Article
Biochemistry & Molecular Biology
Gahyun Lim, Heaji Lee, Yunsook Lim
Summary: Recent research has shown that physical activity can improve cognitive function in sarcopenic obesity. This study investigated the potential effects of resistance exercise on cognitive and muscle functions in sarcopenic obesity. The results suggest that resistance exercise can enhance muscle and cognitive functions, and there is a positive correlation between muscle function and cognitive function.
Article
Sport Sciences
Joungbo Ko, Young C. Jang, John Quindry, Rodney Guttmann, Ludmila Cosio-Lima, Scott K. Powers, Youngil Lee
Summary: This study aimed to investigate the relationship between cardiac anomalies and metabolic disorders, as well as explore the role of endurance exercise in protecting the heart. The results demonstrated that endurance exercise improved obesity and hyperglycemia caused by a high-fat/high-fructose diet, and alleviated cardiac dysfunction. Moreover, endurance exercise inhibited cellular senescence and inflammation, promoted autophagy and apoptosis, thereby protecting the heart from metabolic distress.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Multidisciplinary Sciences
Jessica de Siqueira Guedes, Indira Pla, K. Barbara Sahlin, Gustavo Monnerat, Roger Appelqvist, Gyorgy Marko-Varga, Aleksander Giwercman, Gilberto Barbosa Domont, Aniel Sanchez, Fabio Cesar Sousa Nogueira, Johan Malm
Summary: This study investigated the short-term metabolic changes induced by testosterone depletion and supplementation in healthy young males. The results showed that low testosterone caused major metabolic changes that were partially restored by testosterone supplementation. Carnitine and amino acid metabolism were the most affected metabolic pathways.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Vanni Caruso, Mariachiara Zuccarini, Patrizia Di Iorio, Ishaq Muhammad, Maurizio Ronci
Summary: This review discusses the molecular mechanisms leading to changes in feeding behavior within hypothalamic neurons following purinergic receptor activation, emphasizes the importance of purinergic signaling in metabolic homeostasis, and explores the possibility of targeting its receptors for therapeutic purposes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wasana Pratchayasakul, Busarin Arunsak, Kanokphong Suparan, Sirawit Sriwichaiin, Titikorn Chunchai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: A combination of calorie restriction with exercise is probably the greatest lifestyle modification to diminish brain pathologies and cognitive decline in obesity with or without estrogen deprivation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wasana Pratchayasakul, Busarin Arunsak, Kanokphong Suparan, Sirawit Sriwichaiin, Titikorn Chunchai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study suggests that a combination of calorie restriction with exercise may be the optimal approach to alleviate brain pathologies and cognitive decline associated with obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Physiology
Julianne Touron, Helene Perrault, Laura Maisonnave, Veronique Patrac, Stephane Walrand, Corinne Malpuech-Brugere, Bruno Pereira, Yan Burelle, Frederic Costes, Ruddy Richard
Summary: This study compares eccentric and concentric exercise training and finds that skeletal muscle mitochondrial adaptations are primarily controlled by the extent of metabolic overload, regardless of exercise modality. Eccentric exercise training induces a specific mRNA transcript pattern, which may reflect a different cycle of cellular damage repair or eccentric adaptation.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Sport Sciences
Alexandra Marziou, Benjamin Aubert, Charlene Couturier, Julien Astier, Clothilde Philouze, Philippe Obert, Jean-Francois Landrier, Catherine Riva
Summary: Combining physical exercise and vitamin D supplementation has beneficial effects on body weight management, glucose homeostasis, metabolic inflammation, and liver steatosis in obese mice. This combined strategy could be valuable in obesity management programs.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Biotechnology & Applied Microbiology
Yori Endo, Yuteng Zhang, Shayan Olumi, Mehran Karvar, Shailesh Argawal, Ronald L. Neppl, Indranil Sinha
Summary: Exercise is believed to be beneficial for skeletal muscle function in individuals of all ages, but the response to exercise declines with aging. Transcriptomic changes induced by exercise in aged muscle indicate that neural responses predominate the adaptive response, while the absence of upregulations in anabolic pathways highlights them as potential pharmacological targets for optimizing therapies for sarcopenia.
Article
Biochemistry & Molecular Biology
Manuela Moriggi, Sara Belloli, Pietro Barbacini, Valentina Murtaj, Enrica Torretta, Linda Chaabane, Tamara Canu, Silvia Penati, Maria Luisa Malosio, Antonio Esposito, Cecilia Gelfi, Rosa Maria Moresco, Daniele Capitanio
Summary: The study revealed gender-specific responses to obesity in mice, with males showing various metabolic alterations while females exhibited activation of compensatory mechanisms. Bioinformatics analysis identified upstream molecules regulating pathways differently in males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Falk Mersmann, Theresa Domroes, Nikolaos Pentidis, Meng-Shiuan Tsai, Sebastian Bohm, Arno Schroll, Adamantios Arampatzis
Summary: This study investigated the effects of evidence-based tendon exercise intervention on high-level patellar tendon strain, micromorphological integrity, and pain in adolescent basketball players. The results suggest that functional high-load tendon exercises may reduce the prevalence of high-level patellar tendon strain and impairments of its micromorphology in adolescent athletes, providing new opportunities for tendinopathy prevention.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Review
Biochemistry & Molecular Biology
Hamza O. Dhafar, Ahmed S. BaHammam
Summary: This article discusses the relationship between narcolepsy and changes in weight and metabolic rate, and explores potential mechanisms for weight gain and metabolic changes. It suggests that patients with narcolepsy are more likely to be obese and experience rapid weight gain during the disease's outset. The precise mechanisms causing this weight gain are still unknown, and the role of orexin in weight gain in narcolepsy patients is still controversial.
Article
Geriatrics & Gerontology
Melissa L. Borg, Julie Massart, Thais De Castro Barbosa, Adria Archilla-Ortega, Jonathon A. B. Smith, Johanna T. Lanner, Jorge Alsina-Fernandez, Benjamin Yaden, Alexander E. Culver, Hakan K. R. Karlsson, Joseph T. Brozinick, Juleen R. Zierath
Summary: The study showed that modified UCN2 peptides were effective in combating skeletal muscle wasting associated with obesity and immobilization. The treatment increased muscle weight, regulated protein synthesis and degradation pathways, enhanced muscle strength, and altered the expression of relevant genes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Neurosciences
Brendan M. Gabriel, Juleen R. Zierath
Summary: Metabolic health is influenced by innate physiology and environmental factors, with circadian physiology playing a key role in regulating diurnal hormones and metabolites. Skeletal muscle experiences significant diurnal variations due to physical activity and external Zeitgebers. The intricate orchestration of circadian metabolism in skeletal muscle involves molecular pathways with diurnal variation, including the central role of the mitochondrion in regulating metabolites.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Nutrition & Dietetics
Brittney Knott, Matthew A. Kocher, Henry A. Paz, Shelby E. Hamm, William Fink, Jordan Mason, Robert W. Grange, Umesh D. Wankhade, Deborah J. Good
Summary: This study demonstrated that Snord116(m+/p-) mice and mice with a deletion of both Snord116 alleles showed weight and fat loss on a high-fat/CLA diet, indicating that the genotype did not interfere with CLA actions. There were no changes in food intake or metabolic rate, and only moderate differences in exercise performance. RNA-seq and microbiome analyses identified hypothalamic mRNAs and differentially populated gut bacteria, supporting future mechanistic analyses.
Review
Nutrition & Dietetics
Ag Dulloo, J. Jacquet, J. L. Miles-Chan, Y. Schutz
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2017)
Editorial Material
Substance Abuse
Marewa Glover, Bernhard H. Breier, Linda Bauld
NICOTINE & TOBACCO RESEARCH
(2017)
Article
Physiology
Jennifer L. Miles-Chan, Elie-Jacques Fares, Redina Berkachy, Philippe Jacquet, Laurie Isacco, Yves Schutz, Jean-Pierre Montani, Abdul G. Dulloo
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Sport Sciences
Wendy J. O'Brien, Sarah P. Shultz, Ridvan T. Firestone, Lily George, Bernhard H. Breier, Rozanne Kruger
EUROPEAN JOURNAL OF SPORT SCIENCE
(2017)
Article
Endocrinology & Metabolism
S. Hunma, H. Ramuth, J. L. Miles-Chan, Y. Schutz, J-P Montani, N. Joonas, A. G. Dulloo
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Psychology, Biological
Sarah Cowie, Michael Davison, Douglas Elliffe
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2017)
Article
Endocrinology & Metabolism
Maharani Retna Duhita, Yves Schutz, Jean-Pierre Montani, Abdul G. Dulloo, Jennifer L. Miles-Chan
Review
Endocrinology & Metabolism
A. G. Dulloo, J. L. Miles-Chan, J. -P. Montani, Y. Schutz
Editorial Material
Endocrinology & Metabolism
A. G. Dulloo, J. L. Miles-Chan, J. -P. Montani
Article
Multidisciplinary Sciences
Cathrfona R. Monnard, Jennifer L. Miles-Chan
Article
Psychology, Biological
Michael Davison
Summary: In choice measurements under concurrent schedules, it is important to exclude reinforced responses to avoid bias. The way concurrent-schedule values are varied can also affect the linearity of choice.
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2021)
Article
Psychology, Biological
Sarah Cowie, Michael Davison
Summary: The study showed that pigeons tended to make investing responses at the beginning of a trial, even when the consequences were temporally and spatially distant.
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2021)
Article
Psychology, Biological
Michael Davison, Sarah Cowie
Summary: This experiment explores the effect of animals' discrimination of response-reinforcer contingencies on timing, showing that choice changes appropriately across time when stimuli are discriminable, and subjective equality points decrease with decreasing stimulus difference. A model based on redistributions of reinforcers in time bins and between response locations accurately accounts for the data, highlighting the critical importance of stimulus-response-reinforcer discriminability in timing measures.
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2022)
Article
Psychology, Biological
Timothy A. Shahan, Gabrielle M. Sutton, Anthony N. Nist, Michael Davison
Summary: A study found that adding electric shock punishment to extinction can accelerate response suppression, but responding increases when the shock is removed. This result partly supports the view that reinforcement and punishment are asymmetrical processes. However, further experiments indicate that this result may be more due to the shock serving as a discriminative stimulus for the absence of reinforcement rather than the direct effects of punishment itself.
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2023)
Article
Physiology
Elie-Jacques Fares, Laurie Isacco, Cathriona R. Monnard, Jennifer L. Miles-Chan, Jean-Pierre Montani, Yves Schutz, Abdul G. Dulloo
PHYSIOLOGICAL REPORTS
(2017)