Article
Cell Biology
Adrian Zajac, Aleksandra Maciejczyk, Joanna Sumorek-Wiadro, Kamil Filipek, Kamil Derylo, Ewa Langner, Jaroslaw Pawelec, Magdalena Wasiak, Mateusz Scibiorski, Wojciech Rzeski, Marek Tchorzewski, Michal Reichert, Joanna Jakubowicz-Gil
Summary: This study found that the formation of the Bcl-2:beclin-1 complex and the dominance of apoptosis can be achieved in glioma cells through the use of inhibitors, providing new therapeutic perspectives against gliomas.
Review
Oncology
Mila S. Griffioen, David C. de Leeuw, Jeroen J. W. M. Janssen, Linda Smit
Summary: Venetoclax is a promising therapy for AML patients ineligible for induction chemotherapy, with ongoing trials evaluating its efficacy as frontline treatment. Response rates vary based on patient characteristics and mutational profiles. Factors influencing venetoclax sensitivity and resistance in AML cells are being studied for potential biomarkers and combination therapies to enhance treatment outcomes.
Article
Biochemistry & Molecular Biology
Xiangjian Zhang, Xinxin Zhang, Ruokuo Han, Zhaojun Wang, Qiuhui Yang, Yiming Huang, Yuxiang Yan
Summary: The selective inhibitor BLU-554 of fibroblast growth factor receptor 4 (FGFR4) has been found to inhibit proliferation and invasion of gastric cancer cells while promoting apoptosis and cell cycle arrest.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Vicente Fresquet, Maria J. Garcia-Barchino, Marta Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria J. Larrayoz, Maria J. Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Alvaro Martinez-Baztan, Bruno Paiva, Maria J. Moreno-Aliaga, Maria D. Odero, Xabier Agirre, Oscar Yanes, Felipe Prosper, Jose A. Martinez-Climent
Summary: Epigenetic therapies induce viral mimicry in cancer cells, reshaping mitochondrial metabolism and driving caspase-independent tumor cell death, leading to increased sensitivity to BCL2 inhibitor drugs.
Article
Pharmacology & Pharmacy
Cynthia L. Bristow, Ronald Winston
Summary: This study investigates the role of plasma α1-proteinase inhibitor (α1PI) in lipoprotein regulation and the development of orally available small molecules as substitutes for α1PI. It demonstrates that certain beta-lactam compounds have the potential to act as α1PI surrogates by binding to specific proteins and reducing LDL levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Vinod A. Pullarkat, Norman J. Lacayo, Elias Jabbour, Jeffrey E. Rubnitz, Ashish Bajel, Theodore W. Laetsch, Jessica Leonard, Susan Colace, Seong Lin Khaw, Shaun A. Fleming, Ryan J. Mattison, Robin Norris, Joseph T. Opferman, Kathryn G. Roberts, Yaqi Zhao, Chunxu Qu, Mohamed Badawi, Michelle Schmidt, Bo Tong, John C. Pesko, Yan Sun, Jeremy A. Ross, Deeksha Vishwamitra, Lindsey Rosenwinkel, Su Young Kim, Amanda Jacobson, Charles G. Mullighan, Thomas B. Alexander, Wendy Stock
Summary: In this phase I study, combining venetoclax with low-dose navitoclax and chemotherapy showed good tolerability and promising efficacy in patients with relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma. Responses were observed in patients across histologic and genomic subtypes, even in those who had failed stem cell transplant therapies.
Article
Cell Biology
Joshua Abd Alla, Ursula Quitterer
Summary: RKIP is a protein with dual inhibitory effects on RAF1 kinase and GRK2. It plays an important role in tumor suppression and cardiac protection, but the beneficial and detrimental functions of RKIP in the heart counteract each other. Studying the role of RKIP can provide insights for the development of cardioprotective drugs.
Article
Biochemistry & Molecular Biology
Andras aron Soos, Andrea Kelemen, Adrian Orosz, Zsuzsanna Szvicsek, Tamas Tolgyes, Kristof Dede, Attila Bursics, Zoltan Wiener
Summary: In colorectal cancer, CD142 high-expressing fibroblasts stimulate the proliferation of tumor cells through increased secretion of hepatocyte growth factor (HGF), leading to poor prognosis. Combination therapy with various inhibitors has a synergistic effect on colorectal cancer cells. Importantly, HSP90 inhibitor targets CD142 high-expressing fibroblasts, and both CRC cells and CAFs are sensitive to BCL-xL inhibitor. Therefore, targeting BCL-xL and HSP90 may eliminate cancer cells and reduce the tumor-promoting CD142 high-expressing fibroblast population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Hematology
Isacco Ferrarini, Antonella Rigo, Carlo Visco
Summary: Mitochondria play a critical role in intrinsic apoptosis, and the impact of different anti-apoptotic members of the BCL-2 protein family varies in blood cancers. By uncovering the anti-apoptotic dependencies of blood cancers, new therapeutic strategies can be developed. The mechanisms and potential strategies to overcome resistance to BH3 mimetics are also discussed. Combining mitochondrial apoptosis with precision medicine may lead to more successful treatment of complex hematologic malignancies.
Article
Neurosciences
Varsha Ramesh, Vettriselvi Venkatesan, Darling Chellathai, Santhi Silamban
Summary: This study aimed to investigate the relationship between serum biomarker levels, BDNF val66met polymorphism, and response to SSRIs in patients with major depressive disorder. The results showed that baseline hsCRP and BDNF levels predicted patients' response to SSRIs, with Val/Val patients responding better compared to those carrying the Met allele.
NEUROPSYCHOBIOLOGY
(2021)