Article
Agriculture, Dairy & Animal Science
Liang Li, Xun Deng, Silu Hu, Zhifu Cui, Zifan Ning, Taotao Gui, Xiaoling Zhao, Diyan Li, Yan Wang, Huadong Yin, Lin Ye, Yaofu Tian, Yao Zhang, Hua Li, Qing Zhu
Summary: This study investigated the expression of lncRNAs and mRNAs in chicken granulosa cells at different stages of the ovulatory cycle, identifying a large number of differentially abundant genes in the luteinizing hormone surge stage. Genes related to cell proliferation and metabolism were enriched in the early and middle stages, while those involved in oxidative stress, steroids regulation, and inflammatory processes were enriched in the luteinizing hormone surge stage. This data provides a foundation for improving chicken reproductive performance and understanding mechanisms underlying female ovarian diseases.
Article
Obstetrics & Gynecology
Lauriane Relav, Esdras Correa Dos Santos, Gustavo Zamberlam, Christopher A. Price
Summary: Ovulatory disorders are a significant cause of infertility in both humans and economically important species. This study reveals that LH and the Hippo pathway regulate the expression of DUSP1 and DUSP6 genes in bovine pre-ovulatory granulosa cells, suggesting a complex control of MAPK signaling during ovulation.
REPRODUCTIVE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Colin M. Clay, Brian D. Cherrington, Amy M. Navratil
Summary: Gonadotropes cells in the anterior pituitary gland play a critical role in reproductive health by generating the LH surge required for ovulation through increasing sensitivity to GnRH, elevating GnRHR expression, and altering cellular morphology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doan T. Dinh, James Breen, Barbara Nicol, Natalie J. Foot, David C. Bersten, Alaknanda Emery, Kirsten M. Smith, Ying Y. Wong, Simon C. Barry, Humphrey H. C. Yao, Rebecca L. Robker, Darryl L. Russell
Summary: Progesterone receptor (PGR) plays diverse roles in reproductive tissues and coordinates mammalian fertility. The molecular mechanisms for PGR function in ovulation are poorly understood. Through genomic analysis, we identified a novel PGR transcriptional mechanism specific to ovulation and potential targets for infertility treatments or contraceptives.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Philippe Godin, Mayra F. Tsoi, Martin Morin, Nicolas Gevry, Derek Boerboom
Summary: This study found that LH hormone activates the Hippo signaling pathway in murine granulosa cells through protein kinase A. Yap1 and Taz play important roles in regulating the LH signaling pathway, as they are involved in the induction of multiple LH target genes and the activation of the ERK1/2 pathway. The collaboration between the Hippo signaling pathway and the cAMP/PKA and ERK1/2 pathways ensures the precise regulation of the LH cascade, and YAP1 directly targets Areg to mediate its actions in the ovary.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Genetics & Heredity
Jiamin Jin, Peipei Ren, Xiang Li, Yinyi Zhang, Weijie Yang, Yerong Ma, Mengru Lai, Chao Yu, Songying Zhang, Yin-Li Zhang
Summary: Histone deacetylation is observed in granulosa cells during the process of ovulation, which is mediated by FSH and hCG. This process is regulated by CK2 alpha-mediated HDAC2 phosphorylation and is essential for successful ovulation.
EPIGENETICS & CHROMATIN
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Yinghui Wei, Xiaoxuan Li, Chengyu Li, Liangliang Zhang, Zhaojun Liu, Yan Cao, Weijian Li, Xiying Zhang, Jiaqing Zhang, Ming Shen, Honglin Liu
Summary: CORT inhibits Lhcgr expression in mouse ovarian granulosa cells (GCs), leading to impaired follicular development. The effect of CORT is mediated by its receptor Nr3c1 in GCs. Nr3c1 may regulate Lhcgr transcription by inhibiting the expression of Lhcgr transcription factors AP1 and Creb.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
F. Rodovalho-Callegari, I Rodrigues-Santos, A. B. Lucion, G. Rodovalho, C. M. Leite, B. B. De Paula, N. Pestana-Oliveira, J. A. Anselmo-Franci
Summary: The stress experienced during rape may induce ovulation, leading to higher pregnancy rates in raped women than from consensual intercourse. Acute stresses mimic the conditions of rape, releasing adrenal progesterone and central norepinephrine, which can anticipate the LH surge and facilitate conception. The study found that acute stress applied to female rats in a proestrus state increased progesterone levels and activated noradrenergic neurons, resulting in an earlier and enhanced LH surge.
Article
Agriculture, Dairy & Animal Science
Lucas Oliveira e Silva, NatAlia P. Folchini, Rodrigo L. O. R. Alves, Guilherme Madureira, Carlos E. C. Consentini, JEssica C. L. Motta, Milo C. Wiltbank, Roberto Sartori
Summary: This study aimed to determine the effect of circulating progesterone concentrations produced by a corpus luteum or released by an intravaginal progesterone implant on GnRH-induced LH release, ovulatory response, and subsequent CL development. Rating: 7/10.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Obstetrics & Gynecology
H. Jeon, Y. Choi, M. Brannstrom, J. W. Akin, T. E. Curry, M. Jo
Summary: This study shows that cortisol/glucocorticoid receptors play a crucial role in regulating steroidogenesis and the ovulatory cascade during ovulation and early luteinization in humans.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Silvia Leon, Chrysanthi Fergani, Rajae Talbi, Caroline A. Maguire, Achi Gerutshang, Stephanie B. Seminara, Victor M. Navarro
Summary: Tachykinins play an important role in the neuroendocrine control of reproduction by stimulating Kiss1 neurons to control GnRH pulsatility. Knockout mice for Tac1 (NKA/SP) and Tac2 (NKB) genes are fertile, suggesting compensatory mechanisms among different tachykinin systems. Further research confirmed the fundamental role of tachykinins in puberty onset, LH pulsatility, and facilitation of the preovulatory LH surge.
NEUROENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Jamie L. Stewart, Liying Gao, Jodi A. Flaws, Vitor R. G. Mercadante, Nicholas W. Dias, Igor F. Canisso, Fabio S. Lima
Summary: This study assessed the direct effects of purified bovine NGF on steroidogenesis and angiogenic markers in the bovine pre-ovulatory follicle. The results showed that NGF can stimulate testosterone production in the follicle wall cells and accelerate the cellular remodeling that occurs during early luteal development.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Yu-Ting Wan, Shan Liu, Shan-Ke Zhao, Yi-Yang Luo, Ya-Su Lv, Dan-Ni Qu, Ming-Hui Liu, Yuan Li
Summary: The research found that LH levels have similar effects on GCs in the low and high groups, with changes in molecules and pathways. In GCs cultured in vitro, both insufficient and excessive rLH can impair the activity of mitochondrial dehydrogenase. Under moderate rLH concentrations, abundant cell connections, mitochondria, and liposomes were observed.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Article
Reproductive Biology
Corie M. Owen, Laurinda A. Jaffe
Summary: The present study reveals that LH stimulation induces granulosa cell ingression in the mural granulosa layer, leading to changes in the follicular structure. This cellular ingression begins shortly after the LH surge and continues until ovulation, with an increase in the proportion of LH receptor-expressing cells in the inner half of the mural granulosa layer. Additionally, the study also observes changes in cell shape and follicular structure during this process.
BIOLOGY OF REPRODUCTION
(2023)