Article
Biochemistry & Molecular Biology
Yangbing Yuan, Yuanqin Zhu, Yawen Li, Xusheng Li, Rui Jiao, Weibin Bai
Summary: This study compared the cholesterol-lowering activities of Vitisin A with Cyanidin-3-O-glucoside (C3G) and found that Vitisin A inhibited cholesterol biosynthesis and enhanced LDL uptake in HepG2 cells. It also regulated the expression of genes and proteins associated with cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tiffany Scully, Abora Ettela, Nathan Kase, Derek LeRoith, Emily Jane Gallagher
Summary: Tumor uptake of exogenous cholesterol is associated with cancer proliferation. Amplifying the expression of LDL receptor (LDLR) in breast cancer cells promotes tumor growth, but unregulated and prolonged LDL uptake is detrimental.
ENDOCRINE-RELATED CANCER
(2023)
Article
Food Science & Technology
Jin-Taek Hwang, Eunji Choi, Hyo-Kyoung Choi, Jae-Ho Park, Min-Yu Chung
Summary: The study investigated the mechanism by which CBE with icaritin and icaritin alone mediate hypocholesterolemic activity through LDLR and PCSK9 in obese mice and HepG2 cells. Results showed that CBE significantly reduced cholesterol levels in obese mice by decreasing PCSK9 gene expression, while icaritin suppressed intracellular PCSK9 and increased LDLR in HepG2 cells. The use of CBE and icaritin could be a potential alternative therapeutic approach in hypercholesterolemia treatment.
Article
Chemistry, Multidisciplinary
Quentin Laurent, Remi Martinent, Dimitri Moreau, Nicolas Winssinger, Naomi Sakai, Stefan Matile
Summary: Oligonucleotide phosphorothioates (OPS) are DNA or RNA mimics with one phosphate oxygen replaced by a sulfur atom, which have been shown to enter mammalian cells more efficiently. This study reveals that OPS enter cells through thiol-mediated uptake, providing insights into the mechanism for their cellular uptake and potential applications in drug delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Jiachen Lin, Zhifa Zheng, Jieying Liu, Guihua Yang, Ling Leng, Hai Wang, Guixing Qiu, Zhihong Wu
Summary: Nutritional microenvironment plays a crucial role in determining the specification of progenitor cells, with lipid availability impacting osteogenesis in skeletal progenitors. The study found that lipid scarcity suppresses the osteogenic differentiation of BMSCs, while LRP5 mediates lipid uptake in BMSCs and influences osteogenic specification.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Jianqing Zhang, Xiaoxia Yan, Qinghao Jin, Jing Chen, Lin Yang, Wenlong Wei, Hua Qu, Changliang Yao, Jinjun Hou, Likun Gong, Wanying Wu, De-an Guo
Summary: This study explored natural small molecules with anti-hyperlipidemia activity through PCSK9 from Alisma plantago-aquatica. It discovered six novel triterpenoids, including three unusual nor-triterpenoids and three protostane-type triterpenoids, along with thirty-four known ones. The results indicate that protostane triterpenoids may serve as a new source for PCSK9 inhibitors, with potential anti-hyperlipidemia effects.
Article
Biology
Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee
Summary: Structural, biophysical, and imaging data demonstrate that self-assembly of the pericentrosomal proteins Cep63 and Cep152 is a stepwise and concentration-dependent process. Defects in this process disrupt proper centriole duplication mediated by Plk4. This study provides insights into the organization and function of pericentriolar materials (PCM) and offers a potential model for studying PCM-related diseases in other species.
COMMUNICATIONS BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yao Liu, Chun Kit K. Choi, Huiling Hong, Yu Xiao, Man Long Kwok, Hanzhuang Liu, Xiao Yu Tian, Chung Hang Jonathan Choi
Summary: Polydopamine-coated nanoparticles show interaction with dopamine receptors, with catechol and amine groups enhancing the binding to D2DR and cellular uptake. In vivo studies in mice also demonstrate preferential association of the nanoparticles with D2DR-rich Kupffer cells.
Article
Medical Laboratory Technology
Josephine Vasse, Audrey Lassartesse, Oriane Marmontel, Sybil Charriere, Caroline Bouveyron, Nathanael Marrie, Philippe Moulin, Mathilde Di Filippo
Summary: This study compared the accuracy of the Sampson, extended-Martin-Hopkins, and Friedewald equations in fasting hypertriglyceridemia and non-fasting states, and assessed their clinical impact on risk classification and lipid treatment goals. The results showed that the Sampson equation was the most accurate in fasting state, while the extended-Martin-Hopkins equation was the most accurate in the non-fasting state. Overall, the Sampson equation had a negative bias, potentially leading to undertreatment, while the extended-Martin-Hopkins equation had a positive bias.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Katherine A. B. Kellett, Kate Fisher, Harry Aldworth, Nigel M. M. Hooper
Summary: Bone morphogenetic protein 1 (BMP1), a member of the astacin family of zinc-metalloproteases, cleaves LDL receptor (LDLR) within its ligand-binding domain, reducing LDL-cholesterol binding and uptake. Only BMP1, among the other astacin proteases, was found to contribute to the cleavage of LDLR. Mutations at the P1' and P2 positions of the cleavage site rendered mouse LDLR susceptible to BMP1 cleavage. This study provides insight into the mechanisms regulating LDLR function.
Article
Chemistry, Medicinal
Nurjannatul Naim Kamaruddin, Lukman Hakim Mohd Din, Allicia Jack, Aina Farahiyah Abdul Manan, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad
Summary: This study investigated the effects of a selected fraction of A. planci on PCSK9 gene expression, LDLR protein level, and LDL-C uptake. The results showed that the selected fraction reduced PCSK9 gene expression, increased LDLR protein level, and promoted LDL-C uptake. These findings suggest that the selected fraction has the potential to lower circulating LDL-C levels and may be a promising therapeutic intervention for preventing the progression of atherosclerosis.
Article
Multidisciplinary Sciences
Magdalena Zimon, Yunfeng Huang, Anthi Trasta, Aliaksandr Halavatyi, Jimmy Z. Liu, Chia-Yen Chen, Peter Blattmann, Bernd Klaus, Christopher D. Whelan, David Sexton, Sally John, Wolfgang Huber, Ellen A. Tsai, Rainer Pepperkok, Heiko Runz
Summary: Studying the contribution of pairs of genes to complex traits has been challenging. Here, the authors combine exome and genotype data with RNAi to screen for genetic interactions between 30 genes identified in lipid GWAS to hint at pairs whose joint modulation may improve lipid-lowering therapies.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Azra Alajbegovic, Johan Holmberg, Fatima Daoud, Catarina Rippe, Gabriella Kalliokoski, Mari Ekman, Sebastien Daudi, Sigurdur Ragnarsson, Karl Sward, Sebastian Albinsson
Summary: This study reveals that the transcriptional co-activator MRTFA promotes lipid accumulation in smooth muscle cells through various mechanisms, and plays an important role in vascular remodeling in humans. Thus, MRTFA could potentially be a new therapeutic target for inhibiting vascular lipid accumulation.
VASCULAR PHARMACOLOGY
(2021)
Article
Oncology
Ashley G. Zhao, Kiran Shah, Brett Cromer, Huseyin Sumer
Summary: This study optimized the isolation method for EVs derived from MSCs and found that 1 hour of differential ultracentrifugation is the optimal method for isolating high-quality and quantity of MSC-derived EVs.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Haixia Wang, Shumei Wang, Wei Wang, Lin Xu, Lydia R. J. Welsh, Marek Gierlinski, Stephen C. Whisson, Piers A. Hemsley, Petra C. Boevink, Paul R. J. Birch
Summary: Cytoplasmic RXLR effectors from Phytophthora infestans enter plant host cells via clathrin-mediated endocytosis. Transient silencing of clathrin heavy chain or the endosome marker gene attenuated P. infestans infection and reduced translocation of RXLR effectors into host cells. Co-localization of RXLR effectors with clathrin-coated vesicles and immunoprecipitation experiments confirmed the uptake of RXLR effectors via clathrin-mediated endocytosis.
Article
Environmental Sciences
Muqiu Hu, Xin Zhao, Jinghan Gu, Lulu Qian, Zhiqing Wang, Yuanyuan Nie, Xiaoyu Han, Long An, Haiqiang Jiang
Summary: Due to its simple process, environmental friendliness, and low operating costs, biometallurgy has become a popular technology for metals recovering from low-grade ores and tailings. An optimized agar was used to isolate and grow functional bacteria, resulting in the successful isolation of six functional stains. These strains were further tested for their ability to leach metals from polymetallic sulfide tailings, with significant improvements observed when the strains were mixed together. The selection of leaching process should be based on tailings composition and target metals.
ENVIRONMENTAL RESEARCH
(2024)
Review
Environmental Sciences
Saqib Hassan, Aswin Thacharodi, Anshu Priya, R. Meenatchi, Thanushree A. Hegde, R. Thangamani, Ht Nguyen, Arivalagan Pugazhendhi
Summary: An Endocrine Disrupting Chemical (EDC) is a compound that disrupts the function of the endocrine system and is found in the environment. EDCs, such as Bisphenol A and pesticides, have been shown to have negative effects on the female reproductive system. Understanding the relationship between EDCs and women's health is crucial for developing strategies to protect reproductive health and informing public policy decisions.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Lichang Zhou, Zhaoling Li, Boyi Cheng, Jinqi Jiang, Xinqi Bi, Zongping Wang, Guanghao Chen, Gang Guo
Summary: Thiosulfate can promote sulfur-mediated bacterial activity, inhibit glycogen accumulating organisms, and enhance denitrification efficiency. After the carbon source is reduced, the competitive ability of glycogen accumulating organisms increases, resulting in reduced sulfate reduction.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Claire E. Campbell, Devyn L. Cotter, Katherine L. Bottenhorn, Elisabeth Burnor, Hedyeh Ahmadi, W. James Gauderman, Carlos Cardenas-Iniguez, Daniel Hackman, Rob McConnell, Kiros Berhane, Joel Schwartz, Jiu-Chiuan Chen, Megan M. Herting
Summary: Recent studies have found a connection between air pollution and increased risk for behavioral problems during development. However, more longitudinal studies are needed to investigate how exposure during the transition to adolescence may affect emotional behaviors.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Jing-hong Liang, Ru-yu Yang, Mei-ling Liu, Ying-qi Pu, Wen-wen Bao, Yu Zhao, Li-xin Hu, Yu-shan Zhang, Shan Huang, Nan Jiang, Xue-ya Pu, Shao-yi Huang, Guang-hui Dong, Ya-jun Chen
Summary: This study examines the association between urban Green and blue spaces (GBS) exposure and Emotion and behavior problems (EBP) in youth populations. The findings suggest that higher exposure to GBS, particularly green spaces (GS) and blue spaces (BS), is associated with a decrease in the risk of developing total difficulties in young individuals. The joint effect of GS and BS may also contribute to the decrease in EBPs.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Diego Ruiz-Sobremazas, Mario Ruiz Coca, Miguel Morales-Navas, Rocio Rodulfo-Cardenas, Caridad Lopez-Granero, Maria Teresa Colomina, Cristian Perez-Fernandez, Fernando Sanchez-Santed
Summary: Air pollution is associated with a range of health issues and gestational exposure to environmental pollutants may be linked to neurodevelopmental disorders. This study investigated the effects of oral gestational exposure to particulate matter (PM) on ultrasonic vocalizations (USV). The findings suggest that this exposure may lead to social deficits and abnormal gene expression related to neurotransmitter systems. Further research is needed to better understand the effects of air pollution on neurodevelopmental disorders and the neurotransmission systems involved.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Yagmur Kabakci, Sadiye Kosar, Ozgur Dogan, Fehmi Gorkem Uctug, Osman Atilla Arikan
Summary: This study investigated the effect of electrohydrolysis pretreatment on municipal solid waste. The results showed that applying electrohydrolysis pretreatment increased methane production and reduced the time required for hydrolysis, suggesting it is a promising method to improve anaerobic digestion efficiency.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Chuanwu Zhao, Yaozhong Pan, Hanyi Wu, Yu Zhu
Summary: This study analyzed the impact of industrial zones on urban heat islands using remote sensing images and a novel spectral index. The research found that the contraction or expansion of industrial zones has a significant effect on land surface temperature. The results are valuable for environmental assessment and fine management of industrial cities.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Bang Du, Zhongzhong Wang, Piet N. L. Lens, Xinmin Zhan, Guangxue Wu
Summary: This study investigated the performance, syntrophic relationships, microbial communities, and metabolic pathways of ethanol-fed reactors with different operational modes and solids retention times. The results showed that different microorganisms were enriched under different SRT conditions, and syntrophic bacteria related to methane production could be enriched under low SRT conditions.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Gokulan Ravindiran, Sivarethinamohan Rajamanickam, Muralikrishnan Ramalingam, Gasim Hayder, Balamurugan Karupaiya Sathaiah, Madhava Krishna Reddy Gaddam, Senthil Kumar Muniasamy, Priya Arunkumar
Summary: The present study investigated the sustainable approach for wastewater treatment using waste algal blooms. The biochar produced by the marine algae Ulva reticulata was used to remove chromium, nickel, and zinc from aqueous solutions. The study examined the adsorbents' properties and stability using SEM/EDX, FTIR, and XRD. The results showed that the biochar had high removal efficiency for the toxic metals, and the packed bed column effectively removed the heavy metal ions. The Thomas and Adams-Bohart models were found to best fit the regression values, and desorption studies were conducted to understand the sorption and elution processes.
ENVIRONMENTAL RESEARCH
(2024)
Review
Environmental Sciences
Vignesh Vinayagam, Kavitha Nagarasampatti Palani, Sudha Ganesh, Siddharth Rajesh, Vedha Varshini Akula, Ramapriyan Avoodaiappan, Omkar Singh Kushwaha, Arivalagan Pugazhendhi
Summary: The presence of pollutants in water contributes to global pollution and poses significant threats to humans and wildlife. Finding effective wastewater treatment techniques is crucial for reducing pollutant accumulation in the environment. This paper highlights recent advances in the electrochemical advanced oxidation method and other processes for treating pharmaceuticals, dyes, and pesticide-polluted effluents.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
M. M. M. Ahmed, Kai-Yue Chen, Fang-Yu Tsao, Yi-Cheng Hsieh, Yu-Ting Liu, Min Tzou
Summary: This study investigated the sorption of citric acid onto humic acid-iron hydr(o)xide coprecipitate (HAFHCP) and the reciprocal effects of citric acid and P sorption on HAFHCP. The results showed that citric acid could increase P availability and have an impact on P sorption.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Xibo Xu, Zeqiang Wang, Xiaoning Song, Wenjie Zhan, Shuting Yang
Summary: The selection of predictor variables is crucial in building a digital mapping model for potentially toxic elements (PTEs) in soil. Traditionally, spatial and spectral parameters have been used as predictor variables, but the temporal dimension is often overlooked. This study demonstrates the value of incorporating temporal indices in the model, leading to significant performance improvements. The temporal-spatial-spectral covariate combinations used in a random forest (RF) algorithm achieve satisfactory mapping accuracy and outperform other methods.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Yan Pei, Xun Liu, Mengbo Cao, Zijun Wang, Hongbing Yang
Summary: Heteroatom doping can reconfigure the electronic structure of heterogeneous catalysts, leading to the development of advanced oxidation water purification materials with superior performance and stability. In this study, a series of catalysts with different elemental doping were prepared using a simple and environmentally friendly method. The S-doped NiCo2O4 catalyst showed excellent catalytic performance for the removal of Tetracycline, with significantly increased kinetic constant and high oxidation and mineralization efficiency in a wide pH range. The degradation process was dominated by non-radical oxidation pathway after S doping, and the overall process moved towards low toxicity.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Srivalli Thimmarayan, Harshavardhan Mohan, Gaddapara Manasa, Karthi Natesan, Shanmugam Mahendran, Pavithra Muthukumar Sathya, Byung-Taek Oh, R. Ravi Kumar, Rangasamy Sigamani Gandhimathi, Arul Jayaprakash, Kamala-Kannan Seralathan
Summary: This study investigated the bacterial degradation of naphthalene (NPT) isolated from crude oil-contaminated soil. Bacillus sp. GN 3.4, a potential bacteria for NPT biodegradation, was isolated and the optimal conditions for NPT degradation were determined. The study suggests that Bacillus sp. GN 3.4 could potentially aid in bioremediation by eliminating NPT from the soil.
ENVIRONMENTAL RESEARCH
(2024)