Article
Oncology
Sang Il Kim, Joo Hee Yoon, Soo Young Hur
Summary: The study revealed high expression of MIS/AMHRII in endometrial cancer and showed that MIS/AMH treatment inhibits the growth of MIS/AMH receptor-expressing tumor cells through regulation of autophagy, apoptosis, and cell cycle pathways, as well as inhibition of Wnt signaling pathways. This suggests that MIS/AMH functions as a tumor suppressor and may be an effective therapeutic agent in endometrial cancer.
Article
Immunology
Renwei Lu, Ziqi Peng, Panpan Lian, Junaid Wazir, Chaode Gu, Chujun Ma, Lulu Wei, Li Li, Wenyuan Pu, Jun Liu, Hongwei Wang, Zhonglan Su
Summary: This study found that vitamin D has a significant therapeutic effect in the treatment of atopic dermatitis, possibly by inhibiting the phosphorylation of STAT3, reducing inflammatory cell infiltration and chemokine release, decreasing AQP3 protein expression, and inhibiting cell proliferation to restore the skin barrier function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Antonela Gverovic Antunica, Ljubo Znaor, Mira Ivankovic, Velibor Puzovic, Irena Markovic, Snjezana Kastelan
Summary: Diabetic retinopathy, the most common eye disease complication of diabetes, is associated with hypovitaminosis D. Vitamin D2 and D3 are the main forms of vitamin D, with sunlight being a major source. Vitamin D plays a crucial role not only in maintaining healthy bones and immune system but also in the development of various diseases, including diabetic retinopathy. Diagnosis of vitamin D deficiency, which is prevalent worldwide, is done through measuring serum concentration of 25-hydroxyvitamin D. Supplementation of vitamin D has been proven effective in treating diabetic retinopathy, but under the recommendation and supervision of a doctor to prevent potential negative side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marie-Charlotte Meinsohn, Hatice D. Saatcioglu, Lina Wei, Yi Li, Heiko Horn, Maeva Chauvin, Motohiro Kano, Ngoc Minh Phuong Nguyen, Nicholas Nagykery, Aki Kashiwagi, Wesley R. Samore, Dan Wang, Esther Oliva, Guangping Gao, Mary E. Morris, Patricia K. Donahoe, David Pepin
Summary: MIS treatment inhibits follicle development in neonatal mice by suppressing proliferation in granulosa cells, surface epithelial cells, and ovarian stromal cells, while inducing a unique quiescent state in granulosa cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Nutrition & Dietetics
Milosz Caban, Urszula Lewandowska
Summary: This article reviews the current knowledge on the link between vitamin D and its receptor and the occurrence of eye disease, as well as the influence of analogues of calcitriol, an active metabolite of vitamin D. It is found that patients with various ocular disorders generally have vitamin D deficiency, and vitamin D may modulate the course of eye diseases and serve as a marker. Supplementation of vitamin D could potentially alleviate some eye disorders, but further randomized trials are recommended to clarify the link and activity between vitamin D and eye disease.
Review
Oncology
Ioanna-Maria Gkotinakou, Ilias Mylonis, Andreas Tsakalof
Summary: Vitamin D functions as a nutrient as well as a hormone, regulating various physiological functions. The relationship between calcitriol and HIF signaling in cancer development and treatment needs further investigation.
Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Article
Biotechnology & Applied Microbiology
Jiaye Liu, Junyi Shen, Chunyang Mu, Yang Liu, Dongsheng He, Han Luo, Wenshuang Wu, Xun Zheng, Yi Liu, Sunrui Chen, Qiuwei Pan, Yiguo Hu, Yinyun Ni, Yang Wang, Yong Liu, Zhihui Li
Summary: The study demonstrates a new method involving the one-step self-assembly of calcitriol and amphiphilic cholesterol-based conjugates to form a stable minimalist micellar nanosystem for anticancer treatment, which shows promising efficacy and biocompatibility.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Xinyue Yu, Baocai Liu, Ning Zhang, Qian Wang, Guanghui Cheng
Summary: Radiotherapy is a key treatment for various types of cancer, but enhancing its effectiveness remains a challenge. Radiation resistance is a major factor in cancer progression, making overcoming treatment resistance a top challenge for clinicians. Vitamin D can synergistically enhance the effects of radiotherapy, potentially contributing to improved treatment outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Li Niu, Shuangshuang Chen, Xue Yang, Chunliang Ma, Chunling Pan, Hongyan Wang, Qian Li, Fengxue Geng, Xiaolin Tang
Summary: The study found that calcitriol helps degrade and eliminate Porphyromonas gingivalis within macrophages by promoting the autophagy process. Additionally, the autophagy process plays a critical role in the degradation of intracellular Porphyromonas gingivalis.
Review
Oncology
Beata Filip-Psurska, Honorata Zachary, Aleksandra Strzykalska, Joanna Wietrzyk
Summary: This article reviews the impact of vitamin D-3 on Th17 cells in breast cancer, finding that its effectiveness depends on factors such as age, menopausal status, and obesity. Moreover, the role of vitamin D-3 in breast cancer development is controversial. Due to the scarcity of scientific data on Th17 lymphocytes and breast cancer, further clinical trials and studies are needed to assess the importance of vitamin D in breast cancer.
Article
Biochemistry & Molecular Biology
Artem Zhukov, Alexandra Povaliaeva, Zaur Abilov, Elena Kovaleva, Liliya Usoltseva, Anna Eremkina, Vitaliy Ioutsi, Larisa Dzeranova, Ekaterina Pigarova, Liudmila Rozhinskaya, Natalia Mokrysheva
Summary: This study evaluated the extended spectrum of vitamin D metabolites in patients with HypoPT compared to healthy individuals. The results showed that patients with HypoPT achieved an adequate level of 25(OH)D-3 with standard doses of cholecalciferol, but they had supraphysiological levels of 1,25(OH)(2)D-3 and increased production of inactive metabolite. The abnormality of vitamin D metabolism does not seem to interfere with the achievement of hypoparathyroidism compensation.
Review
Biochemistry & Molecular Biology
Euclides Avila, Bryan Javier Noriega-Mejia, Jocelyn Gonzalez-Macias, Ulises Cortes-Hernandez, Janice Garcia-Quiroz, Rocio Garcia-Becerra, Lorenza Diaz
Summary: Vitamin D and the vitamin D endocrine system play a crucial role in regulating calcium homeostasis and have antitumoral effects in various human cancers, including cervical cancer. Studies have shown an inverse relationship between cervical neoplasia and vitamin D levels. This review supports the idea that the vitamin D endocrine system has a preventive role in cervical cancer, particularly in the early stages, by suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and potentially clearing HPV-dependent lesions. However, vitamin D seems to have little effectiveness in advanced cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chee-Keng Mok, Yan Ling Ng, Bintou Ahmadou Ahidjo, Zhen Qin Aw, Huixin Chen, Yi Hao Wong, Regina Ching Hua Lee, Marcus Wing Choy Loe, Jing Liu, Kai Sen Tan, Parveen Kaur, De Yun Wang, Erwei Hao, Xiaotao Hou, Yong Wah Tan, Jiagang Deng, Justin Jang Hann Chu
Summary: The COVID-19 pandemic has presented unprecedented challenges in medicine and healthcare globally. A drug screening process using four compound libraries has identified 121 potential anti-SARS-CoV-2 compounds, with seven shortlisted for further validation. Calcitriol, the active form of vitamin D, exhibits strong antiviral potency against SARS-CoV-2 through modulation of the vitamin D receptor pathway. However, the effects of calcitriol on SARS-CoV-2 infection in K18-hACE2 mice were negligible, indicating the need for further investigation using other animal models.
Review
Psychology, Multidisciplinary
Ana Beatriz Januario da Silva, Waleska Maria Almeida Barros, Mayara Luclecia da Silva, Jose Mauricio Lucas Silva, Ana Patricia da Silva Souza, Karollainy Gomes da Silva, Matheus Santos de Sousa Fernandes, Antonietta Claudia Barbosa da Fonseca Carneiro, Viviane de Oliveira Nogueira Souza, Claudia Jacques Lagranha
Summary: Vitamins and minerals can influence various functions in the central nervous system, including cognition. A potential association between low levels of vitamin D and deficits in cognitive function is discussed. This systematic review of randomized clinical trials in healthy non-athlete adults found positive changes in cognitive domains such as verbal memory, attention, and executive function with vitamin D supplementation. Low doses of 400-600 IU/d were found to be more effective than higher doses, and more research is needed on the effects of food fortification and enrichment with vitamin D. Trials evaluating vitamin D levels in healthy adults are important for minimizing health problems, particularly cognitive decline. Encouraging the development of more clinical trials on this topic is recommended.
FRONTIERS IN PSYCHOLOGY
(2022)