Article
Oncology
Daisuke Takayanagi, Hourin Cho, Erika Machida, Atsushi Kawamura, Atsuo Takashima, Satoshi Wada, Takuya Tsunoda, Takashi Kohno, Kouya Shiraishi
Summary: This review provides updates on the epidemiology, diagnosis, and management of gastroenteropancreatic neuroendocrine neoplasms. The incidence of these malignancies originating from the pancreatic and gastrointestinal neuroendocrine cell system has been increasing. Advances in molecular diagnosis, treatment strategies, and liquid biopsy have contributed to personalized management for patients.
Article
Oncology
Niko Hiltunen, Jukka Rintala, Juha P. Vayrynen, Jan Bohm, Tuomo J. Karttunen, Heikki Huhta, Olli Helminen
Summary: This study found that high MCT4 expression is associated with improved prognosis in small bowel neuroendocrine tumors (SB-NETs), while MCT1 expression is not correlated with survival.
Article
Endocrinology & Metabolism
Marta Opalinska, Anna Sowa-Staszczak, Helena Olearska, Magdalena Ulatowska-Bialas, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk
Summary: Ovarian neuroendocrine tumors are rare neoplasms that most commonly occur within mature cystic teratomas, with a minority presenting as monodermal teratomas (strumal carcinoid). The prognosis for patients with ovarian neuroendocrine tumors is good, with surgical intervention proving to be an effective treatment method.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Yuki Fujii, Ching-Wei Tzeng, Yi-Ju Chiang, Daniel M. Halperin, Arvind Dasari, Michael P. Kim, Matthew H. G. Katz, Jeffrey E. Lee, Naruhiko Ikoma
Summary: The study found that the presence of regional LN metastases and the extent of surgery did not affect overall survival among patients with D-NETs. Radical resection to clear occult LN metastases for nonfunctioning, sporadic D-NETs was not supported by the current study.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Oncology
Emma N. Rizen, Alexandria T. Phan
Summary: This review summarizes recent findings and updates in the management of neuroendocrine neoplasms (NENs), highlighting the improvement in NENs classification and the expansion of epidemiological understanding through global collaborations and tumor registries. The review also discusses the evolving utility of some NET biomarkers, the increasing knowledge of molecular drivers of tumorigenesis, and the multiple drug approvals for the treatment of advanced NENs. The authors emphasize the importance of further understanding molecular drivers and the role of immunotherapy in transforming care for all NENs patients.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Hyung Kyu Park, Ghee Young Kwon
Summary: This study compared the metastatic patterns of neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and non-neuroendocrine neoplasms (non-NENs), and found significant differences between NETs/NECs and non-NENs. The key factor causing these differences may be associated with the multigene program of neuroendocrine differentiation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Oncology
Cedric Nesti, Konstantin Braeutigam, Marta Benavent, Laura Bernal, Hessa Boharoon, Johan Botling, Antonin Bouroumeau, Iva Brcic, Maximilian Brunner, Guillaume Cadiot, Maria Camara, Emanuel Christ, Thomas Clerici, Ashley K. Clift, Hamish Clouston, Lorenzo Cobianchi, Jaroslaw B. Cwikla, Kosmas Daskalakis, Andrea Frilling, Rocio Garcia-Carbonero, Simona Grozinsky-Glasberg, Jorge Hernando, Valerie Hervieu, Johannes Hofland, Pernille Holmager, Frediano Inzani, Henning Jann, Paula Jimenez-Fonseca, Enes Kacmaz, Daniel Kaemmerer, Gregory Kaltsas, Branislav Klimacek, Ulrich Knigge, Agnieszka Kolasinska-Cwikla, Walter Kolb, Beata Kos-Kudla, Catarina Alisa Kunze, Stefania Landolfi, Stefano La Rosa, Carlos Lopez Lopez, Kerstin Lorenz, Maurice Matter, Peter Mazal, Claudia Mestre-Alagarda, Patricia Morales del Burgo, Els J. M. Nieveen van Dijkum, Kira Oleinikov, Lorenzo A. Orci, Francesco Panzuto, Marianne Pavel, Marine Perrier, Henrik Mikael Reims, Guido Rindi, Anja Rinke, Maria Rinzivillo, Xavier Sagaert, Ilker Satiroglu, Andreas Selberherr, Alexander R. Siebenhuener, Margot E. T. Tesselaar, Michael J. Thalhammer, Espen Thiis-Evensen, Christos Toumpanakis, Timon Vandamme, Jose G. van den Berg, Alessandro Vanoli, Marie-Louise F. van Velthuysen, Chris Verslype, Stephan A. Vorburger, Alessandro Lugli, John Ramage, Marcel Zwahlen, Aurel Perren, Reto M. Kaderli
Summary: This study investigated whether patients with 1-2 cm appendiceal neuroendocrine tumors (NETs) need to undergo right-sided hemicolectomy, and found that right-sided hemicolectomy is not necessary after appendectomy for appendiceal NETs. Furthermore, it was found that regional lymph node metastases of appendiceal NETs are clinically irrelevant and additional postoperative exclusion of metastases and histopathological evaluation of risk factors is not supported. These findings should inform the development of treatment guidelines.
Article
Oncology
Mathilde Prieto, Guillaume Chassagnon, Audrey Lupo, Marie-Christine Charpentier, Eglantine Cabanne, Lionel Groussin, Marie Wislez, Marco Alifano, Ludovic Fournel
Summary: DIPNECH-associated carcinoid tumors exhibit negative pathological features and may require specialized perioperative management. Patients with DIPNECH are older, more frequently female, and more likely to have comorbidities such as diabetes or hypertension. Atypical histology and mediastinal lymph nodes involvement are independent factors of pN2 invasion in DIPNECH patients.
Review
Oncology
M. S. D. Engel, R. J. L. van der Lans, J. C. Jansen, C. R. Leemans, E. Bloemena, B. I. Lissenberg-Witte, J. A. Rijken, C. F. Smit, E. F. Hensen
Summary: MEANTs are rare and unpredictable middle ear tumors, with some having locally invasive and metastatic disease. Treatment mainly consists of surgery, with initial local tumor control being crucial.
Letter
Medicine, General & Internal
Malgorzata Panek, Marek Szymczak, Maria Stepaniuk, Wojciech Gorecki, Aleksandra Gawlowska-Marciniak, Przemyslaw Wolak, Dariusz Zbyrad, Marek Rybkiewicz, Kamila Chrobak, Ryszard Noparlik, Jerzy Niedzielski, Przemyslaw Janik, Jan Nowak, Witold Miaskiewicz, Andrzej Kaminski, Wojciech Fischer, Bozena Dembowska-Baginska, Piotr Kalicinski
Summary: This study examined the management of pediatric ANET in Poland and found that using ENETS guidelines resulted in a 100% overall survival rate for patients with NET. The majority of patients were diagnosed with well-differentiated NET G1/G2, and only a small percentage experienced recurrence after secondary surgery.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Surgery
Hilary R. Keller, Sri H. Senapathi, Anthony Morada, David Bertsch, Burt Cagir
Summary: This study evaluated the 5-year overall survival (OS) and cancer-specific survival (CSS) of neuroendocrine neoplasms (NENs) of the colon, rectum, and small intestine (SI). The results showed that well-differentiated neuroendocrine tumors (NETs) of the rectum had improved 5-year OS. However, rectal poorly-differentiated neuroendocrine carcinomas (NECs) had lower 5-year OS compared to colon and SI. More frequent surveillance and timely initiation of systemic therapy should be considered for rectal NECs.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Otorhinolaryngology
Rik J. L. van der Lans, Michelle S. D. Engel, Johannes A. Rijken, Erik F. Hensen, Elisabeth Bloemena, Marein van der Torn, Charles R. Leemans, Conrad F. G. M. Smit
Summary: Middle ear adenomatous neuroendocrine tumors (MEANTs) are rare temporal bone tumors with uncertain clinical behavior and prognosis. Complete surgical resection is the preferred treatment, but recurrence rates are high, and there are currently no effective prognostic biomarkers.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Yi-Wei Li, Yi-Ping He, Fang-Qi Liu, Jun-Jie Peng, San-Jun Cai, Ye Xu, Ming-He Wang
Summary: This study compared the clinicopathologic features of rectal neuroendocrine tumors (NETs) with G1 and G2 grades. The results showed that G2 tumors were larger and more invasive than G1 tumors, with a significantly higher incidence of lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Otorhinolaryngology
Katerina Marini, Konstantinos Garefis, James Philip Skliris, Astreinidou Anna, Jiannis Hajiioannou, Vasiliki Florou
Summary: MEANT is a rare type of middle ear tumor, difficult to diagnose, but complete surgical resection is the definitive treatment.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Oncology
Jennifer H. Foster, Andrew Sher, Victor Seghers, Jay Poston, Donald Wells, Ebrahim S. Delpassand, Samara Potter, Priya Mahajan, Rajkumar Venkatramani
Summary: Neuroendocrine tumors of the pancreas and midgut are rare in children, with poor survival in those presenting with metastatic disease. Recent trials in adults have shown that Lu-177-DOTATATE treatment for NETs has a high disease control rate.
PEDIATRIC BLOOD & CANCER
(2021)