Psychomotor effects, pharmacokinetics and safety of the orexin receptor antagonist suvorexant administered in combination with alcohol in healthy subjects

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

(2014) David Michelson et al.   LANCET NEUROLOGY

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

(2013) C J Winrow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators

(2013) Andres D. Ramirez et al.   Frontiers in Neuroscience

Dual orexin receptor antagonism by almorexant does not potentiate impairing effects of alcohol in humans

(2012) Matthias Hoch et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant

(2012) W. J. Herring et al.   NEUROLOGY

Prevalence and Perceived Health Associated with Insomnia Based on DSM-IV-TR; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision; and Research Diagnostic Criteria/International Classification of Sleep Disorders, Second Edition Criteria: Results from the America Insomnia Survey

(2011) Thomas Roth et al.   BIOLOGICAL PSYCHIATRY

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

(2011) Paolo Bettica et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

(2011) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Context Dependent Benzodiazepine Modulation of GABAA Receptor Opening Frequency

(2010) Matt Bianchi   Current Neuropharmacology

Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat

(2010) Michel A Steiner et al.   NEUROPSYCHOPHARMACOLOGY