Perifosine-mediated Akt inhibition in neuroendocrine tumor cells: role of specific Akt isoforms

Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT

(2011) Bernhard Svejda et al.   CANCER

Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration

(2011) Myoung W. Lee et al.   CANCER SCIENCE

Perifosine Plus Bortezomib and Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma Previously Treated With Bortezomib: Results of a Multicenter Phase I/II Trial

(2011) Paul G. Richardson et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Placebo-Controlled Phase II Trial of Perifosine Plus Capecitabine As Second- or Third-Line Therapy in Patients With Metastatic Colorectal Cancer

(2011) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study

(2011) Marianne E Pavel et al.   LANCET

Akt2 and Akt3 play a pivotal role in malignant gliomas

(2011) H. Mure et al.   NEURO-ONCOLOGY

Everolimus for Advanced Pancreatic Neuroendocrine Tumors

(2011) James C. Yao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Akt1 deficiency delays tumor progression, vascular invasion and distant metastasis in a murine model of thyroid cancer

(2011) M Saji et al.   ONCOGENE

Compensatory activation of Akt in response to mTOR and Raf inhibitors – A rationale for dual-targeted therapy approaches in neuroendocrine tumor disease

(2010) Kathrin Zitzmann et al.   CANCER LETTERS

Clinical and Translational Studies of a Phase II Trial of the Novel Oral Akt Inhibitor Perifosine in Relapsed or Relapsed/Refractory Waldenstrom's Macroglobulinemia

(2010) I. M. Ghobrial et al.   CLINICAL CANCER RESEARCH

mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours

(2010) A. Kasajima et al.   ENDOCRINE-RELATED CANCER

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

(2009) R. L. Dillon et al.   CANCER RESEARCH

Reduction of Akt2 inhibits migration and invasion of glioma cells

(2009) Baogang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Perifosine: Update on a novel Akt inhibitor

(2009) Joell J. Gills et al.   Current Oncology Reports