Article
Multidisciplinary Sciences
Masato Takeuchi, Satomi Yoshida, Chihiro Kawakami, Koji Kawakami, Shuichi Ito
Summary: This study analyzed data from The Japan Environment and Children's Study to investigate the association between perinatal exposure to four heavy metals (mercury, lead, cadmium, and manganese) and isolated cleft lip and palate (cleft L/P). The results showed no association between exposure to these metals during pregnancy and the risk of cleft L/P in offspring.
Review
Environmental Sciences
A. Kofi Amegah, Christian Sewor, Jouni J. K. Jaakkola
Summary: Exposure to cadmium is associated with adverse birth outcomes, such as low birth weight, preterm birth, and small-for-gestational age. The risk for all outcomes decreases with decreasing exposure. For preterm birth, the formal dose-response meta-analyses suggest a causal association.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Environmental Sciences
Yunjiang Yu, Xiao-Di Qin, Michael S. Bloom, Chu Chu, Xin Dai, Qin-Qin Li, Zan-Xiong Chen, Min-Li Kong, Yan-Qi Xie, Wen-Jie Meng, Bo-Yi Yang, Li-Wen Hu, Xiao-Wen Zeng, Xiao-Miao Zhao, Yang Zhou, Guang-Hui Dong
Summary: The study found that high maternal PFAS exposure was associated with an increased risk of preterm birth, while individual paternal PFAS exposure showed a contradictory relationship. Family-level PFAS mixture concentration was positively associated with preterm birth risk.
ENVIRONMENTAL RESEARCH
(2022)
Review
Environmental Sciences
Lilia Bliznashka, Aditi Roy, Lindsay M. Jaacks
Summary: The impact of pesticide exposure on child growth and birth outcomes in low-and middle-income countries remains inconclusive. Further studies with accurate data are needed to understand the influence of pesticides on child growth.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Lin Chen, Chuanliang Tong, Xiaona Huo, Jun Zhang, Ying Tian
Summary: Most PFAS concentrations declined during pregnancy, while some were negatively associated with birth length, particularly in the first trimester for female fetuses. No significant associations were found between PFAS and birth weight or head circumference. The sensitive window of exposure for adverse effects on birth outcomes appeared to be in the first trimester.
Article
Environmental Sciences
Ram C. Siwakoti, Amber Cathey, Kelly K. Ferguson, Wei Hao, David E. Cantonwine, Bhramar Mukherjee, Thomas F. McElrath, John D. Meeker
Summary: This study found that prenatal exposure to PFAS may have an impact on pregnancy outcomes, including preterm birth and large-for-gestational age (LGA). However, the effects of PFAS on these outcomes depend on the fetal sex. Specifically, certain PFAS were associated with placental preterm birth, with stronger associations observed in male fetuses. For LGA, different PFAS had different effects in females and males.
ENVIRONMENTAL RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Reiko Kishi, Atsuko Ikeda-Araki, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Naomi Tamura, Machiko Minatoya, Rahel Mesfin Ketema, Kritika Poudel, Ryu Miura, Hideyuki Masuda, Mariko Itoh, Takeshi Yamaguchi, Hisanori Fukunaga, Kumiko Ito, Houman Goudarzi
Summary: The Hokkaido Study on Environment and Children's Health aims to investigate the effects of environmental chemical exposures on birth outcomes and child development, including genetic susceptibility and additive effects of chemicals. Recent findings have revealed various risk factors of parental characteristics on birth outcomes and the mediating effect of socioeconomic status on children that are small for gestational age.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2021)
Article
Environmental Sciences
Ying Wu, Fulin Zeng, Jinhui Li, Yukang Jiang, Shi Zhao, Luke D. Knibbs, Xiaojun Zhang, Yiding Wang, Qianqian Zhang, Qiong Wang, Qiansheng Hu, Xiaobo Guo, Yumeng Chen, Ganxiang Cao, Jing Wang, Xingfen Yang, Xueqin Wang, Tao Liu, Bo Zhang
Summary: This study investigated the impact of maternal metal exposure on birth weight in a Chinese birth cohort. It found that metal exposure had sex-specific effects on birth weight, with negative associations in girls and positive associations in boys. Cadmium and nickel were associated with higher and lower birth weight in girls, respectively. Thallium concentration also influenced the associations between cadmium, nickel, and birth weight in girls. The findings highlight the complex effects of intrauterine metal exposure on birth weight and the sex heterogeneity in fetal development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Wanrong Wang, Siqi Mu, Weizhen Yan, Naiyu Ke, Han Cheng, Rui Ding
Summary: Adverse pregnancy outcomes (APOs), including preterm birth, low birth weight, small for gestational age, stillbirth, and change in birthweight, are significantly associated with maternal exposure to PM2.5 during pregnancy, according to this meta-analysis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
Marisa A. Patti, Noelle B. Henderson, Priya Gajjar, Melissa Eliot, Medina Jackson-Browne, Joseph M. Braun
Summary: The results of the study suggest a stronger inverse association between triclosan exposure and infant birth weight in populations with higher triclosan exposure, but no significant association with GA-standardized birth weight.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Lifeng Wang, Lei Fang, Zhenya Fang, Meihua Zhang, Lin Zhang
Summary: This study analyzed the geographic distribution of Jinan and its contribution to air pollution. Based on a sample of 424 couples, it found that the basin structure of Jinan hinders the diffusion of ambient pollutants. The results showed that prenatal exposure to multiple air pollutants is associated with an increased risk of preterm birth and reduced gestational age.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Sylvester Dodzi Nyadanu, Jennifer Dunne, Gizachew Assefa Tessema, Ben Mullins, Bernard Kumi-Boateng, Michelle Lee Bell, Bereket Duko, Gavin Pereira
Summary: This study systematically reviewed and evaluated the associations between air pollutants and birth outcomes, finding plausible causal effects and consistent positive associations. However, more high-quality studies are needed to strengthen the evidence.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biology
Jie Zhao, Bohan Fan, Jian Huang, Benjamin John Cowling, Shiu Lun Ryan Au Yeung, Andrea Baccarelli, Gabriel M. Leung, C. Mary Schooling, Sihoon Lee
Summary: Through an environment-wide association study and an epigenome-wide association study, this research systematically assessed the factors associated with obesity at the onset and end of puberty. The study identified several factors, such as maternal second-hand smoking, maternal weight, and birth weight, that were consistently associated with obesity. It also found that factors like diet, physical activity, snoring, binge eating, and earlier puberty were positively associated with BMI at the end of puberty. These findings provide important information for future interventions to improve population health in Hong Kong and similar Chinese settings.
Review
Environmental Sciences
Shiqi Lin, Jiajia Li, Xiaojin Yan, Lijun Pei, Xuejun Shang
Summary: This systematic review and meta-analysis examined the association between prenatal maternal pesticide exposure and the risk of preterm birth and length of gestational age. The results indicated that a ten-fold increase in pesticide concentrations may be associated with a higher risk of preterm birth and a shortened gestational age.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Environmental Sciences
Sana Amjad, Dagmara Chojecki, Alvaro Osornio-Vargas, Maria B. Ospina
Summary: The evidence suggests that maternal wildfire exposure during late pregnancy is associated with reduced birth weight and preterm birth. However, the association between wildfire exposure and small for gestational age as well as infant mortality remains inconclusive. Well-designed comprehensive studies are needed to further understand the perinatal effects of wildfires.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Allergy
Anna Kilanowski, Elisabeth Thiering, Gang Wang, Ashish Kumar, Sara Kress, Claudia Flexeder, Carl-Peter Bauer, Dietrich Berdel, Andrea von Berg, Anna Bergstroem, Monika Gappa, Joachim Heinrich, Gunda Herberth, Sibylle Koletzko, Inger Kull, Erik Melen, Tamara Schikowski, Annette Peters, Marie Standl
Summary: This study identified seven trajectories of allergic diseases and investigated their associations with early-life determinants, genetic factors, and clinical characteristics. The results revealed that family history of allergies, specific polygenic risk scores, and clinical characteristics were associated with these trajectories.
Article
Obstetrics & Gynecology
Mette Jorgensen Langergaard, Andreas Ernst, Nis Brix, Anne Gaml-Sorensen, Sandra S. Tottenborg, Jens Peter E. Bonde, Gunnar Toft, Karin S. Hougaard, Cecilia H. Ramlau-Hansen
Summary: This study found that later maternal age at menarche was associated with impaired semen characteristics, lower testes volume, and altered levels of reproductive hormones in sons. However, earlier maternal age at menarche was not strongly associated with reproductive outcomes in sons. These findings may suggest a shared heritability or underlying epigenetic profile of reproductive health, but the exact mechanism remains unknown.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Ian Hough, Matthieu Rolland, Ariane Guilbert, Emie Seyve, Barbara Heude, Remy Slama, Sarah Lyon-Caen, Isabelle Pin, Cecile Chevrier, Itai Kloog, Johanna Lepeule
Summary: This study aimed to evaluate the association between ambient temperature and preterm delivery. The results showed that night-time heat and cold exposure were associated with an increased risk of preterm birth in a temperate climate.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Natacha Tessier, Romain Boissonnot, Virginie Desvignes, Marie Frochen, Mathilde Merlo, Olivier Blanchard, Cecile Chevrier, Laurence Guldner, Corinne Mandin, Ohri Yamada, Jean-Luc Volatier
Summary: This study investigated pesticide usage in French households and compiled a list of pesticides and active ingredients stored at home. The findings showed that 75% of households had used at least one pesticide in the past year, with insecticides, particularly pyrethroids, being the most commonly used type.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, Eric Gaudreau, Joan O. Grimalt, Jesus Ibarluzea, Fabrice Laine, Sabrina Llop, Maria-Jose Lopez-Espinosa, Florence Rouget, Loreto Santa -Marina, Martine Vrijheid, Cecile Chevrier, Maribel Casas, Charline Warembourg
Summary: Several studies have shown that prenatal exposure to certain persistent organic pollutants (POPs) is associated with higher adiposity in childhood. This study aimed to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. The findings suggest that prenatal exposure to POPs, especially organochlorine pesticides, is linked to unfavorable cardiometabolic health up to the age of 12.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Julia Sanguesa, Sandra Marquez, Mariona Bustamante, Jordi Sunyer, Carmen Iniguez, Jesus Vioque, Loreto Santa-Marina Rodriguez, Alba Jimeno-Romero, Matias Torrent, Maribel Casas, Martine Vrijheid
Summary: This study examines the association between prenatal vitamin D levels and growth and adiposity in late childhood. The results suggest a sex-specific programming effect of early pregnancy vitamin D levels on offspring body composition, which is observed in boys but not in girls.
Article
Medicine, General & Internal
Sandra Florian, Mathieu Ichou, Lidia Panico, Stephanie Pinel-Jacquemin, Tanja G. M. Vrijkotte, Margreet W. Harskamp-van Ginkel, Rae-Chi Huang, Jennie Carson, Loreto Santa Marina Rodriguez, Mikel Subiza-Perez, Martine Vrijheid, Silvia Fernandez-Barres, Tiffany C. Yang, John Wright, Eva Corpeleijn, Marloes Cardol, Elena Isaevska, Chiara Moccia, Marjolein N. Kooijman, Ellis Voerman, Vincent Jaddoe, Marieke Welten, Elena Spada, Marisa Rebagliato, Andrea Beneito, Luca Ronfani, Marie-Aline Charles
Summary: Research shows that immigrants have better health outcomes than natives, known as the 'immigrant health paradox'. However, this advantage does not necessarily transfer to their children in the form of higher birth weight. The study found that children of immigrants in France and Australia had higher birth weight, while children of immigrants in the UK and the Netherlands had lower birth weight compared to native children.
Correction
Medicine, General & Internal
Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrom, Thorkild I. A. Sorensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot de Moira, Barbara Heude, Carmen Iniguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae-Chi Huang, Rebecca C. Wilson, Sido Haakma, Silvia Fernandez-Barres, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen
Article
Biology
Oliver Robinson, ChungHo E. Lau, Sungyeon Joo, Sandra Andrusaityte, Eva Borras, Paula de Prado-Bert, Lida Chatzi, Hector C. Keun, Regina Grazuleviciene, Kristine B. Gutzkow, Lea Maitre, Dries S. Martens, Eduard Sabido, Valerie Siroux, Jose Urquiza, Marina Vafeiadi, John Wright, Tim S. Nawrot, Mariona Bustamante, Martine Vrijheid
Summary: In this study of European school-age children, we found that accelerated biological age is related to child developmental outcomes, including growth and adiposity, cognition, behavior, lung function, and the onset of puberty. These results suggest that biological aging in children is a multi-faceted process, and adiposity plays an important role in accelerated biological aging.
Article
Environmental Sciences
Sarah Warkentin, Jeroen de Bont, Alicia Abellan, Andrea Pistillo, Apolline Saucy, Marta Cirach, Mark Nieuwenhuijsen, Sara Khalid, Xavier Basagana, Talita Duarte-Salles, Martine Vrijheid
Summary: Air pollution exposure due to residential relocation is associated with changes in body mass index (BMI) in children and adolescents. Moving to areas with more air pollution leads to increased BMI, while moving to areas with similar or less air pollution leads to decreased BMI.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
L. Notario-Barandiaran, A. Irizar, M. Begona-Zubero, R. Soler-Blasco, G. Riutort-Mayol, A. Fernandez-Somoano, A. Tardon, M. Casas, M. Vrijheid, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. O. Grimalt, J. Vioque, A. J. Signes-Pastor
Summary: In this study, the association between adherence to the Mediterranean diet (MD) and urinary metal concentrations in children was evaluated. It was found that high adherence to MD was associated with increased urinary levels of arsenic and copper, but also an increase in non-toxic arsenobetaine concentrations.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Paulina Jedynak, Marta Gallego, Laura Ciaran, Karine Audouze, Maribel Casas, Martine Vrijheid
Summary: Health effects of endocrine disrupting chemicals (EDCs) are difficult to detect in the general population. Omics technologies are commonly used in epidemiological studies to identify early biological changes, explore toxic mechanisms, and enhance the plausibility of associations. This scoping review summarizes the application of omics in EDCs-associated biological effects research, identifying gaps and priorities for future studies. The review highlights the need for larger longitudinal studies, wider coverage of exposures and biomarkers, replication studies, and standardization of research methods and reporting. Rating: 7 out of 10.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carlos Ruiz-Arenas, Leire Abarrategui, Carles Hernandez-Ferrer, Xavier Escriba-Montagut, Dolors Pelegri-Siso, Patricia Ryser-Welch, Martine Vrijheid, Mariona Bustamante, Regina Grazuleviciene, Johanna Lepeule, Mathew Mathai, Marina Vafeiadi, Sergi Beltran, Luis A. Perez-Jurado, Juan R. Gonzalez
Summary: Epimutations are rare alterations of DNA methylation pattern that can lead to rare diseases. In this study, we developed epimutacions, a Bioconductor package, to detect and visualize epimutations. We validated the performance of epimutacions using public datasets and population cohorts, and provided guidelines for experiment design and data analysis. Furthermore, we demonstrated the clinical application of epimutacions by detecting novel epimutations in children with autism disorder.
Article
Public, Environmental & Occupational Health
Mikel Subiza-Perez, Gonzalo Garcia-Baquero, Ana Fernandez-Somoano, Isolina Riano, Llucia Gonzalez, Juana Maria Delgado-Saborit, Monica Guxens, Serena Fossati, Martine Vrijheid, Amanda Fernandes, Jesus Ibarluzea, Nerea Lertxundi
Summary: The availability of green and blue spaces in residential areas is related to children's mental health, but this association is not evenly distributed among socio-economic groups. This study did not find significant associations between green and blue spaces and mental health in children.