Article
Environmental Sciences
Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al Senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
Summary: This study demonstrates that vitamin D can improve the harmful effects of type 2 diabetes by increasing insulin secretion and sensitivity, improving beta-cell function, reducing cortisol levels, and exerting anti-inflammatory and antioxidant effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biology
Jona Merx, Rianne E. van Outersterp, Udo F. H. Engelke, Veronique Hendriks, Ron A. Wevers, Marleen C. D. G. Huigen, Huub W. A. H. Waterval, Irene M. L. W. Korver-Keularts, Jasmin Mecinovie, Floris P. J. T. Rutjes, Jos Oomens, Karlien L. M. Coene, Jonathan Martens, Thomas J. Boltje
Summary: Biomarkers of hyperprolinemia type II (HPII) were identified and characterized using metabolomics and spectroscopy methods. These biomarkers showed similar metabolic signatures as in patients with hyperprolinemia type I (HPI) and pyridoxine-dependent epilepsy, and could differentiate HPII from HPI.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Analytical
Lei Wen, Xinyu Ma, Jing Yang, Minmin Jiang, Chao Peng, Zhongyun Ma, Huan Yu, Yinhui Li
Summary: This study proposed a new design strategy based on pi-conjugation modulation for fluorescent probes, which can generate different emission bands in the presence and absence of the target. The newly designed fluorescence probe, Rhod-DCM-B, exhibited outstanding sensitivity and excellent selectivity towards ONOO-. It was successfully employed to determine endogenous and exogenous ONOO- in living cells, and effectively monitored the ONOO- in vivo.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Oseeyi Daudu, Kaylen R. Meeks, Lu Zhang, Javier Seravalli, John J. Tanner, Donald F. Becker
Summary: This study investigated the Thr171Met variant of PYCR1, which is found in patients with malignant melanoma and lung adenocarcinoma. The variant significantly affects the catalytic activity of PYCR1 but does not affect thermostability. The results suggest that the impact of the T171M variant on PYCR1 function in cancer is not due to increased catalytic activity.
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kamila Filip, Anna Lewinska, Jagoda Adamczyk-Grochala, Antonella Marino Gammazza, Francesco Cappello, Marianna Lauricella, Maciej Wnuk
Summary: 5-azaC can attenuate oxidant-induced senescence, stimulate autophagic response without pro-apoptotic action, and increase necrotic cell death in cells with higher nitric oxide levels under oxidative stress conditions.
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Felix Frimpong, Carel W. Windt, Dagmar van Dusschoten, Ali A. Naz, Michael Frei, Fabio Fiorani
Summary: The study found that barley genotypes carrying a wild allele at P5cs1 locus have an advantage in drought resistance at the reproductive stage by accumulating proline, maintaining photosynthetic activity, and intrinsic water use efficiency, ultimately achieving higher seed productivity.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Yao Zheng, Cecile Cabassa-Hourton, Holger Eubel, Guillaume Chevreux, Laurent Lignieres, Emilie Crilat, Hans-Peter Braun, Sandrine Lebreton, Arnould Savoure
Summary: This study reveals evidence of physical proximity and interactions among ProDH, P5CDH, and OAT in the mitochondria of Arabidopsis during dark-induced leaf senescence, suggesting the formation of a complex during P5C metabolism.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Physical
Mengyu Sun, Yanjuan Sang, Qingqing Deng, Zhengwei Liu, Jinsong Ren, Xiaogang Qu
Summary: A nanozyme-based NO generator, cerium oxide (CeO2)-AT, has been developed to selectively produce nitric oxide (NO) in cancer cells for tumor treatment. The generator can disrupt the mitochondrial respiratory chain of tumor cells and induce cell apoptosis by catalyzing the production of NO in the mitochondria of cancer cells. Furthermore, the generator can improve the performance of NO gas therapy by catalyzing H2O2 to produce O-2. This study provides a new approach for safe and specific cancer therapy using highly selective NO-based treatment.
Article
Plant Sciences
Xiaoxiao Liu, Di Gong, Qingbo Ke, Lina Yin, Shiwen Wang, Tianpeng Gao
Summary: A meta-analysis of 86 studies has shown that nitric oxide (NO) can significantly improve plant biomass, alleviate oxidative damage, and increase the content of Ca, Fe, and Mg in heavy metal-stressed plants. The optimal concentration of SNP (an NO donor) for hydroponic culture is in the range of 75-150 μM. These findings provide valuable insights for the future application of NO as a plant growth regulator for enhancing heavy metal stress tolerance in agriculture and breeding.
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata
Summary: The study revealed a significant association between higher serum ADMA levels and severe glaucoma, which remained significant after adjusting for potential confounders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Plant Sciences
Juan Manuel Peralta, Eliana Bianucci, Maria C. Romero-Puertas, Ana Furlan, Stella Castro, Claudia Travaglia
Summary: The presence of arsenic in groundwater poses a potential agronomic problem by accumulating in the food chain. Using plant growth-promoting bacteria (PGPB) is an important tool to reduce metal toxicity. When maize plants were exposed to arsenate, different strains of bacteria led to morphological changes in root exodermis, decreased photosynthetic pigments, and induced oxidative stress, with differential antioxidant responses observed.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Environmental Sciences
Rajesh Koley, Debojyoti Mishra, Naba Kumar Mondal
Summary: In this study, magnesium oxide nanoparticles (MgO NPs) synthesized through a green route were evaluated for their efficacy in reducing arsenic (As) accumulation and phytotoxicity in rice plants. The results showed that the application of MgO NPs significantly reduced As accumulation in the roots and shoots of rice seedlings, and improved their growth and antioxidant defense system activity. These findings suggest the potential use of MgO NPs for mitigating As contamination and improving rice yield.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)