Article
Obstetrics & Gynecology
Marcela C. Smid, Torri D. Metz, Gwen A. McMillin, Lisa Mele, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, John M. Thorp, George R. Saade, Alan T. N. Tita, Emily S. Miller, Dwight J. Rouse, Baha Sibai, Maged M. Costantine, Brian M. Mercer, Steve N. Caritis
Summary: This study examined the association between the presence of nicotine or cannabis metabolites in maternal urine and child neurodevelopmental outcomes. The results showed that prenatal nicotine or cannabis exposure was not associated with differences in IQ. However, cannabis exposure was associated with lower attention scores in early childhood. The study highlights the need for longitudinal studies to assess the association between prenatal nicotine and cannabis exposure and child neurodevelopmental outcomes, with a focus on timing and quantity of exposure.
OBSTETRICS AND GYNECOLOGY
(2022)
Review
Environmental Sciences
Laura Maria Antonangeli, Saniya Kenzhebekova, Claudio Colosio
Summary: This study evaluates new research conducted between 2009 and 2021 to understand the neurobehavioral risk associated with long-term insecticide exposure. After reviewing 86 scientific papers, contradictory and difficult-to-compare results were found, and the presence of a previous poisoning episode and hospitalization hampered confirmation of a causal association with insecticide exposure in most studies that showed neurobehavioral impairment. Interestingly, applicators who did not wear personal protective equipment performed worse on neurobehavioral tests among the highly exposed groups. There is sufficient evidence to suggest that prenatal organophosphate exposure may increase the risk of ADHD in children.
Article
Environmental Sciences
Qian Yao, Angela Vinturache, Xiaoning Lei, Zixia Wang, Chengyu Pan, Rong Shi, Tao Yuan, Yu Gao, Ying Tian
Summary: This study found potential associations between prenatal PFAS exposure and early neurodevelopmental deficiencies, particularly in the gross motor domain. The associations were partly explained by thyroid hormone mediator effects.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Chengyu Pan, Jinxia Yu, Qian Yao, Nan Lin, Zhenping Lu, Yan Zhang, Shasha Zhao, Zixia Wang, Xiaoning Lei, Ying Tian, Yu Gao
Summary: This study investigated the prenatal exposure to neonicotinoid insecticides (NEOs) in pregnant women in China and assessed its association with birth outcomes. The study found that exposure to NEOs may have an impact on the head circumference and ponderal index of newborns, and this association may be mediated by urinary 8-OHdG. These findings are important for understanding the effects of NEOs on human health.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Engineering, Environmental
Zhenzhen Xie, Hong Liang, Maohua Miao, Ziliang Wang, Yao Chen, Lan Yang, Yan Zhou, Wencheng Cao, Wei Yuan
Summary: Prenatal exposure to PFASs is linked to increased attention problems in children, which can be mitigated by higher maternal nut intake.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Zhenzhen Xie, Jing Tan, Guanghong Fang, Honglei Ji, Maohua Miao, Yuan Tian, Hui Hu, Wencheng Cao, Hong Liang, Wei Yuan
Summary: Findings from this study suggest that prenatal exposure to multiple PFASs may have some effects on neurobehavioral development in children, but there is no clear evidence of negative effects. However, the modest associations found still suggest the potential developmental neurotoxicity of prenatal PFAS exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Shuman Li, Yongjie Liu, Bin Liu, Yun-Qing Hu, Yu-Qiang Ding, Jun Zhang, Liping Feng
Summary: The study finds that prenatal exposure to particulate matter (PM) can affect fetal brain development and have adverse effects on neurobehavior and molecular signal regulation.
Review
Biochemistry & Molecular Biology
Dae D. Chung, Marisa R. Pinson, Lokeshwar S. Bhenderu, Michael S. Lai, Rhea A. Patel, Rajesh C. Miranda
Summary: Prenatal alcohol exposure can have toxic and teratogenic effects on fetal development and individual health, with potential lifelong consequences. Current research focuses on understanding the mechanisms behind the immediate and long-term impacts of alcohol on health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jingwen Wang, Fei Chen, Shiheng Zhu, Xinya Li, Wenhao Shi, Zhiqing Dai, Lanting Hao, Xinyi Wang
Summary: Dexamethasone is widely used in clinical practice to enhance fetal lung maturity and reduce disease risks, but its administration must consider the potential adverse effects on pregnant women and fetal development.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Tamar Wainstock, Israel Yoles, Ruslan Sergienko, Itai Kloog, Eyal Sheiner
Summary: This study found an association between PM2.5 exposure and IUFD risk among Jewish women only, suggesting ethnicity as a possible effect modifier. In a multivariable model, for every 10 μg/m3 unit increase in PM2.5, the risk for IUFD increased by 2.98 during the first trimester and by 3.61 during the entire pregnancy.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Pharmacology & Pharmacy
Hanwen Gu, Bin Li, Liang Liu, Xufeng Li, Hui Wang, Liaobin Chen
Summary: This study aimed to investigate the toxic effects of prenatal amoxicillin exposure (PAE) on fetal cartilage development at different stages, doses, and courses. The results showed that PAE caused reduced chondrocyte number and inhibited matrix synthesis in male fetal mice during late pregnancy at a clinical dose and multiple courses. This study provides a theoretical and experimental basis for understanding the potential chondrodevelopmental toxicity associated with amoxicillin during pregnancy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Neurosciences
L. N. Jenna Sprowles, L. C. Kelsey Dzwilewski, M. Francheska Merced-Nieves, M. A. Salma Musaad, L. Susan Schantz, D. Sarah Geiger
Summary: This study explored the relationship between prenatal exposure to phthalates and infant neurodevelopment, highlighting the sex- and age-specific associations between different phthalates and infant neurobehavior.
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Article
Environmental Sciences
Chenhui Yang, Jing Fang, Xiaojie Sun, Wenxin Zhang, Juxiao Li, Xiaomei Chen, Ling Yu, Wei Xia, Shunqing Xu, Zongwei Cai, Yuanyuan Li
Summary: The study found that prenatal exposure to beta-HCH was associated with increased BMI z-score and higher risk of overweight status in infants, especially at 12 and 24 months of age, with stronger effects observed in girls. Other OCPs did not show significant relationships with infant growth.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Pediatrics
Nicole B. Salvi, Akhgar Ghassabian, Sara G. Brubaker, Hongxiu Liu, Linda G. Kahn, Leonardo Trasande, Shilpi S. Mehta-Lee
Summary: In this cohort study, there were no clinically meaningful associations found between early pregnancy phthalate exposure and fetal penile length or width.
PEDIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
Lorenz Harst, Stefanie Deckert, Frederik Haarig, Joerg Reichert, Juergen Dinger, Peter Hellmund, Jochen Schmitt, Mario Ruediger
Summary: The systematic review focused on the effects of prenatal methamphetamine exposure (PME) on child development, showing that PME is associated with lower birth weight, shorter body length, smaller head circumference, as well as psychological and neurocognitive abnormalities. Some differences persist into toddler years, especially in children growing up in problematic environments.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Psychology, Developmental
Ariadna Pinar-Marti, Silvia Fernandez-Barres, Florence Gignac, Cecilia Persavento, Anna Delgado, Dora Romaguera, Iolanda Lazaro, Emilio Ros, Monica Lopez-Vicente, Jordi Salas-Salvado, Aleix Sala-Vila, Jordi Julvez
Summary: Omega-3 fatty acids, especially DHA, play a critical role in brain function, particularly during adolescence. While previous research has focused on the cognitive effects of DHA, little is known about DHA and attention in healthy adolescents. This study examined the associations between DHA and ALA, and attention function in a young and healthy population. The results showed that higher levels of DHA were associated with better attention performance, while the role of ALA in attention is still unclear. Further intervention studies are necessary to understand the causality of these associations and provide dietary recommendations for brain health during adolescence.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Fanny Petermann-Rocha, Desiree Valera-Gran, Paula Fernandez-Pires, Dries S. Martens, Jordi Julvez, Cristina Rodriguez-Dehli, Ainara Andiarena, Manuel Lozano, Ana Fernandez-Somoano, Aitana Lertxundi, Sabrina Llop, Monica Guxens, Tim S. Nawrot, Eva-Maria Navarrete-Munoz
Summary: This study aimed to explore the association between sleep duration and telomere length (TL) in children. The results showed that children who slept more hours per day had longer TL at 4 years, independently of confounding factors. However, there was no significant association between sleep duration at 4 years and TL at 7-9 years. This suggests that sleep duration may have a significant impact on TL during early childhood, but further research is needed to explain the association between sleep duration and TL.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Julia Sanguesa, Jordi Sunyer, Raquel Garcia-Esteban, Alicia Abellan, Ana Esplugues, Judith Garcia-Aymerich, Monica Guxens, Amaia Irizar, Jordi Julvez, Leire Luque-Garcia, Ana Cristina Rodriguez-Dehli, Adonina Tardon, Maties Torrent, Jesus Vioque, Martine Vrijheid, Maribel Casas
Summary: The study suggests that vitamin D levels in pregnant women and children are associated with allergic and asthma-related symptoms in childhood. Higher vitamin D levels at 4 years old are linked to a lower risk of atopic eczema in later years.
PEDIATRIC RESEARCH
(2023)
Correction
Pediatrics
Jennifer Ish, Elaine Symanski, David Gimeno Ruiz de Porras, Maribel Casas, George L. Delclos, Monica Guxens, Jesus M. Ibarluzea, Carmen Iniguez, Aitana Lertxundi, Marisa Rebagliato, Michael D. Swartz, Kristina W. Whitworth
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Barrak Alahmad, Haitham Khraishah, Dominic Roye, Ana Maria Vicedo-Cabrera, Yuming Guo, Stefania I. Papatheodorou, Souzana Achilleos, Fiorella Acquaotta, Ben Armstrong, Michelle L. Bell, Shih-Chun Pan, Micheline de Sousa Zanotti Stagliorio Coelho, Valentina Colistro, Tran Ngoc Dang, Do Van Dung, Francesca K. De Donato, Alireza Entezari, Yue-Liang Leon Guo, Masahiro Hashizume, Yasushi Honda, Ene Indermitte, Carmen Iniguez, Jouni J. K. Jaakkola, Ho Kim, Eric Lavigne, Whanhee Lee, Shanshan Li, Joana Madureira, Fatemeh Mayvaneh, Hans Orru, Ala Overcenco, Martina S. Ragettli, Niilo R. I. Ryti, Paulo Hilario Nascimento Saldiva, Noah Scovronick, Xerxes Seposo, Francesco Sera, Susana Pereira Silva, Massimo Stafoggia, Aurelio Tobias, Eric Garshick, Aaron S. Bernstein, Antonella Zanobetti, Joel Schwartz, Antonio Gasparrini, Petros Koutrakis
Summary: A study found that exposure to extreme hot and cold temperatures is associated with an increased risk of cardiovascular disease mortality. The study used data from 567 cities in 27 countries and found a positive correlation between high and low temperatures and mortality from various cardiovascular diseases. The highest risks were observed for heart attacks and stroke during exposure to extreme temperatures.
Article
Multidisciplinary Sciences
Rocio Fernandez-Iglesias, Ana Fernandez-Somoano, Cristina Rodriguez-Dehli, Rafael Venta-Obaya, Isolina Riano-Galan, Adonina Tardon
Summary: This study aimed to investigate subgroups of children with different clusters of cardiovascular disease (CVD) risk factors at 4 and 8 years of age, and their patterns of change between these two time points. At 4 years, three subgroups were identified: no disorders (55.9%); some disorders (21.2%), and central obesity (22.9%). At 8 years, three subgroups were identified: no disorders (59.8%); hypertension (17.9%), and central obesity (22.3%). Children who did not present any disorder at 4 years tend to remain in that state at 8 years. Central obesity may play a major role in the development of other disorders.
Article
Psychiatry
Lene B. Dypas, Nur Duale, Ann-Karin Olsen, Mariona Bustamante, Lea Maitre, Georgia Escaramis, Jordi Julvez, Sofia Aguilar-Lacasana, Sandra Andrusaityte, Maribel Casas, Marina Vafeiadi, Regina Grazuleviciene, Barbara Heude, Johanna Lepeule, Jose Urquiza, John Wright, Tiffany C. Yang, Martine Vrijheid, Kristine B. Gutzkow
Summary: Blood miRNAs associated with ADHD traits have been identified as potential biomarkers for earlier and easier diagnosis. These miRNAs are involved in pathways related to neurodevelopment and function, and are also linked to other neurodevelopmental or psychiatric disorders that overlap with ADHD.
Article
Environmental Sciences
Massimo Stafoggia, Paola Michelozzi, Alexandra Schneider, Ben Armstrong, Matteo Scortichini, Masna Rai, Souzana Achilleos, Barrak Alahmad, Antonis Analitis, Christofer Astrom, Michelle L. Bell, Neville Calleja, Hanne Krage Carlsen, Gabriel Carrasco, John Paul Cauchi, Micheline D. S. Z. S. Coelho, Patricia M. Correa, Magali H. Diaz, Alireza Entezari, Bertil Forsberg, Rebecca M. Garland, Yue Leon Guo, Yuming Guo, Masahiro Hashizume, Iulian H. Holobaca, Carmen Iniguez, Jouni J. K. Jaakkola, Haidong Kan, Klea Katsouyanni, Ho Kim, Jan Kysely, Eric Lavigne, Whanhee Lee, Shanshan Li, Marek Maasikmets, Joana Madureira, Fatemeh Mayvaneh, Chris Fook Sheng Ng, Baltazar Nunes, Hans Orru, Nicolas Ortega, Samuel Osorio, Alfonso D. L. Palomares, Shih-Chun Pan, Mathilde Pascal, Martina S. Ragettli, Shilpa Rao, Raanan Raz, Dominic Roye, Niilo Ryti, Paulo H. N. Saldiva, Evangelia Samoli, Joel Schwartz, Noah Scovronick, Francesco Sera, Aurelio Tobias, Shilu Tong, Cesar D. L. C. Valencia, Ana Maria Vicedo-Cabrera, Ales Urban, Antonio Gasparrini, Susanne Breitner, Francesca K. de Donato
Summary: Suggestive evidence of effect modification between air temperature and air pollutants on mortality during the warm period was found in a global dataset of 620 cities.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
L. Notario-Barandiaran, A. Irizar, M. Begona-Zubero, R. Soler-Blasco, G. Riutort-Mayol, A. Fernandez-Somoano, A. Tardon, M. Casas, M. Vrijheid, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. O. Grimalt, J. Vioque, A. J. Signes-Pastor
Summary: In this study, the association between adherence to the Mediterranean diet (MD) and urinary metal concentrations in children was evaluated. It was found that high adherence to MD was associated with increased urinary levels of arsenic and copper, but also an increase in non-toxic arsenobetaine concentrations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Elba Mauriz, Jose P. Fernandez-Vazquez, Cristina Diez-Flecha, Sofia Reguero-Celada, Tania Fernandez-Villa, Ana Fernandez-Somoano, Joan A. Cayla, Jesus A. Lozano-Garcia, Ana M. Vazquez-Casares, Vicente Martin-Sanchez
Summary: This study investigated the impact of a COVID-19 outbreak in a long-term care facility for the elderly after the initial vaccination. The results showed that 75.0% of residents and 56.3% of workers tested positive 4 days after vaccination. Among the 68 vaccinated individuals, 95.58% of the elderly residents were infected with symptoms, with 34.9% requiring hospitalization and 25.8% dying.
Article
Mathematics
Rocio Fernandez-Iglesias, Pablo Martinez-Camblor, Adonina Tardon, Ana Fernandez-Somoano
Summary: This study presents an analysis of cardiovascular measures in children, discussing the challenges in dealing with missing data and selecting the appropriate regression model. It also explores the impact of different decisions on the results.
Article
Public, Environmental & Occupational Health
Carolina Blanco, Ferran Ballester, Rosario Baguena, Silvia Marin, Sabrina Llop, Ulises Lopez-Gonzalez, Gabriel Riutort-Mayol, Raquel Soler-Blasco
Summary: A study was conducted on the concentrations of total mercury (THg) and methylmercury (MeHg) in fish species consumed in Comunitat Valenciana from 2011 to 2017. It was found that swordfish, fresh tuna/albacore, and canned tuna had the highest concentrations. The overall trend of THg levels decreased, with swordfish showing an average annual decrease of 7%.
REVISTA ESPANOLA DE SALUD PUBLICA
(2023)
Article
Environmental Sciences
Kerstin Persson Waye, Jesper Love, Peter Lercher, Angel M. Dzhambov, Maria Klatte, Dirk Schreckenberg, Christin Belke, Larisa Leist, Gordana Ristovska, Sonja Jeram, Katja M. Kanninen, Jenny Selander, Arzu Arat, Thomas Lachmann, Charlotte Clark, Dick Botteldooren, Kim White, Jordi Julvez, Maria Foraster, Jaakko Kaprio, Gabriele Bolte, Achilleas Psyllidis, John Gulliver, Hendriek Boshuizen, Alessandro Bozzon, Janina Fels, Maarten Hornikx, Peter van den Hazel, Miriam Weber, Marco Brambilla, Ella Braat-Eggen, Irene Van Kamp, Natalia Vincens, Equal life Sci Team
Summary: Mental disorders among children and adolescents are a significant global challenge. The exposome framework provides opportunities to understand the causes and processes related to mental health and cognitive development. This paper highlights the importance of a child perspective and the vulnerability of children to environmental exposures. It also emphasizes the interplay between structure and agency.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pediatrics
Llucia Gonzalez-Safont, Marisa Rebagliato, Ane Arregi, Paula Carrasco, Monica Guxens, Oscar Vegas, Jordi Julvez, Marisa Estarlich
Summary: Sleep problems and attention deficit hyperactivity disorder (ADHD) are interrelated in childhood and preadolescence. Sleep problems may serve as an alarm sign for the development of ADHD later on. This study suggests that healthcare systems should focus on children's sleep habits and sleep hygiene to prevent and manage ADHD problems.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)