-Aguiar, Vinicius Santos Alves, Robson Coutinho-Silva, Angela T. S. Wyse
Summary: Purinergic signaling is a crucial cell communication pathway mediated by extracellular nucleotides and nucleosides. Activation of P2 receptors influences the redox balance of cells, while enzymes like E-NTPDase1/CD39 and ecto-5'-nucleotidase/CD73 play key roles in regulating this process.
Article
Biology
Jack Greiner, Thomas Glonek
Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.
Article
Neurosciences
Yaru Xu, Ge Gao, Xiaoru Sun, Qidong Liu, Cheng Li
Summary: Postoperative delirium (POD) is a major complication after surgery with general anesthesia, and the neurotoxicity of general anesthetics plays a key role. Sevoflurane, a common general anesthetic, is shown to induce inflammatory response and caspase-3 activation through upregulation of ATPIF1 in microglia. ATP supplementation may be a potential therapeutic strategy for alleviating sevoflurane-induced POD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Duo Wang, Zirui Zeng, Mengyue Shen, Ryuji Okazaki, Hironori Miyata, Tomo Yonezawa, Yasuhiro Yoshida
Summary: Neutrophil endocytosis is closely related to ATP-centered energy metabolism. Inhibition of dynamin inhibits ATP consumption triggered by neutrophil endocytosis, while inhibition of ATP synthase and nicotinamide adenine dinucleotide phosphate oxidase suppresses neutrophil endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
William D. Watson, Peregrine G. Green, Andrew J. M. Lewis, Per Arvidsson, Giovanni Luigi De Maria, Hakan Arheden, Einar Heiberg, William T. Clarke, Christopher T. Rodgers, Ladislav Valkovic, Stefan Neubauer, Neil Herring, Oliver J. Rider
Summary: The study shows that even in nonischemic heart failure patients with severely impaired systolic function, the heart retains significant metabolic flexibility, including the ability to change substrate use to match arterial supply and workload changes. Increasing the uptake and oxidation of long-chain fatty acids is associated with improved myocardial energetics and contractility.
Review
Biology
Yixiang Fan, Xinmiao Ji, Lei Zhang, Xin Zhang
Summary: Studies have shown that static magnetic fields have positive effects on pain relief, with factors such as treatment time and pain types influencing the outcomes. Higher intensity and treatment time may lead to better pain relief effects. Initial mechanistic studies suggest that membrane receptors may be involved in the analgesic effects of static magnetic fields.
BIOELECTROMAGNETICS
(2021)
Article
Chemistry, Applied
Yuzhao Lin, Hetong Lin, Lingzhen Zeng, Yi Zheng, Yazhen Chen, Yifen Lin, Zhongqi Fan, Yifen Lin
Summary: Compared with the P. longanae-infected longan, the DNP-treated P. longanae-infected fruit showed a more severe pulp breakdown, higher production rate of O2???, and higher MDA content, but lower activities of APX, SOD and CAT, lower transcript levels of DlAPX6, DlSOD1, DlSOD2, DlSOD3 and DlCAT1, lower values of AsA, GSH, flavonoid and total phenolics, lower scavenging ability of DPPH radical, and a lower value of reducing power. In contrast, the ATP-treated P. longanae-infected samples exhibited opposite results.
Article
Developmental Biology
Qiushi Wang, Ruijun He, Lianwan Chen, Qi Zhang, Jin Shan, Peng Wang, Xia Wang, Yanmei Zhao
Summary: In nematodes, MIG-23 regulates sperm migration by modulating extracellular ATP levels, which is essential for major sperm protein dynamics and sperm motility.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofei Tian, Yue Lv, Yixiang Fan, Ze Wang, Biao Yu, Chao Song, Qingyou Lu, Chuanying Xi, Li Pi, Xin Zhang
Summary: The study assessed the biological effects of 7.0-33.0 T static magnetic fields on healthy adult mice, with most indicators showing no significant changes and exposure for 1 hour did not have detrimental effects on normal adult mice.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Cell Biology
Zhiyuan Li, Xin Zhang
Summary: The study found that mitotic ULK1 and ATG13 are substrates of the key cell cycle regulator CDK1-CCNB, and CDK1-induced phosphorylation promotes cell cycle progression and tumor cell proliferation, significantly affecting both processes.
Review
Biology
Yixiang Fan, Xinmiao Ji, Lei Zhang, Xin Zhang
Summary: Studies have shown that static magnetic fields have positive effects on pain relief, with factors such as treatment time and pain types influencing the outcomes. Higher intensity and treatment time may lead to better pain relief effects. Initial mechanistic studies suggest that membrane receptors may be involved in the analgesic effects of static magnetic fields.
BIOELECTROMAGNETICS
(2021)
Article
Oncology
Xingxing Yang, Chao Song, Lei Zhang, Junjun Wang, Xin Yu, Biao Yu, Vitalii Zablotskii, Xin Zhang
Summary: Studies have shown that 9.4 Tesla high-field magnetic resonance imaging (MRI) has advantages in improving image resolution and capacity, with its safety being validated. Additionally, moderate to high intensity Static Magnetic Fields (SMFs) have anti-cancer effects. Among which, the upward direction 9.4 T SMF significantly inhibits lung cancer growth and affects cellular functions in vitro.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lihong Zhang, Chaowen Chen, Jia Zhang, Bin Liu, Guopeng Teng, Junjun Wang, Xin Zhang, Dongqing Cai, Zhengyan Wu
Summary: In this study, an alternating magnetic field-responsive controlled-release system, MRCIN, was developed for the efficient release of IM. By manipulating the frequency and voltage, it demonstrated excellent controlled-release performance and showed potential for sustainable pest control and green agriculture. This system also exhibited good biocompatibility and recyclability, providing a promising approach to reduce environmental pollution.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Lv, Yixiang Fan, Xiaofei Tian, Biao Yu, Chao Song, Chuanlin Feng, Lei Zhang, Xinmiao Ji, Vitalii Zablotskii, Xin Zhang
Summary: Exposure to 11.1-33.0 T SMF for 1 hour or 7 T SMF for 8 hours did not have detrimental effects on healthy or depressed mice, instead, these ultra-high field SMFs have anti-depressive potentials.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Cell Biology
Chuanlin Feng, Biao Yu, Chao Song, Junjun Wang, Lei Zhang, Xinmiao Ji, Ying Wang, Yanwen Fang, Zhongcai Liao, Min Wei, Xin Zhang
Summary: This study showed that moderate static magnetic fields (SMFs) can effectively reduce blood glucose levels and alleviate diabetic complications in mice. The SMFs improved wound healing, reduced liver lipid accumulation, and improved renal defects. In vitro experiments also demonstrated that SMFs could decrease oxidative stress and improve cell vitality, proliferation, and migration. These findings suggest that SMF therapy may be a cost-effective physical therapy strategy for multiple diabetic complications.
Article
Nanoscience & Nanotechnology
Kun Ma, Ze Wang, Tongxiang Tao, Shuai Xu, Sajid Ur Rehman, Xu Yan, Jun Fang, Ruiguo Chen, Hui Wang, Xin Zhang, Can Xie, Yang Lu, Qingyou Lu, Junfeng Wang
Summary: In this study, the size and uniformity of magnetic nanoparticles were controlled by applying gradient magnetic fields during the solvothermal method. The results show that stronger magnetic fields result in smaller nanoparticles, and greater product of the applied field and its gradient lead to better uniformity. In vitro and in vivo experiments demonstrate that magnetic field treatment produces uniform nanoparticles with improved T-1 contrast performance.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Hongji Liu, Junjun Wang, Chao Song, Ke Zhou, Biao Yu, Jialiang Jiang, Junchao Qian, Xin Zhang, Hui Wang
Summary: A nanozyme consisting of iron oxide nanocrystals embedded in N-doped carbon nanosheets has been designed for synergistic cascade tumor therapy triggered by near-infrared light, showing promising potential for imaging-guided cancer treatment. This nanozyme can generate Fe2+/Fe3+ in a weak acid environment, induce thermal ablation of cancer cells, and enhance oxidative stress through the Fenton reaction and glutathione peroxidase activity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofei Tian, Chentai Wang, Biao Yu, Yixiang Fan, Lei Zhang, Xin Zhang
Summary: 9.4 T SMF has anti-tumor effects and can enhance the anti-tumor effect of imatinib mesylate while reducing its side effects and improving mental health in mice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Yixiang Fan, Xin Yu, Biao Yu, Xinmiao Ji, Xiaofei Tian, Chao Song, Xin Zhang
Summary: Living organisms, including mice, can benefit from long-term exposure to a moderate static magnetic field (SMF) by improving lifespan and healthspan. The experiments showed that SMFs significantly enhanced exploratory and locomotive activities in aged mice, as well as their spatial learning ability and memory. Additionally, SMFs reduced oxidative stress in the brain of aged mice, suggesting their potential as an adjuvant physical therapy to reduce aging-related health risks in animals and humans.
Article
Biochemistry & Molecular Biology
Xin Yu, Xinmiao Ji, Yixiang Fan, Biao Yu, Xinyu Wang, Chuanlin Feng, Lei Zhang, Chao Song, Xin Zhang
Summary: Moderate static magnetic fields (SMFs) can reduce cisplatin-induced kidney toxicity by inhibiting cell death and reducing oxidative stress. This novel physical method shows potential for mitigating the side effects of cisplatin in cancer treatment.
Article
Multidisciplinary Sciences
Junjun Wang, Xiaofei Tian, Chuanlin Feng, Chao Song, Biao Yu, Ying Wang, Xinmiao Ji, Xin Zhang
Summary: KimH3 is a kinase that can phosphorylate H3Ser10 in both interphase and mitosis, and it is upregulated in various human cancers. Its high expression is associated with reduced median survival time in cancer patients. CDK1 phosphorylates KimH3 in mitosis, while EGF activates it in interphase, and both processes regulate the phosphorylation of H3Ser10.
Article
Radiology, Nuclear Medicine & Medical Imaging
Md Hasanuzzaman Khan, Xinfeng Huang, Xiaofei Tian, Changjie Ouyang, Dongmei Wang, Shuang Feng, Jutao Chen, Tian Xue, Jin Bao, Xin Zhang
Summary: This study evaluated the effects of 3.5-23.0 T SMF exposure on mouse behavior. The results showed that short exposures to high-field SMFs had minimal side effects on healthy mice and may even have positive effects on mood and memory.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Biao Yu, Juanjuan Liu, Jing Cheng, Lei Zhang, Chao Song, Xiaofei Tian, Yixiang Fan, Yue Lv, Xin Zhang
Summary: Research indicates that a downward static magnetic field can effectively reduce symptoms in high-fat-diet-induced T2D mice and improve related conditions, offering a low-cost non-invasive method for preventing and treating T2D in the future.