Correction
Urology & Nephrology
Francesco Pizzarelli, Vincenzo Cantaluppi, Vincenzo Panichi, Alessandro Toccafondi, Giuseppe Ferro, Serena Farruggio, Elena Grossini, Pietro Claudio Dattolo, Vincenzo Miniello, Massimiliano Migliori, Cristina Grimaldi, Aldo Casani, Maurizio Borzumati, Stefano Cusinato, Alessandro Capitanini, Alessandro Quercia, Oliviero Filiberti, Lucia Dani
JOURNAL OF NEPHROLOGY
(2021)
Article
Dermatology
Lara Camillo, Elena Grossini, Serena Farruggio, Patrizia Marotta, Laura Cristina Gironi, Elisa Zavattaro, Paola Savoia
Summary: This study found that alpha-tocopherol can improve cell viability and proliferation in human dermal fibroblasts subjected to oxidative stress by modulating oxidants/antioxidants, inflammation, and mitochondrial function. It also shows potential anti-inflammatory effects against photoaging-related skin cancers.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Carla Gramaglia, Eleonora Gattoni, Debora Marangon, Diego Concina, Elena Grossini, Carmela Rinaldi, Massimiliano Panella, Patrizia Zeppegno
Summary: This systematic review examined the non-pharmacological treatments used for treating depressed older adults in LTCFs. Despite some mixed or negative findings, most studies indicated that these interventions were effective. However, the limitations and heterogeneity of the studies hinder the generalizability and replication of the results.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Jouko Levijoki, Piero Pollesello, Elena Grossini, Zoltan Papp
Summary: OR-1855 and OR-1896 are metabolites of levosimendan with hemodynamic activity, but their mechanism of action is still not fully understood. Unlike levosimendan, forskolin does not potentiate the positive inotropic effect of these metabolites. However, forskolin does potentiate the effects of milrinone.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Physiology
Elena Grossini, Diego Concina, Carmela Rinaldi, Sophia Russotto, Divya Garhwal, Patrizia Zeppegno, Carla Gramaglia, Seval Kul, Massimiliano Panella
Summary: The study found that the redox state of the elderly was relatively balanced, mitochondrial function was associated with patient outcomes, and elderly patients with symptoms suggestive of COVID-19 had lower mitochondrial membrane potential.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Immunology
Marco Quaglia, Guido Merlotti, Andrea Colombatto, Stefania Bruno, Alessandra Stasi, Rossana Franzin, Giuseppe Castellano, Elena Grossini, Vito Fanelli, Vincenzo Cantaluppi
Summary: Acute kidney injury is a common and serious complication of hospitalized patients. Current treatment options are limited, but stem cell-derived extracellular vesicles show promise in treating acute kidney injury by directly interfering with pathogenic mechanisms and promoting cell protection, regeneration, and immunomodulation. Additionally, extracellular vesicles may have an impact on the transition from acute kidney injury to chronic kidney disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elena Grossini, Divya Garhwal, Sakthipriyan Venkatesan, Daniela Ferrante, Angelica Mele, Massimo Saraceno, Ada Scognamiglio, Jessica Mandrioli, Amedeo Amedei, Fabiola De Marchi, Letizia Mazzini
Summary: This study analyzed the plasma redox system and nitric oxide levels in ALS patients and investigated the effects of plasma on mitochondrial function in endothelial vascular cells and astrocytes. The results showed that oxidative stress and neurovascular unit changes play a central role in ALS, and unknown plasma factors may be involved in the disease pathogenesis.
Article
Neurosciences
Elena Grossini, Alessandro Stecco, Carla Gramaglia, Daniel De Zanet, Roberto Cantello, Benedetta Gori, Davide Negroni, Danila Azzolina, Daniela Ferrante, Alessandro Feggi, Alessandro Carriero, Patrizia Zeppegno
Summary: This study aimed to better understand misophonia through various methods. The results showed that participants with misophonia exhibited sympathetic activation when exposed to trigger sounds, and there were differences in brain activity, heart rate variability, and skin conductance compared to healthy controls. These findings are important for the diagnosis, classification, and treatment of this disorder.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Elena Grossini, Sakthipriyan Venkatesan, Micol Alkabes, Caterina Toma, Stefano de Cilla
Summary: Research has shown that Membrane Blue Dual (MBD) exerts greater protective effects, especially when combined with polyethylene glycol (PEG), by modulating mitochondrial function to increase cell viability, mitochondrial membrane potential, proliferation, and migration in human retinal pigment epithelial cells (ARPE-19) and retinal ganglion cells-like (RGC-5).
Article
Biochemistry & Molecular Biology
Elena Grossini, Carlo Smirne, Sakthipriyan Venkatesan, Stelvio Tonello, Davide D'Onghia, Rosalba Minisini, Vincenzo Cantaluppi, Pier Paolo Sainaghi, Cristoforo Comi, Adele Tanzi, Benedetta Bussolati, Mario Pirisi
Summary: In this study, the role of extracellular vesicles (EVs) as pathogenic factors for the onset of HCV-related endothelial dysfunction was evaluated. The results showed that EVs from HCV patients were mainly of endothelial and lymphocyte origin and were able to reduce cell viability and mitochondrial membrane potential of vascular endothelial cells, while increasing reactive oxygen species (ROS) release. These harmful effects could be reduced by pretreatment with specific blockers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Grossini, Teresa Esposito, Michela Viretto, Sakthipriyan Venkatesan, Ilaria Licari, Daniela Surico, Francesco Della Corte, Luigi Castello, Stefania Bruno, Marco Quaglia, Cristoforo Comi, Vincenzo Cantaluppi, Rosanna Vaschetto
Summary: This study reveals the potential role of circulating extracellular vesicles (EVs) in the onset of subarachnoid hemorrhage (SAH) complications, particularly vasospasm (VP). The EVs isolated from SAH patients express specific markers, have larger size and higher concentration compared to healthy controls. Moreover, these EVs adversely affect endothelial and smooth muscle cells, leading to endothelial damage and enhanced smooth muscle reactivity. These findings have significant implications for the use of EVs as potential diagnostic/prognostic markers and therapeutic tools in SAH management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Grossini, Fabiola De Marchi, Sakthipriyan Venkatesan, Angelica Mele, Daniela Ferrante, Letizia Mazzini
Summary: Oxidative stress, mitochondrial function, and the neurovascular unit play a crucial role in the pathogenesis of ALS. Our study indicates that ALS patients have altered plasma redox system and nitric oxide levels, which negatively affect human cells. These findings can serve as disease markers for ALS and potential markers for evaluating the effects of drugs in clinical practice and trials.
Letter
Clinical Neurology
E. Grossini, D. De Zanet, D. Apostolo, V. R. Mallela, G. La Rocca, A. Greco, G. Coratza, R. Minisini, M. Pirisi
CLINICAL AUTONOMIC RESEARCH
(2023)
Article
Medicine, General & Internal
Carlo Smirne, Roberto Carbone, Cosimo Colletta, Paolo Scivetti, Pier Paolo Sainaghi, Grossini Elena, Mario Pirisi
Summary: The study aimed to investigate the behavior of Italian clinicians regarding sofosbuvir plus ribavirin therapy in genotype 2 cirrhotic patients and the possible impact of therapy durations on sustained virological responses and patient safety. Results showed that treatment with sofosbuvir plus ribavirin for more than 12 weeks in genotype 2 cirrhotic patients achieved a real-life-sustained virological response rate of almost 96%, without significant impact on treatment duration.
EURASIAN JOURNAL OF MEDICINE
(2022)
Article
Health Care Sciences & Services
Maurizio Sabbatini, Serena Faruggio, Giovanni Verna, Valeria Magnelli, Francesco Dondero, Renzo Boldorini, Mario Cannas, Elena Grossini
Summary: The study analyzed the morphological changes in fat mass used for refilling by Coleman's procedure or washing/fragmenting procedure. It was found that the washing/fragmenting procedure led to reduced immune cells, larger adipocytes, and increased vessel activity, contributing to better integration at the recipient site. Follow-up monitoring supported a reduction in re-interventions in patients treated with the washing/fragmenting procedure.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2021)