Article
Multidisciplinary Sciences
Yanli Cheng, Zhongtian Shen, Yaqi Gao, Feilong Chen, Huisha Xu, Qinling Mo, Xinlei Chu, Chang-liang Peng, Takese T. McKenzie, Bridgitte E. Palacios, Jian Hu, Hao Zhou, Jiafu Long
Summary: The study reveals that the binding of oncoprotein SS18-SSX to chromatin remodeling complex and its phase separation are crucial for the transformation activity in synovial sarcomas.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Minze Zhang, Xiaoliang Han, Klaus Osterrieder, Michael Veit
Summary: The major membrane proteins GP5 and M of porcine reproductive and respiratory syndrome virus are palmitoylated at cysteines, which is essential for virus growth. Acylation is required for the formation of infectious particles and viruses lacking acylation sites show reduced growth in cell culture. Multiple fatty acids attached to GP5 and M are necessary for clustering of dimerized proteins at Golgi membranes and virus assembly.
Article
Biology
Elizabeth T. Wiles, Colleen C. Mumford, Kevin J. McNaught, Hideki Tanizawa, Eric U. Selker
Summary: Establishing and maintaining appropriate gene repression is crucial for multicellular organisms. H3K27 methylation is a common modification associated with gene repression, and recent research has identified the involvement of ISWI and ACF1 genes in the repression of H3K27-methylated genes in the filamentous fungus Neurospora crassa. These genes form an ACF chromatin-remodeling complex and interact with chromatin throughout the genome. Proper nucleosome positioning is critical for the repression of H3K27-methylated genes.
Article
Nursing
Katie Gallagher, Julia Petty, Joanne Cooper, Neil Marlow
Summary: This study aimed to investigate neonatal nursing led research activity in the UK. The results indicated a limited number of neonatal nurses conducting or leading research, highlighting the need for further support and training.
Article
Biochemistry & Molecular Biology
Sudeep Karki, Matti Javanainen, Shahid Rehan, Dale Tranter, Juho Kellosalo, Juha Huiskonen, Lotta Happonen, Ville Paavilainen
Summary: This study reveals the mechanism by which TRAP assists in polypeptide translocation by presenting the structure of the core Sec61/TRAP complex bound to a mammalian ribosome using cryo-EM.
Review
Pediatrics
Mark S. Scher
Summary: Gene-environment interactions influence brain development from conception, affecting maternal/placental/fetal triads, neonates, and children with short- and long-term effects. Lifelong developmental neuroplasticity is more likely to occur during critical/sensitive periods within the first 1,000 days. Fetal/neonatal programs focusing on trimester-specific mechanisms can better identify brain malformations and destructive lesions in the maternal/placental/fetal triad.
FRONTIERS IN PEDIATRICS
(2021)
Editorial Material
Pediatrics
Sampsa Vanhatalo, Nathan J. Stevenson, Ronit M. Pressler, Nicholas S. Abend, Stephane Auvin, Francesco Brigo, M. Roberta Cilio, Cecil D. Hahn, Hans Hartmann, Lena Hellstrom-Westas, Terrie E. Inder, Solomon L. Moshe, Magda L. Nunes, Renee A. Shellhaas, Kollencheri P. Vinayan, Linda S. de Vries, Jo M. Wilmshurst, Elissa Yozawitz, Geraldine B. Boylan
Summary: Brain monitoring plays a crucial role in neonatal neurocritical care, but recent research failed to prove its effectiveness in seizure treatment.
PEDIATRIC RESEARCH
(2023)
Article
Nursing
Ana Choperena
Summary: This study analyzed the personal experiences of Jane Stuart Woolsey in "Hospital Days", which revealed her contributions to bringing order, training, and quality to nursing activities during the American Civil War. The article emphasized the importance of proper training for nurses in wartime contexts and highlighted the pioneering role of Jane Woolsey.
NURSE EDUCATION IN PRACTICE
(2023)
Article
Chemistry, Medicinal
Lin Yang, Ziru Wang, Hongsheng Ouyang, Yuanzhu Zhang, Wenyu Xiao, Ying Liu, Jiacheng Deng, Mengjing Li, Lerong Ma, Chunyun Qi, Daxin Pang, Hongming Yuan
Summary: The study found that ZC3H11A plays an important role in the proliferation of PRV and PCV2 in pigs, and the inactivation of ZC3H11A also inhibits the proliferation of these two viruses. This research suggests that ZC3H11A is important for maintaining the export of mRNAs, which in turn facilitates the proliferation of PRV and PCV2.
ACS INFECTIOUS DISEASES
(2022)
Article
Biology
Giovanni Messina, Yuri Prozzillo, Francesca Delle Monache, Maria Virginia Santopietro, Patrizio Dimitri
Summary: The subunits of the SRCAP and p400/Tip60 chromatin remodeling complexes relocate from chromatin to the mitotic apparatus during cell division, playing crucial roles in the proper execution of cell division.
Article
Immunology
Ming Qiu, Shubin Li, Yanzhao Xiao, Jixiang Li, Youwen Zhang, Xinshuai Li, Binghui Feng, Chen Li, Hong Lin, Jianzhong Zhu, Nanhua Chen
Summary: This study provides evidence that significant proliferations of PEDV and PKV are closely associated with severe diarrhea in neonatal piglets, while PAstVs likely play limited roles in neonatal piglet diarrhea.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Zongcheng Lin, Fei Xie, Marina Trivino, Tao Zhao, Frederik Coppens, Lieven Sterck, Maurice Bosch, Vernonica E. Franklin-Tong, Moritz K. Nowack
Summary: In this study, the researchers identified the key role of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in self-incompatibility (SI) in plants. They discovered the HLD1/AtPGAP1 gene as a critical component required for SI response and demonstrated its function as a GPI-inositol deacylase.
Article
Multidisciplinary Sciences
Christopher M. Richards, Sabrina Jabs, Wenjie Qiao, Lauren D. Varanese, Michaela Schweizer, Peter R. Mosen, Nicholas M. Riley, Malte Klussendorf, James R. Zengel, Ryan A. Flynn, Arjun Rustagi, John C. Widen, Christine E. Peters, Yaw Shin Ooi, Xuping Xie, Pei-Yong Shi, Ralf Bartenschlager, Andreas S. Puschnik, Matthew Bogyo, Carolyn R. Bertozzi, Catherine A. Blish, Dominic Winter, Claude M. Nagamine, Thomas Braulke, Jan E. Carette
Summary: LYSET is a critical factor in the M6P trafficking machinery of cells, and mutations in LYSET can explain the phenotype of the associated disorder.
Article
Biology
Sikao Guo, Ipsita Saha, Saveez Saffarian, Margaret E. Johnson
Summary: To make HIV virions infectious, the immature Gag lattice on the virion membrane needs to be cleaved. However, only a small fraction of the Gag polyproteins, called Gag-Pol, carry the required protease domain. The mechanism of Gag-Pol dimerization is not well understood.
Article
Biochemistry & Molecular Biology
Ourlad Alzeus G. Tantengco, Lauren S. Richardson, Paul Mark B. Medina, Arum Han, Ramkumar Menon
Summary: This study developed an organ-on-chip model of the cervical epithelial layer that can recapitulate the ectocervical and endocervical regions of the cervix. It was found that LPS and TNF alpha stimulation can lead to increased apoptosis, necrosis, senescence, and pro-inflammatory cytokine production in cervical epithelial cells.
