Article
Chemistry, Inorganic & Nuclear
Donald Poirier, Imad Raad, Jenny Roy, Rene Maltais
Summary: The passage discusses the anticancer activity of a new family of steroid derivatives, emphasizing the importance of the combination of an androstane-3,17-diol nucleus and a 2 beta-N-alkylamidopiperazino sidechain. By studying the impact of A-ring substitution on biological activity, it was confirmed that the compound with the 2 beta-sidechain/3 alpha-OH orientation exhibited the best efficiency compared to other configurations tested.
Article
Multidisciplinary Sciences
Haruka Tanabe, Hitoshi Mutai, Daimei Sasayama, Hidehiko Sasamoto, Yoshimichi Miyashiro, Nobuhiro Sugiyama, Shinsuke Washizuka
Summary: The study found significant differences in 3 beta Adiol and E2 levels, as well as depression scores, over the menstrual cycle in women. Women had lower levels of 3 beta Adiol and Delta 5-diol compared to men, while E2 levels were higher in women. DHEA levels did not differ significantly between genders.
Article
Cell Biology
Seongcheol Kim, Nicholas Knesek Kubelka, Heather M. Laporte, Vignesh R. Krishnamoorthy, Meharvan Singh
Summary: Estrogens have been shown to protect neuronal function in the presence of oxidative stress, and this protection may be mediated by the glial cells, specifically astrocytes, through the protein connexin 43 (Cx43). This study found that estradiol (E2) and the estrogenic metabolite 3 beta-diol were protective against oxidative stress in astrocytes, and this protection was dependent on estrogen receptors. However, the hormones did not affect Cx43 mRNA levels but inhibited Cx43 channel permeability. Understanding the relationship between gonadal steroids and Cx43 channels may contribute to a better understanding of sex differences in various diseases.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Immunology
Ciana Diskin, Sarah E. Corcoran, Victoria J. Tyrrell, Anne F. McGettrick, Zbigniew Zaslona, Valerie B. O'Donnell, Derek P. Nolan, Luke A. J. O'Neill
Summary: Trypanosoma brucei, the causative agent of human African trypanosomiasis, secretes a metabolite that inhibits specific protein production in macrophages, potentially promoting the survival of both the host and the parasite.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Jose Antonio Mondragon, Yesenia Serrano, Andrea Torres, Martin Orozco, Jose Segovia, Gabriel Manjarrez, Marta Catalina Romano
Summary: Glioblastoma cells express key enzymes involved in androgen synthesis, making these enzymes potential targets for new therapeutic approaches. The expression of 3 beta-hydroxysteroid dehydrogenase, P450c17, 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase proteins in glioblastoma cells was confirmed through immunocytochemistry, immunofluorescence, and Western blot analyses.
ENDOCRINOLOGY DIABETES & METABOLISM
(2021)
Article
Behavioral Sciences
George Briassoulis, Margaret F. Keil, Bilal Naved, Sophie Liu, Matthew F. Starost, Maria Nesterova, Nirmal Gokarn, Anna Batistatos, T. John Wu, Constantine A. Stratakis
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Endocrinology & Metabolism
Ashley L. Russell, Jamie Moran Grimes, Danette F. Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J. Weiser, Michael R. Landauer, Robert J. Handa, T. John Wu, Darwin O. Larco
HORMONE AND METABOLIC RESEARCH
(2017)
Article
Neurosciences
Ashley L. Russell, Jamie Moran Grimes, Darwin O. Larco, Danette F. Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J. Weiser, Michael R. Landauer, Robert J. Handa, T. John Wu
NEUROSCIENCE LETTERS
(2017)
Article
Endocrinology & Metabolism
Bradly M. Bauman, Weiling Yin, Andrea C. Gore, T. John Wu
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Darwin O. Larco, Bradly M. Bauman, Madelaine Cho-Clark, Shaila K. Mani, T. John Wu
FRONTIERS IN ENDOCRINOLOGY
(2018)
Review
Endocrinology & Metabolism
Ashley L. Russell, Jeffrey G. Tasker, Aldo B. Lucion, Jenny Fiedler, Carolina D. Munhoz, Tao-yiao John Wu, Terrence Deak
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Review
Neurosciences
Lisa S. Robison, Olivia J. Gannon, Abigail E. Salinero, Kristen L. Zuloaga
Review
Endocrinology & Metabolism
Charly Abi-Ghanem, Lisa S. Robison, Kristen L. Zuloaga
BIOLOGY OF SEX DIFFERENCES
(2020)
Article
Immunology
Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas, Abigail E. Salinero, Charly Abi-Ghanem, Yannick Poitelon, Sophie Belin, Kristen L. Zuloaga
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Neurosciences
Ashley L. Russell, Lauren Miller, Hannah Yi, Rita Keil, Robert J. Handa, T. John Wu
Summary: The study revealed that deletion of the Per2 gene impacts CORT levels, mRNA expression, behaviors, and startle response, indicating that disruption of the circadian system dysregulates the HPA stress axis, leading to increased depressive-like behaviors and deficits in startle response.
Article
Immunology
Olivia J. Gannon, Lisa S. Robison, Abigail E. Salinero, Charly Abi-Ghanem, Febronia M. Mansour, Richard D. Kelly, Alvira Tyagi, Rebekah R. Brawley, Jordan D. Ogg, Kristen L. Zuloaga
Summary: This study investigated the impact of diet-induced prediabetes and biological sex on cognitive function and neuropathology in mouse models of AD and MxD. The results showed that high-fat diet had more severe metabolic, cognitive, and neuropathological consequences in AD and MxD females compared to males.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Endocrinology & Metabolism
Alex M. Miller, Renata M. Daniels, Julietta A. Sheng, T. John Wu, Robert J. Handa
Summary: The ventromedial prefrontal cortex (vmPFC) regulates various functions and exhibits diurnal rhythms in the molecular clock gene and dendritic spine, which are dependent on glucocorticoid oscillations.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Olivia J. Gannon, Janvie S. Naik, David Riccio, Febronia M. Mansour, Charly Abi-Ghanem, Abigail E. Salinero, Richard D. Kelly, Heddwen L. Brooks, Kristen L. Zuloaga
Summary: The majority of women with dementia are post-menopausal, but menopause is not well represented in rodent models of dementia. This study aimed to determine if menopause worsens cognitive impairment in a mouse model of vascular contributions to cognitive impairment and dementia (VCID). The results showed that menopause causes metabolic dysfunction and increases cognitive impairment in this mouse model, indicating the need for further studies to identify the underlying mechanisms.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Lisa S. Robison, Olivia J. Gannon, Abigail E. Salinero, Charly Abi-Ghanem, Richard D. Kelly, David A. Riccio, Febronia M. Mansour, Kristen L. Zuloaga
Summary: Alzheimer's disease is associated with cognitive decline and affects multiple brain regions. The hypothalamus, which controls energy and glucose homeostasis, is also affected. Changes in metabolism may serve as biomarkers for Alzheimer's disease and contribute to disease progression. In this study, sex differences in metabolic disturbances and hypothalamic inflammation were observed in Alzheimer's disease mice.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Ashley L. Russell, M. Riley Richardson, Bradly M. Bauman, Ian M. Hernandez, Samantha Saperstein, Robert J. Handa, T. John Wu