Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Yao Jian, Zhihui Jin, Shuang Qi, Xuwen Da, Zhanhua Wang, Xuesong Wang, Qianxiong Zhou
Summary: In this study, a Ru2 drug was constructed that specifically labeled the surface of Gram-positive bacteria through bio-orthogonal click reaction, achieving specific and effective photo-inactivation against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus without affecting mammalian cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Danielle O. Maia, Valdenice F. Santos, Cristina R. S. Barbosa, Yuri N. Froes, Debora F. Muniz, Ana L. E. Santos, Maria H. C. Santos, Romerio R. S. Silva, Claudio G. L. Silva, Racquel O. S. Souza, Joicy C. S. Sousa, Henrique D. M. Coutinho, Claudener S. Teixeira
Summary: The schiff base complex [Ni(L2)] showed moderate toxicity, significant leishmanicidal activity, and antibacterial effects against P. aeruginosa, but did not have clinically relevant minimum inhibitory concentration against S. aureus and E. coli. The combination of [Ni(L2)] complex with antibacterial drugs enhanced the antibiotic activity against multi-resistant strains, suggesting its potential as a promising molecule for new therapies against resistant bacteria and leishmaniasis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Xiaofang Liu, Hongchi Xie, Shi Zhuo, Yuanhong Zhou, Mohamed S. Selim, Xiang Chen, Zhifeng Hao
Summary: The abuse of antibiotics has led to microbial drug resistance, necessitating the development of new antimicrobial materials. We have developed a nanocomposite material, Ru@MXene, which combines Ru(bpy)(dcb)(2+) and MXene nanosheets for photothermal and photodynamic antibacterial effects. When exposed to light, Ru@MXene exhibits high bactericidal activity against Escherichia coli and Staphylococcus aureus, potentially serving as a non-drug antimicrobial therapy to avoid antibiotic resistance.
Article
Biochemical Research Methods
Navaneetha Nambigari, Aruna Kodipaka, Ravi Kumar Vuradi, Praveen Kumar Airva, Satyanarayana Sirasani
Summary: In this study, mononuclear Ru(II) polypyridyl complexes were synthesized and their antibacterial activity and interaction with DNA were investigated. The complexes were found to bind to DNA predominantly through intercalation, with the ancillary ligand playing a significant role in determining their specificity for DNA binding. Furthermore, the complexes showed significant antibacterial activity against both Gram-negative and Gram-positive bacteria.
JOURNAL OF FLUORESCENCE
(2022)
Article
Chemistry, Multidisciplinary
Austin P. Lanquist, Sayak Gupta, Kathlyn F. Al-Afyouni, Malik Al-Afyouni, Jeremy J. Kodanko, Claudia Turro
Summary: A series of five ruthenium complexes containing triphenyl phosphine groups were synthesized and characterized, with one complex showing enhanced cytotoxicity upon irradiation with blue light due to apoptosis mechanism. These findings highlight the enhancement of photochemotherapy by -CF3 groups and provide insight for future design of photocages for photochemotherapeutic drug delivery.
Article
Biochemistry & Molecular Biology
Gregory F. Grawe, Katia M. Oliveira, Celisnolia M. Leite, Tamires D. de Oliveira, Analu R. Costa, Carlos A. F. Moraes, Joao Honorato, Marcia R. Cominetti, Eduardo E. Castellano, Rodrigo S. Correa, Sergio P. Machado, Alzir A. Batista
Summary: This study reports on three new ruthenium(II) complexes and their cytotoxicity against lung and breast cancer cell lines. The results show that these complexes have potential as anticancer agents, with better selectivity than cisplatin. The complexes also exhibit interactions with DNA and human serum albumin, indicating their promising therapeutic effects.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Immunology
Peng Liu, Jianqiang Wu, Dandan Sun, Haolong Li, Zhihong Qi, Xiaoyue Tang, Wei Su, Yongzhe Li, Xuzhen Qin
Summary: This study aimed to identify and validate candidate protein biomarkers for cryoglobulinemia (CGE) using a TMT-PRM-ELISA workflow. APOA1 and PCSK9 were confirmed to be increased in CGE patients, indicating the involvement of proteins in cholesterol metabolism in the development of CGE. These findings provide valuable insights for pathogenesis research and biomarker discovery in CGE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Mst. Sabina Begum, Dipto Das, Ennio Zangrando, Shofiur Rahman, Abdullah Alodhayb, Mst. Khurshida Begum, Chan Miya Sheikh, Ryuta Miyatake, Md. Belayet Hossain Howlader, Md. Rabiul Karim, Md. Belal Chowdhury
Summary: The nickel(II) complex NiL2 was synthesized using the bidentate ligand S-hexyl-beta-N-(4-nitrobenzylidene)dithiocarbazate (HL) and characterized using various physicochemical techniques including single crystal X-ray diffraction. The metal complex exhibited increased fluorescence intensity compared to the free ligand. Analysis of the non-covalent interactions of the complex NiL2 was conducted using Hirshfeld surface analysis and density functional theory (DFT) calculations. The antibacterial activity of the ligand and complex against Escherichia coli and Klebsiella pneumoniae was found to be inactive.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Khaled Bin Break, Tan Yew Fung, May Zie Koh, Wan Yong Ho, Mohamed Ibrahim Mohamed Tahir, Omar Ashraf Elfar, Rahamat Unissa Syed, Weam M. A. Khojali, Turki Mubarak Alluhaibi, Bader Huwaimel, Christophe Wiart, Teng-Jin Khoo
Summary: A series of novel macroacyclic Schiff base ligands and their Cu (II) complexes were synthesized and evaluated for their anticancer and antibacterial activities. Among them, Cu1 showed the highest cytotoxic activity against breast cancer cells, while compound 3 exhibited the most potent antibacterial activity against K. rhizophila and S. aureus. The results suggested that these compounds have potential applications as anticancer and antibacterial agents.
Article
Chemistry, Multidisciplinary
Sean J. Steinke, Sayak Gupta, Eric J. Piechota, Curtis E. Moore, Jeremy J. Kodanko, Claudia Turro
Summary: This paper reports two new tris-heteroleptic Ru(II) complexes with triphenylphosphine coordination, which show suitable photochemical properties for photochemotherapeutic applications. The study reveals that under visible light irradiation, the complexes exhibit increased activity due to the photoinduced substitution reaction of PPh3 ligand in the excited state. These complexes represent a new design motif for the selective release of PPh3 and CH3CN for use in photochemotherapy.
Review
Chemistry, Inorganic & Nuclear
Gabriel H. Ribeiro, Analu R. Costa, Aparecido R. de Souza, Fabiana V. da Silva, Felipe T. Martins, Ana M. Plutin, Alzir A. Batista
Summary: This review discusses the development of ruthenium complexes with acylthiourea ligands for potential antitumor activity. It highlights the increased biological activity of the coordination products compared to their precursor complexes and free ligands. The structure-activity relationships of different structure scaffolds of ruthenium complexes with N-mono- and disubstituted acylthiourea ligands are discussed in relation to their cytotoxic properties and antitumor activity. The mode of binding of Ru-acylthiourea complexes to DNA is also explored to understand their cytotoxic action.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Crystallography
Kholood A. Dahlous, Atallh A. M. Alotaibi, Necmi Dege, Ayman El-Faham, Saied M. Soliman, Heba M. Refaat
Summary: The crystal structure of a new penta-coordinated Cd(II) complex, [Cd(BPMT)Br-2], was presented and its biological activities were evaluated. The complex exhibited better anticancer and antibacterial activities compared to the free BPMT ligand, with the highest anticancer activity against lung carcinoma (A-549).
Article
Pharmacology & Pharmacy
Gabriela Marinescu, Daniela C. Culita, Teodora Mocanu, Raul-Augustin Mitran, Simona Petrescu, Miruna S. Stan, Mariana C. Chifiriuc, Marcela Popa
Summary: A series of nanostructured materials were obtained by functionalizing SBA-15 mesoporous silica with Ru(II) and Ru(III) complexes bearing Schiff base ligands. The resulting materials showed antitumoral activity against lung tumor cells and inhibitory effects against bacteria.
Article
Engineering, Environmental
Sheng-qi Rao, Ru-yi Zhang, Rui Chen, Ya-jun Gao, Lu Gao, Zhen-quan Yang
Summary: A new hybrid antibacterial agent (SLP-AgNPs) was prepared by using silver nanoparticles and Lactobacillus buchneri-isolated surface-layer proteins, showing significantly enhanced antibacterial activity. The synergistic antibacterial mechanism of SLP-AgNPs may be achieved through the enhanced adhesion to bacteria, antibacterial ability of SLP, and sustained release of silver ions.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Qingyu He, Ruigen Pan
Summary: This study analyzed the application value of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) based on computer semi-automatic segmentation (CSS) algorithm in the histological grading of breast cancer patients. Results showed that CSS had lower false positive rate (FPR) and higher true positive rate (TPR) compared to fuzzy-c-means (FCM) and wavelet transform (WT) algorithms. The CSS algorithm was found to be superior to FCM and WT in evaluating breast tumor histological grading. Furthermore, the obtained tumor diameter, fractional anisotropy (FA) value, apparent diffusion coefficient (ADC) value, and number of lymph node metastasis based on DCE-MRI were significantly different among patients with grade I, II, and III, and could be used to predict the histological grading of breast cancer patients.
Article
Biochemical Research Methods
Xuejuan Gao, Qionghua Lian, Baiye Guan, Qiu-Yu Liu, Meng Meng, Yang Chen, Jingjie Jin, Huihua Li, Xiaohui Liu, Zhenghua Sun, Langxia Liu, Qing-Yu He, Gong Zhang
Summary: This study investigated the function and mechanism of ZSWIM1 in lung adenocarcinoma. ZSWIM1 was found to be upregulated in lung adenocarcinoma and correlated with poor prognosis. It promoted cancer cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition. The protein interactome of ZSWIM1 was identified, and its interaction with STK38 was verified. ZSWIM1 antagonized the function of STK38 and activated the MEKK2/ERK1/2 pathway. Overall, ZSWIM1 acts as an oncogene in lung adenocarcinoma and its effects are mediated through the STK38/MEKK2/ERK1/2 axis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hui-Fang Hu, Gui-Bin Gao, Xuan He, Yu-Ying Li, Yang-Jia Li, Bin Li, Yunlong Pan, Yang Wang, Qing-Yu He
Summary: This study identifies the ARF1-IQGAP1 interaction-mediated reactivation of ERK signaling as critical for vemurafenib resistance and cancer metastasis. LY2835219 is shown to be a promising therapeutic agent for CRC, both alone and in combination with vemurafenib, with significant inhibitory effects on ARF1-mediated cancer.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Oncology
Kun Meng, Yuyu Hu, Dingkang Wang, Yuying Li, Fujin Shi, Jiangli Lu, Yang Wang, Yun Cao, Chris Zhiyi Zhang, Qing-Yu He
Summary: A seven-mitochondrial-gene signature was generated to predict prognosis of ccRCC patients, with EFHD1 being less studied but found to be correlated with unfavorable outcome. Overexpression of EFHD1 reduced mitochondrial Ca2+ and inhibited cell migration and tumor metastasis by binding to mitochondrial calcium uniporter (MCU) and deactivating the Hippo/YAP pathway. Upregulation of STARD13 induced by EFHD1 enhanced the phosphorylation of YAP at Ser-127. The EFHD1-MCU-STARD13 axis serves as a novel regulator in ccRCC progression.
Article
Biochemistry & Molecular Biology
Kun Meng, Shaohua Lu, Yu-Ying Li, Li-Ling Hu, Jing Zhang, Yun Cao, Yang Wang, Chris Zhiyi Zhang, Qing-Yu He
Summary: The study discovered a microprotein encoded by LINC00493, called SMIM26, which is localized in mitochondria and tends to be downregulated in ccRCC. SMIM26 suppresses ccRCC growth and metastasis by interacting with AGK and SLC25A11. This interaction increases the mitochondrial localization of AGK and inhibits AGK-mediated AKT phosphorylation. The study shows the importance of hidden proteins in human cancers.
Article
Infectious Diseases
Dan Lei, Linlin Cao, Tairan Zhong, Qing-Yu He, Xuesong Sun
Summary: In this study, the researchers found that the mutation of the key residue Lys219 leads to a conformational change in CpxR, resulting in loss of its regulatory ability in antibiotic resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Instruments & Instrumentation
Lihui Zhou, Qingyu He, Xinglu Que, Andreas W. W. Rost, Hide Takagi
Summary: Cryogenic scanning tunneling microscopy and spectroscopy with a high vector magnetic field is used to image surface magnetic structures, study anisotropic superconductivity, and explore spin physics in quantum materials. This paper describes the design, construction, and performance of a low-temperature, ultra-high-vacuum spectroscopic imaging STM with a vector magnet capable of applying a field of up to 3 T in any direction. The STM can operate at variable temperatures and is suitable for studying layered compounds and thin films.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Review
Geosciences, Multidisciplinary
Min Li, Song Huang, Tianyao Hao, Miao Dong, Ya Xu, Jian Zhang, Qingyu He, Gui Fang
Summary: This paper reviews the initiation models of Neogene subduction in the western Pacific, including polarity-reversal, induced subduction re-initiation, and non-inherited subduction initiation. It also collates the parameters of different subduction zones to form five categories: basic features, subducting plate features, upper plate features, kinematic features, and subsequent activity. The regularity of the subduction processes, the specificity of different subduction cases, and the possible constraints between subduction initiation types and subduction zone parameters are discussed and analyzed. The compiled dataset of subduction zone parameters can provide data support for related studies.
SCIENCE CHINA-EARTH SCIENCES
(2023)
Article
Medicine, General & Internal
Wen Wen, Long Liao, Wei Dai, Can-Can Zheng, Xiang-Peng Tan, Yan He, Qi-Hua Zhang, Zhi-Hao Huang, Wen-You Chen, Yan-Ru Qin, Kui-Sheng Chen, Ming-Liang He, Simon Law, Maria Li Lung, Qing-Yu He, Bin Li
Summary: Through genome-wide CRISPR/Cas9 screening and gene profiling, the MEST-PURA-SRCIN1/RASAL1-ERK-snail signaling cascade was identified as an important mechanism underlying cancer metastasis in esophageal squamous cell carcinoma. Blocking the interaction between MEST and PURA could be a potential therapeutic approach for managing tumor metastasis.
Article
Gastroenterology & Hepatology
Wenli Tang, Huimin Zheng, Shuangbin Xu, Pan Li, Li Zhan, Xiao Luo, Zehan Dai, Qianwen Wang, Guangchuang Yu
Summary: The gut metabolome plays a crucial role in the relationship between gut microbiota and the host, and has great potential for diagnosis and therapy. This study developed a computational framework called Microbe-Metabolite INteractions-based metabolic profiles Predictor (MMINP) to predict the metabolic profiles associated with the gut microbiota. The predictive value of MMINP was demonstrated and the factors influencing the prediction performance of data-driven methods were identified.
Article
Biochemistry & Molecular Biology
Qianqian Yang, Lulu Wang, Yuehong Liang, Qingyu He, Qi Sun, Jing Luo, Hongdi Cao, Yi Fang, Yang Zhou, Junwei Yang, Ping Wen, Lei Jiang
Summary: Mitochondrial dysfunction, regulated by UCP2, plays a crucial role in the development of podocyte injury and proteinuria.
Article
Engineering, Electrical & Electronic
Xu Zhang, Honglin Ji, Ming Luo, Qingyu He, Chao Yang, Jie Li, Wu Liu, Chao Li, Qibing Wang, Zichen Liu, Chuyu Peng, Hao Guo, Huang Yu, Zhiwen Fan, Zhixue He, Xi Xiao, Shaohua Yu
Summary: We experimentally demonstrate a 3.61 Pbit/s estimated throughput of generalized mutual information (GMI) achieved through combined space division multiplexing (SDM) and wavelength division multiplexing (WDM) over a 19-core single-mode fiber. The transmission utilizes 680 wavelength channels covering a 17 THz bandwidth in the S, C, and L bands, delivering probabilistically constellation-shaped (PCS) 256 quadrature amplitude modulation (QAM) and PCS-64QAM signals at a data rate of 24.5 GBaud. The measured data rate shows significant potential for enhancing the achievable data rate in multi-core fibers.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Shaohua Lu, Hong Lu, Tingkai Zheng, Huiming Yuan, Hongli Du, Youhe Gao, Yongtao Liu, Xuanzhen Pan, Wenlu Zhang, Shuying Fu, Zhenghua Sun, Jingjie Jin, Qing-Yu He, Yang Chen, Gong Zhang
Summary: The development of high-throughput omics technology has greatly promoted the development of biomedicine, but its poor reproducibility limits its application. The use of standard reference materials is necessary to test and calibrate the accuracy and reproducibility of omics workflows. In this study, we demonstrated that the human hepatocellular cell line MHCC97H has a very stable transcriptome and proteome after 9 subculturing generations, providing a steady standard sample for industrial-scale production in the long term. Furthermore, this stability was consistent across labs and platforms.
Review
Chemistry, Physical
Yisha Huang, Xuejuan Gao, Qing-Yu He, Wanting Liu
Summary: This article investigates the role of TRIM21 in intracellular immunity and proposes a model for how TRIM21 interacts with proteins. The model suggests that TRIM21 participates in inflammatory responses through ubiquitination and facilitates antibody destruction of target proteins by detecting antibody complexes. This systematic understanding of TRIM21's interactions provides insights into the pathogenesis of related diseases and potential applications.
Article
Biochemistry & Molecular Biology
Kun Meng, Yu-Ying Li, Dan-Ya Liu, Li-Ling Hu, Yun-Long Pan, Chris Zhiyi Zhang, Qing-Yu He
Summary: By analyzing the datasets of TCGA and CPTAC, we established a five-protein prognostic signature for ccRCC. This signature was closely correlated with advanced stage, higher pathological grade, and unfavorable survivals in ccRCC patients. Further studies revealed that GBP2 plays an oncogenic role by modulating JAK-STAT signaling and tumor immune infiltration.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)