Article
Medicine, General & Internal
Minmin Chen, Chenyan Li, Shiqiao Peng, Mengyuan Liu, Yiling Li, Mingjun Sun, Xuren Sun
Summary: This article reports the first case of Wilson disease complicated by Crohn disease. The patient presented with repeated low fever, elevated C-reactive protein for 3 years, and anal fistula for 6 months. Ustekinumab was found to be safe and effective in the treatment. The study suggests that copper metabolism and oxidative stress play key roles in both Wilson disease and Crohn disease.
Review
Nutrition & Dietetics
Stefan Pilz, Verena Theiler-Schwetz, Pawel Pludowski, Sieglinde Zelzer, Andreas Meinitzer, Spyridon N. Karras, Waldemar Misiorowski, Armin Zittermann, Winfried Maerz, Christian Trummer
Summary: Pathogenic mutations of CYP24A1 should be considered in cases of hypercalcemia with low parathyroid hormone. Pregnancy may trigger hypercalcemia in affected patients, and obstetric complications are frequently reported. Strictly avoiding vitamin D supplementation seems to be effective in preventing or reducing hypercalcemia.
Review
Medicine, General & Internal
Marouf Alhalabi
Summary: Ustekinumab is increasingly being used off-label for children with inflammatory bowel disease, but there is a lack of pediatric pharmacokinetic data. This review evaluates its therapeutic effects and recommends the best treatment regimen.
Article
Immunology
Shin Ju Oh, Young Nam Kwon, Chang Kyun Lee, Jin San Lee
Summary: This is the first report of infliximab-associated anti-NMDAR encephalitis in Crohn's disease, highlighting the need for clinicians to recognize the possibility of a paradoxical autoimmune response occurring with novel biological therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
P. Garieri, M. Marcasciano, A. Greto Ciriaco, R. Spagnuolo, T. Vitagliano, J. Kaciulyte, D. Casella, F. Lo Torto, P. Parisi, D. Ribuffo, M. Greco
Summary: Dedicated multidisciplinary teams should be involved in the treatment of PG, with every specialist playing a crucial role from diagnosis to treatment and long-term follow-up.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Immunology
Lin Li, Pengwei Liu, Xiaoping Niu, Chiyi He
Summary: This article elaborates on the rare extraintestinal manifestations of Crohn's disease (CD) and emphasizes the importance of short-term chest computed tomography (CT) for differential diagnosis. Based on a case report, the patient showed excellent response to systemic steroid therapy and infliximab treatment, with significant improvement in symptoms.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pediatrics
Qiao Zhang, Yizhen Luo, Jianli Zhou, Shaoming Zhou, Zhaoxia Wang
Summary: This case report demonstrates that Neuro-Behcet's disease is prone to misdiagnosis and missed diagnosis, and should be diagnosed based on clinical manifestations and results from colonoscopy, pathological examination, and MRI or MRV.
FRONTIERS IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Zhijie Lv, Xiaoqi Zhang, Li Wu
Summary: Infliximab-induced seizures are rare in Crohn's disease patients and the mechanism remains unclear. Before and during treatment with infliximab, neurological assessment and tight clinical monitoring should be conducted in patients with pre-existing seizure disorders.
BMC GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Zhu, Jing Hu, Xia Wang, Cuiping Li, Yankun Gao, Jianying Li, Yaqiong Ge, Xingwang Wu
Summary: This study suggests that a CTE-based radiomics model has potential value in predicting mucosal healing in CD patients. A nomogram constructed by combining radiomics signatures and clinical features can help clinicians select appropriate therapeutic strategies for CD patients.
EUROPEAN RADIOLOGY
(2022)
Review
Pharmacology & Pharmacy
I Mignini, M. Pizzoferrato, L. Larosa, A. Gasbarrini, G. L. Rapaccini, A. Armuzzi
Summary: Acute pancreatitis may present as an initial clinical manifestation of parathyroid carcinoma, which is a rare cause of hypercalcemia-induced acute pancreatitis. While the causal relationship between primary hyperparathyroidism and acute pancreatitis is still controversial, suspicion of hypercalcemia-induced acute pancreatitis should arise when hypercalcemia and abdominal symptoms are present.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Fuqiong Chen, Qinqin Xu, Wenzhu Yue, Xuefeng Yu, Shiying Shao
Summary: This is a case report of hyperparathyroidism caused by MEN1 gene mutation. The patient was diagnosed with a mutation in the MEN1 gene through genetic analysis. The patient's condition improved after undergoing parathyroidectomy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Rheumatology
Pingyang Han, Chen Sun, Juzhen Yan
Summary: We report a case of severe symptomatic hypercalcemia caused by IgG4-related disease. The patient presented with sustained bilateral periorbital swelling and proptosis for more than 5 years, and developed significant symptoms including nausea, vomiting, loss of appetite, fatigue, and pruritus. Laboratory tests showed severe hypercalcemia, renal dysfunction, and elevated levels of IgG4 subclass and bone metabolism markers. The patient responded well to treatment.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Pagona Flevari, Ersi Voskaridou, Frederic Galacteros, Giovanna Cannas, Gylna Loko, Laure Joseph, Pablo Bartolucci, Justine Gellen-Dautremer, Emmanuelle Bernit, Corine Charneau, Anoosha Habibi
Summary: This article reports a case of myelodysplastic syndrome and highlights the lack of significant conclusions due to the scarcity of similar cases.
Article
Pediatrics
Jae Hoon Jung, Sujin Choi, Youra Kang, Dae-Chul Cho, So Mi Lee, Tae In Park, Byung-Ho Choe, Dongsub Kim, Ben Kang
Summary: This article reports a rare case of a 16-year-old female with Crohn's disease who developed tuberculosis spondylitis during treatment with infliximab. Despite receiving sufficient treatment at each stage of tuberculosis development, tuberculosis spondylitis still occurred.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Lorenzo Zelano, Pietro Locantore, Carlo Antonio Rota, Caterina Policola, Andrea Corsello, Esther Diana Rossi, Vittoria Rufini, Luca Zagaria, Marco Raffaelli, Alfredo Pontecorvi
Summary: Parathyroid carcinoma is an extremely rare disease that is usually associated with continuous secretion of PTH, leading to hypercalcemia and symptoms of primary hyperparathyroidism. Radical surgery is the preferred treatment, while other therapies should be considered for specific cases. This article reports on a severe case of parathyroid carcinoma and provides a comprehensive evaluation of diagnostic and therapeutic approaches, along with a review of relevant literature.
FRONTIERS IN ENDOCRINOLOGY
(2022)
