Article
Cardiac & Cardiovascular Systems
Cheng Ni, Yongjian Chen, Yinchuan Xu, Jing Zhao, Qingju Li, Changchen Xiao, Yan Wu, Jingyi Wang, Yingchao Wang, Zhiwei Zhong, Ling Zhang, Rongrong Wu, Qingnian Liu, Xianpeng Wu, Changle Ke, Wei Zhu, Jinghai Chen, Jijun Huang, Yibin Wang, Jian'an Wang, Xinyang Hu
Summary: The expression of FMO2 is significantly downregulated in cardiac fibrosis, and its fibroblast-specific expression can reduce fibrosis and inhibit the SMAD2/3 signaling pathway, independent of its enzymatic activity. FMO2 interacts with CYP2J3 and disrupts the interaction between CYP2J3 and SMURF2, leading to the inhibition of SMAD2/3 signaling.
CIRCULATION RESEARCH
(2022)
Article
Engineering, Biomedical
Jianping Yuan, Hong Yang, Chunxia Liu, Lianbo Shao, Haixin Zhang, Kunyan Lu, Jingjing Wang, Yuanyuan Wang, Qian Yu, Yanxia Zhang, Yunsheng Yu, Zhenya Shen
Summary: Myocardial infarction (MI) is a severe cardiovascular disease that leads to uncontrolled and excessive cardiac fibrosis. A biocompatible microneedle patch loaded with exosomes containing miR-29b mimics is developed to prevent fibrosis after MI. The patch effectively delivers the exosomes to cardiac fibroblasts, upregulating miR-29b expression and downregulating fibrosis-related proteins, resulting in reduced inflammation, infarct size, fibrosis, and improved cardiac function in a mouse MI model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jan Traub, Katja Grondey, Tobias Gassenmaier, Dominik Schmitt, Georg Fette, Stefan Frantz, Valerie Boivin-Jahns, Roland Jahns, Stefan Stoerk, Guido Stoll, Theresa Reiter, Ulrich Hofmann, Martin S. Weber, Anna Frey
Summary: The study found that serum levels of glial fibrillary acidic protein (GFAP) increased in the first 3 months after ST-elevation myocardial infarction (STEMI), and remained elevated without further increases after 6 and 12 months. In contrast, neurofilament light chain (NfL) levels remained unchanged throughout the one-year period. These findings support the idea of central nervous system involvement after myocardial infarction, with GFAP potentially serving as a peripheral biomarker for chronic glial damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Weifeng Song, Zhen Chen, Meng Zhang, Haixia Fu, Xianqing Wang, Jifang Ma, Xiaobiao Zang, Juan Hu, Fen Ai, Ke Chen
Summary: Myocardial infarction (MI) is a severe cardiovascular disease that leads to sudden death globally. Cardiac injury following MI causes apoptosis and fibrosis. Bilobalide (Bilo) from Ginkgo biloba leaves has shown cardioprotective effects, but its role in MI has not been investigated. In vitro experiments using H9c2 cells and in vivo experiments using an MI mouse model were conducted. Bilo inhibited cell apoptosis, improved cardiac function, reduced infarct size and myocardial fibrosis, and suppressed protein levels of p-JNK and p-p38.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sohta Ishihama, Satoya Yoshida, Tatsuya Yoshida, Yu Mori, Noriyuki Ouchi, Shunsuke Eguchi, Teruhiro Sakaguchi, Takuma Tsuda, Katsuhiro Kato, Yuuki Shimizu, Koji Ohashi, Takahiro Okumura, Yasuko K. Bando, Hiroaki Yagyu, Nina Wettschureck, Naoto Kubota, Stefan Offermanns, Takashi Kadowaki, Toyoaki Murohara, Mikito Takefuji
Summary: The study reveals that the LPL/AQP7/GPD2-mediated glycerol metabolism plays a crucial role in preventing myocardial ischemia-related damage. Deficiencies in these enzymes and proteins can lead to exacerbated cardiac dysfunction and apoptosis following myocardial infarction. Additionally, the activation of GPD2 under ischemic conditions facilitates ATP synthesis, while LPL deficiency can impact the effectiveness of PPAR alpha agonist treatment for MI-induced cardiac dysfunction.
Article
Pharmacology & Pharmacy
Yuze Zhang, Julia Steinmetz-Spah, Helena Idborg, Liyuan Zhu, Huihui Li, Haojie Rao, Zengrong Chen, Ziyi Guo, Lejia Hu, Chuansheng Xu, Hong Chen, Marina Korotkova, Per-Johan Jakobsson, Miao Wang
Summary: Inhibition of mPGES-1 can prevent chronic adverse cardiac remodeling after myocardial infarction, which may serve as a potential therapeutic strategy for HFrEF.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zihan Liu, Zhihao Liu, Xiao Xu, Yuyang Zhou, Hu Chen, Huixin Zhou, Zeyan Li, Fuding Guo, Zhen Zhou, Yuhong Wang, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: Psychological stress is a contributing factor to worsened prognosis following myocardial infarction. This study identified the role of the VMHVL-PVN-SCG sympathetic pathway in the post-MI heart and proposed denervation as a promising strategy to mitigate cardiac prognosis in stressful rats. Understanding this mechanism is of great significance in improving cardiac outcomes in patients with psychological stress.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Chengzhe Liu, Saiting Xu, Jun Wang, Fuding Guo, Shoupeng Duan, Qiang Deng, Ji Sun, Fu Yu, Yuyang Zhou, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: In this study, it was found that adiponectin can protect the heart by modulating the function and neural activity of the stellate ganglia, as well as reducing sympathetic nervous system activity. Adiponectin also improves heart rate variability, decreases cardiac sympathetic activity, serum noradrenaline and neuropeptide Y levels, and reduces the expression of nerve growth factors and growth associated proteins. These findings suggest that adiponectin may be a potential therapeutic strategy for the treatment of myocardial infarction.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Nutrition & Dietetics
Michael J. Macartney, Sean R. Notley, Christophe L. Herry, Ronald J. Sigal, Pierre Boulay, Glen P. Kenny
Summary: In middle-aged-to-older individuals with type 2 diabetes, 7 days of exercise-heat acclimation did not significantly affect heart rate and HRV, indicating further research is needed to understand the relationship between exercise-heat acclimation and cardiac autonomic modulation in individuals with T2D.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Zhiyu He, Xiaojun Zeng, Deke Zhou, Peiying Liu, Dunzheng Han, Lingling Xu, Tong Bu, Jinping Wang, Mengmeng Ke, Xiudi Pan, Yipeng Du, Hao Xue, Dongfeng Lu, Bihui Luo
Summary: This study identifies the novel ability of lncRNA Chaer in regulating cardiomyocyte apoptosis by promoting phosphorylation of AMPK in acute myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Gabriel A. Grilo, Sirin N. Cakir, Patti R. Shaver, Rugmani P. Iyer, Kaitlin Whitehead, Joseph M. Mcclung, Ali Vahdati, Lisandra E. de Castro Bras
Summary: A peptide mimetic called p1159, derived from collagen, was found to reduce left ventricular dilation and fibrosis in a mouse model of myocardial infarction. This study aimed to test the potential of p1159 to reduce adverse cardiac remodeling in a chronic MI model and to elucidate its mode-of-action. The results showed that p1159 significantly improved systolic function post-MI and promoted the formation of a compliant and organized infarct scar, leading to reduced adverse cardiac remodeling.
Article
Cardiac & Cardiovascular Systems
Daile Jia, Siqin Chen, Peiyuan Bai, Chentao Luo, Jin Liu, Aijun Sun, Junbo Ge
Summary: This study reveals the importance of cardiac resident macrophages in the efficient clearance and degradation of apoptotic cardiomyocytes during myocardial infarction, which is crucial for inflammation resolution and tissue repair. The researchers identified Lgmn as a key gene involved in this process and demonstrated its functional significance through various experiments.
Article
Cardiac & Cardiovascular Systems
Mark C. Petrie, Pardeep S. Jhund, Eugene Connolly, Patrick B. Mark, Michael R. MacDonald, Michele Robertson, Stefan D. Anker, Sunil Bhandari, Kenneth Farrington, Philip A. Kalra, David C. Wheeler, Charles R. Tomson, Ian Ford, John J. McMurray, Iain C. Macdougall
Summary: This study aimed to investigate the effect of high-dose vs. low-dose intravenous iron on myocardial infarction in patients on maintenance haemodialysis. The results showed that high-dose IV iron reduced myocardial infraction in patients receiving haemodialysis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Cagla Eren Cimenci, Nick J. R. Blackburn, Veronika Sedlakova, Justina Pupkaite, Marcelo Munoz, Benjamin H. Rotstein, David A. Spiegel, Emilio I. Alarcon, Erik J. Suuronen
Summary: The study demonstrates that fisetin-collagen hydrogel therapy can reduce the negative effects of MG post-MI by increasing glyoxalase-1 levels, decreasing MG-AGE accumulation, and reducing oxidative stress, leading to improved cardiac function. Additionally, the therapy promotes neovascularization, increases pro-healing macrophages, and decreases pro-inflammatory macrophages in the infarct area.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Yihai Liu, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang
Summary: The study demonstrated that the SGLT2 inhibitor empagliflozin could improve cardiac remodeling in early myocardial infarction of non-diabetic mice by reducing cardiomyocyte apoptosis, oxidative stress, and restoring mitochondrial membrane potential. The activation of AMP-activated protein kinase (AMPK) signaling pathway may mediate the cardioprotective role of empagliflozin.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)