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Biochemistry & Molecular Biology
Francis Feldman, Mireille Koudoufio, Ramy El-Jalbout, Mathilde Foisy Sauve, Lena Ahmarani, Alain Theophile Sane, Nour-El-Houda Ould-Chikh, Thierry N'Timbane, Natalie Patey, Yves Desjardins, Alain Stintzi, Schohraya Spahis, Emile Levy
Summary: The study investigates the efficacy of cranberry proanthocyanidins (PACs) in improving metabolic syndrome (MetS) and liver complications. The results show that PACs can alleviate obesity, insulin resistance, and hyperlipidemia, and reduce oxidative stress and inflammation. Additionally, PACs improve fatty liver disease and inhibit liver gluconeogenesis.
Review
Multidisciplinary Sciences
Basma H. Sobieh, Hala O. El-Mesallamy, Dina H. Kassem
Summary: Osteoarthritis (OA) is a prevalent progressive disease frequently associated with obesity. Recent findings have revealed the important role of adipose tissue in OA pathogenesis, shifting the perspective from aging and mechanical stress to metabolic effects of obesity on cartilage tissue. Adipokines such as metrnl and retinol-binding protein 4 (RBP4) have emerged as significant mediators in the development of OA. This review summarizes the latest research on the metabolic contribution of obesity in OA pathogenesis, with a focus on dyslipidemia, insulin resistance, and adipokines.
Review
Pharmacology & Pharmacy
Richa Garg, Sanjana Kumariya, Roshan Katekar, Saurabh Verma, Umesh K. Goand, Jiaur R. Gayen
Summary: Metabolic Syndrome is a multifactorial disease associated with increased risk of cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc., with stress kinase activation potentially playing a crucial role in regulating whole-body metabolism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Phiwayinkosi Dludla, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Tawanda M. Nyambuya, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Khanyisani Ziqubu, Ilenia Cirilli, Fabio Marcheggiani, Johan Louw, Luca Tiano
Summary: Metformin is widely used for glucose-lowering, promoting weight loss, improving insulin resistance, and reducing levels of adiponectin and resistin, which leads to improvement in patients with metabolic syndrome.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Leigh Goedeke, Gerald Shulman
Summary: This review focuses on recent advances in the mechanisms of mitochondrial uncouplers in regulating biological processes and diseases, particularly in metabolic associated fatty liver disease (MAFLD), nonalcoholic hepatosteatosis (NASH), insulin resistance, and type 2 diabetes (T2D). The challenges that need to be addressed before synthetic and natural mitochondrial uncouplers can enter the clinic are also discussed.
MOLECULAR METABOLISM
(2021)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Review
Biochemistry & Molecular Biology
Ming Yang, Chenrui Li, Lin Sun
Summary: MAMs are cellular structures connecting ER and mitochondria, playing roles in various cellular processes including metabolic regulation and ER stress response. Dysfunction of MAMs is associated with the development of metabolic syndrome, making them a potential therapeutic target.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Andrea C. Salcedo, Jane Yun, Cody Carter, Elaine Hart
Summary: Therapeutic carbohydrate restriction diets can lead to weight loss and improve metabolic disorders, potentially preventing and treating gynecologic disorders.
Review
Biochemistry & Molecular Biology
Salima Akter, Hajara Akhter, Habib Sadat Chaudhury, Md Hasanur Rahman, Andrew Gorski, Mohammad Nazmul Hasan, Yoonhwa Shin, Md Ataur Rahman, Minh Nam Nguyen, Tae Gyu Choi, Sung-Soo Kim
Summary: This article summarizes the common pathophysiology of metabolic syndrome and its relationship with carbohydrates, intrauterine nutrition, genetic predisposition, lifestyle factors, and treatment methods. It emphasizes the importance of dietary carbohydrates as key factors in the etiology and therapeutic targets of obesity and metabolic syndrome.
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rim Hamze, Etienne Delangre, Stefania Tolu, Manon Moreau, Nathalie Janel, Danielle Bailbe, Jamileh Movassat
Summary: The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly with the aging of the population. There is a strong association between type 2 diabetes and an increased risk of dementia. The amyloid cascade, altered glucose metabolism, and insulin signaling may play key roles in the pathophysiology of Alzheimer's disease. Impaired insulin and IGF-1 signaling, as well as GSK3 beta and DYRK1A, could be potential therapeutic targets for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
George E. Zakynthinos, Vasiliki Tsolaki, Evangelos Oikonomou, Manolis Vavouranakis, Gerasimos Siasos, Epaminondas Zakynthinos
Summary: Metabolic syndrome and atrial fibrillation are closely related, as metabolic syndrome affects the left atrium in multiple ways, leading to the progression of atrial fibrillation. A holistic treatment approach can improve patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Editorial Material
Endocrinology & Metabolism
Kristina I. Rother, Rebecca J. Brown
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Endocrinology & Metabolism
Gayatri Sarkar, May Alattar, Rebecca J. Brown, Michael J. Quon, David M. Harlan, Kristina I. Rother
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Endocrinology & Metabolism
Ranganath Muniyappa, Rebecca J. Brown, Andrea Mari, Jalaja Joseph, Mary A. Warren, Elaine K. Cochran, Monica C. Skarulis, Phillip Gorden
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Endocrinology & Metabolism
Yehuda Handelsman, Elif A. Oral, Zachary T. Bloomgarden, Rebecca J. Brown, Jean L. Chan, Daniel Einhorn, Alan J. Garber, Abhimanyu Garg, W. Timothy Garvey, George Grunberger, Robert R. Henry, Norman Lavin, Carmen D. Tapiador, Christian Weyer
ENDOCRINE PRACTICE
(2013)
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Endocrinology & Metabolism
F. Kamran, K. I. Rother, E. Cochran, E. Safar Zadeh, P. Gorden, R. J. Brown
HORMONE RESEARCH IN PAEDIATRICS
(2012)
Review
Psychology, Developmental
Tammy T. Nguyen, Vikas Jayadeva, Giovanni Cizza, Rebecca J. Brown, Radha Nandagopal, Luisa M. Rodriguez, Kristina I. Rother
JOURNAL OF ADOLESCENT HEALTH
(2014)
Review
Endocrinology & Metabolism
Rebecca J. Brown, Kristina I. Rother
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2012)
Article
Endocrinology & Metabolism
Rebecca J. Brown, Elaine Cochran, Phillip Gorden
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
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Endocrinology & Metabolism
John D. Christensen, Andreea O. Lungu, Elaine Cochran, Michael T. Collins, Rachel I. Gafni, James C. Reynolds, Kristina I. Rother, Phillip Gorden, Rebecca J. Brown
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2014)
Article
Endocrinology & Metabolism
Jalaja Joseph, Robert D. Shamburek, Elaine K. Cochran, Phillip Gorden, Rebecca J. Brown
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2014)
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Gastroenterology & Hepatology
Elika Safar Zadeh, Andreea O. Lungu, Elaine K. Cochran, Rebecca J. Brown, Marc G. Ghany, Theo Heller, David E. Kleiner, Phillip Gorden
JOURNAL OF HEPATOLOGY
(2013)
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Nutrition & Dietetics
John Foreyt, Ronald Kleinman, Rebecca J. Brown, Rachel Lindstrom
JOURNAL OF NUTRITION
(2012)
Review
Endocrinology & Metabolism
Rebecca J. Brown, Jack A. Yanovski
PEDIATRIC DIABETES
(2014)
Article
Multidisciplinary Sciences
Felicity Payne, Koini Lim, Amandine Girousse, Rebecca J. Brown, Nora Kory, Ann Robbins, Yali Xue, Alison Sleigh, Elaine Cochran, Claire Adams, Arundhati Dev Borman, Bormanf David Russel-Jones, Phillip Gorden, Robert K. Semple, Vladimir Saudek, Stephen O'Rahilly, Tobias C. Walther, Ines Barroso, David B. Savage
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Review
Endocrinology & Metabolism
G. Cizza, R. J. Brown, K. I. Rother
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2012)