Article
Endocrinology & Metabolism
Jiska van Schaik, Mila S. Welling, Corjan J. de Groot, Judith P. van Eck, Alicia Juriaans, Marcella Burghard, Sebastianus B. J. Oude Ophuis, Boudewijn Bakker, Wim J. E. Tissing, Antoinette Y. N. Schouten-van Meeteren, Erica L. T. van den Akker, Hanneke M. van Santen
Summary: This study retrospectively evaluated the treatment of children with HO with dextroamphetamine. The results showed that dextroamphetamine treatment can improve BMI, decrease hyperphagia, and improve energy level and behavior in some patients. However, some patients experienced side effects such as hypertension during treatment. Future studies are needed to further validate these findings.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Miwoo Lee, Min-Jung Park, Kyung Hwa Lee, Jung Hee Kim, Hyung Jin Choi, Yong Hwy Kim
Summary: This study investigated the multifaceted characteristics of hypothalamic obesity and found that damage to the hypothalamus can lead to severe obesity due to alterations in brain response, attention, satiety, and eating behaviors. These findings provide new neuro-psycho-behavioral mechanisms for the treatment of hypothalamic obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ulrich Dischinger, Laura Kotzner, Petia Kovatcheva-Datchary, Helena Kleinschmidt, Christina Haas, Jose Perez, Cornelius Presek, Ann-Cathrin Koschker, Alexander D. Miras, Mohammed K. Hankir, Christoph-Thomas Germer, Martin Fassnacht, Martin J. Herrmann, Florian Seyfried, Jorg Vogel
Summary: Hypothalamic integrity is necessary for the effectiveness of bariatric surgery in humans. Peripheral changes after bariatric surgery are not sufficient to induce satiety and long-term weight loss in patients with hypothalamic damage.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
Dicle Canoruc Emet, Alev Ozon, Ayfer Alikasifoglu, Nurgun Kandemir, Nazli Gonc
Summary: Leptin and BDNF concentrations were correlated with BMI, while alpha-MSH showed no correlation. Alpha-MSH levels were significantly higher in CP with obesity, suggesting a potential biomarker for hypothalamic obesity in craniopharyngioma.
Article
Endocrinology & Metabolism
Meghan Craven, Julia H. Crowley, Lucas Chiang, Cassie Kline, Fatema Malbari, Matthew C. Hocking, Shana E. McCormack
Summary: Hypothalamic obesity in individuals treated for pediatric craniopharyngioma has a significant impact on social function. Families use various approaches for weight management, but medication trials are less common. Social function is more impaired in individuals with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhuoran Xu, Xiaoan Ke, Xianxian Yuan, Linjie Wang, Lian Duan, Yong Yao, Kan Deng, Feng Feng, Hui You, Xin Lian, Renzhi Wang, Hongbo Yang, Hui Pan, Lin Lu, Huijuan Zhu
Summary: This study analyzed the clinical characteristics and metabolic abnormalities of adults with hypothalamic dysfunction (HD). The results showed that temperature dysregulation and hypogonadotropic hypogonadism were the most common physiological and endocrine dysfunctions in HD patients. Metabolic syndrome (MetS) and unfavorable metabolic profiles were prevalent in these patients, and HD was identified as a significant risk factor for MetS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kharisa N. N. Rachmasari, Sara B. B. Strauss, C. Douglas Phillips, Joshua E. E. Lantos, Anjile An, Babacar Cisse, Rohan Ramakrishna, Theodore H. H. Schwartz, Georgiana A. A. Dobri
Summary: In patients with craniopharyngioma, tumor involvement in the posterior hypothalamus observed on pre-operative MRI predicts the development of hypothalamic obesity. Posterior hypothalamic involvement on pre-operative MRI is also associated with the development of diabetes insipidus after surgery.
Review
Endocrinology & Metabolism
Paul Dimitri
Summary: The hypothalamus plays a crucial role in regulating energy balance and appetite. Maldevelopment or damage to the hypothalamus can lead to hypothalamic obesity. Current treatment options have limited impact, highlighting the need for novel approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Julia Beckhaus, Carsten Friedrich, Svenja Boekhoff, Gabriele Calaminus, Brigitte Bison, Maria Eveslage, Beate Timmermann, Joerg Flitsch, Hermann L. Mueller
Summary: This cohort study aimed to investigate the clinical presentation and outcome of pediatric patients with craniopharyngiomas (CP) in relation to age at diagnosis. The results showed that children diagnosed with CP before the age of 6 had lower event-free survival but better quality of life. Posterior hypothalamic involvement and hypothalamic lesion were independent risk factors for reduced survival and obesity. Age at diagnosis did not contribute to obesity and reduced quality of life.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Wei Wu, Quanya Sun, Xiaoming Zhu, Boni Xiang, Qiongyue Zhang, Qing Miao, Yongfei Wang, Yiming Li, Hongying Ye
Summary: The study found that adult-onset patients with craniopharyngioma are at risk for significant weight gain postoperatively, especially those with lower preoperative BMI and the adamantinomatous subtype. The prevalence of HO after craniopharyngioma surgery is relatively high, with only preoperative BMI identified as an independent risk factor for postoperative HO.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ichelle M. A. A. van Roessel, Antoinette Y. N. Schouten-van Meeteren, Lisethe Meijer, Eelco W. Hoving, Boudewijn Bakker, Hanneke M. van Santen
Summary: The transition from diencephalic syndrome to hypothalamic obesity in children with suprasellar low grade glioma may be associated with age rather than tumor behavior, treatment characteristics, or pituitary function. The development of central precocious puberty in these children does not seem to be related to obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Selveta S. van Santen, Peter Wolf, Natalia Kremenevski, Cesar L. Boguszewski, Hannes Beiglbock, Marta Fiocco, Mark Wijnen, Ville R. Wallenius, Marry M. Van den Heuvel-Eibrink, Aart J. van der Lely, Gudmundur Johannsson, Anton Luger, Michael Krebs, Michael Buchfelder, Patric J. D. Delhanty, Sebastian J. C. M. M. Neggers, Daniel S. Olsson
Summary: The study showed that obese patients with craniopharyngioma achieved a substantial mean weight loss of 22% at a 5-year follow-up after bariatric surgery, regardless of the type of surgery performed. The weight loss was lower compared to obese controls after Roux-en-Y gastric bypass, but there were no major changes in hormonal replacement therapy post-surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Oncology
Luigi Albano, Marco Losa, Lina Raffaella Barzaghi, Ajay Niranjan, Zaid Siddiqui, John C. Flickinger, Lawrence Dade Lunsford, Pietro Mortini
Summary: A systematic review and meta-analysis of outcomes of Gamma Knife radiosurgery for pituitary tumors over the past twenty years showed that it is safe and effective, with good tumor control and remission rates for both non-secreting and secreting tumors.
Review
Multidisciplinary Sciences
Amber R. Dassen, Jiska van Schaik, Pepijn van den Munckhof, P. R. Schuurman, Eelco W. Hoving, Hanneke M. van Santen
Summary: Hypothalamic dysfunction can lead to morbid obesity and neurobehavioral dysfunction. Deep brain stimulation (DBS) may be an effective treatment for hypothalamic dysfunction, but the evidence is limited and more research is needed.
Article
Endocrinology & Metabolism
Alberto Luigi Gallotti, Lina Raffaella Barzaghi, Luigi Albano, Marzia Medone, Filippo Gagliardi, Marco Losa, Pietro Mortini
Summary: This study compared transcranial and extended transsphenoidal approaches in treating craniopharyngioma patients, finding no significant difference in hormone secretion disorders and obesity risk between the two surgical methods, but the extended transsphenoidal approach was more effective in improving visual function.
Review
Endocrinology & Metabolism
Laura van Iersel, Renee L. Mulder, Christian Denzer, Laurie E. Cohen, Helen A. Spoudeas, Lillian R. Meacham, Elaine Sugden, Antoinette Y. N. Schouten-van Meeteren, Eelco W. Hoving, Roger J. Packer, Gregory T. Armstrong, Sogol Mostoufi-Moab, Aline M. Stades, Dannis van Vuurden, Geert O. Janssens, Cecile Thomas-Teinturier, Robert D. Murray, Natascia Di Iorgi, Sebastian J. C. M. M. Neggers, Joel Thompson, Andrew A. Toogood, Helena Gleeson, Cecilia Follin, Edit Bardi, Lilibeth Torno, Briana Patterson, Vera Morsellino, Grit Sommer, Sarah C. Clement, Deokumar Srivastava, Cecilie E. Kiserud, Alberto Fernandez, Katrin Scheinemann, Sripriya Raman, Kevin C. J. Yuen, W. Hamish Wallace, Louis S. Constine, Roderick Skinner, Melissa M. Hudson, Leontien C. M. Kremer, Wassim Chemaitilly, Hanneke M. van Santen
Summary: This study summarizes the guidelines provided by the International Late Effects of Childhood Cancer Guideline Harmonization Group for surveillance of endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers, emphasizing the importance of regular monitoring for at-risk survivors and timely referrals to specialized services.
Article
Endocrinology & Metabolism
Anne-Sophie C. A. M. Koning, Philippe C. Habets, Marit Bogaards, Jan Kroon, Hanneke M. van Santen, Judith M. de Bont, Onno C. Meijer
Summary: This study aims to evaluate whether dexamethasone leads to reduced MR activation in the human brain. The results suggest that dexamethasone may induce MR nuclear translocation in the human brain. However, further research is needed to determine the specific effects of dexamethasone on gene expression in the brain.
ENDOCRINE CONNECTIONS
(2022)
Article
Pediatrics
Christiaan A. J. Oudmaijer, Winnie M. C. van den Boogaard, Daphne S. J. Komninos, Emma J. Verwaaijen, Hanneke M. van Santen, Marc R. Lilien, Jan H. J. Hoeijmakers, Marc H. W. Wijnen, Marry M. van den Heuvel-Eibrink, Wilbert P. Vermeij
Summary: Childhood renal tumors, particularly Wilms tumor, account for a significant proportion of childhood cancers. Short-term fasting (STF) has the potential to mitigate the risk of acute kidney injury (AKI) associated with renal surgery and improve renal function recovery in children. This study aims to investigate the effect of STF on postoperative renal function recovery in children with unilateral renal tumors.
FRONTIERS IN PEDIATRICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah C. Clement, Godelieve A. M. Tytgat, A. S. Paul van Trotsenburg, Leontien C. M. Kremer, Hanneke M. van Santen
Summary: The prevalence of thyroid dysfunction does not seem to be increased in patients with neuroblastic tumors who received I-123-MIBG combined with thyroid protection.
ANNALS OF NUCLEAR MEDICINE
(2022)
Correction
Oncology
Chantal A. Lebbink, Medard F. M. van den Broek, Annemiek B. G. Kwast, Joep P. M. Derikx, Miranda P. Dierselhuis, Schelto Kruijff, Thera P. Links, A. S. Paul van Trotsenburg, Gerlof D. Valk, Menno R. Vriens, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Henrike E. Karim-Kos
Article
Medicine, Research & Experimental
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Maxime C. F. Pilon, Saskia M. F. Pluijm, Margriet van der van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Hanneke M. van Santen, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Margreet A. Veening, Arend Bokenkamp
Summary: The prevalence of SPS among CCS exposed to potentially nephrotoxic therapy is low, with most cases being explained by non-GFR determinants.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2022)
Editorial Material
Endocrinology & Metabolism
H. M. van Santen, E. Spinedi, H. L. Muller
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hanneke M. van Santen, Jiska van Schaik, Ichelle M. A. A. van Roessel, Julia Beckhaus, Svenja Boekhoff, Hermann L. Mueller
Summary: Hypothalamic syndrome (HS) in childhood is a rare condition with limited epidemiological knowledge. Diagnostic criteria and a scoring system for presence of HS were developed and validated in a retrospective cohort study of 120 patients at risk for hypothalamic dysfunction. The criteria and scoring system can aid in early recognition and provide care purposes and research benefits.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Oncology
Elizabeth A. M. Feijen, Jop C. Teepen, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Margriet van der Heiden-van der Loo, Helena J. H. van der Pal, Andrica C. H. de Vries, Marloes Louwerens, Dorine Bresters, Birgitta Versluys, Hanneke de Ridder, Margreet Veening, Flora E. van Leeuwen, Martha Grootenhuis, Heleen Maurice-Stam, Hanneke M. van Santen, Sebastian J. C. M. M. Neggers, Saskia Pluijm, Jaap den Hartogh, Cecile M. Ronckers, Wim J. E. Tissing, Jacqueline J. Loonen, Leontien C. M. Kremer
Summary: The Dutch Childhood Cancer Survivor Study (DCCSS) conducted a cross-sectional clinical study (LATER 2 study) to investigate the health risks of childhood cancer survivors. Physical and psychosocial health outcomes were assessed through various measurements and questionnaires, and DNA samples were extracted. The study results will fill important gaps in knowledge and contribute to improving the quality of life and care for childhood cancer survivors.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Jop C. Teepen, Judith L. Kok, Elizabeth A. M. Feijen, Jacqueline J. Loonen, Marry M. van den Heuvel-Eibrink, Helena J. van der Pal, Wim J. E. Tissing, Dorine Bresters, Birgitta Versluys, Martha A. Grootenhuis, Marloes Louwerens, Sebastian J. C. M. M. Neggers, Hanneke M. van Santen, Andrica de Vries, Geert O. Janssens, Jaap G. den Hartogh, Flora E. van Leeuwen, Nynke Hollema, Nina Streefkerk, Ellen Kilsdonk, Margriet van der Heiden-van der Loo, Eline van Dulmen-den Broeder, Cecile M. Ronckers, Leontien C. M. Kremer
Summary: This study describes the design, methodology, characteristics, and data availability of the Dutch Childhood Cancer Survivor Study LATER cohort. The aim of the study is to identify the risk of and risk factors for specific health outcomes in childhood cancer survivors. The data collected from the LATER cohort will provide new insights into risk stratification for survivors and inform the development of interventions to prevent long term adverse health outcomes.
Article
Endocrinology & Metabolism
Jenneke E. van Atteveld, Demi T. C. de Winter, Vincent G. Pluimakers, Marta Fiocco, Rutger A. J. Nievelstein, Monique G. G. Hobbelink, Andrica C. H. de Vries, Jacqueline J. Loonen, Eline van Dulmen-den Broeder, Helena J. van der Pal, Saskia M. F. Pluijm, Leontien C. M. Kremer, Cecile M. Ronckers, Margriet van der Heiden-van der Loo, A. Birgitta Versluijs, Marloes Louwerens, Dorine Bresters, Hanneke M. van Santen, Daniel S. Olsson, Imo Hoefer, Sjoerd A. A. van den Berg, Jaap den Hartogh, Wim J. E. Tissing, Sebastian J. C. M. M. Neggers, Marry M. van den Heuvel-Eibrink, Dutch LATER Study Grp
Summary: This study examined the risk factors for low bone mineral density (BMD), fractures, and vertebral fractures in adult childhood cancer survivors in the Netherlands. The results showed that childhood cancer survivors have an increased risk of fractures, and factors associated with low BMD and fractures include gender, underweight, radiotherapy dose, hormone disorders, lack of physical activity, and vitamin D deficiency. The findings highlight the importance of monitoring bone health and providing interventions for endocrine disorders and vitamin deficiencies in childhood cancer survivors.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ichelle Maa Van Roessel, Boudewijn Bakker, Hanneke M. Van Santen, Wassim Chemaitilly
Summary: Childhood cancer survivors are prone to developing endocrine disorders such as growth hormone, thyroid hormone, and sex hormone deficiencies. The safety of using these hormones as treatments in survivors of childhood cancer and brain tumors is a concern due to their impact on cell growth and metabolism. This article provides an overview of current knowledge, controversies, and areas for future research in this field.
ENDOCRINE CONNECTIONS
(2023)
Article
Oncology
Chantal A. Lebbink, Cor van den Bos, Miranda P. Dierselhuis, Marta Fiocco, Annemarie Verrijn A. Stuart, Eef G. W. M. Lentjes, Sabine L. A. Plasschaert, Wim J. E. Tissing, Hanneke M. van Santen
Summary: A prospective study was conducted on children with cancer, revealing a low risk of developing subclinical hypothyroidism or hyperthyroidism in the first three months of treatment, but a significant decline in free thyroid hormone concentration.
Review
Radiology, Nuclear Medicine & Medical Imaging
Bas de Lijster, Clara T. M. M. de Kanter, Bart de Keizer, Godelieve A. M. Tytgat, Thomas Vulsma, Martin Offringa, Hanneke M. van Santen
Summary: There is currently no consensus on the most effective protective strategy for preventing I-131 uptake in the thyroid during medical interventions in children. This study aimed to collect evidence on pharmacological interventions to protect the thyroid gland from radioactive iodine (RAI) damage. The results suggest that pharmacological interventions may not effectively prevent RAI uptake or thyroid damage, although the administration of potassium iodide (KI) before exposure appeared to be the most effective method.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)