Article
Biology
Emmet M. Power, Dharshini Ganeshan, Karl J. Iremonger
Summary: The effect of estradiol replacement therapy on CRH neuron excitability is complex, as it increases two types of potassium channel currents but does not change overall spiking excitability.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yiqing Yang, Bowen Liu, Gengxiang Wu, Jing Yang
Summary: In PCOS patients, progesterone level is correlated with clinical pregnancy rate while P/E2 ratio is not. In subgroup analysis using three different COS protocols, a significant association between progesterone level and clinical pregnancy rate can be observed in the long GnRH agonist protocol and ultralong GnRH agonist protocol. Progesterone level is significantly better than the P/E2 ratio in predicting the pregnancy outcome of PCOS patients, especially in ultralong GnRH agonist cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Tadamitsu Morimoto, Tomoko Yoshikawa, Mamoru Nagano, Yasufumi Shigeyoshi
Summary: This study investigated the regional variation of circadian periods in the SCN using a transgenic rat model. The researchers identified a short period region (SPR) and a long period region (LPR) within the SCN. They also discovered the mechanism of synchronization between these regions.
Review
Neurosciences
Alfonso junior Apicella, Ivan Marchionni
Summary: GABAergic neurons, especially those expressing vasoactive intestinal polypeptide (VIP), play a crucial role in shaping cortical activity by exerting inhibitory effects on somatostatin-expressing inhibitory neurons and disinhibitory effects on excitatory pyramidal neurons. These neurons can also affect other GABAergic and non-GABAergic neurons, suggesting diverse circuit roles. The heterogeneity of VIP-expressing neurons indicates potential involvement in different functions via modulation of local and distal inhibitory/disinhibitory pathways, with implications for animal behavior.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Obstetrics & Gynecology
Yutaka Osuga, Yoshifumi Seki, Masataka Tanimoto, Takeru Kusumoto, Kentarou Kudou, Naoki Terakawa
Summary: This study evaluated the efficacy and safety of relugolix in treating endometriosis-associated pain, showing that oral administration of relugolix alleviated pain in a dose-response manner and was generally well tolerated. Relugolix demonstrated efficacy and safety comparable to leuprorelin, another treatment option.
FERTILITY AND STERILITY
(2021)
Article
Multidisciplinary Sciences
Ben R. Cairns, Benjamin Jevans, Atchariya Chanpong, Dale Moulding, Conor J. McCann
Summary: This study revealed structural and molecular remodeling of the ENS upon loss of nNOS signaling, with compensatory transcriptional upregulation of neuronal subtype targets. The use of machine learning approaches and automated computational image analysis proved valuable in detecting previously unrecognized changes in ENS structure, providing insights into pathological mechanisms in various enteric neuropathies.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Anna Passarelli, Antonella Lettieri, Tugba Nur Demirci, Paolo Magni
Summary: The coordinated and pulsatile secretion of GnRH plays a central role in vertebrate reproductive function. The development of the HPG axis involves complex molecular signals that control the migration and secretion of GnRH neurons. The pulsatile release of GnRH is regulated by central and peripheral factors and is crucial for the secretion of luteinizing hormone and follicle-stimulating hormone.
MINERVA ENDOCRINOLOGY
(2022)
Article
Biology
Junpei Yamashita, Yuji Nishiike, Thomas Fleming, Daichi Kayo, Kataaki Okubo
Summary: In a study using the medaka model, it was found that two neuropeptides, Pacap and Vip, exhibit sexually dimorphic expression in the preoptic area, with estrogen playing a role in maintaining their sex-dependent activity. This study highlights the importance of alternative preoptic neuropeptides in regulating pituitary hormones in males and females.
COMMUNICATIONS BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Santosh Rijal, Seon Hui Jang, Dong Hyu Cho, Seong Kyu Han
Summary: This study found that reactive oxygen species (ROS) can act as signaling molecules to regulate the excitability of gonadotropin-releasing hormone (GnRH) neurons, and adult GnRH neurons are sensitive to increased ROS concentration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kayla E. Rohr, Thomas Inda, Jennifer A. Evans
Summary: The study found that arginine vasopressin (AVP) signaling through V1A and V1B receptors influences molecular rhythmicity in suprachiasmatic nucleus (SCN) neurons. V1A/B receptor agonists reset the phase of the SCN molecular clock in a time-dependent manner, with more pronounced responses observed in female SCN. Additionally, the study showed that both G(alpha q) and G(alpha s) signaling pathways interact with V1A/B-induced SCN resetting, and this response requires vasoactive intestinal polypeptide (VIP) signaling. These findings highlight the importance of studying clock function in both sexes and suggest that signal integration in central clock circuits plays a crucial role in the control of daily rhythms in behavior and physiology.
NEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Zachariah Bertels, Elizaveta Mangutov, Kendra Siegersma, Haley C. Cropper, Alycia Tipton, Amynah A. Pradhan
Summary: Research suggests that chronic use of opioids can lead to opioid-induced hyperalgesia (OIH) and medication overuse headache (MOH), and pituitary adenylate cyclase activating polypeptide (PACAP) is upregulated in both conditions. This study investigates whether PACAP acts as a bridge between opioids and pain chronification through blocking PACAP-PAC1 receptor. Results show that the PAC1 antagonist, M65, reverses chronic allodynia induced by combining morphine with the migraine trigger, nitroglycerin; and inhibits the exacerbation of cortical spreading depression, a correlate of migraine aura, caused by chronic opioids. In situ hybridization reveals co-expression of µ-opioid receptor (MOR) and PACAP in trigeminal ganglia, and near complete overlap between MOR and PAC1 in the trigeminal nucleus caudalis and periaqueductal gray. PACAPergic mechanisms may play a role in facilitating the transition to chronic headache following opioid use, and interventions targeting this system may be particularly beneficial for OIH and MOH.
Article
Multidisciplinary Sciences
Krystyna Makowska, Piotr Lech, Mariusz Majewski, Andrzej Rychlik, Slawomir Gonkowski
Summary: This study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibers containing VIP in the porcine urinary bladder trigone, indicating that VIP participates in adaptive processes of the urinary bladder evoked by BPA.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Jihui Ai, Lei Jin, Yu Zheng, Jingji Gong, Biao Chen, Xiyuan Dong
Summary: The estradiol/oocyte ratio is associated with the percentage of MII oocytes, but does not predict the quality of individual follicles. In the process of IVF treatment, there might be a higher risk of miscarriage within a certain range of E-2/O ratio.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Cell Biology
J. Julius Zhu
Summary: This study developed a recording system that enables the reconstruction of complex cortical neuronal circuits. The method revealed the disinhibitory neuronal circuits across different cortices in mice. The modular circuits optimize cortical complexity and exhibit age-dependent deficits in an animal model of Alzheimer's disease, correlating with cognitive impairments.
Review
Biochemistry & Molecular Biology
Amir Dudai, Nadav Yayon, Hermona Soreq, Michael London
Summary: The urgent task of neuroscience is to understand how neuronal circuits operate, what causes them to fail, and how they can be repaired. This review focuses on a specific type of cortical neurons marked by the expression of VIP and ChAT, which can release both GABA and ACh. Despite their sparse population, these neurons may have a significant impact on cortical circuit function.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Caroline Adams, R. Anthony DeFazio, Catherine A. Christian, Lorin S. Milescu, Santiago Schnell, Suzanne M. Moenter
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Ammar L. Ujjainwala, Connor D. Courtney, Natalia M. Wojnowski, Justin S. Rhodes, Catherine A. Christian
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Neurosciences
Catherine A. Christian
Editorial Material
Clinical Neurology
Lola Lozano, Catherine A. Christian
Editorial Material
Clinical Neurology
Connor D. Courtney, Catherine Christian-Hinman
Review
Pharmacology & Pharmacy
Catherine A. Christian, Doodipala Samba Reddy, Jamie Maguire, Patrick A. Forcelli
PHARMACOLOGICAL REVIEWS
(2020)
Editorial Material
Clinical Neurology
Catherine A. Christian-Hinman
Summary: This study demonstrates the effectiveness of gene therapy by transducing preprodynorphin into the epileptogenic focus, leading to suppression of seizures and prevention of long-term decline in spatial learning and memory. The potential clinical translation of dynorphins in suppressing seizure-like activity was also observed in human hippocampal slices obtained from epilepsy surgery.
Article
Neurosciences
Jiang Li, Leanna K. Leverton, Laxmi Manisha Naganatanahalli, Catherine A. Christian-Hinman
EXPERIMENTAL NEUROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Kwan Young Lee, Jiuhe Zhu, Cathryn A. Cutia, Catherine A. Christian-Hinman, Justin S. Rhodes, Nien-Pei Tsai
Summary: The study reveals that the Nedd4-2 protein plays a crucial role in maintaining excitatory synapses in hippocampal neurons, allowing for long-term synaptic potentiation, and is necessary for various forms of hippocampus-dependent learning and memory. Loss of Nedd4-2 leads to decreased actin polymerization, affecting phosphorylation of cofilin and ultimately impacting hippocampal synapse function and learning capabilities. Restoring cofilin phosphorylation in Nedd4-2 knockout neurons can partially reverse the deficits in hippocampus-dependent learning, shedding light on potential therapeutic strategies for infantile spasms.
Review
Endocrinology & Metabolism
Thierry Alquier, Catherine A. Christian-Hinman, Julieta Alfonso, Nils J. Faergeman
Summary: Four decades ago, two polypeptides, DBI and ACBP, were discovered in the brain and liver respectively, with different roles. Despite being studied in parallel, there is no clear and integrated understanding of the dual roles of ACBP/DBI. The recent genetic loss-of-function models have provided new insights into the physiological roles of ACBP/DBI in vivo.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Clinical Neurology
Jennifer M. Walters, Eung Chang Kim, Jiaren Zhang, Han Gil Jeong, Archit Bajaj, Brian C. Baculis, Gregory C. Tracy, Baher Ibrahim, Catherine A. Christian-Hinman, Daniel A. Llano, Graham R. Huesmann, Hee Jung Chung
Summary: This study is the first to demonstrate that the drug TC-2153 has inhibitory effects on hippocampal excitability and seizure severity in both sexes. TC-2153 can reduce seizure severity and decrease overall hippocampal excitability.
Article
Multidisciplinary Sciences
Eung Chang Kim, Jiaren Zhang, Andy Y. Tang, Eric C. Bolton, Justin S. Rhodes, Catherine A. Christian-Hinman, Hee Jung Chung
Summary: This study reveals that impaired axonal surface expression of K(v)7 channels in KCNQ2-related epileptic encephalopathy is associated with epileptic seizures, cognitive and behavioral deficits, and neuronal loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Yuan-Zhi Liu, Carlos Renteria, Connor D. Courtney, Baher Ibrahim, Sixian You, Eric J. Chaney, Ronit Barkalifa, Rishyashring R. Iyer, Mantas Zurauskas, Haohua Tu, Daniel A. Llano, Catherine A. Christian-Hinman, Stephen A. Boppart
Article
Biology
Niraj Lawande, Ammar L. Ujjainwala, Catherine A. Christian
Article
Biology
Leanna K. Pantier, Jiang Li, Catherine A. Christian
