Article
Biochemical Research Methods
Francesca Di Cesare, Leonardo Tenori, Claudio Luchinat, Edoardo Saccenti
Summary: This study investigates the associations between plasma metabolites, lipoprotein parameters, blood groups and the Rh blood system. The results suggest blood group-dependent (re)shaping of lipoprotein metabolism in healthy subjects, which may explain the differential susceptibility to certain diseases observed in different blood groups.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Markus Axmann, Birgit Plochberger, Mario Mikula, Florian Weber, Witta Monika Strobl, Herbert Stangl
Summary: Cholesterol transfer between lipoprotein particles and the plasma membrane is crucial for lipid supply in the human body. Different density lipoprotein particles deliver cholesterol to cells through redundant pathways, which can compensate for defects in one pathway but may lead to systemic diseases later on. Intracellular membrane-membrane contact sites and the plasma membrane itself play roles in cholesterol transfer.
Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Guido Rossi-Herring, Thalia Belmonte, Andrea Rivas-Urbina, Sonia Benitez, Noemi Rotllan, Javier Crespo, Vicenta Llorente-Cortes, Jose Luis Sanchez-Quesada, David de Gonzalo-Calvo
Summary: This study examined the expression profiles of miRNAs in lipoprotein fractions (VLDL, LDL, and HDL) isolated from the serum through various methods. The results showed stable detection of different miRNAs in each fraction, with VLDL-specific miRNAs detected for the first time. Functional enrichment analysis indicated the potential roles of lipoprotein-carried miRNAs in cardiovascular disease-related mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Alberto Cordero, Natalia Munoz-Garcia, Teresa Padro, Gemma Vilahur, Vicente Bertomeu-Gonzalez, David Escribano, Emilio Flores, Pilar Zuazola, Lina Badimon
Summary: This study investigated the role of lipoprotein functionality as well as particle number and size in patients with acute coronary syndrome (ACS) and on-target LDL-C levels. It was found that ACS patients had higher susceptibility to LDL oxidation and lower HDL-antioxidant capacity. They also had lower HDL-C and Apolipoprotein A-I levels compared to non-ACS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Article
Oncology
Amarilis de Lima Campos, Maria Isabela Bloise Alves Caldas Sawada, Monique Fatima de Mello Santana, Rodrigo Tallada Iborra, Sayonara Ivana Santos de Assis, Mozania Reis, Jacira Xavier de Carvalho, Luiz Henrique Gebrim, Marisa Passarelli
Summary: This study investigated the composition and antioxidant activity of HDL in women with triple-negative breast cancer (TNBC) compared to controls. The results showed that TNBC patients had higher HDL antioxidant activity, which may help mitigate oxidative and inflammatory damage in breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Yu Luo, Jiating Wang, Chenfei Wang, Dongbin Wang, Chengji Li, Bin Zhang, Xiaoting Zhong, Linkang Chen, Hao Li, Hongtian Su, Qiuyi Zheng, Dajian Zhu, Huanwen Tang, Lianxian Guo
Summary: This study investigates the potential of microbial detoxification via gut microbiome in the treatment of sub-chronic arsenic poisoning. The results show that in situ arsenic-induced fecal microbiome can stably colonize and interact with indigenous microbes in the recipient mice in two weeks, and the recipient mice demonstrated lower fecal arsenic excretion, liver and plasma arsenic accumulation after treatment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Takumi Nakamura, Takeshi Kawarabayashi, Tetsuya Ueda, Sachiko Shimomura, Masaki Hoshino, Ken Itoh, Kazushige Ihara, Shigeyuki Nakaji, Masamitsu Takatama, Yoshio Ikeda, Mikio Shoji
Summary: This study measured the plasma levels of total ApoE, ApoE2, ApoE3, and ApoE4 in 498 participants using mass spectrometry. The results showed that plasma ApoE levels are associated with lipids and multiple metabolic pathways, but not directly with aging or Alzheimer's disease biomarkers. These findings provide new insights into the mechanisms by which peripheral ApoE4 influences the progression of Alzheimer's disease and atherosclerosis.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Environmental Sciences
Golam Jalal Ahammed, Youxin Yang
Summary: Plants detoxify toxic metals by accumulating diverse metabolites, with some metabolites chelating metal ions. In addition to classical detoxification pathways involving thiol-containing compounds, secondary metabolites like anthocyanins have emerged as playing a significant role in metal detoxification. Anthocyanins, with their ability to scavenge reactive oxygen species, contribute to enhanced arsenic tolerance in plants and may offer potential for improving crop yield and food safety in arsenic polluted areas.
ENVIRONMENTAL POLLUTION
(2022)
Article
Oncology
Giovanna Revilla, Lidia Cedo, Mireia Tondo, Antonio Moral, Jose Ignacio Perez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, T. Srivinasa Reddy, Francisco Blanco-Vaca, Eugenia Mato, Joan Carles Escola
Summary: Cholesterol is crucial for various functions in endocrine-related cells, including hormone and steroid production. While LDL-cholesterol and HDL-cholesterol were not consistently associated with endocrine-related cancer risk, LDL receptor plays a critical role in endocrine-related tumor cells by enhancing circulating LDL-C uptake.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Environmental Sciences
Zhongqing Huang, Bingyu Chen, Jing Zhang, Changliang Yang, Jie Wang, Fei Song, Shigang Li
Summary: This study found that the presence of copper (Cu) can promote the absorption and accumulation of arsenic (As) by algae, which has significance in the possible bioremediation of arsenic pollution in aquatic environments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: This article summarizes the changes in the quantity, quality, and functionality of high-density lipoproteins (HDL) in the context of health and disease, and discusses their potential role in the diagnosis and treatment of diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Cheng Fang, Yunlong Luo, Xian Zhang, Hongping Zhang, Annette Nolan, Ravi Naidu
Summary: This study compares two decoding approaches for visualising microplastics and nanoplastics via Raman imaging. The first approach maps Raman intensity at characteristic peaks when standard spectra are available, while the second approach uses PCA to decode the spectrum matrix for complex samples without standard spectra. The PCA-based algorithm shows advantages in analysing and identifying microplastics from other materials.
Article
Environmental Sciences
Yongliang Chen, Masud Hassan, Md Nuruzzaman, Huiming Zhang, Ravi Naidu, Yanju Liu, Ling Wang
Summary: Adsorption is a promising remediation technology for separating organic and inorganic agrochemicals from contaminated soil and water. This study focuses on the use of iron-modified base-activated biochar (FeBBC) as a low-cost adsorbent for removing the insecticide imidacloprid from water. The FeBBC exhibits high adsorption capacity and both physical and chemical interactions contribute to the sorption process. The results demonstrate the potential of FeBBC as an effective adsorbent for removing organic contaminants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agronomy
Solmaz Bidast, Ahmad Golchin, Ahmad Baybordi, Amir Mohseni, Ravi Naidu
Summary: The potential of bare and carboxymethyl cellulose (CMC)-coated iron oxide nanoparticles (FeONPs) for stabilising lead (Pb), zinc (Zn), and cadmium (Cd) in contaminated soil was investigated. The results showed that CMC-coated FeONPs were more effective in decreasing the availability of potentially toxic elements in the soil. CMC-coated goethite was the most effective treatment for reducing Zn and Cd availability, while CMC-coated magnetite was the most effective for Pb stabilisation.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Article
Environmental Sciences
M. A. A. Wijayawardena, K. Yan, Y. Liu, R. Naidu
Summary: Mouse models have been commonly used to predict the bioavailability of metals and chemicals in humans. In this study, the effectiveness of mouse models in predicting the bioavailability of lead in metal mixtures was confirmed, while their ability to predict the bioavailability of arsenic was found to be limited.
Article
Environmental Sciences
Sara Ghavamifar, Ravi Naidu, Vahid Mozafari, Zhaohui Li
Summary: In this study, two sorbents, calcite and saponite, were used to investigate their capacity to sorb glyphosate. It was found that the morphology of calcite transformed and the zeta potential became positive in alkaline pH, contradicting previous research. The modified sorbents were added to soil samples to study their effects on glyphosate sorption.
Article
Environmental Sciences
Yunlong Luo, Ravi Naidu, Cheng Fang
Summary: This study investigates the surface functional group changes and release of microplastics and nanoplastics during the combustion process of an outdoor plastic chair. Scanning electron microscopy (SEM) and Raman imaging techniques are used to characterize the fragments created when the plastic is burned and deposited on solid surfaces. Different algorithms, including logic-based, non-supervised PCA-based, algebra-based, and hybrid algorithms, are tested and optimized to extract key information for plastics characterization, particularly in distinguishing different degrees of burning. The findings estimate that tens of microplastics and nanoplastics are created per square micron during the combustion process.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Matthew Dietrich, Cynthia F. Barlow, Jane A. Entwistle, Diana Meza-Figueroa, Chenyin Dong, Peggy Gunkel-Grillon, Khadija Jabeen, Lindsay Bramwell, John T. Shukle, Leah R. Wood, Ravi Naidu, Kara Fry, Mark Patrick Taylor, Gabriel M. Filippelli
Summary: Lead (Pb) contamination continues to pose health risks in all countries, especially low-and middle-income countries. Predicting elevated household dust Pb levels and the potential impact of low-cost interventions has been a challenge. A global dataset of household dust samples was used to predict elevated dust Pb levels, with housing age being a significant predictor. The predictive accuracy of the model is lower for countries outside of England, the U.S., and Australia due to differences in regulations and data availability. Implementing simple household interventions in these countries could result in significant cost savings and reduced exposure to harmful Pb dust sources globally.
ENVIRONMENTAL POLLUTION
(2023)
Review
Environmental Sciences
Anwar Ul Haq Khan, Ravi Naidu, Raja Dharmarajan, Cheng Fang, Hokyong Shon, Zhaomin Dong, Yanju Liu
Summary: This review focuses on the occurrence and interactions of engineered nanoparticles (ENPs) and brominated flame retardants (BFRs) in water systems, as well as the formation of complex compounds in the environment. It summarizes the release of ENPs and BFRs, their key interaction mechanisms, and their influence on the behavior and toxic effects of PBDEs. The study highlights the distinct behavior of mixed compounds (ENPs-BFRs) and emphasizes the importance of understanding the interactions in comprehensive risk assessments.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Engineering, Environmental
Yunlong Luo, Ravi Naidu, Cheng Fang
Summary: Raman imaging can directly visualize the adsorption of perchlorate and allow real-time monitoring due to the low Raman activity and minimal interference of water. The enhancement of perchlorate's Raman signal on porous silver enables the monitoring of low-level adsorption.
Review
Fisheries
Nepheronia Jumalon Ogburn, Luchun Duan, Suresh Ramraj Subashchandrabose, Patrick Sorgeloos, Wayne O'Connor, Mallavarapu Megharaj, Ravi Naidu
Summary: Aquaculture, as one of the fastest growing food industry sectors, is facing sustainability challenges due to increasing global population and protein demand. The use of agricultural waste to produce Artemia, a kind of aquatic species, provides an environmentally sustainable solution for supporting aquaculture demand.
REVIEWS IN AQUACULTURE
(2023)
Article
Chemistry, Analytical
Md. Rashidul Islam, Peter Sanderson, Mathew P. Johansen, Timothy E. Payne, Ravi Naidu
Summary: This study evaluated the environmental behavior of beryllium in soil-water systems under different sorption conditions, and found that certain ions and factors such as temperature and concentration can affect the sorption and desorption of beryllium.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Environmental Sciences
Yunlong Luo, Ashkan Khoshyan, Md Al Amin, Annette Nolan, Fiona Robinson, Jim Fenstermacher, Junfeng Niu, Mallavarapu Megharaj, Ravi Naidu, Cheng Fang
Summary: In this study, a hybrid system combining electrochemical treatment with ultrasound irradiation is proposed for enhanced degradation of PFAS. The electrochemical process using a titanium suboxide anode effectively removes PFOA, and when combined with ultrasound irradiation, achieves 100% PFOA removal and 63.5% defluorination, indicating synergistic removal/oxidation effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yunlong Luo, Ravi Naidu, Cheng Fang
Summary: The sources of microplastics and nanoplastics are widespread and include everyday activities. However, the limited techniques for characterization hinder the determination of their sources. We propose advancing Raman imaging by combining it with various algorithms to improve signal-noise ratio and imaging certainty, enabling the characterization of microplastics. We can capture and identify microplastics carried by smartphones, which are released from clothing and plastic decoration trinkets, accumulating on the phone surface or in ports. Further methodological improvements are necessary due to the complexity of the samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Aravind Unnithan, Dawit Nega Bekele, Sreenivasulu Chadalavada, Ravi Naidu
Summary: This study presents a 2-D model for chlorinated vapour intrusion, taking into account the role of highly permeable utility lines as a preferential pathway. The model's results are comparable to other models and show that the presence of highly permeable utility lines increases indoor air concentration.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Juan C. Sanchez-Hernandez, Cristobal Narvaez, Ximena Andrade Cares, Pablo Sabat, Ravi Naidu
Summary: Earthworms are being studied for their potential in bioremediation due to their impact on pollutant fate. Different earthworm species have varying sensitivities and capacities to break down contaminants, and Lumbricus terrestris is the most suitable species for bioremediation of OP-contaminated soil due to its higher levels of detoxification enzymes and oxidative homeostasis mechanisms compared to Eisenia fetida andAporrectodea caliginosa. These findings suggest L. terrestris as a better candidate for soil bioremediation than epigeic earthworms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)