Review
Endocrinology & Metabolism
T. Chevalley, M. L. Brandi, E. Cavalier, N. C. Harvey, G. Iolascon, C. Cooper, D. Hannouche, J. F. Kaux, A. Kurth, S. Maggi, G. Maier, K. Papavasiliou, N. Al-Daghri, M. Sosa-Henriquez, N. Suhm, U. Tarantino, J. Y. Reginster, R. Rizzoli
Summary: This narrative review discusses the role of vitamin D deficiency in the pathophysiology, healing, and rehabilitation of fragility fractures, emphasizing the positive influence of vitamin D on these processes. The fracture liaison service model can help improve management for patients with fragility fractures by highlighting the importance of optimal vitamin D status.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Critical Care Medicine
Mustafa Caner Okkaoglu, Erdi Ozdemir, Ugur Yaradilmis, Murat Altay
Summary: This study investigated the relationship between radiographic osteoporotic hip morphology and mortality in patients with intertrochanteric femur fractures. The results showed that patients with Dorr type C femur had a 2.1 times increased mortality rate at 6 months following the fracture.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Review
Health Care Sciences & Services
Ramona Dobre, Dan Alexandru Niculescu, Razvan-Cosmin Petca, Razvan-Ionut Popescu, Aida Petca, Catalina Poiana
Summary: A systematic review found that anti-osteoporotic treatment after hip fracture can reduce mortality rates, with conflicting data on re-fracture risk. More data are needed to validate the actual effects of such treatment on secondary prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Endocrinology & Metabolism
M. Barake, R. El Eid, S. Ajjour, M. Chakhtoura, L. Meho, T. Mahmoud, J. Atieh, A. M. Sibai, G. El-Hajj Fuleihan
Summary: The study revealed that Asia is projected to have the largest proportion of osteoporotic fractures worldwide, while data from the Middle East is scarce. Most patients in Arab League countries with osteoporotic fractures were not tested or treated, with high mortality rates observed at 1 to 3 years post-fracture.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Omar Suhail Alsaed, Nabeel Abdulla, Abdo Lutf, Ibrahim Abdulmomen, Fiaz Alam, Samar A. Razaq Alemadi
Summary: This study estimated the annual incidence rate of osteoporotic hip fractures in Qatar and found it to be comparable to regional countries and lower than North America and European countries.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Thomas J. Hjelholt, Soren P. Johnsen, Peter K. Brynningsen, Grethe Andersen, Alma B. Pedersen
Summary: Considerable uncertainty exists regarding the risk factors for recurrent fracture among older patients with hip fracture. This study aimed to investigate the relationship between prefracture stroke history, baseline mobility, and the risk of recurrent hip fracture. The findings showed that stroke history was associated with the cumulative incidence of recurrent hip fracture within one year, but its association varied depending on the baseline mobility of the patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Orthopedics
Marziyeh Rajabi, Afshin Ostovar, Ali Akbari Sari, Sayed Mahmoud Sajjadi-Jazi, Noushin Fahimfar, Bagher Larijani, Rajabali Daroudi
Summary: This study estimated the direct costs of hip, vertebral, and forearm fractures in the first year after fracture incidence in Iran, finding that the direct cost of osteoporotic fractures in Iran is high. The findings may be useful for economic evaluation and estimating the economic burden of osteoporotic fractures in Iran.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
W. Pluskiewicz, R. Wilk, P. Adamczyk, M. Hajzyk, M. Swoboda, A. Sladek, B. Koczy
Summary: This study analyzed the impact of the COVID-19 pandemic on the incidence of arm, forearm, and hip fractures, as well as the cost of managing these fractures. During the pandemic, a decrease in the incidence of fractures and cost of management was observed.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Zhimin Yang, Wenchao Zhang, Xiaolei Ren, Chao Tu, Zhihong Li
Summary: Exosomes play a crucial role in the occurrence and healing of osteoporotic fractures by mediating various physiological processes and regulating osteoblastogenesis, osteoclastogenesis, and angiogenesis. They offer novel therapeutic strategies for osteoporotic fractures in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Farzad Shabani, Georigs Tsinaslanidis, Ravindra Thimmaiah, Mohammad Khatak, Pritom Shenoy, Bright Offorha, Ouwatobi Onafowokan, Chika Edward Uzoigwe, Emeka Oragui, Robert P. Smith, Rory G. Middleton, Nicholas Alan Johnson
Summary: Hospitals that treat more patients with osteoporotic hip fractures do not necessarily have better care outcomes. Larger units tend to perform more consistent health assessments and mobilize patients more expeditiously post-operatively. However, there is no relationship between unit volume and most other healthcare outcomes.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Orthopedics
Jing Zhu, Xue-qin Jin, Xiao-yan Li, Li Sun, Yuan Peng
Summary: This study aimed to investigate the relationship between preoperative oral carbohydrate intake and outcomes in elderly patients undergoing surgical treatment for osteoporotic fractures (OPFs). Through a retrospective cohort study, it was found that preoperative oral carbohydrate intake was associated with reduced mortality risk within 60 days post-surgery and improved outcomes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
Juan Cristobal Ormeno, Rosario Martinez, Carolina Frias, Constanza Von Plessing, Ivan Quevedo
Summary: This study analyzes the impact of the COVID-19 pandemic on annual hip fracture rates and weekly emergency department consultations and hospitalizations due to trauma in older people in Chile. The results show that during the pandemic, the rates of hip fractures and consultations and hospitalizations due to trauma decreased. Mobility restrictions and an increase in self-reliant older adults in the population are possible factors contributing to this decrease.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Chemistry, Multidisciplinary
Can Liu, Weilu Liu, Baoyu Qi, Lei Fan, Shencai Liu, Qinfeng Yang, Yusheng Yang, Shuofei Yang, Yili Zhang, Xu Wei, Liguo Zhu
Summary: Researchers have developed kaempferol-loaded mesoporous bioactive glass nanoparticles (MBGNs) doped orthopedic adhesives to assist in the treatment and restoration of bone homeostasis in osteoporotic fractures. The adhesive possesses high flexibility, hemostatic performance, and the ability to adapt to complex clinical scenarios. The release of Ca2+ and SiO44- ions from MBGNs promotes osteogenesis through the PI3K/AKT pathway, while kaempferol inhibits osteoclastogenesis and slows down the bone resorption process through the NF-κB pathway, regulating bone regeneration and remodeling. The adhesive is validated as an effective closed-loop management approach for restoring dysregulated bone homeostasis in osteoporotic fractures.
Article
Orthopedics
Yang-Jae Kang, Jun-Il Yoo, Kyung-Wan Baek
Summary: This study aimed to report the RNA sequencing profile of elderly patients with osteoporotic hip fracture with or without sarcopenia, identifying a key genetic factor candidate for sarcopenia-induced hip fracture in elderly individuals with osteoporosis. Through RNA sequencing and qPCR validation, important genes related to osteosarcopenia were identified, along with potential therapeutic targets for sarcopenia in elderly osteoporosis patients.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Anesthesiology
R. Griffiths, S. Babu, P. Dixon, N. Freeman, D. Hurford, E. Kelleher, I Moppett, D. Ray, O. Sahota, M. Shields, S. White
Summary: This article introduces the update of the guidance on peri-operative management of people with hip fracture by the Association of Anaesthetists, emphasizing the core aims and principles of peri-operative management and recommending greater standardization of anaesthetic practice. In addition to retaining the applicable content of the 2011 guidance, new evidence and consensus have informed additional recommendations, particularly related to analgesia and medicolegal practice.