Article
Gastroenterology & Hepatology
Issei Hirata, Akiyoshi Tsuboi, Yuka Matsubara, Akihiko Sumioka, Takeshi Takasago, Hidenori Tanaka, Ken Yamashita, Hidehiko Takigawa, Takahiro Kotachi, Ryo Yuge, Yuji Urabe, Shiro Oka
Summary: This study investigated the long-term outcomes of 461 patients with OGIB after CE, revealing that rebleeding from the small bowel was rare in the P0 group, and a history of endoscopic hemostasis and P1 CE findings were predictive of small-bowel rebleeding.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Joo Hye Song, Ji Eun Kim, Hwe Hoon Chung, Sung Noh Hong, Heejung Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim
Summary: Performing video capsule endoscopy within 24 hours of gastrointestinal bleeding can increase the diagnostic yield for patients with overt obscure gastrointestinal bleeding and may result in a higher rate of therapeutic intervention.
Article
Medicine, General & Internal
Young Kyu Cho, Heesu Park, Jung Rock Moon, Seong Ran Jeon, Hyun Gun Kim, Tae Hee Lee, Junseok Park, Jin-Oh Kim, Joon Seong Lee, Hyeon Jeong Goong, Bong Min Ko, Suyeon Park
Summary: Despite negative CE and CT findings, patients with OGIB have a significant potential risk of rebleeding. While there was no significant difference in rebleeding rates between the P0 and P1 groups on CE, the P1 group has independent predictive factors.
Article
Medicine, General & Internal
Samanta Romeo, Benedetto Neri, Michelangela Mossa, Maria Elena Riccioni, Ludovica Scucchi, Giorgia Sena, Saverio Potenza, Carmelina Petruzziello, Livia Biancone
Summary: In a real-world prospective study, small bowel capsule endoscopy (SBCE) demonstrated a high diagnostic yield in patients with obscure gastrointestinal bleeding (OGIB), detecting clinically relevant lesions in the majority of cases. SBCE was found to be valuable in determining the diagnostic work-up and clinical outcome in patients with OGIB.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
Halim Awadie, Ahmad Zoabi, Ian M. Gralnek
Summary: Obscure gastrointestinal bleeding refers to small bowel bleeding of unknown etiology after endoscopic evaluation. It can be either overt or occult. This review discusses the differential diagnosis and the role of endoscopic and radiographic techniques in its evaluation and treatment.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2022)
Article
Multidisciplinary Sciences
Yuga Komaki, Shuji Kanmura, Kazuki Yutsudo, Kosuke Kuwazuru, Fukiko Komaki, Akihito Tanaka, Hidehito Maeda, Shiho Arima, Shiroh Tanoue, Fumisato Sasaki, Shinichi Hashimoto, Masahisa Horiuchi, Akio Ido
Summary: This study retrospectively examined the clinical features and risk factors of obscure gastrointestinal bleeding (OGIB) in patients who underwent capsule endoscopy. The study found that the use of direct oral anticoagulants was frequently associated with OGIB, and OGIB patients without vascular lesions may be treated conservatively.
Article
Surgery
Satimai Aniwan, Vichai Viriyautsahakul, Thanawat Luangsukrerk, Phonthep Angsuwatcharakon, Panida Piyachaturawat, Pradermchai Kongkam, Natanong Kongtab, Sombat Treeprasertsuk, Pinit Kullavanijaya, Rungsun Rerknimitr
Summary: This study demonstrated that patients with positive DBE requiring therapeutic intervention had a lower rebleeding rate, and about one-fifth of patients may have false negative results after DBE.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Koji Otani, Sunao Shimada, Toshio Watanabe, Yuji Nadatani, Akira Higashimori, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara
Summary: This study aimed to determine the long-term rebleeding rate and predictive factors for rebleeding in patients with obscure GI bleeding (OGIB) using capsule endoscopy (CE). The study found that rebleeding is common during the long-term follow-up of patients with OGIB. Overt OGIB, anticoagulants, positive balloon-assisted enteroscopy findings after CE, and iron supplements without therapeutic intervention were associated with rebleeding. Moreover, liver cirrhosis was identified as an independent predictor of rebleeding in patients with OGIB.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Ran Zhao, Masanao Nakamura, Shan Wu, Genta Uchida, Takeshi Yamamura, Yun-Jie Gao, Hidemi Goto, Mitsuhiro Fujishiro, Zhi-Zheng Ge
Summary: The study revealed that early video capsule endoscopy can enhance the diagnostic rate of obscure gastrointestinal bleeding (OGIB) and reduce the risk of rebleeding after treatment, improving patient prognosis and treatment outcomes.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Miguel Mascarenhas Saraiva, Tiago Ribeiro, Patricia Andrade, Helder Cardoso, Guilherme Macedo
Summary: This study compared the performance of capsule enteroscopy and scintigraphy in the diagnosis of obscure gastrointestinal bleeding, finding significant diagnostic discrepancies between the two modalities, with capsule enteroscopy showing better correlation with hemoglobin values.
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2022)
Article
Gastroenterology & Hepatology
Xavier Dray, Gabriel Rahmi, Maria Elena Riccioni, Geoffroy Vanbiervliet, Gabriele Wurm Johansson, Chloe Leandri, Peter Baltes, Clotilde Duburque, Franck Cholet, Anastasios Koulaouzidis, Lucille Queneherve
Summary: Small bowel capsule endoscopy (SBCE) is a feasible method for investigating complex gastrointestinal bleeding in patients with surgically altered gastric anatomy. This study showed that SBCE had comparable diagnostic yield, completion rate, and adverse events rate to non-operated patients.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Surgery
Shawn M. Purnell, Daniel J. Vargo, Michael Sarap, John J. Nguyen-Lee, Chelsea Allen, Brian J. Dunkin
Summary: The study surveyed rural surgeons on their requirements and preferences for a simulation model for rehearsing the endoscopic management of NVUGIB. Results showed that most rural surgeons lack experience with simulation models but are interested in further training.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Medicine, General & Internal
Apurva Patel, Deepanjali Vedantam, Devyani S. Poman, Lakshya Motwani, Nailah Asif
Summary: The translation provides a definition of obscure gastrointestinal bleeding (OGIB) and introduces capsule endoscopy (CE) as an ideal procedure. It also mentions the goal of this review is to explore the impact of CE on OGIB.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Surgery
Damiano Bisogni, Giovanni Alemanno, Andrea Galli, Annamaria Di Bella, Luca Novelli, Tommaso Innocenti, Paolo Prosperi
Summary: Jejunoileal neuroendocrine tumours (NETs) are often multifocal and a common cause of obscure gastrointestinal bleeding (OGIB). This case report highlights the discrepancy between pre-operative imaging and capsule endoscopy in detecting multiple lesions, leading to the use of intraoperative balloon-assisted enteroscopy (BAE) for accurate diagnosis and resection of the bleeding lesions.
JOURNAL OF MINIMAL ACCESS SURGERY
(2021)
Article
Medicine, Research & Experimental
Boying Liu, Sudong Liu, Pingwu Wen, Shengbing Wang, Fuqun Wang, Xiaodong Gu
Summary: Patients with rebleeding in OGIB were older, had lower hemoglobin, higher blood urea nitrogen levels, higher rates of diabetes mellitus and overt bleeding, and were more likely to require blood transfusions. Drinking alcohol, anemia, and blood transfusion were identified as risk factors for rebleeding in OGIB patients.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jihye Park, Jae Hee Cheon, Kang-Moon Lee, Young-Ho Kim, Byong Duk Ye, Chang Soo Eun, Sung Hyun Kim, Sun Hee Lee, Joon Ho Lee, Stefan Schreiber
Summary: This study aimed to compare the clinical efficacy and safety of CT-P13 and originator infliximab in Crohn's disease treatment. The study found a significant correlation between early serum infliximab trough levels and treatment outcomes, and there were no statistical differences in serum trough levels and anti-drug antibody levels between CT-P13 and originator infliximab.
Article
Gastroenterology & Hepatology
Jun Young Park, Jae Myung Park, Ga-Yeong Shin, Joon Sung Kim, Yu Kyung Cho, Tae Ho Kim, Byung-Wook Kim, Myung-Gyu Choi
Summary: This study aimed to identify the clinical and endoscopic factors affecting the achievement of a normal diet with only bougie dilation in patients with benign esophageal stricture (BES). Results showed that approximately one-third of BES patients can achieve a normal diet through fewer than four dilation sessions, short length of stricture, pre-procedural dysphagia status, and larger dilator diameter.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim
Summary: This study provides evidence that infliximab is effective and well-tolerated in patients with moderate-to-severe active intestinal Behcet's disease.
Article
Gastroenterology & Hepatology
Kyuwon Kim, Kookhwan Choi, Sung Wook Hwang, Jong Pil Im, Byong Duk Ye, Joo Sung Kim, Kyu Joo Park, Suk-Kyun Yang, Seong-Joon Koh, Sang Hyoung Park
Summary: CD-associated SBA did not differ in overall survival from sporadic SBA, but CD is an independent risk factor for mortality.
Article
Pharmacology & Pharmacy
Geert D'Haens, Walter Reinisch, Stefan Schreiber, Fraser Cummings, Peter M. M. Irving, Byong Duk Ye, Dong-Hyeon Kim, SangWook Yoon, Shomron Ben-Horin
Summary: This study compared the pharmacokinetics, efficacy, and immunogenicity of subcutaneous infliximab monotherapy and combotherapy in biologic-naive patients with inflammatory bowel disease. The results showed comparable outcomes between the two treatment groups.
CLINICAL DRUG INVESTIGATION
(2023)
Editorial Material
Gastroenterology & Hepatology
Byong Duk Ye
Article
Gastroenterology & Hepatology
Gwang Ha Kim, Myung-Gyu Choi, Jin Il Kim, Soo Teik Lee, Hoon Jai Chun, Kook Lae Lee, Suk Chei Choi, Jae-Young Jang, Yong Chan Lee, Jae Gyu Kim, Ki Bae Kim, Ki-Nam Shim, Chong Il Sohn, Sung Kook Kim, Sang Gyun Kim, Jin Seok Jang, Nayoung Kim, Hwoon-Yong Jung, Hyojin Park, Kyu Chan Huh, Kwang Jae Lee, Su Jin Hong, Song Baek, Jin Joo Han, Oh Young Lee
Summary: This study assessed the efficacy and safety of Fexuprazan in patients with acute or chronic gastritis. The results showed that Fexuprazan 20 mg q.d. and 10 mg b.i.d. for 2 weeks had superior therapeutic efficacy compared to placebo in patients with gastritis.
Article
Gastroenterology & Hepatology
Hyun Ho Choi, Soo-Yoon Sung, Bo-In Lee, Hyun Cho, Yunho Jung, Jae Myung Park, Young-Seok Cho, Kang-Moon Lee, Sang Woo Kim, Hwang Choi, Hiun-Suk Chae, Myung-Gyu Choi
Summary: This study investigated the association between endoscopists' personality traits and the effect of interventions for improving colonoscopy quality. The results showed that education can improve colonoscopy quality, and the effectiveness of education is related to endoscopists' personal traits such as perfectionism and fear of negative evaluation.
Article
Multidisciplinary Sciences
Kabsoo Shin, Joori Kim, Se Jun Park, Myung Ah Lee, Jae Myung Park, Myung-Gyu Choi, Donghoon Kang, Kyo Young Song, Han Hong Lee, Ho Seok Seo, Sung Hak Lee, Bohyun Kim, Okran Kim, Juyeon Park, Nahyeon Kang, In-Ho Kim
Summary: The study investigated the prognostic significance of soluble PD-L1 (sPD-L1) and exosomal PD-L1 (exoPD-L1) in patients with gastric cancer receiving chemotherapy. It was found that low levels of sPD-L1 and exoPD-L1 were associated with better overall survival and progression-free survival. Pretreatment sPD-L1 could be used as an independent prognostic factor for overall survival, while exoPD-L1 may reflect the immunosuppressive state of patients.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Gastroenterology & Hepatology
Jun Su Lee, Sang-Bum Kang, Kwangbeom Park, Yong Sik Yoon, Chang Sik Yu, Sung Wook Hwang, Byong Duk Ye, Suk-Kyun Yang, Jong Lyul Lee, Sang Hyoung Park
INTESTINAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sol Kim, Yu Kyung Cho, Jun Young Park, Dong Hoon Kang, Jae Myung Park, Myung-Gyu Choi
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Hyun Min Kim, Donghoon Kang, Jun Young Park, Yu Kyung Cho, Myung-Gyu Choi, Jae Myung Park
Summary: A new scoring system has been developed in this study to predict the mortality rate of patients with upper gastrointestinal cancer bleeding. This scoring system is more accurate compared to existing systems and can be used to predict and prepare patients at high risk of death.
Article
Gastroenterology & Hepatology
Kyuwon Kim, Sojung Park, Yoonho Lee, Jiwon Baek, Yongjae Kim, Sung Wook Hwang, Jong Lyul Lee, Sang Hyoung Park, Suk-Kyun Yang, Buhm Han, Kyuyoung Song, Yong Sik Yoon, Ho-Su Lee, Byong Duk Ye
Summary: This study investigated the transcriptional profile and compositional features of creeping fat (CF) in Crohn's disease (CD). The results showed that CF in CD patients had a large number of genes related to immune cell responses, while genes with a decremental pattern were associated with cell migration. Cell analysis revealed significant changes in cellular composition between CD-CF and Con-MAT groups.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Suhyun Park, Jae Yong Lee, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
Summary: This study aimed to investigate the effect of stenting-related factors, including endoscopists' expertise, on clinical outcomes after bridge-to-surgery (BTS) stenting for obstructive colorectal cancer (CRC). The results showed that the expertise of endoscopists was associated with better short-term outcomes, including high stenting success rate and low rate of stent-related complications after BTS stenting. The interval between stenting and surgery also played a role in postoperative complications.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eun Mi Song, Soo-Young Na, Sung Noh Hong, Siew Chien Ng, Tadakazu Hisamatsu, Byong Duk Ye
Summary: A web-based survey was conducted to evaluate the current treatment of inflammatory bowel disease (IBD) in Asian countries/regions. The results showed that anti-tumor necrosis factor (TNF) agents, anti-integrins, and anti-interleukin-12/23 agents were commonly used in Asian countries/regions. Treatment strategies were mostly similar among Asian doctors, but it is important to identify the most appropriate therapeutic strategy for Asian IBD patients.
INTESTINAL RESEARCH
(2023)