Article
Psychology, Multidisciplinary
Pety So, Andre I. Wierdsma, Cornelis L. Mulder, Robert R. J. M. Vermeiren
Summary: There is evidence that the COVID-19 pandemic and social distancing measures have affected adolescents' mental health. The number of psychiatric emergency consultations for adolescents has increased over time, with a pronounced increase among girls with internalizing problems during the second wave of the pandemic.
Article
Psychology, Developmental
Alexander Neumann, Alexia Jolicoeur-Martineau, Eszter Szekely, Hannah M. Sallis, Kieran O'Donnel, Celia M. T. Greenwood, Robert Levitan, Michael J. Meaney, Ashley Wazana, Jonathan Evans, Henning Tiemeier
Summary: The study found that PRS based on current GWAS of psychiatric phenotypes tends to be associated with general psychopathology, or both general and specific psychiatric domains, but not with one specific psychopathology domain only. Furthermore, PRSs can be combined to improve predictive ability. Users of PRS should be aware of nonspecificity and consider using multiple PRSs simultaneously when predicting psychiatric disorders.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Review
Psychology, Clinical
Roman Kotov, David C. Cicero, Christopher C. Conway, Colin G. DeYoung, Alexandre Dombrovski, Nicholas R. Eaton, Michael B. First, Miriam K. Forbes, Steven E. Hyman, Katherine G. Jonas, Robert F. Krueger, Robert D. Latzman, James J. Li, Brady D. Nelson, Darrel A. Regier, Craig Rodriguez-Seijas, Camilo J. Ruggero, Leonard J. Simms, Andrew E. Skodol, Irwin D. Waldman, Monika A. Waszczuk, David Watson, Thomas A. Widiger, Sylia Wilson, Aidan G. C. Wright
Summary: The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative approach to psychiatric nosology that identifies psychopathology constructs based on patterns of co-variation among signs and symptoms. HiTOP is a living model that undergoes revision as new data become available. It has advantages in psychiatric practice and research and can contribute to progress in psychiatry and complement traditional nosologies. It also facilitates research on genetic and environmental causes of psychopathology, as well as the search for neurobiologic mechanisms and novel treatments. It has implications for public health programs and prevention of mental disorders.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Rashida S. S. Smith-Webb, Ruby Barnard-Mayers, Martha M. M. Werler, Samantha E. E. Parker
Summary: Acetaminophen, a commonly used medication during pregnancy, has been linked to adverse neurodevelopmental outcomes in childhood, but its associations with outcomes in adolescence are less known.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychology, Clinical
Kenneth S. Kendler, Sara L. Lonn, Jan Sundquist, Kristina Sundquist
Summary: The study found that resting pulse is negatively and positively associated with the risk for externalizing and internalizing disorders, respectively. Family studies showed that the nature of these associations differs, with elevated pulse directly increasing the risk for internalizing disorders while reduced pulse may be a risk index for traits predisposing to externalizing disorders.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Environmental Sciences
Claire E. Campbell, Devyn L. Cotter, Katherine L. Bottenhorn, Elisabeth Burnor, Hedyeh Ahmadi, W. James Gauderman, Carlos Cardenas-Iniguez, Daniel Hackman, Rob McConnell, Kiros Berhane, Joel Schwartz, Jiu-Chiuan Chen, Megan M. Herting
Summary: Recent studies have found a connection between air pollution and increased risk for behavioral problems during development. However, more longitudinal studies are needed to investigate how exposure during the transition to adolescence may affect emotional behaviors.
ENVIRONMENTAL RESEARCH
(2024)
Article
Medicine, General & Internal
Emily Neuhaus, Anthony Osuna, Daina M. Tagavi, Sina Shah-Hosseini, Shannon Simmons, Jennifer Gerdts, Alysha D. Thompson
Summary: Children with autism spectrum disorder and developmental disabilities (ASD/DD) who require inpatient psychiatric care have unique characteristics and clinical care needs. This study examined electronic health records of over 2300 children and adolescents admitted to a pediatric psychiatric inpatient unit and found that ASD/DD patients accounted for a significant proportion of inpatients and admissions. They were younger, more likely to be readmitted, male, and had Medicaid insurance. Clinically, they had more externalizing concerns compared to other patients. Patient age, sex, and race/ethnicity also influenced various aspects of clinical care. The study highlights the importance of appropriate psychiatric screening tools and the integration of anti-racist practices in inpatient care for ASD/DD populations, particularly regarding the use of physical restraint.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Morgan Steele, Mirko Uljarevic, Gaelle Rached, Thomas W. Frazier, Jennifer M. Phillips, Robin A. Libove, Robyn M. Busch, Patricia Klaas, Julian A. Martinez-Agosto, Siddharth Srivastava, Charis Eng, Mustafa Sahin, Antonio Y. Hardan
Summary: Our study compared psychiatric characteristics among children and adolescents with PTEN mutation with and without ASD, as well as ASD with macrocephaly but no PTEN mutation. We found significant group effects for broad symptom scores and specific syndrome scores, with greater behavioral symptoms in ASD groups compared to those without ASD. While there were no significant differences between PTEN-ASD and macro-ASD groups, the latter showed a trend for higher levels of aggressive behaviors.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Developmental
Kari Skulstad Gardvik, Marite Rygg, Terje Torgersen, Stian Lydersen, Marit Saebo Indredavik
Summary: In a clinical psychiatric cohort from adolescence to young adulthood, the overall rate of psychiatric disorders decreased, but there was a marked increase in anxiety disorders among girls. Chronic pain, smoking, and trying illicit drugs were associated with persisting psychiatric disorders.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Psychiatry
Bori Jung, Hyunsik Kim
Summary: Transdiagnostic factors have been shown to predict the continuity of comorbidity classes over time, indicating a complex and uncertain pattern of symptom manifestation in psychopathology.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Substance Abuse
Ashley L. L. Watts, David Watson, Andrew C. C. Heath, Kenneth J. J. Sher
Summary: Alcohol use disorder is often comorbid with other forms of psychopathology. This study found that different combinations of symptoms within alcohol use disorder can lead to disorder-specific expressions as well as tendencies towards externalizing and internalizing psychopathology.
Article
Psychology, Multidisciplinary
Jennifer E. Khoury, Hargun Kaur, Andrea Gonzalez
Summary: The study examined changes in child internalizing and externalizing problems during the pandemic, finding that children experienced significant increases in both during this period. Parenting behavior and parental mental health were associated with changes in child mental health problems.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Developmental
Stella Tsotsi, Shaun Goh, Robert J. Coplan, Evalill Bolstad, Nikolai O. Czajkowski, Dinka Smajlagic, Mona Bekkhus
Summary: The goal of this longitudinal study was to investigate whether co-occurrent internalizing difficulties and aggression in early childhood increase the risk for mental health problems in middle childhood. The findings demonstrated that children with co-occurrent internalizing difficulties and aggression exhibited higher levels of depressive, anxiety, and oppositional defiant symptoms at age 8. Most children remained stable in their profiles between ages 3 and 5, but transitions between risk profiles were also observed. These results highlight the importance of person-centered monitoring and early identification of difficulties in early childhood for preventive measures.
INTERNATIONAL JOURNAL OF BEHAVIORAL DEVELOPMENT
(2023)
Article
Psychology, Clinical
Courtney T. Blondino, Elizabeth C. Prom-Wormley
Summary: The use of conventional cigarettes, alcohol, marijuana, and sedatives is often associated with internalizing and externalizing disorders. It is uncertain how these relationships extend to electronic cigarettes and prescription drugs, and if there are gender differences.
ADDICTIVE BEHAVIORS
(2022)
Article
Clinical Neurology
Jianghong Liu, Andrea L. Glenn, Naixue Cui, Adrian Raine
Summary: The study found bidirectional relationships between sleep problems and behavior problems, indicating that early interventions targeting both issues may effectively prevent the aggravating health-behavior cycle.
Article
Psychology, Clinical
Carlos Blanco, Melanie M. Wall, Nicolas Hoertel, Robert F. Krueger, Mark Olfson
Summary: Most risk factors for psychiatric disorders are mediated through broad psychopathological dimensions, supporting the need for a trans-diagnostic approach to etiological research and intervention.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Margaux Chene, Marina Sanchez-Rico, Carlos Blanco, Rachel Pascal De Raykeer, Cecile Hanon, Pierre Vandel, Frederic Limosin, Nicolas Hoertel
Summary: In older adults with major psychiatric disorders, all psychiatric symptoms are associated with increased mortality, mainly through a general psychopathology dimension. No BPRS item or lower order factor has a significant effect on mortality beyond the general psychopathology factor. Greater number of medical conditions, older age, male sex, and being hospitalized or institutionalized at baseline are significantly associated with this increased risk, independently from the general psychopathology factor.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Oncology
Jacques Medioni, Daniel Scimeca, Yecenia Lopez Marquez, Emmanuelle Leray, Marie Dalichampt, Nicolas Hoertel, Mohammed Bennani, Pascal Trempat, Naoual Boujedaini
Summary: This study evaluated the benefits of homeopathy on the quality of life of patients with nonmetastatic breast cancer. The use of homeopathy in patients with breast cancer after diagnosis has increased, leading to a decrease in medications for palliating cancer treatment side effects. This indicates an improvement in quality of life for patients who use homeopathy.
CLINICAL BREAST CANCER
(2023)
Editorial Material
Psychiatry
Cedric Lemogne, Clement Gouraud, Victor Pitron, Brigitte Ranque
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychiatry
Carlos Blanco, Leonie Kampe, Melanie M. Wall, Shang-Min Liu, Shuai Wang, Eve Caligor, Mark Olfson
Summary: Despite the lack of published studies on the prevalence and correlates of defense mechanisms in nationally representative samples, this study used approximations from personality traits assessments to estimate the prevalence and correlates of 12 defense mechanisms in a representative sample of US adults. The results showed that neurotic, immature, and pathological defense mechanisms are prevalent in the general population and associated with psychosocial impairment. Recognizing defense mechanisms may be important in clinical practice regardless of treatment modality.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Emmanuel Leleu, Marina Sanchez-Rico, Miriam Abellan, Carlos Blanco, Sunthavy Yeim, Esther Chaugne, Frederic Limosin, Nicolas Hoertel
Summary: This study examines the association between lithium use and all-cause mortality and specific causes of death among older adults with psychiatric disorders. The results show that lithium use is not significantly associated with all-cause or disease-related mortality, and may be associated with a reduced risk of suicide.
AGING & MENTAL HEALTH
(2023)
Article
Psychiatry
Joane Matta, Emmanuel Wiernik, Olivier Robineau, Gianluca Severi, Mathilde Touvier, Clement Gouraud, Charles Ouazana-Vedrines, Victor Pitron, Brigitte Ranque, Nicolas Hoertel, Omer Van den Bergh, Michael Witthoeft, Sofiane Kab, Marcel Goldberg, Marie Zins, Cedric Lemogne
Summary: This study aimed to investigate the association between trust in different sources of information on COVID-19 at the beginning of the pandemic and the burden of incident persistent symptoms. Using data from the French CONSTANCES population-based cohort, the study found that participants with higher trust in government/journalists had fewer incident persistent symptoms at follow-up. Trust in government/journalists and medical doctors/scientists was also associated with a lower likelihood of having at least one symptom.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychology, Developmental
Mark Olfson, Melanie M. Wall, Shuai Wang, Carlos Blanco
Summary: The objective of this study was to estimate the prevalence of current DSM-5 disorders in children aged 9 to 10 and their associations with sociodemographic and physical characteristics. The study found that the prevalence of any current mental disorder was 10.11%, with higher rates among boys and children from low-income families. Boys, children from families with incomes below $25,000 and $25,000 to $49,000, and obese children were at increased risk for any current child mental disorder. Children from low-income families were particularly at risk for attention-deficit/hyperactivity disorder and disruptive behavior disorders.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Axel Baptista, Valerian Chambon, Nicolas Hoertel, Mark Olfson, Carlos Blanco, David Cohen, Pierre O. Jacquet
Summary: This study found that the emergence of borderline personality disorder (BPD) is associated with prioritizing short-term reproductive goals over long-term somatic maintenance goals, which can be seen as a developmental response to adverse early life experiences. Early life adversity is directly or indirectly associated with a diagnosis of BPD, and prioritizing short-term reproductive goals further increases the risk of BPD. These findings help explain the physiological and behavioral correlates of BPD.
Article
Biochemistry & Molecular Biology
Baptiste Pignon, Valentina Decio, Philippe Pirard, Olivier Bouaziz, Emmanuelle Corruble, Pierre A. Geoffroy, Viviane Kovess-Masfety, Marion Leboyer, Cedric Lemogne, Jonathan Messika, Vittorio Perduca, Franck Schurhoff, Nolwenn Regnault, Sarah Tebeka
Summary: COVID-19 may not increase the risk of hospitalization for psychotic disorders, as patients initially hospitalized for COVID-19 had a lower rate of subsequent hospitalization for psychotic disorders compared to those initially hospitalized for other reasons. This finding contradicts the hypothesis that there is an increased risk of psychotic disorders after a severe COVID-19 infection. Importantly, a history of psychotic disorder was found to be a major determinant of hospitalization for psychotic disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Chemistry, Medicinal
Nicolas Hoertel, Katayoun Rezaei, Marina Sanchez-Rico, Alfonso Delgado-Alvarez, Johannes Kornhuber, Erich Gulbins, Mark Olfson, Charles Ouazana-Vedrines, Alexander Carpinteiro, Celine Cougoule, Katrin Anne Becker, Jesus M. Alvarado, Frederic Limosin
Summary: The study suggests that the use of medications inhibiting acid sphingomyelinase (FIASMA) can reduce the risk of mortality in patients with SARS-CoV-2 infection. The multicenter retrospective observational study included 72,105 adult patients and found a significant association between FIASMA medication use and reduced 28-day mortality risk.
Article
Public, Environmental & Occupational Health
Svenja Hummel, Ina Michelsen, Ali Zafar, Steffen Moritz, Charles Benoy, Cedric Lemogne, Rosa Almeida, Raquel Losada, Oscar Ribeiro, Vincenza Frisardi, Ilaria Tarricone, Silvia Ferrari, Frieder Dechent, Christian G. Huber, Steffi Weidt, Gwendolyn Mayer, Jobst-Hendrik Schultz
Summary: The COVID-19 pandemic has had a severe impact on the lives and work conditions of Europeans, especially healthcare professionals. This study aimed to examine the job-related stressors and coping strategies of physicians, nurses, and nonmedical staff during the pandemic. The results revealed the most significant stressors and common coping strategies for healthcare professionals in two periods. Additionally, the study identified the psychosocial stressors and unmet needs of individuals.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Editorial Material
Health Care Sciences & Services
Cedric Lemogne, Victor Pitron
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Psychiatry
Marina Sanchez-Rico, Katayoun Rezaei, Alfonso Delgado-Alvarez, Frederic Limosin, Nicolas Hoertel, Jesus M. Alvarado
Summary: Psychiatric and non-psychiatric comorbidity may be associated with increased 28-day mortality among patients with psychiatric disorders and COVID-19, with the exception of a lower risk of death observed in patients with mood disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
