Article
Gastroenterology & Hepatology
Lazaros-Dimitrios Lazaridis, Georgios Tziatzios, Ervin Toth, Hanneke Beaumont, Xavier Dray, Rami Eliakim, Pierre Ellul, Ignacio Fernandez-Urien, Martin Keuchel, Simon Panter, Emanuele Rondonotti, Bruno Rosa, Cristiano Spada, Rodrigo Jover, Pradeep Bhandari, Konstantinos Triantafyllou, Anastasios Koulaouzidis
Summary: Internationally, endoscopists adhere to some extent to ESGE guidelines for small-bowel capsule endoscopy, but variations in practice have been identified, requiring further evaluation.
Review
Gastroenterology & Hepatology
Apostolis Papaefthymiou, Apostolos Koffas, Faidon-Marios Laskaratos, Owen Epstein
Summary: Video capsule can illuminate the entire gastrointestinal mucosa. Upper gastrointestinal capsule endoscopy has the potential to detect pathology in the esophagus, stomach, and duodenum, and determine the need for biopsy or intervention. Sequential innovations were required to address the challenges in esophageal and gastric imaging. The latest development of high frame rate upper gastrointestinal capsule endoscopy has surpassed dedicated esophageal capsule technology.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Joo Hye Song, Ji Eun Kim, Hwe Hoon Chung, Sung Noh Hong, Heejung Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim
Summary: Performing video capsule endoscopy within 24 hours of gastrointestinal bleeding can increase the diagnostic yield for patients with overt obscure gastrointestinal bleeding and may result in a higher rate of therapeutic intervention.
Article
Multidisciplinary Sciences
Amber Charoen, Averill Guo, Panisara Fangsaard, Supakorn Taweechainaruemitr, Nuwee Wiwatwattana, Theekapun Charoenpong, Harlan G. Rich
Summary: This study presents a large VCE dataset that can be used for the development of algorithms to improve VCE. VCE is the least invasive tool for complete visualization of the small bowel and is the preferred method for initial diagnostic evaluation.
Article
Gastroenterology & Hepatology
Michael Bretthauer, Yuichi Mori, Jasmin Zessner-Spitzenberg, Michal F. F. Kaminski, Peter D. D. Siersema, Thierry Ponchon, Helmut Messmann, Ian M. M. Gralnek, Raf Bisschops, Cesare Hassan
Summary: The European Union has introduced stricter regulations for the approval of medical devices, affecting both endoscopists and patients. The new regulations require more clinical trials and observational studies to ensure the clinical benefit and reduce patient harm. The European Society of Gastrointestinal Endoscopy (ESGE) will play an active role in establishing the new system.
Article
Gastroenterology & Hepatology
Tomonori Aoki, Atsuo Yamada, Ryota Niikura, Ayako Nakada, Nobumi Suzuki, Yoku Hayakawa, Yoshihiro Hirata, Kazuhiko Koike, Mitsuhiro Fujishiro
Summary: Early small bowel capsule endoscopy identified a suspected small bowel bleeding source in 12% of acute-onset presumptive CDB patients, but did not significantly improve major clinical outcomes.
Article
Gastroenterology & Hepatology
Pradeep Bhandari, Gaius Longcroft-Wheaton, Diogo Libanio, Pedro Pimentel-Nunes, Eduardo Albeniz, Mathieu Pioche, Reena Sidhu, Cristiano Spada, Andrea Anderloni, Alessandro Repici, Rehan Haidry, Marc Barthet, Helmut Neumann, Giulio Antonelli, Alberto Testoni, Thierry Ponchon, Peter D. Siersema, Lorenzo Fuccio, Cesare Hassan, Mario Dinis-Ribeiro
Summary: Over the past four years, 27% of research questions in the field of endoscopy have been answered, with another 27% requiring redefinition. Seven research priorities were removed, seven were redefined, and nineteen remained unchanged for researchers and funding bodies to target.
Review
Medicine, General & Internal
Ioannis Tziortziotis, Faidon-Marios Laskaratos, Sergio Coda
Summary: Capsule endoscopy is increasingly used in medical practice, but faces challenges and limitations. Artificial intelligence shows promise in improving CE performance and is likely to have a significant impact on endoscopy clinical practice in the future.
Article
Gastroenterology & Hepatology
Fanny E. R. Vuik, Stella A. Nieuwenburg, Sarah Moen, Eline H. Schreuders, Marinka D. Oudkerk Pool, Elisabeth F. P. Peterse, Cristiano Spada, Owen Epstein, Ignacio Fernandez-Urien, Albert Hofman, Ernst J. Kuipers, Manon C. W. Spaander
Summary: The study found that gastrointestinal lesions are very common in a largely asymptomatic Western population, with clinically relevant lesions found in 12% during CCE. These findings provide a reference frame for the prevalence rates of GI lesions in the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chao Zhou, Kunpeng Qiu, Can Chen, Dengyin Zhang, Yongxin Guo
Summary: This study addresses two challenges in wireless capsule endoscopy (WCE) applications, namely the lack of high-resolution counterparts and the difficulty of utilizing temporal correlations to enhance recovery performance. A novel training dataset and an effective alignment network are proposed to tackle these challenges. Experimental results demonstrate the superiority of the proposed method in practical WCE applications over other approaches.
IEEE SENSORS JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yaling Han, Zhuan Liao, Yi Li, Xianxian Zhao, Shuren Ma, Dan Bao, Miaohan Qiu, Jie Deng, Jinhai Wang, Peng Qu, Chunmeng Jiang, Shaobin Jia, Shaoqi Yang, Leisheng Ru, Jia Feng, Wei Gao, Yonghui Huang, Ling Tao, Ying Han, Kan Yang, Xiaoyan Wang, Wenjuan Zhang, Bangmao Wang, Yue Li, Youlin Yang, Junxia Li, Jiangqiu Sheng, Yitong Ma, Min Cui, Sicong Ma, Xiaozeng Wang, Zhaoshen Li, Gregg W. Stone
Summary: This study assessed the effects of different antiplatelet regimens on gastrointestinal mucosal injury in patients at low bleeding risk using a novel capsule endoscopy system.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Helmut Messmann, Raf Bisschops, Giulio Antonelli, Diogo Libanio, Pieter Sinonquel, Mohamed Abdelrahim, Omer F. Ahmad, Miguel Areia, Jacques J. G. H. M. Bergman, Pradeep Bhandari, Ivo Boskoski, Evelien Dekker, Dirk Domagk, Alanna Ebigbo, Tom Eelbode, Rami Eliakim, Michael Haefner, Rehan J. Haidry, Rodrigo Jover, Michal F. Kaminski, Roman Kuvaev, Yuichi Mori, Maxime Palazzo, Alessandro Repici, Emanuele Rondonotti, Matthew D. Rutter, Yutaka Saito, Prateek Sharma, Cristiano Spada, Marco Spadaccini, Andrew Veitch, Ian M. Gralnek, Cesare Hassan, Mario Dinis-Ribeiro
Summary: The ESGE defines the expected value of AI for the diagnosis and management of gastrointestinal neoplasia and sets recommendations for its acceptance in different aspects of endoscopy.
Article
Oncology
Kai-Yao Yang, Yu-Jen Fang, Riya Karmakar, Arvind Mukundan, Yu-Ming Tsao, Chien-Wei Huang, Hsiang-Chen Wang
Summary: Video capsule endoscopy (VCE) is a small, patient-friendly tool used for medical imaging, but lacks narrow band imaging (NBI) functionality. This study successfully developed a method to convert white light images (WLI) from VCE into NBI-like images, offering a promising solution for better cancer detection.
Review
Medicine, General & Internal
Ji Hyung Nam, Kwang Hoon Lee, Yun Jeong Lim
Summary: Capsule endoscopy (CE) is a non-invasive diagnostic tool that allows direct visualization of the gastrointestinal tract. Initially developed for small-bowel investigation, its clinical application is expanding and there are ongoing technological advances. The future development of a mouth to anus (M2A) capsule that can investigate the entire GI tract with a single capsule is discussed in this review.
Article
Medicine, General & Internal
Sangyup Oh, Dongjun Oh, Dongmin Kim, Woohyuk Song, Youngbae Hwang, Namik Cho, Yun Jeong Lim
Summary: This study presents a novel neural encoder based on the Transformer architecture, which takes the entire video frames as input and improves the accuracy of lesion detection. By utilizing the power of Transformer architecture in extracting long-term global correlation within and between frames, as well as capturing the temporal context and attentional features, automated lesion detection for images is significantly enhanced.
Review
Gastroenterology & Hepatology
Antonio Facciorusso, Paraskevas Gkolfakis, Daryl Ramai, Georgios Tziatzios, Janice Lester, Stefano Francesco Crino, Leonardo Frazzoni, Ioannis S. Papanikolaou, Marianna Arvanitakis, Daniel Blero, Arnaud Lemmers, Pierre Eisendrath, Lorenzo Fuccio, Konstantinos Triantafyllou, Armando Gabbrielli, Jacques Deviere
Summary: All treatments except mechanical lithotripsy were more effective than sphincterotomy in terms of stone removal rate. Cholangioscopy ranked the highest in increasing the success rate of stone removal, followed by S+EPLBD. None of the interventions showed significant differences in adverse event rates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Antonio Facciorusso, Stefano Francesco Crino, Daryl Ramai, Giovanni Marchegiani, Janice Lester, Jameel Singh, Andrea Lisotti, Pietro Fusaroli, Renato Cannizzaro, Paraskevas Gkolfakis, Ioannis S. Papanikolaou, Konstantinos Triantafyllou, Siddharth Singh
Summary: It is unclear whether patients with intraductal papillary mucinous neoplasia have a higher risk of developing extrapancreatic malignancies. This study provides a pooled estimate of the incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasia and compares it to the general population. The findings suggest that the risk of developing extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasia is not higher than that of the general population.
Article
Gastroenterology & Hepatology
Ian M. Gralnek, Cesare Hassan, Alanna Ebigbo, Andre Fuchs, Ulrike Beilenhoff, Giulio Antonelli, Raf Bisschops, Marianna Arvanitakis, Pradeep Bhandari, Michael Bretthauer, Michal F. Kaminski, Vicente Lorenzo-Zuniga, Enrique Rodriguez de Santiago, Peter D. Siersema, Tony C. Tham, Konstantinos Triantafyllou, Alberto Tringali, Andrei Voiosu, George Webster, Marjon de Pater, Bjorn Fehrke, Mario Gazic, Tatjana Gjergek, Siiri Maasen, Wendy Waagenes, Mario Dinis-Ribeiro, Helmut Messmann
Review
Medicine, General & Internal
Pablo Cortegoso Valdivia, Karolina Skonieczna-Zydecka, Alfonso Elosua, Martina Sciberras, Stefania Piccirelli, Maria Rullan, Trevor Tabone, Katarzyna Gawel, Adam Stachowski, Artur Leminski, Wojciech Marlicz, Ignacio Fernandez-Urien, Pierre Ellul, Cristiano Spada, Marco Pennazio, Ervin Toth, Anastasios Koulaouzidis
Summary: This study conducted a systematic review and meta-analysis to evaluate the performance measures of capsule endoscopy (CE), including completion, detection, and retention rates. The results showed that the pooled rates for all capsule types were acceptable, with obscure GI bleeding being the most common indication for CE.
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Liboria Laterza, Marina La Marca, Rocco Maurizio Zagari, Franco Radaelli, Cesare Hassan, Alessandro Repici, Antonio Facciorusso, Paraskevas Gkolfakis, Cristiano Spada, Konstantinos Triantafyllou, Franco Bazzoli, Mario Dinis-Ribeiro, Lorenzo Fuccio
Summary: This study assessed the diagnostic performance of alarm features (rectal bleeding, anemia, change in bowel habit, and weight loss) for colorectal cancer (CRC) diagnosis through a systematic review and meta-analysis. The results showed variable accuracy for each alarm feature, and rectal bleeding and anemia were identified as the most practical features for selecting patients for colonoscopy.
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Review
Gastroenterology & Hepatology
Apostolis Papaefthymiou, Daryl Ramai, Marcello Maida, Georgios Tziatzios, Michael Fernandez Y. Viesca, Ioannis Papanikolaou, Konstantina Paraskeva, Konstantinos Triantafyllou, Alessandro Repici, Cesare Hassan, Cecilia Binda, Torsten Beyna, Antonio Facciorusso, Marianna Arvanitakis, Paraskevas Gkolfakis
Summary: This systematic review and meta-analysis found that motorized spiral enteroscopy (mSE) has high rates of diagnostic and therapeutic success with a low prevalence of severe adverse events.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Microbiology
Georgios Tziatzios, Paraskevas Gkolfakis, Gabriela Leite, Ruchi Mathur, Georgia Damoraki, Evangelos J. J. Giamarellos-Bourboulis, Konstantinos Triantafyllou
Summary: Functional dyspepsia (FD) is a common disorder with no definitive, universal treatment. Probiotics have been suggested as a potential therapeutic option for FD due to their effects on gastrointestinal symptoms in patients with Irritable Bowel Syndrome (IBS). However, the evidence for the efficacy of probiotics in FD remains unclear. This review aims to summarize the available evidence for the use of probiotics in FD.
Article
Gastroenterology & Hepatology
Peter J. Lee, Ali Lahooti, Stacey Culp, Andrew Boutsicaris, Phillip Holovach, Kayla Wozniak, Ila Lahooti, Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin Traian Babu, Haq Nawaz, Silvia Cristina Gutierrez, Narcis Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Phil A. Hart, Somashekar G. Krishna, Luis Lara, Samuel Han, Georgios I. Papachristou
Summary: This study aimed to determine the adjusted effects of body mass index (BMI) and alcoholic etiology on the risk of multisystem organ failure (MSOF) in patients with acute pancreatitis (AP). The results showed that alcoholic etiology was independently associated with increased risk of MSOF compared to non-alcohol etiologies, and obese men (but not women) were more susceptible to MSOF.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Simon M. Everett, Konstantinos Triantafyllou, Cesare Hassan, Klaus Mergener, Tony C. Tham, Nuno Almeida, Giulio Antonelli, Andrew Axon, Raf Bisschops, Michael Bretthauer, Vianna Costil, Farid Foroutan, James Gauci, Istvan Hritz, Helmut Messmann, Maria Pellise, Philip Roelandt, Andrada Seicean, Georgios Tziatzios, Andrei Voiosu, Ian M. Gralnek
Summary: All endoscopic procedures carry risks, so endoscopists should involve patients in the decision-making process and respect their right to self-determination. The European Society of Gastrointestinal Endoscopy has established a series of statements as a minimum standard of practice for informed consent, but there is a lack of guidance in many countries, leading to variations in care and potential legal risks.
Review
Microbiology
Maroulla D. Nikolaki, Arezina N. Kasti, Konstantinos Katsas, Konstantinos Petsis, Sophia Lambrinou, Vasiliki Patsalidou, Sophia Stamatopoulou, Katerina Karlatira, John Kapolos, Konstantinos Papadimitriou, Konstantinos Triantafyllou
Summary: This review explores the role of branched short-chain fatty acids (BCFAs) on gut inflammation in patients with irritable bowel syndrome (IBS) and the impact of low-FODMAP diet (LFD) on BCFAs production. The included studies have contradictory findings about the effects of BCFAs on intestinal health in IBS patients.
Review
Medicine, General & Internal
Thomas Vasilakis, Dimitrios Ziogas, Georgios Tziatzios, Paraskevas Gkolfakis, Eleni Koukoulioti, Christina Kapizioni, Konstantinos Triantafyllou, Antonio Facciorusso, Ioannis S. Papanikolaou
Summary: Gastric subepithelial lesions (SELs) are intramural lesions beneath the gastric mucosa. Accurate diagnosis is crucial as SELs can be benign, malignant, or have malignant potential. Endosonography is the gold standard for diagnosis, but histological examination may be necessary for certain lesions, particularly smaller ones. New methods such as contrast enhanced endosonography, EUS elastography, and artificial intelligence systems have been developed to assist decision making. This review provides a comprehensive overview and summarizes the latest diagnostic advances in endosonography for gastric SELs in the past decade.
Review
Gastroenterology & Hepatology
Magdalini Manti, Georgios Tziatzios, Antonio Facciorusso, Apostolis Papaefthymiou, Daryl Ramai, Ioannis Papanikolaou, Cesare Hassan, Konstantinos Triantafyllou, Konstantina Paraskeva, Paraskevas Gkolfakis
Summary: Add-on devices with projections placed on the distal tip of the colonoscope improve the detection of precancerous lesions during colonoscopy for screening purposes. Meta-analysis results indicate that the use of these devices results in a higher adenoma detection rate compared to standard colonoscopy.
ANNALS OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Eleni Manthopoulo, Daryl Ramai, Alexandros Ioannou, Paraskevas Gkolfakis, Ioannis S. Papanikolaou, Benedetto Mangiavillano, Konstantinos Triantafyllou, Stefano Francesco Crino, Antonio Facciorusso
Summary: Endoscopic ultrasound (EUS) is a technique that allows for the collection of tissue samples via a fine needle while visualizing the area. This study focuses on EUS tissue acquisition in organs other than the pancreas, including the liver, biliary tree, lymph nodes, and gastrointestinal tracts. The review discusses the evolving techniques used for tissue sampling under EUS guidance, as well as the importance of needle type and size in sample quality.
ANNALS OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Paraskevas Gkolfakis, Christina Kapizioni, Georgios Tziatzios, Antonio Facciorusso, Leonardo Frazzoni, Konstantinos Thomopoulos, Spyros Potamianos, Dimitrios Christodoulou, Vasilios Papadopoulos, Lorenzo Fuccio, Cesare Hassan, Konstantinos Triantafyllou
Summary: This study evaluated the comparative efficacy of predictive scores in predicting inadequate bowel cleansing among hospitalized patients undergoing colonoscopy. The results showed that Model B outperformed its comparators in predicting inadequate bowel preparation, particularly in mobilized inpatients.
ANNALS OF GASTROENTEROLOGY
(2023)