Article
Medicine, General & Internal
Gil Gutvirtz, Tamar Wainstock, Eyal Sheiner, Gali Pariente
Summary: Respiratory morbidity is a significant complication of prematurity, with preterm children having a higher risk of hospitalizations due to respiratory issues compared to term children. This study suggests that 30 weeks' gestation may be a critical threshold for long-term respiratory morbidity in offspring.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Melinda Matyas, Monica Hasmasanu, Ciprian N. Silaghi, Gabriel Samasca, Iulia Lupan, Kovacs Orsolya, Gabriela Zaharie
Summary: The study reveals that early preeclampsia increases the risk of complications in preterm neonates and is correlated with hematological changes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chiara Bruzzone, Ruben Gil-Redondo, Marisa Seco, Rocio Barragan, Laura de la Cruz, Claire Cannet, Hartmut Schaefer, Fang Fang, Tammo Diercks, Maider Bizkarguenaga, Beatriz Gonzalez-Valle, Ana Lain, Arantza Sanz-Parra, Oscar Coltell, Ander Lopez de Letona, Manfred Spraul, Shelly C. Lu, Elisabetta Buguianesi, Nieves Embade, Quentin M. Anstee, Dolores Corella, Jose M. Mato, Oscar Millet
Summary: Metabolic syndrome (MetS) is a complex condition without a clear medical definition. This study used NMR metabolomics to analyze urine samples from a European cohort, revealing a unique molecular signature of MetS. The results showed that MetS progression is associated with specific changes in the urine metabolome, which can be used to identify individuals with MetS and provide insight into the transitional states between healthy individuals and MetS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Nutrition & Dietetics
Lila S. Nolan, Angela N. Lewis, Qingqing Gong, James J. Sollome, Olivia N. DeWitt, Robert D. Williams, Misty Good
Summary: Metabolomics analysis of breast milk from mothers of preterm infants revealed significant differences in metabolites related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins, and oxidative stress between mothers of infants with different birth weights. Understanding these differences may provide insights into tailored nutrition and care for preterm newborns in the future.
Article
Pediatrics
Allison M. Peluso, Hasan F. Othman, Sreenivas Karnati, Ibrahim Sammour, Hany Z. Aly
Summary: The usage of inhaled nitric oxide (iNO) in preterm infants <35 weeks significantly increased after 2010, especially in small for gestational age (SGA) and congenital heart disease (CHD) neonates. There was lower mortality in Epoch 2, but the cost of hospitalization doubled.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
David J. Askenazi, Patrick J. Heagerty, Robert H. Schmicker, Patrick Brophy, Sandra E. Juul, Sangeeta Hingorani, Stuart L. Goldstein
Summary: Our understanding of normative concentrations of urine biomarkers in premature neonates is limited. Gestational age and sex have an impact on urine biomarker concentrations. Some biomarkers increase over time, while others decrease. Most biomarkers differ by gestational age at 27 weeks PMA, but are similar by 34 weeks PMA. Epo treatment does not affect urine biomarkers.
PEDIATRIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Seung-Ho Seo, Chang-Su Na, Seong-Eun Park, Eun-Ju Kim, Woo-Seok Kim, ChunKyun Park, Seungmi Oh, Yanghee You, Mee-Hyun Lee, Kwang-Moon Cho, Sun Jae Kwon, Tae Woong Whon, Seong Woon Roh, Hong-Seok Son
Summary: Age-related changes in gut microbes and urine metabolites were studied in 568 healthy individuals. The richness and evenness of fecal microbiota increased with age, and 16 genera showed significant abundance differences between young and old groups. Additionally, 17 urine metabolites contributed to the age-related differences. Bacteroides and Prevotella 9 were found to be correlated with some urine metabolites. The machine learning algorithm XGBoost achieved the best age prediction performance, with a mean absolute error of 5.48 years. Including urine metabolite data improved the accuracy to 4.93 years. This study highlights the potential of using gut microbiota and urine metabolic profiles for age prediction in healthy individuals.
Article
Health Care Sciences & Services
Zilma Silveira Nogueira Reis, Roberta Maia de Castro Romanelli, Rodney Nascimento Guimaraes, Juliano de Souza Gaspar, Gabriela Silveira Neves, Marynea Silva do Vale, Paulo de Jesus Nader, Martha David Rocha de Moura, Gabriela Luiza Nogueira Vitral, Marconi Augusto Aguiar Dos Reis, Marcia Margarida Mendonca Pereira, Patricia Franco Marques, Silvana Salgado Nader, Augusta Luize Harff, Ludmylla de Oliveira Beleza, Maria Eduarda Canellas de Castro, Rayner Guilherme Souza, Gisele Lobo Pappa, Regina Amelia Pessoa Lopes de Aguiar
Summary: The study validates a device that uses newborns' skin maturity and machine learning models to assess gestational age. The device accurately predicted gestational age and identified preterm newborns. In cases where the last menstrual period was absent or unreliable, the device showed higher accuracy compared to traditional methods.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jesus Brezmes, Maria Llambrich, Raquel Cumeras, Josep Guma
Summary: Metabolomics is a crucial method for discovering novel biomarkers and their application in precision medicine. NMR-based metabolomics in urine can serve as a powerful clinical tool in precision oncology. This review provides a comprehensive evaluation of NMR metabolomics for the detection of colorectal cancer (CRC) in urine, identifying potential relevant compounds and metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Alessandro Perri, Annamaria Sbordone, Maria L. Patti, Stefano Nobile, Chiara Tirone, Lucia Giordano, Milena Tana, Vito D'Andrea, Francesca Priolo, Francesca Serrao, Riccardo Riccardi, Giorgia Prontera, Chiara Maddaloni, Jacopo Lenkowicz, Luca Boldrini, Giovanni Vento
Summary: This study aims to propose an early lung ultrasound score to predict the need for respiratory assistance in newborns with a gestational age (GA) of at least 33 weeks presenting respiratory distress. The study found that the early LUS score is a good noninvasive predictor for the need of respiratory assistance with CPAP and surfactant administration in newborns with GA ≥ 33 weeks.
PEDIATRIC PULMONOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kerti Ausmees, Nele Reimets, Indrek Reile
Summary: Parahydrogen hyperpolarization is a promising tool for sensitively enhancing NMR metabolomics, allowing for resolution and quantification of low-abundance metabolites. The reliable identification of analytes producing parahydrogen hyperpolarized NMR signals currently requires the addition of internal standards, which can be laborious. This study demonstrates that generating libraries of hyperpolarized analyte signals, similar to regular NMR metabolomics, can address this limitation.
Article
Immunology
Gabriela Gajek, Anna S. Swierzko, Dariusz Jarych, Damian Mikulski, Paulina Kobiela, Karolina Chojnacka, Maja Kufelnicka-Babout, Agnieszka Szala-Pozdziej, Jedrzej Chrzanowski, Katarzyna Sobczuk, Wojciech Fendler, Misao Matsushita, Iwona Domzalska-Popadiuk, Jan Mazela, Jaroslaw Kalinka, Hideharu Sekine, Maciej Cedzynski
Summary: This study found that low concentration of Ficolin-2 in cord blood serum is associated with complications related to premature birth, especially an increased risk of respiratory distress syndrome (RDS).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Parul Singh, Noora Al Mohannadi, Selvasankar Murugesan, Fajr Almarzooqi, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Annalisa Terranegra, Rose McGready, Francois Nosten, Damien Chaussabel, Souhaila Al Khodor
Summary: This study investigated the microbial communities in breast milk of mothers with preterm deliveries and found that the microbial communities became increasingly diverse and distinct as the breast milk matured. There were significant differences in the community structures between preterm and term breast milk samples. This study highlights the significant influence of pregnancy-related complications on the composition and diversity of breast milk microbiota, paving the way for improving maternal and infant health outcomes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Gabriela Luiza Nogueira Vitral, Roberta Maia de Castro Romanelli, Tiago Alves Leonel, Juliano de Souza Gaspar, Regina Amelia Lopes Pessoa de Aguiar, Zilma Silveira Nogueira Reis
Summary: This systematic review compares the influence of last menstrual period (LMP) and ultrasound (USG) on prematurity and small-for-gestational-age (SGA) proportions. The study found that LMP-based gestational age estimation has little effect on prematurity proportions compared to USG, but there is limited data on the influence on SGA proportions.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Xiao-ling He, Xiao-jing Hu, Bai-yu Luo, Yin-Yin Xia, Ting Zhang, Richard Saffery, Jamie De Seymour, Zhen Zou, Ge Xu, Xue Zhao, Hong-bo Qi, Ting-Li Han, Hua Zhang, Philip N. Baker
Summary: This study investigates the metabolomic profiling of plasma and urine in pregnancies complicated with gestational diabetes mellitus (GDM) aged 35-40 years at early and late gestation. It is found that several compounds have the potential to be biomarkers for predicting GDM with advanced maternal age.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Biochemistry & Molecular Biology
Maria Ines Costa, Beatriz Santos Lapa, Joana Jorge, Raquel Alves, Isabel Marques Carreira, Ana Bela Sarmento-Ribeiro, Ana Cristina Goncalves
Summary: Zinc plays a dual role in modulating the DNA damage response in acute myeloid leukemia (AML), increasing genotoxicity and cytotoxicity in leukemia cells while preventing damage accumulation in normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer Mancio, Fabio Sousa-Nunes, Rafael Martins, Mariana Fragao-Marques, Gloria Conceicao, Guilherme Pessoa-Amorim, Antonio S. Barros, Catia Santa, Wilson Ferreira, Monica Carvalho, Isabel M. Miranda, Rui Vitorino, Ines Falcao-Pires, Bruno Manadas, Vasco Gama Ribeiro, Adelino Leite-Moreira, Nuno Bettencourt, Ricardo Fontes-Carvalho
Summary: The study found a correlation between abnormal epicardial adipose tissue and heart issues, including left atrial remodeling and post-operative atrial fibrillation. This provides a new direction for early prevention and treatment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Dermatology
Jose Carlos Cardoso, Francisca Alves, Rebeca Calado, Mariana Batista, Isabel Marques Carreira, Oscar Tellechea
Summary: This study examined the clinical and pathological characteristics of post-radiotherapy scalp basal cell carcinomas (BCCs). The results showed that post-radiotherapy BCCs were often multiple and had a relatively high risk of recurrence.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mariana R. Silva, Gualter S. Silva, Sara Fernandes, Joao Almeida, Paulo Fonseca, Marco Oliveira, Helena Goncalves, Francisca Saraiva, Antonio S. Barros, Pedro G. Teixeira, Ricardo L. Lopes, Francisco Sampaio, Silvia O. Diaz, Joao Primo, Ricardo Fontes-Carvalho
Summary: This study aimed to determine the predictors of early recurrence (ER) and late recurrence (LR) after catheter ablation (CA) for atrial fibrillation (AF) and establish the risk of LR in patients who experience ER. The results showed that the risk of LR after CA was significantly higher in patients with ER (five-fold increased risk). These findings highlight the importance of clarifying the clinical role of the blanking period.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sara Lopes Fernandes, Ricardo Ladeiras-Lopes, Mariana Silva, Gualter Silva, Ines Cruz, Silvia O. Diaz, Antonio S. Barros, Francisca Saraiva, Rita Faria, Joao Almeida, Paulo Fonseca, Helena Goncalves, Marco Oliveira, Nuno Ferreira, Joao Primo, Ricardo Fontes-Carvalho
Summary: Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) recurrence, particularly when the score exceeds 100.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Ines Cruz, Sara Lopes Fernandes, Silvia O. Diaz, Francisca Saraiva, Antonio S. Barros, Joao Primo, Francisco Sampaio, Ricardo Ladeiras-Lopes, Ricardo Fontes-Carvalho
Summary: There is no independent association between epicardial adipose tissue (EAT) volume and attenuation and the risk of atrial fibrillation (AF) recurrence after AF ablation.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Oncology
Fernando Osorio, Antonio S. Barros, Barbara Peleteiro, Isabel Amendoeira, Jose Luis Fougo
Summary: In this study, we compared the outcomes of breast cancer among three age groups and found that older patients were more susceptible to suboptimal treatment and had a lower overall survival rate. This was not associated with the cancer itself, but rather with undertreatment. The study suggests that tumor characteristics and treatment compliance are better predictors of survival than chronological age.
Article
Cardiac & Cardiovascular Systems
Marta Leite, Francisco Sampaio, Francisca A. Saraiva, Silvia O. Diaz, Antonio S. Barros, Ricardo Fontes-Carvalho
Summary: Recently, HF guidelines have re-classified HF patients with LVEF between 41% and 49% as HFmrEF. The treatment of HFmrEF patients is often considered a grey zone due to the lack of RCTs exclusively conducted on this population. A network meta-analysis was conducted to compare the treatment effect of different medications in HFmrEF cardiovascular outcomes.
Article
Cardiac & Cardiovascular Systems
Ana Filipa Ferreira, Maria Joao Azevedo, Juliana Morais, Fabio Trindade, Francisca Saraiva, Silvia Oliveira Diaz, Ines Nuno Alves, Mariana Fragao-Marques, Carla Sousa, Ana Paula Machado, Adelino Leite-Moreira, Benedita Sampaio-Maia, Carla Ramalho, Antonio Sousa Barros, Ines Falcao-Marques
Summary: Pregnant women with cardiovascular risk factors are at high risk of developing cardiovascular disease later in life. Our study found that pregnant women undergo cardiovascular remodeling during pregnancy, which reverses after delivery. Arterial hypertension, smoking, and obesity are independent predictors of increased left ventricular mass. Additionally, circulating biomarkers such as C-reactive protein and ST2/IL33 receptors may be associated with worse cardiac remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joao A. Rodrigues, Daniela S. C. Bispo, Monica G. Silva, Rita Araujo, Amadeu M. V. M. Soares, Rosa Freitas, Ana M. Gil
Summary: This study investigates the effects of exposure to 17-α-ethinylestradiol (EE2) on lipophilic extracts of Ruditapes philippinarum clams at 17 degrees C and 21 degrees C. The results show that EE2 exposure at 17 degrees C leads to a slight increase in membrane rigidity at low concentrations, while at higher concentrations, lipid metabolism stabilizes. In contrast, at 21 degrees C, lipid metabolism responds to EE2 at 125 ng/L, with the antioxidant docosahexaenoic acid (DHA) helping to mitigate oxidative stress. The study also identifies new potential markers of stress mitigation, such as high levels of phosphatidylcholine (PtdCho), polyunsaturated fatty acids (PUFAs), and linoleic acid, as well as low PUFA/glycine ratios.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Rita Araujo, Victoria Fabris, Caroline A. Lamb, Andres Elia, Claudia Lanari, Luisa A. Helguero, Ana M. Gil
Summary: The lipid metabolism adaptations of estrogen and progesteronereceptor-positive breast cancer tumors in relation to HD to HI tumor growth transition and HIR tumor acquisition of ET resistance were investigated. Results showed increased nonesterified cholesterol forms and phospholipids, and decreased triglycerides and fatty acids during tumor progression. These changes suggest a shift toward more activated cholesterol synthesis, β-oxidation, and phospholipid biosynthesis to sustain tumor growth. Certain compound levels and ratios were identified as potential markers for HD-HI-HIR progression.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Microbiology
Rita Almeida Teixeira, Claudia Silva, Antonio Carlos Ferreira, Diana Martins, Adelino Leite-Moreira, Isabel M. Miranda, Antonio S. Barros
Summary: Gestational diabetes, affecting 10% of pregnancies, has implications for both mother and child. This study reviewed the literature on the differences in microbiota composition between pregnant women with gestational diabetes and healthy pregnancies. The findings suggest that certain bacteria are more abundant in healthy pregnancies, while others are more abundant in gestational diabetes. The study also highlighted the potential of microbiome-targeted therapies for gestational diabetes.