Article
Environmental Sciences
Guillermina Canesini, German H. Galoppo, Yamil E. Tavalieri, Gisela P. Lazzarino, Cora Stoker, Enrique H. Luque, Jorge G. Ramos, Monica Munoz-de-Toro
Summary: Environmental exposure to agrochemicals during early development can lead to permanent alterations in normal physiology. This study investigated the effects of atrazine exposure on gonadal development in caiman embryos, and found that it disrupts the expression of biomarkers and genes involved in sex determination and gonadal differentiation. The results suggest that atrazine can interfere with gonadal developmental programming and the observed effects may be present in other vertebrate species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Rachel C. Bernardo, Victoria P. Connaughton
Summary: This study investigated the effects of transient exposure to TBT on the visual system development of larval zebrafish. The results showed that TBT exposure caused age-dependent changes in morphology and impaired visual function at different stages of development.
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Article
Engineering, Environmental
Mengqiao Cui, Xiling Wu, Lei Yuan, Yue Zhai, Xin Liang, Zihan Wang, Jinhua Li, Lichun Xu, Weiyi Song
Summary: This study investigated the adverse effects of TDMPP on gonadal development in zebrafish. TDMPP was found to induce ovarian formation in aromatase mutant zebrafish and also delayed puberty onset, retarded sexual maturation, impaired gametogenesis and subfertility. Molecular docking and reporter gene assay indicated the involvement of all three nuclear estrogen receptors (nERs) in the effects of TDMPP.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Ming Jia, Miaomiao Teng, Sinuo Tian, Jin Yan, Zhiyuan Meng, Sen Yan, Ruisheng Li, Zhiqiang Zhou, Wentao Zhu
Summary: The study found that long-term low-dose exposure to PEN did not significantly affect the growth and spawning of zebrafish, but led to significant changes in important hormones and related gene expressions in zebrafish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Marine & Freshwater Biology
Sebastien Baekelandt, Nathalie Leroux, Laura Burattin, Celine Gerard, Celine Delierneux, Jean-Baptiste Robert, Valerie Cornet, Patrick Kestemont
Summary: Natural and synthetic oestrogens are common in aquatic ecosystems. The synthetic oestrogen EE2, widely used in oral contraceptives, has been reported to have ecotoxicological effects on aquatic organisms. The natural oestrogen E4, recently approved for use, may also be present in the aquatic environment. In this study, zebrafish were exposed to E4 and EE2 to compare their endocrine disruptive potential. EE2 showed strong effects on various parameters, while E4 had minimal impact on fecundity. These findings suggest that E4 has a more favorable environmental profile compared to EE2 and is less likely to affect fish reproductive capacity.
AQUATIC TOXICOLOGY
(2023)
Article
Toxicology
Davidson Peruci Moreira, Yves Moreira Ribeiro, Camila Stephanie Ferreira, Samyra Maria dos Santos Nassif Lacerda, Elizete Rizzo
Summary: This study aimed to investigate the effects of chronic exposure to environmentally relevant ACE concentrations on multiple reproductive parameters in zebrafish. The results showed that ACE impaired the reproductive performance of zebrafish, including a decrease in egg and sperm quantity and quality, as well as an imbalance of sex steroids and prostaglandin E-2 levels. These findings indicate the impact of ACE on the reproductive ability of aquatic species.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Adriana Carvalho Natal de Moraes, Hamideh Pourmohammadi Fallah, Valeria Freitas de Magalhaes, Hamid R. Habibi
Summary: This study investigates the direct effects of cylindrospermopsin (CYN) on female reproduction in zebrafish. The results show that CYN increases germinal vesicle breakdown, caspase-3 activity, and testosterone production, while decreasing the abundance of specific transcripts. These findings provide insights into the adverse effects of CYN on female reproduction and offer potential biomarkers for CYN exposure.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Marine & Freshwater Biology
Qi Meng, Karen Yeung, King Ming Chan
Summary: Studies have shown that Octocrylene (OC) has toxic effects on zebrafish and zebrafish liver cells, inducing gene expression and affecting hormone synthesis and antioxidant pathways. The findings support banning the use of OC in cosmetics.
AQUATIC TOXICOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jerrold J. Heindel, Sarah Howard, Keren Agay-Shay, Juan P. Arrebola, Karine Audouze, Patrick J. Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C. Cave, Saurabh Chatterjee, Nicolas Chevalier, Mahua Choudhury, David Collier, Lisa Connolly, Xavier Coumoul, Gabriella Garruti, Michael Gilbertson, Lori A. Hoepner, Alison C. Holloway, George Howell, Christopher D. Kassotis, Mathew K. Kay, Min Ji Kim, Dominique Lagadic-Gossmann, Sophie Langouet, Antoine Legrand, Zhuorui Li, Helene Le Mentec, Lars Lind, P. Monica Lind, Robert H. Lustig, Corinne Martin-Chouly, Vesna Munic Kos, Normand Podechard, Troy A. Roepke, RobertM. Sargis, Anne Starling, Craig R. Tomlinson, Charbel Touma, Jan Vondracek, Frederick vom Saal, Bruce Blumberg
Summary: Obesity is a multifactorial disease caused by genetic and environmental factors. Overeating and lack of exercise are common causes, but environmental substances known as obesogens can also disrupt the balance of energy intake and expenditure, increasing the risk of obesity. Obesogens primarily affect the development and function of adipose tissue, liver, pancreas, gastrointestinal tract, and brain, altering the control of metabolism. The most sensitive period for obesogen exposure is in utero and early childhood, which may lead to changes in gene expression that can be transmitted to future generations.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuan Liu, Xianyi Xie, Hongling Liu
Summary: Exposure to environmental estrogen during the critical gonadal differentiation period not only affects the development of zebrafish, but also influences the population development, leading to a biased sex ratio in the fish population.
Article
Engineering, Environmental
Fabien Pierron, Guillemine Daffe, Flore Daramy, Debora Heroin, Aurelien Barre, Olivier Bouchez, Christelle Clerendeau, Alicia Romero-Ramirez, Macha Nikolski
Summary: Recent research has shown that environmentally-induced epigenetic changes can affect gene transcription across multiple generations, emphasizing the need to investigate the transgenerational impacts of pollutants for long-term population effects. A study on zebrafish over four generations examined the transgenerational effect of cadmium and found sex-dependent inheritance of DNA methylation changes linked to the estradiol receptor alpha gene. These changes were associated with single nucleotide polymorphisms and contributed to the rapid transgenerational adaptation of fish to cadmium.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Environmental Sciences
Fan Wang, Haifang Liu, Fei Liu
Summary: This study investigates the effect of triclosan on the sex differentiation of zebrafish embryos and reveals that triclosan mainly affects the female proportion through the steroid hormone biosynthesis pathway, with aromatase playing a key role. Additionally, retinol metabolism, metabolism of xenobiotics by cytochrome P450, and cortisol synthesis and secretion may also be involved in triclosan-mediated sex differentiation. These findings provide theoretical guidance for ensuring water ecological balance.
Article
Engineering, Environmental
Kun Qiao, Zhuoying Liang, Aoxue Wang, Qiong Wu, Siyu Yang, Yongfang Ma, Shuying Li, Sabrina Schiwy, Jinhua Jiang, Shengli Zhou, Qingfu Ye, Henner Hollert, Wenjun Gui
Summary: In this study, the effects of tebuconazole on the sex differentiation and hormone levels in zebrafish were investigated. The results showed that long-term exposure to tebuconazole significantly increased the proportion of males and led to an increase in testosterone levels and a decrease in estradiol and aromatase gene expression. However, chemically activated luciferase gene expression assays suggested that the male-biased sex differentiation was not caused by direct binding of tebuconazole to sex hormone receptors. Molecular docking and activity assays further confirmed the interaction between tebuconazole and aromatase. These findings highlight the potential threat of tebuconazole in inducing gender imbalance in fish populations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shwetakshi Sharma, Priya Gupta, Annie Gupta, S. M. Kawish, Zeenat Iqbal, Divya Vohora, Kanchan Kohli
Summary: In this study, a validated HPLC method was developed for the simultaneous quantification of exemestane and genistein in combination. The method showed good linearity within the range of 5-110 μg/mL for both drugs. The developed method was found to be suitable for the identification of both drugs simultaneously. Evaluation: 7 out of 10.
Article
Multidisciplinary Sciences
Luzie Jessl, Joerg Oehlmann
Summary: Due to the potential effects of environmental contaminants on endocrine disorders, in vivo tests using avian embryos have been shown to be a promising model for identifying and assessing endocrine disrupting chemicals (EDCs). This study focused on the effects of in ovo exposure to p,p'-DDE, flutamide, and cyproterone acetate (CPA) on gonadal sex differentiation and embryonic development in domestic fowls. The results showed that antiandrogens did not affect sexual differentiation, but exposure to certain concentrations of CPA resulted in smaller embryos.
Article
Biochemistry & Molecular Biology
Kristina Rehberger, Lisa Baumann, Markus Hecker, Thomas Braunbeck
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Lisa Baumann, Helmut Segner, Albert Ros, Dries Knapen, Lucia Vergauwen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Steve U. Ayobahan, Elke Eilebrecht, Matthias Kotthoff, Lisa Baumann, Sebastian Eilebrecht, Matthias Teigeler, Henner Hollert, Stefan Kalkhof, Christoph Schaefers
SCIENTIFIC REPORTS
(2019)
Article
Environmental Sciences
Steve U. Ayobahan, Sebastian Eilebrecht, Lisa Baumann, Matthias Teigeler, Henner Hollert, Stefan Kalkhof, Elke Eilebrecht, Christoph Schaefers
Article
Environmental Sciences
Lisa Baumann, Henrik Holbech, Heike Schmidt-Posthaus, Angela R. Moissl, Mark Hennies, Janina Tiedemann, Lennart Weltje, Helmut Segner, Thomas Braunbeck
Article
Environmental Sciences
Florian Zindler, Franziska Beedgen, Diana Brandt, Madeleine Steiner, Daniel Stengel, Lisa Baumann, Thomas Braunbeck
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Biochemistry & Molecular Biology
Henrik Holbech, Peter Matthiessen, Martin Hansen, Gerrit Schueuermann, Dries Knapen, Marieke Reuver, Frederic Flamant, Laurent Sachs, Werner Kloas, Klara Hilscherova, Marc Leonard, Juergen Arning, Volker Strauss, Taisen Iguchi, Lisa Baumann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Environmental Sciences
Rebecca von Hellfeld, Katharina Brotzmann, Lisa Baumann, Ruben Strecker, Thomas Braunbeck
ENVIRONMENTAL SCIENCES EUROPE
(2020)
Article
Environmental Sciences
Florian Zindler, Saskia Stoll, Lisa Baumann, Sarah Knoll, Carolin Huhn, Thomas Braunbeck
Article
Marine & Freshwater Biology
Larissa Kernen, Audrey Phan, Jun Bo, Elio L. Herzog, John Huynh, Helmut Segner, Lisa Baumann
Summary: This study found that estrogenic endocrine disrupting compounds (EEDCs) can disrupt the development of the adaptive immune system in fish at field-relevant concentrations, particularly affecting the growth of the thymus. The results show that exposure to EE2 reduced thymus growth and transcript levels of thymus marker genes. Additionally, it was observed that the thymic alterations induced by EE2 were reversible in female zebrafish but persisted in males.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Lisa Golz, Lisa Baumann, Pauline Pannetier, Thomas Braunbeck, Dries Knapen, Lucia Vergauwen
Summary: Thyroid hormones are involved in vertebrate eye development. Chemicals disrupting the thyroid hormone system may have severe consequences on the visual system in wildlife. A comprehensive literature review was conducted to establish an adverse outcome pathway (AOP) linking thyroid hormone system disruption to altered eye development in fish.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Maximilian Kraft, Lisa Goelz, Maximilian Rinderknecht, Johannes Koegst, Thomas Braunbeck, Lisa Baumann
Summary: Thyroid hormones play a vital role in developmental and metabolic processes in vertebrates, including eye development. This study demonstrated the effects of two environmental pollutants on thyroid follicle and eye development in transgenic zebrafish, confirming their role as thyroid system-disrupting chemicals. These findings suggest that morphological changes in thyroid follicles and eyes can be used as novel endpoints for the assessment of thyroid system-related effects in fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Lisa Goelz, Pauline Pannetier, Teresa Fagundes, Susanne Knoerr, Laura Behnstedt, Sara Coordes, Peter Matthiessen, Jane Morthorst, Lucia Vergauwen, Dries Knapen, Henrik Holbech, Thomas Braunbeck, Lisa Baumann
Summary: This study aimed to integrate thyroid-related endpoints for fish into a test protocol and evaluate the effects of different endocrine disruptors on the thyroid system in zebrafish. The results showed that exposure to certain chemicals induced changes in thyroid follicles and eye development. The integrated Fish Endocrine Disruption Test (iFEDT) provides a promising tool for assessing the disruption of both the steroid and thyroid endocrine systems in zebrafish.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Editorial Material
Ecology
Francisco Sylvester, Fabian G. Weichert, Veronica L. Lozano, Ksenia J. Groh, Miklos Balint, Lisa Baumann, Claus Baessler, Werner Brack, Barbara Brandl, Joachim Curtius, Paul Dierkes, Petra Doell, Ingo Ebersberger, Sotirios Fragkostefanakis, Eric J. N. Helfrich, Thomas Hickler, Sarah Johann, Jonas Jourdan, Sven Klimpel, Helge Kminek, Florencia Liquin, Darrel Moellendorf, Thomas Mueller, Joerg Oehlmann, Richard Ottermanns, Steffen U. Pauls, Meike Piepenbring, Jakob Pfefferle, Gerrit Jasper Schenk, J. F. Scheepens, Martin Scheringer, Sabrina Schiwy, Antje Schlottmann, Flurina Schneider, Lisa M. Schulte, Maria Schulze-Sylvester, Ernst Stelzer, Frederic Strobl, Andrea Sundermann, Klement Tockner, Tobias Troeger, Andreas Vilcinskas, Carolin Voelker, Ricarda Winkelmann, Henner Hollert
Summary: Chemical pollution research needs to be integrated with other factors contributing to biodiversity loss and the assessment of human impacts on ecosystems in order to provide more effective guidance for biodiversity loss mitigation.
NATURE ECOLOGY & EVOLUTION
(2023)
Review
Toxicology
Kristina Rehberger, Inge Werner, Bettina Hitzfeld, Helmut Segner, Lisa Baumann
CRITICAL REVIEWS IN TOXICOLOGY
(2017)
