Review
Endocrinology & Metabolism
Joan Gil, Mireia Jorda, Berta Soldevila, Manel Puig-Domingo
Summary: Epithelial-mesenchymal transition is a dynamic process that plays essential roles in both physiological and pathological processes, particularly in the growth and invasion of pituitary tumors. Studies have shown the association of EMT with resistance to somatostatin receptor ligands in the treatment of acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Yiyuan Chen, Hua Gao, Qian Liu, Weiyan Xie, Bin Li, Sen Cheng, Jing Guo, Qiuyue Fang, Haibo Zhu, Zhuang Wang, Jichao Wang, Chuzhong Li, Yazhuo Zhang
Summary: Analysis of transcription data reveals the importance of the DLK1/MEG3 locus in the differentiation of PitNETs, particularly somatotroph adenomas, offering potential molecular targets for future patient stratification and treatment.
Review
Medicine, General & Internal
Ana-Maria Gheorghe, Alexandra-Ioana Trandafir, Mihaela Stanciu, Florina Ligia Popa, Claudiu Nistor, Mara Carsote
Summary: This article provides new insights into the challenges of pituitary apoplexy during pregnancy and the postpartum period. The study includes a review of 35 original studies and highlights the importance of prompt recognition of headache as the main clinical feature. Most patients receive conservative management with corticosteroid substitution and dopamine agonists. Surgical intervention is reserved for cases with neuro-ophthalmological deterioration. This study is clinically significant for obstetricians and neurologists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Min Zhao, Kai Li, Hongchuan Niu, Yuanli Zhao, Changyu Lu
Summary: This study used case data analysis to examine changes in hormone levels before and after surgery in patients with pituitary adenoma and investigated the influence of various factors on endocrine function. The findings show that surgical intervention effectively improves endocrine disorders in these patients, with preoperative management of hormone levels facilitating postoperative remission. Multiple surgeries and an extended interval between hormone retesting and surgery can affect postoperative cortisol secretion function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Huy Gia Vuong, Ian F. Dunn
Summary: Sparsely granulated somatotroph adenoma/tumor (SGST) and densely granulated somatotroph adenoma/tumor (DGST) are different in demographics, clinicopathological features, and molecular characteristics. SGST is associated with adverse treatment outcomes and poor response to medical therapy.
Review
Clinical Neurology
Zihao Zhou, Sheng Zhang, Fangqi Hu
Summary: Craniopharyngioma is an intracranial congenital epithelial tumor with main symptoms including high intracranial pressure, visual field defect, endocrine dysfunction, and hypothalamic dysfunction. Surgical treatment is the preferred method, but postoperative endocrine disorders affect the quality of life, with research focusing on improving endocrine dysfunction.
FRONTIERS IN NEUROLOGY
(2021)
Article
Veterinary Sciences
Matthew M. E. Steele, Jack S. Lawson, Christopher Scudder, Alice H. Watson, Nicola T. Z. Ho, Dylan Yaffy, Daniel Batchelor, Joe Fenn
Summary: This article reports a case of successful surgical treatment of a pituitary tumor in a dog, resulting in the resolution of hypersomatotropism, while diabetes mellitus continued to exist.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yifan Tang, Tao Xie, Silin Wu, Qiaoqiao Yang, Tengfei Liu, Chen Li, Shuang Liu, Zhiyong Shao, Xiaobiao Zhang
Summary: This study provides large-scale proteome molecular characteristics of distinct granulation subtypes of somatotroph adenomas. Compared with DG adenomas, The differential protein of SG adenomas mostly enrich in invasive and proliferative functions and pathways at the proteomic level. Cadherin-1 and Catenin beta-1 play key roles in the different biological characteristics of the two tumor subtypes.
Article
Environmental Sciences
Anita A. Thambirajah, Michael G. Wade, Jonathan Verreault, Nicolas Buisine, Veronica A. Alves, Valerie S. Langlois, Caren C. Helbing
Summary: This critical review highlights the complexity of Endocrine Disrupting Chemicals interfering with Thyroid Hormone function through interactions with other hormonal axes, and emphasizes the lack of data generated in non-mammalian vertebrate classes. With the availability of more genomics-based resources, better identification and delineation of EDC effects, modes of action, and identification of effective biomarkers suitable for HPT disruption is possible. The effects of EDCs are likely to cascade into a plurality of complex physiological effects, beyond the few variables tested within research studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Surgery
Yusi Chen, Feng Hu, Junwen Wang, Kuan Huang, Weihua Liu, Yutang Tan, Kai Zhao, Qungen Xiao, Ting Lei, Kai Shu
Summary: This study summarized the clinical features of CP with tumoral hemorrhage. It found that patients with hemorrhage often exhibit symptoms such as drowsiness, acute syndrome, and pituitary deficiency, and also experience more severe post-operative complications.
FRONTIERS IN SURGERY
(2022)
Article
Endocrinology & Metabolism
Meiping Chen, Lian Duan, Wei Sun, Zhengguang Guo, Hui Miao, Na Yu, Shengmin Yang, Linjie Wang, Fengying Gong, Yong Yao, Huijuan Zhu
Summary: Patients with invasive somatotroph PitNETs have a poorer prognosis and lower remission rate compared to those with noninvasive PitNETs. Proteomic analysis reveals the high expression of CTSZ as a contributing factor to the invasive transformation and poor prognosis in somatotroph PitNETs for the first time, providing new insights into the molecular mechanisms of invasive PitNETs.
NEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Zhijie Pei, Yi Fang, Shuwen Mu, Jun Li, Tianshun Feng, Kunzhe Lin, Shousen Wang
Summary: Perioperative assessment of adenohypophyseal hormones can improve therapeutic strategies and evaluate the prognosis of pituitary adenomas. Normalization of hormone levels facilitates overall assessment of the adenohypophysis.
NEUROSURGICAL FOCUS
(2022)
Article
Biotechnology & Applied Microbiology
Yan Zhang, Danrong Wu, Ruoqiu Wang, Min Luo, Dong Wang, Kaiyue Wang, Yi Ai, Li Zheng, Qiao Zhang, Lixin Shi
Summary: This article reports a rare case of ectopic ACTH-secreting pituitary adenoma in the clival region. In addition to the more common organs, special attention should be paid to ectopic ACTH-secreting pituitary adenomas in the clivus region when diagnosing ectopic ACTH syndrome.
ONCOTARGETS AND THERAPY
(2022)
Review
Endocrinology & Metabolism
Jan A. Mennigen, Divya Ramachandran, Katherine Shaw, Radha Chaube, Keerikkattil P. Joy, Vance L. Trudeau
Summary: This article critically reviews the current knowledge of the roles of nonapeptide systems in teleost reproduction, focusing on the roles of arginine vasopressin (AVP) and oxytocin (OXT) in reproductive behavior and the regulation of the hypothalamic-pituitary-gonadal axis. The article also highlights the importance of a gonadal nonapeptide system in steroidogenesis and gamete maturation, and calls for translational studies linking this knowledge to aquaculture, conservation biology, and ecotoxicology.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Anna Hoerder-Suabedissen, Kim V. Korrell, Shuichi Hayashi, Alexander Jeans, Denise M. O. Ramirez, Eleanor Grant, Helen C. Christian, Ege T. Kavalali, Michael C. Wilson, Zoltan Molnar
Article
Neurosciences
Andreia S. Margarido, Ludovic Le Guen, Amandine Falco, Sandrine Faure, Norbert Chauvet, Pascal de Santa Barbara
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Endocrinology & Metabolism
Laura O'Hara, Helen C. Christian, Nathan Jeffery, Paul Le Tissier, Lee B. Smith
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Paul R. Le Tissier, David R. Grattan
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
S. H. Wood, M. M. Hindle, Y. Mizoro, Y. Cheng, B. R. C. Saer, K. Miedzinska, H. C. Christian, N. Begley, J. McNeilly, A. S. McNeilly, S. L. Meddle, D. W. Burt, A. S. I. Loudon
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Delphine Martire, Sarah Garnier, Sebastien Sagnol, Annick Bourret, Stephane Marchal, Norbert Chauvet, Amandine Guerin, Dominique Forgues, Dominique Berrebi, Christophe Chardot, Marc Bellaiche, John Rendu, Nicolas Kalfa, Sandrine Faure, Pascal de Santa Barbara
Summary: Smooth Muscle Cells (SMC) exhibit a unique ability to modulate their phenotype, switching between a quiescent contractile state and a highly proliferative and migratory state. In a study on infants with chronic intestinal pseudo-obstruction (CIPO), it was found that CIPO-SMCs have decreased levels of contractile markers and increased expression of PDGFRA, suggesting a phenotypic switch towards an undifferentiated stage.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Paul R. Le Tissier, Patrice Mollard
Summary: FS cells, specialized cells in the anterior pituitary, play a crucial role in regulating endocrine cell function, coordinating calcium activity, modulating endocrine output, and contributing to pituitary axes. Recent studies have identified FS cells as a source of stem cells and emphasized their potential in fine-tuning and coordinating pituitary axes function.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Peter J. Duncan, Mehran Fazli, Nicola Romano, Paul Le Tissier, Richard Bertram, Michael J. Shipston
Summary: Chronic stress can increase the spontaneous bursting behavior of pituitary corticotrophs, which is mediated by BK channels. Despite the majority of BK channels being inhibited, corticotrophs under chronic stress can still display CRH-induced bursting due to the stochastic behavior of a small number of BK channels. The properties and functional co-localization of BK channels with L-type calcium channels play a crucial role in finely tuning corticotroph excitability under diverse physiological challenges.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Endocrinology & Metabolism
Peter J. Duncan, Heather McClafferty, Oscar Nolan, Qinghui Ding, Natalie Z. M. Homer, Paul Le Tissier, Brian R. Walker, Michael J. Shipston, Nicola Romano, Thomas J. G. Chambers
Summary: The research focuses on the impact of long-term use of glucocorticoids (GC) and their suppression of the HPA axis, mainly focusing on the recovery of the pituitary and hypothalamus. The effects of dexamethasone (DEX) treatment persist after withdrawal, potentially influencing future response to GC treatment and stress.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Biology
Helen E. Chmura, Cassandra Duncan, Ben Saer, Jeanette T. Moore, Brian M. Barnes, C. Loren Buck, Helen C. Christian, Andrew S. Loudon, Cory T. Williams
Summary: This study demonstrates that arctic ground squirrels hibernating in darkness activate the thyroid hormone signaling pathway in the hypothalamus, remodel hypothalamic tanycytes, and activate the reproductive axis. Periodic arousals during hibernation may allow for transient activation of thyroid hormone signaling, cellular remodeling, and re-programming of brain circuits in preparation for the short Arctic summer.
COMMUNICATIONS BIOLOGY
(2022)
Article
Developmental Biology
Pierre Sicard, Amandine Falco, Sandrine Faure, Jerome Thireau, Stephanie E. Lindsey, Norbert Chauvet, Pascal de Santa Barbara
Summary: This study utilized non-invasive high-resolution echography and speckle tracking analysis to observe and quantify gastrointestinal motility in chick embryos. The researchers found that gastrointestinal contractions begin early in development but only become synchronized at the end of the fetal period. The enteric nervous system plays a role in initiating synchronized contractions, and alterations in smooth muscle fiber organization can impair gastrointestinal function.
Review
Endocrinology & Metabolism
Paul R. Le Tissier, Joanne F. Murray, Patrice Mollard
Summary: Plasticity of function is crucial for the anterior pituitary endocrine axes to adapt to changes in hormone demand and environmental challenges. The size and organization of pituitary cell populations play a role in this plasticity. SOX2+ve cells act as sentinels and actuators of cell number, regulating secretion and other aspects of endocrine cell functional mass.
Article
Endocrinology & Metabolism
Ombeline Hoa, Chrystel Lafont, Pierre Fontanaud, Anne Guillou, Yasmine Kemkem, Rhonda D. Kineman, Raul M. Luque, Tatiana Fiordelisio Coll, Paul Le Tissier, Patrice Mollard
Article
Medicine, Research & Experimental
Yi Athena Ren, Teresa Monkkonen, Michael T. Lewis, Daniel J. Bernard, Helen C. Christian, Carolina J. Jorgez, Joshua A. Moore, John D. Landua, Haelee M. Chin, Weiqin Chen, Swarnima Singh, Ik Sun Kim, Xiang H. F. Zhang, Yan Xia, Kevin J. Phillips, Harry MacKay, Robert A. Waterland, M. Cecilia Ljungberg, Pradip K. Saha, Sean M. Hartig, Tatiana Fiordelisio Coll, JoAnne S. Richards