4.7 Article Proceedings Paper

Traffic exposure in a population with high prevalence type 2 diabetes - Do medications influence concentrations of C-reactive protein?

Journal

ENVIRONMENTAL POLLUTION
Volume 159, Issue 8-9, Pages 2051-2060

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2010.12.025

Keywords

Residential traffic exposure; C-reactive protein; Type 2 diabetes; Traffic proximity; Traffic density; Puerto; Rican; Inflammation

Funding

  1. NHLBI NIH HHS [P50HL105185-01, P50 HL105185] Funding Source: Medline
  2. NIA NIH HHS [P01-AG023394, P01 AG023394] Funding Source: Medline
  3. NIEHS NIH HHS [R01 ES015462-03S1, R01 ES015462-01A1, R01 ES015462, R01 ES015462-04, R01 ES015462-03, R01 ES015462-05, R01 ES015462-02] Funding Source: Medline

Ask authors/readers for more resources

Type 2 Diabetes (T2D) and particulate air pollution are associated with inflammatory dysregulation. We assessed the modifying effects of diabetes medications on the association of C-reactive protein (CRP), a marker of inflammation, and traffic exposure in adults with T2D (n = 379). CRP concentrations were significantly positively associated with residence <= 100 m of a roadway, > 100 m and <= 200 m of a roadway and increased traffic density for individuals using insulin. For individuals using oral hypoglycemic medications (OHAs). CRP was significantly negatively associated with residence > 100 m - <= 200 m of a roadway and multiple roadway exposure in an interaction model. Among people with diabetes, individuals on insulin appear to be most vulnerable to the effects of traffic exposure. Disease severity among insulin users may promote the pro-inflammatory response to traffic exposure, though diabetes medications may also modify the response. Possible anti-inflammatory effects of OHAs with traffic exposure merit further evaluation. (C) 2010 Elsevier Ltd. All rights reserved.

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