Article
Environmental Sciences
Konstantin Zolotarev, Anton N. Mikhailov, Marina Mikhailova, Kirill Nakhod, Valeriya Nakhod, Nikolay Bodoev, Dmitry D. Zhdanov
Summary: The study found that Cd2+ treatment significantly affected the expression of NR2A gene in the eyes of juvenile common carp, but had no significant impact on brain gene expression; it also revealed the influence of Cd2+ on the expression of ABCC1 gene in the gills, with different responses observed in the liver.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Sumate Ampawong, Napatara Tirawanchai, Tapanee Kanjanapruthipong, Kamonpan Fongsodsri, Khwanchanok Tuentam, Duangnate Isarangkul, Pornanong Aramwit
Summary: This study aims to examine the effect of sericin on urea cycle enzyme genes and proteins, and found that sericin can promote ammonia detoxification by increasing urea cycle enzyme genes and enhancing hepatic autophagy.
Article
Entomology
Zeyang Sun, Yue Liu, Haixuan Xu, Chuncai Yan
Summary: This study investigated the detoxification ability of non-biting midges to chlorpyrifos, revealing that gut microbiota may influence the host's detoxification capability.
Article
Parasitology
Antonella Schiavone, Daniel R. G. Price, Nicola Pugliese, Stewart T. G. Burgess, Ifra Siddique, Elena Circella, Alasdair J. Nisbet, Antonio Camarda
Summary: The poultry red mite (PRM), Dermanyssus gallinae, is a major threat to the poultry industry globally. Chemical control has led to the development of resistant mites, with molecular mechanisms including target-site insensitivity and enhanced detoxification. This study investigates the expression levels of detoxification enzymes and defense-related genes in PRM populations from Italy. RNA-seq analysis reveals constitutive overexpression of detoxification enzymes, ABC transporters, cuticular proteins, and heat shock proteins in resistant mites, suggesting a combination of target-site insensitivity and overexpression as the basis for acaricide resistance in D. gallinae.
VETERINARY PARASITOLOGY
(2023)
Article
Biology
Tarik Seref Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hyemin Kim, Jennifer Wang, Megan Mair, Huilan Wang, Lifang Li, Alma Perez, Maria de Haro, Ying-Wooi Wan, Genevera Allen, Boxun Lu, Ismael Al-Ramahi, Zhandong Liu, Juan Botas
Summary: Research shows that glia cells play a crucial role in the formation and maintenance of synapses in neurodegenerative diseases. Lowering genes involved in synapse assembly can alleviate pathological and behavioral deficits. Conserved gene dysregulation is observed in patients with neurodegenerative diseases, fruit flies, and mice.
Article
Fisheries
Rongrong Liu, Fei Meng, Xin Li, Hua Li, Guiwen Yang, Shijuan Shan
Summary: This study cloned and characterized common carp STING (CcSTING), and found that it plays a critical role in the immune response against RNA viruses. CcSTING is mainly located in the cytoplasm within the endoplasmic reticulum, and has strong expression in organs such as gills and head kidney. Additionally, overexpression of CcSTING can significantly suppress the replication of SVCV in EPC cells, likely through enhancing IFN and NF-κB activity and up-regulating the phosphorylation of TBK1 and p65.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Joanna Szczygiel, Teresa Kaminska-Gibas, Jules Petit, Patrycja Jurecka, Geert Wiegertjes, Ilgiz Irnazarow
Summary: The study ranked the expression stability of duplicated genes in different tissues of common carp and found that 40s, b2m, ef1 alpha, and actb genes showed the most stable expression across all physiological conditions, while gapdh, odc1, and g6pd genes demonstrated lower stability. Functional divergence between duplicated genes was observed, emphasizing the importance of considering this aspect in selecting reference genes in polyploid species.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xi-Ya Liu, Hui-Mei Sun, Yi-Hong Luo, Mao-Ye Li, Hai-Bing Liu, Su Liu
Summary: In this study, the role of GST genes in the detoxification of pesticides in cigarette beetles was investigated. It was found that the LsGSTE1 gene not only metabolizes the insecticide but also protects against oxidative stress. These findings suggest that LsGSTE1 could be a potential target for sustainable management of the cigarette beetle.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peizhuo Wu, Junyue Zheng, Yun Huang, Yu Zhang, Lihong Qiu
Summary: This study evaluated the effects of different types of commonly used insecticides on the expression of CncC, Keap1, Maf, and multiple detoxification genes in Helicoverpa armigera. The results showed that certain insecticides induced the expression of CncC, suppressed the expression of Keap1, and induced the expression of Maf. Additionally, the expression of multiple detoxification genes, especially cytochrome P450 genes, was up-regulated by certain insecticides.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Daojie Guan, Xuemei Yang, Heng Jiang, Nan Zhang, Zhaolu Wu, Chengyun Jiang, Qinwen Shen, Kun Qian, Jianjun Wang, Xiangkun Meng
Summary: This study reveals the role of ABC transporters in the detoxification mechanism of Chilo suppressalis to abamectin and provides valuable insights into transport-related detoxification mechanisms in insects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Chen, Cuicui Wang, Ying Liu, Tisheng Shan, Xueyan Shi, Xiwu Gao
Summary: This study identified P450 genes involved in thiamethoxam detoxification in Bradysia odoriphaga through transcriptome sequencing and analysis of differentially expressed genes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Environmental Sciences
Wenfeng Yang, Pan Gao, Huixiang Li, Jiayi Huang, Yan Zhang, Huijun Ding, Weihao Zhang
Summary: This study found that nanoplastics had higher inhibition rates on microalgae compared to microplastics, but the inhibitory effect decreased with prolonged exposure time. The mechanisms of nanoplastics' impact on algae varied at different concentrations, including gene expression inhibition, hindered DNA damage repair, and promotion of detoxification.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Roberto Gramignoli, Aarati R. Ranade, Raman Venkataramanan, Stephen C. Strom
Summary: Pro-inflammatory cytokines can affect liver cell functions, particularly ammonia and drug metabolism, but do not necessarily indicate rejection or loss of cell graft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Paulina Pawlak, Alexander Burren, Andreas Seitz, Constanze Pietsch
Summary: Our current understanding of stress responses and the specific roles of different regulatory pathways is still incomplete. This study aimed to investigate the regulation of appetite genes in fish, particularly in response to different stressors. The study conducted a stress trial on koi carp and evaluated the effects of tank manipulation, air exposure, and feed rewarding on appetite gene regulation. The results revealed pronounced responses in different brain regions, including the hypothalamus, to the various stressors.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Food Science & Technology
Petr Pavek, Jan Dusek, Tomas Smutny, Lukas Lochman, Radim Kucera, Josef Skoda, Lucie Smutna, Rajamanikkam Kamaraj, Pavel Soucek, Radim Vrzal, Zdenek Dvorak
Summary: This study suggests that VDR or vitamin D supplementation is unlikely to significantly influence liver detoxification enzymes apart from CYP3A4.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Engineering, Environmental
John Moreman, Aya Takesono, Maciej Trznadel, Matthew J. Winter, Alexis Perry, Mark E. Wood, Nicola J. Rogers, Tetsuhiro Kudoh, Charles R. Tyler
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Yukiko Ogino, Saki Tohyama, Satomi Kohno, Kenji Toyota, Gen Yamada, Ryohei Yatsu, Tohru Kobayashi, Norihisa Tatarazako, Tomomi Sato, Hajime Matsubara, Anke Lange, Charles R. Tyler, Yoshinao Katsu, Taisen Iguchi, Shinichi Miyagawa
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Environmental Sciences
Arthur David, Anke Lange, Charles R. Tyler, Elizabeth M. Hill
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Engineering, Environmental
A. Ross Brown, Jon M. Green, John Moreman, Lina M. Gunnarsson, Sulayman Mourabit, Jonathan Ball, Matthew J. Winter, Maciej Trznadel, Ana Correia, Christian Hacker, Alexis Perry, Mark E. Wood, Malcolm J. Hetheridge, Richard A. Currie, Charles R. Tyler
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Marine & Freshwater Biology
Aoife Parsonsa, Anke Lange, Thomas H. Hutchinson, Shinichi Miyagawa, Taisen Iguchi, Tetsuhiro Kudoh, Charles R. Tyler
AQUATIC TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Luigi Margiotta-Casaluci, Stewart F. Owen, Mariann Rand-Weaver, Matthew J. Winter
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Anke Lange, Josephine R. Paris, Karim Gharbi, Timothee Cezard, Shinichi Miyagawa, Taisen Iguchi, David J. Studholme, Charles R. Tyler
MOLECULAR ECOLOGY RESOURCES
(2020)
Article
Marine & Freshwater Biology
Aoife E. Parsons, Anke Lange, Thomas H. Hutchinson, Shinichi Miyagawa, Taisen Iguchi, Tetsuhiro Kudoh, Charles R. Tyler
AQUATIC TOXICOLOGY
(2020)
Article
Developmental Biology
Ilham J. J. Alshami, Yosuke Ono, Ana Correia, Christian Hacker, Anke Lange, Steffen Scholpp, Masashi Kawasaki, Philip W. Ingham, Tetsuhiro Kudoh
DEVELOPMENTAL BIOLOGY
(2020)
Article
Ornithology
Lowell J. Mills, Jeremy D. Wilson, Anke Lange, Karen Moore, Barry Henwood, Hazel Knipe, Dominique L. Chaput, Charles R. Tyler
JOURNAL OF AVIAN BIOLOGY
(2020)
Article
Fisheries
Hazel Knipe, Ben Temperton, Anke Lange, David Bass, Charles R. Tyler
Summary: The review provides an overview of competitive exclusion mechanisms of shrimp probiotics based on their ability to inhibit the growth of pathogenic bacteria in vitro. Current methods may preferentially select for interference-based competitive mechanisms, potentially overlooking the probiotic potential of many species. Consideration of competitive strategies may improve the efficiency of probiotics in vivo in shrimp farming conditions.
REVIEWS IN AQUACULTURE
(2021)
Article
Toxicology
Kaori Miyaoku, Yukiko Ogino, Anke Lange, Ayaka Ono, Tohru Kobayashi, Masaru Ihara, Hiroaki Tanaka, Kenji Toyota, Hiroshi Akashi, Genki Yamagishi, Tomomi Sato, Charles R. Tyler, Taisen Iguchi, Shinichi Miyagawa
Summary: The study cloned and characterized two genes encoding medaka Gper1, Gper1a and Gper1b, showing that Gper1a can mediate estrogen effects on oocytes through the activation of the MAPK pathway. 17α-ethinylestradiol and bisphenol A enhanced MAPK phosphorylation through medaka Gper1, but did not affect oocyte maturation.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emma M. Wood, Pablo Capilla-Lasheras, Dominic L. Cram, Lindsay A. Walker, Jenny E. York, Anke Lange, Patrick B. Hamilton, Charles R. Tyler, Andrew J. Young
Summary: The study found that dominant birds monopolizing reproduction in a wild social bird species did not have shorter telomeres or faster rates of telomere attrition over the long term, but showed lower rates of telomere attrition over shorter time intervals, suggesting possible telomere lengthening. Dominants may invest more heavily in telomere length regulation to mitigate the long-term costs of reproductive effort, leading to comparable long-term telomere dynamics with subordinates.
Article
Genetics & Heredity
Kenji Toyota, Hiroshi Akashi, Momoka Ishikawa, Katsushi Yamaguchi, Shuji Shigenobu, Tomomi Sato, Anke Lange, Charles R. Tyler, Taisen Iguchi, Shinichi Miyagawa
Summary: Sex determination in vertebrates can be categorized as genotypic or environmental. Environmental temperature plays a significant role in the sex determination of reptiles. Recent sequencing technology allows researchers to investigate gene expression during temperature-sensitive periods, aiding in understanding the controlling mechanisms of temperature-dependent sex determination.
Article
Cell Biology
Paige C. Robinson, Hannah R. Littler, Anke Lange, Eduarda M. Santos
HISTOCHEMISTRY AND CELL BIOLOGY
(2020)