Review
Public, Environmental & Occupational Health
Yuhao Zou, Ling Wang, Jirui Wen, Juan Cheng, Can Li, Zhizhen Hao, Jian Zou, Mingzhong Gao, Weimin Li, Jiang Wu, Heping Xie, Jifeng Liu
Summary: With the increase in individuals living or working in deep underground spaces for prolonged periods, understanding the influence of the deep underground environment (DUGE) on living systems has become crucial. Heping Xie has proposed the concept of deep underground medicine to identify factors in the DUGE that can have either detrimental or beneficial effects on human health. Recent studies have focused on the molecular mechanisms underlying the biological impacts of DUGE factors on model organisms and humans. This article provides a summary of the current landscape of research conducted in deep underground laboratories and mines and suggests future research directions. Most studies indicate that low background radiation can trigger a stress response and affect cell growth, organelles, oxidative stress, defense capacity, and metabolism. Residing or working in the DUGE has been found to have detrimental effects on human health, including discomfort, fatigue, sleep disturbance, and changes in amino acid metabolism. Continued biological and medical research in deep underground laboratories and mines is necessary to ensure safe exploration of uncharted depths.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Mikhail Zarubin, Albert Gangapshev, Yuri Gavriljuk, Vladimir Kazalov, Elena Kravchenko
Summary: The study investigated gene expression changes in D. melanogaster under low background radiation conditions, revealing down-regulation of primary metabolic processes and up-regulation of immune system processes and response to stimuli. Comparative analysis did not find common differentially expressed genes with other experimental results, suggesting an influence of underground conditions on fruit fly gene expression.
Article
Physics, Multidisciplinary
Marco Ampollini, Pasqualino Anello, Marco Balata, Emanuela Bortolin, Federico Chiarelli, Daniele Chiti, Maurizio Chiti, Cinzia De Angelis, Giulia D'Imperio, Raffaella Donghia, Giuseppe Esposito, Francesco Ferella, Angelo Galante, Matthias Laubenstein, Patrizia Morciano, Stefano Nisi, Cristina Nuccetelli, Maria Cristina Quattrini, Maria Antonella Tabocchini, Claudia Tomei
Summary: Radiobiological studies conducted in Deep Underground Laboratories contribute to our understanding of the biological effects induced by ionizing radiation at low doses/dose rates. By comparing the behavior of parallel biological systems maintained in a Reference-Radiation Environment (RRE) and an extremely Low-Radiation Environment (LRE), researchers gain insights into the involvement of different low Linear Energy Transfer (LET) components in determining the response of biological systems.
FRONTIERS IN PHYSICS
(2023)
Article
Public, Environmental & Occupational Health
Qiao Wen, Jing Zhou, Xiaoru Sun, Tengfei Ma, Yilin Liu, Yike Xie, Ling Wang, Juan Cheng, Jirui Wen, Jiang Wu, Jian Zou, Shixi Liu, Jifeng Liu
Summary: This study utilized LC-MS metabolomics to investigate the metabolic differences between different underground environments and sleep qualities. The results suggest that the deep-underground environment may induce specific amino acid metabolism processes and regulate the sleep-wake state by promoting the production of excitatory neurotransmitters.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Physics, Particles & Fields
R. Cerroni, S. Dell'Oro, A. Formicola, S. Ghislandi, L. Ioannucci, M. Laubenstein, B. Lehnert, S. S. Nagorny, S. Nisi, L. Pagnanini
Summary: This study presents new results on the decay of (180m)Ta, obtained through measurements on a tantalum sample stored underground for ten years. The study sets half-life limits on the decay process and tests hypothetical scenarios of dark matter-induced de-excitation of (180m)Ta, constraining the parameter space for strongly-interacting dark matter particles.
EUROPEAN PHYSICAL JOURNAL C
(2023)
Review
Fisheries
Ewen McLean
Summary: The background color has a significant impact on aquatic invertebrates, affecting their growth, feed conversion, survival, reproduction, and metamorphosis. Commercial tank-based facilities typically use green and blue colors, but using alternative colors may provide benefits in terms of production performance, animal welfare, and economic advantage.
Review
Engineering, Electrical & Electronic
Xiaofen Wang, Peng Wang, Xiaotong Zhang, Yadong Wan, Haodong Shi, Wen Liu
Summary: This paper provides a comprehensive review of electromagnetic detection methods and recent advances in underground target detection. Solutions to the inversion and classification problems are summarized based on electromagnetic methods and deep learning. A technical framework based on data acquisition and processing is proposed, and future research hotspots are identified in areas such as soil water content, tree root system research, and underground unexploded ordnance.
IEEE SENSORS JOURNAL
(2022)
Article
Ecology
Ziwen Wang
Summary: With the rapid growth of social and economic development, there have been great challenges to the development of regional resources and environment. The coordinated development of resources, environment, and economic growth is not only the engine of industrial growth but also the accelerator to promote industrial transfer and optimal allocation of resources, injecting a strong impetus into social development.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Construction & Building Technology
Yong-qing Chen, Xiong-ying Ma, Xin-yang Tong, Xin Kang
Summary: Understanding the microstructures evolution and chloride migration characteristics of concrete is crucial in solving durability problems of reinforced concrete structures in ultra-deep buried rail transit projects. A novel experimental system was developed to simulate the corrosion process under high hydraulic pressure and stray current coexistence. The study comprehensively investigated changes in microstructures, phases, elements, minerals, and Ca-leaching, and revealed the mechanisms of pores and cracks propagation, and migration characteristics of chloride ions.
CEMENT & CONCRETE COMPOSITES
(2023)
Article
Engineering, Environmental
Xue-Han Zhang, Xu-Wei Wang, Ye-Shuang Xu
Summary: The utilization of shallow-middle underground space in Shanghai is saturating, and the development of deep underground space should be considered. Groundwater-related engineering disasters in deep underground space should be studied based on the specific characteristics of deep aquifers. During the development of deep underground space, attention should be paid to regional groundwater withdrawal-recharge, deep foundation pit dewatering, paleochannel, and hydrogeochemical characteristics.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2022)
Article
Oncology
Yilin Liu, Yuzhu Gao, Jiahan Cheng, Tengfei Ma, Yike Xie, Qiao Wen, Zimu Yuan, Ling Wang, Juan Cheng, Jiang Wu, Jian Zou, Jifeng Liu, Mingzhong Gao, Weimin Li, Heping Xie
Summary: This study revealed transcriptional differences in FD-LSC-1 cells grown under below-background radiation conditions using whole-transcriptome analysis. Functional analysis showed that these differences were associated with multiple biological processes and canonical pathways of proliferation, including TGF-beta and Hippo signaling.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Jake Pirkkanen, Taylor Laframboise, Peter Liimatainen, Tom Sonley, Stephen Stankiewicz, Mike Hood, Mehwish Obaid, Andrew Zarnke, T. C. Tai, Simon J. Lees, Douglas R. Boreham, Christopher Thome
Summary: The research discusses the effects of sub-NBR exposure within SNOLAB, a deep underground research laboratory in Canada. A Specialized Tissue Culture Incubator (STCI) was designed and installed to reduce background ionizing radiation levels and maintain precise control of experimental variables. The STCI proved capable of maintaining an appropriate experimental environment for sub-NBR experiments by reducing radiological contaminants, particularly radon gas.
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2021)
Article
Medicine, General & Internal
Anne Kerstin Reimers, Isabel Marzi, Franziska Beck, Eliane Engels, Denise Renninger, Adrian Buttazzoni, Claus Krieger, Yolanda Demetriou
Summary: This study aims to quantitatively assess the predictors of adolescent travel behavior and qualitatively understand the decision-making processes of both adolescents and parents. The study will use a mixed-methods approach, featuring online surveys and semi-structured interviews. The findings will be disseminated at scientific conferences and published in peer-reviewed journals.
Review
Chemistry, Physical
Ming Tsuey Chew, David A. Bradley, Bleddyn Jones, Andrew Nisbet, Mark Hill
Summary: This article provides an overview of the effects of reduced low-level radiation on organisms, presenting available evidence and discussing theoretical possibilities.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Engineering, Industrial
Isabelle Y. S. Chan, Hao Chen
Summary: Due to land resource scarcity, sustainable urban development in high-density cities has long been challenging. This study aims to investigate the influences of various underground environment factors on users' health through a holistic approach. The results provide evidence for the importance of distinguishing between underground and aboveground developments in guidelines and standards, especially those related to space management.
ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT
(2023)
Article
Medicine, Research & Experimental
Jie Wang, Jie Ren, Jifeng Liu, Linyun Zhang, Qihang Yuan, Bin Dong
Summary: Accumulating evidence suggests that ferroptosis and pyroptosis play important roles in the tumorigenesis of low-grade glioma (LGG). This research aimed to classify molecular subtypes of LGG and identify a novel multigene signature based on ferroptosis- and pyroptosis-related genes. The study found that the FPRGs had prognostic value and developed a six-gene prognostic signature that outperformed other recognized signatures in predicting the survival probability of LGG patients.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Genetics & Heredity
Jie Ren, Qihang Yuan, Jifeng Liu, Lei Zhong, Hanshuo Li, Guangzhen Wu, Feng Chen, Qizhen Tang
Summary: This study investigated the role of TRPs in KIRC and identified a prognostic signature with superior survival prediction. The study also found differences in immune checkpoint gene expression, tumor mutation burden, and immune subtypes and response between low-risk and high-risk subgroups, and identified potential drugs for different risk populations.
BMC MEDICAL GENOMICS
(2022)
Article
Immunology
Xu Chen, Qihang Yuan, Jifeng Liu, Shilin Xia, Xueying Shi, Yuxin Su, Zhizhou Wang, Shuang Li, Dong Shang
Summary: The functions of ECM-related genes (ECMGs) in pancreatic adenocarcinoma (PAAD) were systematically evaluated. Seven ECMGs were identified as differentially up-regulated in PAAD and significantly linked to tumor stage and prognosis. A novel mRNA-lncRNA-based prognostic panel (ECM-APP) was developed and validated for accurately predicting clinical outcomes of PAAD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Energy & Fuels
Shuo Zhai, Heping Xie, Peng Cui, Daqin Guan, Jian Wang, Siyuan Zhao, Bin Chen, Yufei Song, Zongping Shao, Meng Ni
Summary: The authors introduce a machine learning-driven approach to accelerate the discovery of efficient oxygen reduction electrodes for ceramic fuel cells by utilizing ionic Lewis acid strength as an effective physical descriptor. Experimental validation confirms the superior activity metrics of four oxides out of 6,871 distinct perovskite compositions, highlighting the importance of ISA in improving oxygen reduction reaction activity in perovskite oxides.
Article
Astronomy & Astrophysics
Su-Su Shan, Fan Yang, You-Jun Lu, Xing Wei, Wen-Wu Tian, Hai-Yan Zhang, Rui Guo, Xiao-Hong Cui, Ai-Yuan Yang, Bo Zhang, Ji-Feng Liu
Summary: A precise transit ephemeris is crucial for follow-up exoplanet observations. By comparing TESS Object of Interest (TOI) transit timings with archival ephemeris, it is found that 31 out of 262 hot Jupiters have timing offsets, with WASP-161b showing the largest offset of -203.7 +/- 4.1 minutes. These offsets have a median value of 17.8 minutes, equivalent to 3.6 sigma. Using a self-generated pipeline, TESS timings are generated for these 31 hot Jupiters in each sector, refining and updating the previous ephemeris with a median precision of 0.82 minutes until 2025 and 1.21 minutes until 2030.
ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES
(2023)
Article
Multidisciplinary Sciences
Heping Xie, Zhiyu Zhao, Tao Liu, Yifan Wu, Cheng Lan, Wenchuan Jiang, Liangyu Zhu, Yunpeng Wang, Dongsheng Yang, Zongping Shao
Summary: This article introduces a method for direct seawater electrolysis for hydrogen production, which can solve the problems of side reactions and corrosion. In the experiment, this method stably operated for over 3200 hours under practical application conditions. The method is efficient, size-flexible, scalable, and has high practical value without increasing the operation cost.
Article
Cardiac & Cardiovascular Systems
Chaosheng Liu, Jifeng Liu, Yunshu Zhang, Xi Wang, Yue Guan
Summary: This study aimed to identify and validate the diagnostic and therapeutic potential of differentially expressed immune-related genes (DE-IRGs) in coronary artery disease (CAD). Key marker genes were identified through functional enrichment analysis and immune cell infiltration comparison. Potential targeted drugs were also discovered. The effectiveness of the immune-related prognostic model for CAD was confirmed through validation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Medicine, General & Internal
Jifeng Liu, Qihang Yuan, Jie Ren, Yiming Li, Yunshu Zhang, Dong Shang
CHINESE MEDICAL JOURNAL
(2023)
Article
Obstetrics & Gynecology
Wen Wang, Ji-feng Liu, Hong Yin, Ling Wang, Ge Zhang, Lin-lin Song, Yan Song
Summary: This study aimed to explore the value of fetal HQ analysis based on speckle tracking imaging (STI) to evaluate the global and regional cardiac function of fetuses with early-onset or late-onset FGR. The study found that FGR affected the global and segmental cardiac function of both ventricles and altered Doppler indexes. The results showed that FAC and GLS had satisfactory repeatability in evaluating fetal cardiac function.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Review
Endocrinology & Metabolism
Lei Zhong, Jifeng Liu, Shuo Liu, Guang Tan
Summary: This meta-analysis examines the correlation between metabolic syndrome (MetS) and pancreatic cancer. The results show that MetS is strongly associated with an increased risk of developing pancreatic cancer. This association holds true regardless of gender, and hypertension, hyperglycemia, and low HDL-c levels contribute to this relationship. However, obesity and hypertriglyceridemia are not independently related to pancreatic cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Yongquan Shi, Yunshu Zhang, Jifeng Liu, Yanping Zhao, Wei Liu
Summary: This study investigated the therapeutic effects and potential mechanisms of Wang Bu Liu Xing (SV), a traditional Chinese medicine, on colorectal cancer (CRC) using network pharmacology. The results showed that the active component swerchirin in SV may inhibit CRC by interacting with key targets such as BCL2L1, CDK2, and SERPINE1, and the p53 signaling pathway may be involved in the anti-CRC effect of SV. Molecular docking confirmed the strong binding between swerchirin and its target protein. This study offers a promising approach for understanding the therapeutic pathways and identifying molecules in traditional Chinese medicine.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xue Pan, Jifeng Liu, Lei Zhong, Yunshu Zhang, Chaosheng Liu, Jing Gao, Min Pang
Summary: This study aimed to investigate lipid metabolism-related molecular clusters and develop a diagnostic model for atherosclerosis. A total of 29 differentially expressed lipid metabolism-related genes were identified, primarily involved in cholesterol and lipid metabolism, the PPAR signaling pathway, and regulation of the inflammatory response. A three-gene diagnostic model (ADCY7, SCD, and CD36) was constructed, showing good predictive performance and association with immune cell infiltration.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jifeng Liu, Yiming Li, Jingyuan Ma, Xing Wan, Mingjian Zhao, Yunshu Zhang, Dong Shang
Summary: This study explored lipid metabolism-related clusters in NAFLD and established a prediction biomarker. Dysregulated lipid metabolism-related genes and immune responses were identified in NAFLD. A machine learning model, specifically a random forest model, showed good predictive performance. The final five-gene random forest model exhibited excellent predictive power in two test sets.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Hewen Guan, Xu Chen, Jifeng Liu, Jiaao Sun, Hui Guo, Yuankuan Jiang, Huimin Zhang, Biao Zhang, Jingrong Lin, Qihang Yuan
Summary: We constructed a prognostic survival model based on TLR-related genes for melanoma patients, which accurately assesses patients' prognosis and immune traits.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Cuncai Lv, Jifeng Liu, Pingping Lou, Xiaobo Wang, Linjie Gao, Shufang Wang, Zhipeng Huang
Summary: Packaging electrocatalysts with carbon shells can enhance the stability and efficiency of hydrogen evolution reaction (HER) materials. An ultrathin N-doped carbon-coated self-supported WP nanowire array (WP@NC NA) hybrid has been synthesized, which exhibits improved physicochemical stability, active sites, and conductivity. The carbon shell optimizes various steps in both acidic and alkaline HER reactions. These findings provide scientific guidance for the packaging design of carbon-encapsulating self-supported electrocatalysts.