Review
Medicine, General & Internal
Melissa J. Alldred, Alessandra C. Martini, David Patterson, James Hendrix, Ann-Charlotte Granholm
Summary: Down syndrome is a form of accelerated aging due to the overexpression of multiple genes on Chromosome 21, leading to a predisposition to aging-related conditions and significant accumulation of abnormalities in the brain. This review highlights the major advancements in research over the past few decades, current research status, and essential areas for future studies, as well as discussing comorbidities and clinical research efforts in the United States and Europe. The review also addresses funding efforts and recent recommendations to the NIH regarding research on Down syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Tsuyoshi Isojima, Susumu Yokoya
Summary: Turner syndrome is a chromosomal disorder in females characterized by short stature and gonadal dysgenesis. Girls with untreated TS are significantly shorter than the general population and their growth patterns differ. Growth hormone therapy and estrogen replacement treatment are essential for optimal growth and development in these girls. This review discusses overall growth, pubertal growth, secular trend, growth-promoting treatment, and hormone replacement treatment in girls with Turner syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nursing
Barbara Riegel, Sandra B. Dunbar, Donna Fitzsimons, Kenneth E. Freedland, Christopher S. Lee, Sandy Middleton, Anna Stromberg, Ercole Vellone, David E. Webber, Tiny Jaarsma
Summary: This article discusses the importance and objectives of self-care research, proposes a future research agenda, and shares the vision and mission of a research center dedicated to self-care. It emphasizes the importance of addressing challenges in self-care and strategies to tackle knowledge gaps.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Neurosciences
Vanessa Lozano Wun, Lara C. Foland-Ross, Booil Jo, Tamar Green, David Hong, Judith L. Ross, Allan L. Reiss
Summary: Turner syndrome (TS) is a common sex chromosome abnormality in females, causing various physical, cognitive, and socio-emotional characteristics. This study investigated the effects of TS on the development of cortical gray matter volume, thickness, and surface area in the brain. The results revealed both direct and indirect effects of X-monosomy on brain development in TS, with differences observed in various brain regions. These findings provide valuable insights into the understanding of TS-associated alterations in brain structure.
HUMAN BRAIN MAPPING
(2023)
Article
Health Care Sciences & Services
Martina Bacova, Pengzhu Li, Leonie Arnold, Robert Dalla-Pozza, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer
Summary: This study investigated the cardiovascular care of Turner Syndrome (TS) women in Germany. The results showed that a certain percentage of women did not receive cardiac imaging and annual blood pressure measurements according to the latest clinical practice guidelines. Furthermore, more than half of the women felt poorly informed about TS-specific cardiovascular risk factors.
Article
Business
Sher Jahan Khan, Puneet Kaur, Fauzia Jabeen, Amandeep Dhir
Summary: Environmental pollution has worsened in recent decades, putting pressure on firms to adopt green process innovations. However, existing literature on GPcIs is disjointed, lacking a comprehensive understanding. A systematic literature review identified seven themes and gaps in the literature, suggesting future research directions.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2021)
Article
Endocrinology & Metabolism
Monika Obara-Moszynska, Lukasz Dzialach, Barbara Rabska-Pietrzak, Marek Niedziela, Karina Kapczuk
Summary: Most girls and women with Turner syndrome require estrogen replacement therapy for pubertal development. Uterine growth promotion is a fundamental effect of ERT in hypogonadism. Pubertal induction in patients with TS results in a significant increase in uterine volume, but the mature uterus is smaller compared to the healthy population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Emanuele Scala, Sara Cacciapuoti, Natalie Garzorz-Stark, Matteo Megna, Claudio Marasca, Peter Seiringer, Thomas Volz, Kilian Eyerich, Gabriella Fabbrocini
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. The pathogenesis involves follicular occlusion, immune responses, and results in an inflammatory vicious circle. Therapeutic approaches are limited, often requiring surgical interventions, presenting a challenge in treating this debilitating disease.
Article
Urology & Nephrology
Christina B. Ching, Martin A. Koyle
Summary: Despite the availability of international medical volunteer opportunities in pediatric urology, dissemination of information to interested individuals and lack of time serve as barriers to participation. Among SPU members, there is a divide in attitudes regarding the importance of trainee participation, but trainees strongly support IMV participation.
Review
Biochemical Research Methods
Ingela Lanekoff, Varun V. Sharma, Catia Marques
Summary: Single-cell metabolomics with mass spectrometry allows for the detection of multiple metabolites from individual cells simultaneously, providing insights into phenotypes at the single-cell level. This field is steadily progressing, with an increasing number of research groups, advancements in cell sampling and ionization techniques, data analysis tools, and applications in various biomedical and environmental studies.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Rachel J. J. Stephenson, Istvan Toth
Summary: Cocaine is a widely used illegal drug that has significant medical and social consequences. The lack of effective pharmacological treatments has led to the development of anti-cocaine vaccines. Despite years of research, no approved pharmacological treatments exist to help individuals overcome cocaine addiction or prevent relapse.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Tianzhu Zhang, Han Qiu, Marco Mellia, Yuanjie Li, Hewu Li, Ke Xu
Summary: With the increasing adoption of artificial intelligence techniques in networking, interpretability has become a significant concern. Networking researchers are exploring explainable AI techniques to improve the interpretability and trustworthiness of AI models. This article provides an overview of AI applications in networking, reviews current research on interpreting AI-based networking solutions, and discusses future challenges.
IEEE COMMUNICATIONS MAGAZINE
(2022)
Article
Medicine, General & Internal
David Rodriguez-Buritica, Meaghan Mones, Siddharth K. Prakash, Michelle Rivera, Melissa Aldrich, Megan Rogge, Kate Richardson
Summary: This study found that skin conditions are highly prevalent in Turner syndrome patients during the early decades of life, highlighting the importance of utilizing these conditions in the diagnostic process and emphasizing the need for specialized dermatology referrals to address the detrimental impacts on quality of life.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Nathalie Y. Ly, Sophia Fruechte, Maria K. Hordinsky, Neil Sadick, Suleima Arruda, Ronda S. Farah
Summary: Novel androgenetic alopecia treatments include low-dose oral minoxidil, spironolactone, finasteride, and nutritional supplements. Technological advancements in minimally invasive procedures include photobiomodulation and platelet-rich plasma. Hair transplantation techniques such as follicular unit extraction and robotics are now available to clinicians.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Gabriela Albuquerque, Felipe Fernandes, Ingridy M. P. Barbalho, Daniele M. S. Barros, Philippi S. G. Morais, Antonio H. F. Morais, Marquiony M. Santos, Leonardo J. Galvao-Lima, Ana Isabela L. Sales-Moioli, Joao Paulo Q. Santos, Paulo Gil, Jorge Henriques, Cesar Teixeira, Thaisa Santos Lima, Karilany D. Coutinho, Talita K. B. Pinto, Ricardo A. M. Valentim
Summary: Syphilis is a curable infectious disease with increasing rates worldwide. Computational methods can be used to analyze data and assist in formulating public policies for preventing and controlling STIs. This systematic review demonstrates the usefulness of computational tools in improving the understanding of syphilis, guiding public policy and practice, and supporting surveillance and prevention actions.
FRONTIERS IN PUBLIC HEALTH
(2023)