Article
Endocrinology & Metabolism
Srividya Kidambi, John A. Batsis, William T. Donahoo, Ania M. Jastreboff, Scott Kahan, Katherine H. Saunders, Steven B. Heymsfield
Summary: The Perspective Statement highlights the lack of regulatory oversight and rigorous testing of weight loss supplements in the United States, urging healthcare providers to be cautious of the lack of evidence in dietary supplements marketed for weight loss. Regulatory authorities are called upon to protect consumers by ensuring accurate and safe marketing claims and preventing promotion of unproven and potentially unsafe products and claims.
Article
Medicine, General & Internal
Natalie A. Bello, Hui Zhou, T. Craig Cheetham, Eliza Miller, Darios T. Getahun, Michael J. Fassett, Kristi Reynolds
Summary: This study compared the effects of using ACC/AHA and ACOG guidelines for defining hypertension in pregnant women. Results showed that using the ACC/AHA criteria led to better identification of women at risk for developing preeclampsia in the future.
Review
Medicine, General & Internal
Sevda Aygun, Lale Tokgozoglu
Summary: The dyslipidemia guidelines of the three major societies have been recently revised to prioritize lowering LDL-C levels. Although there are some differences in risk estimation systems and goals, the main principles and messages are consistent across the guidelines. To combat the epidemic of cardiovascular disease, it is crucial to focus on implementing these guidelines in our region.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Heesun Lee, Hyo-Jeong Ahn, Hyo Eun Park, Donghee Han, Hyuk-Jae Chang, Eun Ju Chun, Hae-Won Han, Jidong Sung, Hae Ok Jung, Su-Yeon Choi
Summary: This study aimed to investigate the risk of coronary artery calcification (CAC) progression in young adults with non-optimal lipid levels. The results showed a significant association between non-optimal lipid levels and the risk of CAC progression, even in low-risk individuals. Screening and intervention for non-optimal lipid levels, particularly triglycerides, from an early age may have clinical value.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pediatrics
Jessica Persson, Michael Shorofsky, Ryan Leahy, Richard Friesen, Amber Khanna, Lyndsey Cole, John S. Kim
Summary: This case report presents a 15-year-old girl with coronary thrombosis-induced ST-elevation myocardial infarction associated with COVID-19. It is noteworthy that while ST-elevation MI has been identified as a presentation of COVID-19 in adults, it has not been reported in children. This highlights the importance of considering MI in children with myocardial dysfunction associated with COVID-19.
Article
Clinical Neurology
Huaguang Zheng, Hongwei Li, Yilong Wang, Zhanquan Li, Bo Hu, Xiaogang Li, Lu Fu, Hongtao Hu, Zhiyu Nie, Bilian Zhao, Di Wei, Bjorn W. Karlson, Michiel L. Bots, XiangWen Meng, Yundai Chen, Yongjun Wang
Summary: This study demonstrates that rosuvastatin significantly reduces the progression of CIMT in Chinese adults with subclinical atherosclerosis and is well tolerated. The findings contribute to a deeper understanding of atherosclerosis and provide guidance for clinical practice.
Review
Medicine, General & Internal
Antonio Facciorusso, Joshua Demb, Babu P. Mohan, Samir Gupta, Siddharth Singh
Summary: This systematic review and meta-analysis of 8 randomized clinical trials with 110,644 participants found that adding financial incentives to promotion interventions may lead to a modest increase in colorectal cancer screening completion rates. However, there was no clear benefit observed in underserved populations with adverse social determinants of health.
Article
Medical Informatics
Joao B. Augusto, Rhodri H. Davies, Anish N. Bhuva, Kristopher D. Knott, Andreas Seraphim, Mashael Alfarih, Clement Lau, Rebecca K. Hughes, Luis R. Lopes, Hunain Shiwani, Thomas A. Treibel, Bernhard L. Gerber, Christian Hamilton-Craig, Ntobeko A. B. Ntusi, Gianluca Pontone, Milind Y. Desai, John P. Greenwood, Peter P. Swoboda, Gabriella Captur, Joao Cavalcante, Chiara Bucciarelli-Ducci, Steffen E. Petersen, Erik Schelbert, Charlotte Manisty, James C. Moon
Summary: An automated machine learning algorithm was developed for measuring left ventricular maximum wall thickness in hypertrophic cardiomyopathy patients, with superior precision compared to international experts. This has potential implications for diagnosis, risk stratification, and clinical trials.
LANCET DIGITAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Tatsuhiro Shibata, Shogo Oishi, Atsushi Mizuno, Takashi Ohmori, Tomonao Okamura, Hideyuki Kashiwagi, Akihiro Sakashita, Takuya Kishi, Hitoshi Obara, Tatsuyuki Kakuma, Yoshihiro Fukumoto
Summary: This study evaluated the effectiveness of the HEPT program for comprehensive care providers in heart failure palliative care. The results showed that physicians who completed HEPT had significant improvements in practice, difficulty, and knowledge scales in HF palliative care.
Article
Cardiac & Cardiovascular Systems
Siling Li, Joseph E. Schwartz, Daichi Shimbo, Paul Muntner, James M. Shikany, John N. Booth, Norrina B. Allen, Byron C. Jaeger, Adam P. Bress, Jordan B. King, Donald Clark, Kenneth R. Butler, Adolfo Correa, Andrew E. Moran, Brandon K. Bellows, Yiyi Zhang
Summary: This study found a high prevalence of masked asleep hypertension among US adults, highlighting the need for further research on the cardiovascular risk reduction benefits of treating asleep hypertension.
Article
Medicine, General & Internal
Amy L. Peterson, Matthew Bang, Robert C. Block, Nathan D. Wong, Dean G. Karalis
Summary: Many physicians do not conduct cascade screening and are less likely to screen individuals with family history of known HeFH, compared to those with high cholesterol or premature ASCVD family history. Most physicians are willing to screen pediatric patients but only a few are willing to start treatment at recommended ages. Further education is needed to improve the diagnosis and treatment of HeFH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Lukasz Wolowiec, Joanna Osiak, Anna Wolowiec, Aleksandra Wijata, Elzbieta Grzesk, Mariusz Kozakiewicz, Joanna Banach, Alicja Nowaczyk, Jacek Nowaczyk, Grzegorz Grzesk
Summary: Dyslipidemia is an important risk factor for cardiovascular disease. Statins have been the basis of lipid-lowering therapy, but their efficacy is often limited. The discovery of PCSK9 protein has led to the development of new protein-based drugs, including antibody drugs and siRNA drugs. This article aims to summarize the molecular mechanisms, pharmacokinetics, and pharmacodynamics of the siRNA drug inclisiran, and review the latest research.
Article
Biochemistry & Molecular Biology
Vanessa Bianconi, Giacomo Cafaro, Massimo Raffaele Mannarino, Carlo Perricone, Elena Cosentini, Onelia Bistoni, Rita Paltriccia, Rita Lombardini, Roberto Gerli, Matteo Pirro, Elena Bartoloni
Summary: This study found that patients with primary Sjogren's syndrome (pSS) have significantly higher plasma PCSK9 levels compared to healthy controls (HCs), despite having a lower prevalence of dyslipidaemia. However, the relationship between PCSK9 and cardiovascular (CV) risk in pSS patients requires further investigation.
Review
Biochemistry & Molecular Biology
Guzel Bikbova, Toshiyuki Oshitari, Mukharram Bikbov
Summary: There is a clear connection between diabetes and atherosclerotic cardiovascular disease, necessitating therapeutic approaches that target both diseases. Ongoing clinical trials are examining the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a crucial role in diabetes pathophysiology and associated metabolic disorders, leading to increased interest in targeting inflammation for diabetes prevention and control. Diabetic retinopathy, a neurodegenerative and vascular disease that develops after poorly controlled diabetes, is also increasingly linked to inflammation. Molecular pathways such as oxidative stress and advanced glycation end-products contribute to the inflammatory response in diabetes-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
A. T. Tita, J. M. Szychowski, K. Boggess, L. Dugoff, B. Sibai, K. Lawrence, B. L. Hughes, J. Bell, K. Aagaard, R. K. Edwards, K. Gibson, D. M. Haas, L. Plante, T. Metz, B. Casey, S. Esplin, S. Longo, M. Hoffman, G. R. Saade, K. K. Hoppe, J. Foroutan, M. Tuuli, M. Y. Owens, H. N. Simhan, H. Frey, T. Rosen, A. Palatnik, S. Baker, P. August, U. M. Reddy, W. Kinzler, E. Su, I Krishna, N. Nguyen, M. E. Norton, D. Skupski, Y. Y. El-Sayed, D. Ogunyemi, Z. S. Galis, L. Harper, N. Ambalavanan, N. L. Geller, S. Oparil, G. R. Cutter, W. W. Andrews
Summary: In pregnant women with mild chronic hypertension, a strategy of targeting a blood pressure of less than 140/90 mm Hg was associated with better pregnancy outcomes compared to a strategy of reserving treatment only for severe hypertension, without increasing the risk of small-for-gestational-age birth weight.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
