Journal
ENVIRONMENTAL POLLUTION
Volume 184, Issue -, Pages 360-369Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2013.09.022
Keywords
Parabens; Fish embryo toxicity; Morphometry; Histology; Risk assessment
Categories
Funding
- Spanish Government [RTA2010-00004-C02, CTM2010 19779-C02-01]
Ask authors/readers for more resources
Here we proposed a battery of non-invasive biomarkers and a histological survey to examine physiological/anatomical features in embryos, eleutheroembryos (13 days post-fertilization, dpf), and larvae (28 -42 dpf) of medaka to investigate the effects of embryonic exposure to propylparaben (PrP). Concentrations <1000 mu g PrP/L didn't exert early or late toxic effects. However, survivorship was affected at 4000 mu g/L in eleutheroembryos and at >= 1000 mu g/L in larvae. Histological alterations were found in 37.5% of eleutheroembryos exposed to 4000 mu g PrP/L. Morphometric analysis of the gallbladder revealed significant dilation at >= 400 mu g/L throughout embryo development. Ethoxyresorufin-O-deethylase (EROD), as indicator of cytochrome P4501A activity, didn't reveal induction/inhibition although its combination with a P4501A agonist (i.e. beta-naphthoflavone) resulted in a synergic EROD response. Results suggest a low toxicity of PrP for fish and support the use of fish embryos and eleutheroembryos as alternatives of in vivo biomarkers indicative of exposure/toxicity. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available