Article
Endocrinology & Metabolism
Mei Shi, Xiaolin Ji, Yuting Xie, Ting Zhong, Rong Tang, Li Fan, Xia Li
Summary: A new definition of partial remission (PR) for patients with type 1 diabetes (T1D) is proposed using insulin dose and glycated albumin (GA), and the optimal cut-off values for stimulated C-peptide to diagnose PR in different age-groups are determined. It is not recommended to use stimulated C-peptide alone to diagnose PR for patients with insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jeongseon Yoo, Youngah Choi, Shin Ae Park, Ji Yeon Seo, Chul Woo Ahn, Jaehyun Han
Summary: The study found that glycated albumin and GA/HbA1c ratio in patients with type 2 diabetes mellitus were associated with the progression of COVID-19 from mild to severe disease. Patients with high blood sugar are more likely to develop severe disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Trinitat Cambras, Odile Romero, Antoni Diez-Noguera, Albert Lecube, Gabriel Sampol
Summary: The study revealed a high prevalence of sleep apnea and circadian rhythm abnormalities in patients with diabetes, which were associated with poor glycemic control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Mohammed Ewid, Abdullah Saleh Algoblan, Elzaki M. Elzaki, Mohamad Ayham Muqresh, Ahmad Riad Al Khalifa, Albaraa Muad Alshargabi, Shahad Abdullah Alotaibi, Abdullah Saleh Alfayez, Mervat Naguib
Summary: This study assessed the prevalence and factors related to suboptimal glycemic control and complications in a group of patients with type 2 diabetes. The results showed that longer disease duration was significantly associated with poor glycemic control, while age was independently associated with macrovascular complications. Hyperlipidemia was significantly associated with neuropathy and retinopathy. Lower physical activity was independently associated with neuropathy.
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo
Summary: The systematic review with meta-analysis showed that resveratrol supplementation has protective effects on diabetes parameters. The analysis revealed significant reduction in insulin resistance and glycated hemoglobin, and a significant impact on fasting blood glucose in individuals with diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Endocrinology & Metabolism
Katherine A. Sauder, Jeanette M. Stafford, Shelley Ehrlich, Jean M. Lawrence, Angela D. Liese, Santica Marcovina, Amy K. Mottl, Catherine Pihoker, Sharon Saydah, Amy S. Shah, Ralph B. D'Agostino, Dana Dabelea
Summary: Disparities in HbA(1c) testing frequency were observed primarily based on health care-related factors, which were associated with diabetes outcomes in type 1 diabetes. Higher frequency of HbA(1c) testing was linked to lower HbA(1c) levels and decreased odds of microvascular complications over time. However, these associations were attenuated after adjusting for HbA(1c) testing correlates.
Article
Medicine, General & Internal
You-Ting Lin, Wei-Lun Huang, Hung-Pin Wu, Man-Ping Chang, Ching-Chu Chen
Summary: This study found that mean HbA1c was consistently associated with HF in patients with T2DM, while the association with HbA1c variability disappeared. Patients with HbA1c-Mean <7% and high variability in HbA1c showed comparable risk of HF to those with HbA1c-Mean>=8%. In addition to absolute HbA1c level, stability of HbA1c was also important for preventing HF in patients with T2DM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jiale Zhang, Zhuoya Zhang, Kaiqi Zhang, Xiaolei Ge, Ranran Sun, Xu Zhai
Summary: Type 2 diabetes is on the rise worldwide, especially among youth. Countries with lower socioeconomic status have higher incidence and burden. Early diagnosis and management are crucial, but current diagnostic criteria have limitations and better criteria are urgently needed to identify high-risk individuals earlier.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Abrar M. Al-Mutairi, Mohammad A. Alshabeeb, Salah Abohelaika, Fadhel A. Alomar, Keshore R. Bidasee
Summary: This study investigated the impact of telemedicine on glycemic control in patients with type 2 diabetes during the COVID-19 lockdown in Saudi Arabia. The results showed that 63.1% of patients maintained good glycemic control and some patients showed improvement through telemedicine. Male patients had better glycemic control compared to female patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Almudena Castro Conde, Domingo Marzal Martin, Raquel Campuzano Ruiz, Maria Rosa Fernandez Olmo, Carlos Morillas Arino, Juan Jose Gomez Doblas, Jose Luis Gorriz Teruel, Pilar Mazon Ramos, Xavier Garcia-Moll Marimon, Maria Jose Soler Romeo, David Leon Jimenez, Vicente Arrarte Esteban, Juan Carlos Obaya Rebollar, Carlos Escobar Cervantes, Juan J. Gorgojo Martinez
Summary: Type 2 diabetes (T2DM) is a significant global public health issue, associated with increased risk of atherosclerotic vascular disease, heart failure, chronic kidney disease, and mortality. Early intervention is crucial, focusing on lifestyle changes and prescription of drugs that reduce complications, aiming for metabolic control and comprehensive vascular risk control. This consensus document provides a more appropriate approach for managing patients with T2DM or its complications, highlighting the importance of cardiovascular risk factor control, weight inclusion in therapeutic goals, patient education, deprescription of non-cardiovascular beneficial drugs, and the use of GLP-1 receptor agonists and SGLT2 inhibitors as cardiovascular protective drugs on par with statins, acetylsalicylic acid, or renin angiotensin system inhibitors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Wanying Su, Meiyi Tao, Lin Ma, Ke Tang, Fang Xiong, Xuan Dai, Yuelan Qin
Summary: This meta-analysis confirms the beneficial impact of resistance training (RT) on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels in patients with type 2 diabetes mellitus (T2DM). Additionally, the study identifies critical training parameters that are important for enhancing HbA1c and FBG reductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yueshu Wang, Yao Qin, Huilan Gu, Linyu Zhang, Jing Wang, Yiting Huang, Yuwen Shi, Qizhen Hu, Yang Chen, Yong Gu, Yun Shi, Yang Tao, Mei Zhang
Summary: This study found that Chinese patients with autoimmune type 1 diabetes have high residual beta-cell mass, suggesting potential implications for therapeutic strategies aimed at preserving and restoring beta-cell function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Sajid Iqbal, Abdulrahim Abu Jayyab, Ayah Mohammad Alrashdi, Silvia Reverte-Villarroya
Summary: This systematic review and meta-analysis aimed to investigate the predictive ability of plasma C-peptide levels in discriminating T1D from T2D. The results showed a significant association between C-peptide levels and the classification and diagnosis of diabetes. Moreover, C-peptide levels were found to have predictive ability in distinguishing T1D from T2D.
ENDOCRINE PRACTICE
(2023)
Article
Medicine, General & Internal
Giulia Testa, Lucia Camacho-Barcia, Carlos Gomez-Martinez, Bernat Mora-Maltas, Rafael de la Torre, Xavier Pinto, Dolores Corella, Roser Granero, Aida Cuenca-Royo, Susana Jimenez-Murcia, Nancy Babio, Rebeca Fernandez-Carrion, Virginia Esteve-Luque, Laura Forcano, Jiaqi Ni, Mireia Malcampo, Sara De las Heras-Delgado, Montse Fito, Jordi Salas-Salvado, Fernando Fernandez-Aranda
Summary: The study found that impulsivity traits in individuals with T2D seem to affect long-term weight control, but not glycemic control.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Samuel Dagogo-Jack, Robert Frederich, Jie Liu, Christopher P. Cannon, Harry Shi, David Z. Cherney, Francesco Cosentino, Urszula Masiukiewicz, Ira Gantz, Richard E. Pratley
Summary: In the VERTIS CV trial, ertugliflozin treatment decreased the likelihood of insulin initiation, delayed the time to insulin initiation by up to approximately 1.8 years, and reduced insulin dose requirements without increasing the incidence of hypoglycemia events.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Hajime Yamazaki, Jui Wang, Shinichi Tauchi, Mitsuru Dohke, Nagisa Hanawa, Akio Katanuma, Yoshifumi Saisho, Tsukasa Kamitani, Shunichi Fukuhara, Yosuke Yamamoto
Summary: The study revealed that patients with fatty liver had a lower rate of type-2 diabetes remission over a 2-year follow-up period, while improvement of fatty liver was significantly associated with a higher rate of type-2 diabetes remission.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Obstetrics & Gynecology
Yoshifumi Kasuga, Kei Miyakoshi, Yoshifumi Saisho, Satoru Ikenoue, Daigo Ochiai, Mamoru Tanaka
Summary: This study investigated the clinical and metabolic features of underweight women with gestational diabetes (GDM). The results showed that impaired early phase insulin secretion was associated with GDM onset in underweight women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hironobu Sasaki, Yoshifumi Saisho, Jun Inaishi, Yuusuke Watanabe, Tami Tsuchiya, Masayoshi Makio, Midori Sato, Masaru Nishikawa, Minoru Kitago, Taketo Yamada, Hiroshi Itoh
Summary: The study revealed that both the size and number of beta cells are reduced in participants with type 2 diabetes, with the decrease in number being the major contributor to the reduced beta cell mass in type 2 diabetes.
Article
Endocrinology & Metabolism
Midori Sato, Jun Inaishi, Yoshifumi Saisho, Yasunori Sato, Issei Komuro, Hiroshi Itoh
Summary: In Japanese patients with type 2 diabetes, long-term glycemic variability is associated with the risk of cardiovascular events, independent of mean-HbA1c. Variability and mean HbA1c could be important glycemic indicators in managing type 2 diabetes patients, especially for those with a mean-HbA1c of <7%.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Kazutoshi Sugiyama, Yoshifumi Saisho, Yoshifumi Kasuga, Daigo Ochiai, Hiroshi Itoh
Summary: The strategy proposed by the Japanese Society of Diabetes and Pregnancy using random plasma glucose and glycated hemoglobin measured 1 month after delivery combined with pre-pregnancy body mass index showed high specificity but low sensitivity for detecting postpartum glucose intolerance.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Yoshifumi Kasuga, Tomoko Kawai, Kei Miyakoshi, Yoshifumi Saisho, Masumi Tamagawa, Keita Hasegawa, Satoru Ikenoue, Daigo Ochiai, Mariko Hida, Mamoru Tanaka, Kenichiro Hata
Summary: This study revealed an association between gestational diabetes mellitus and neonatal plasma glucose level at 1 hour after birth as well as DNA methylation changes at the alternative transcription start site of ZNF696 in cord blood cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Endocrinology & Metabolism
Kazutoshi Sugiyama, Yoshifumi Saisho
Letter
Endocrinology & Metabolism
Hironobu Sasaki, Yoshifumi Saisho
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Jun Inaishi, Yoshifumi Saisho, Yuusuke Watanabe, Tami Tsuchiya, Hironobu Sasaki, Tatsuhiro Masaoka, Hiroshi Itoh
Summary: The study investigated the effects of switching from exenatide twice-daily formulation (BID) to once-weekly formulation (QW) on blood glucose fluctuation, gastric emptying, and vascular endothelial function in patients with type 2 diabetes. The results showed that postprandial glucose levels increased after switching, but glycemic variability (GV) remained relatively stable and there was no significant deterioration in vascular endothelial function. This supports the superiority of exenatide QW over exenatide BID in clinical practice, but proper monitoring and management of postprandial glucose levels should be emphasized.
BMC ENDOCRINE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Hironobu Sasaki, Arata Itoh, Yasuhiro Watanabe, Yuya Nakajima, Yoshifumi Saisho, Junichiro Irie, Shu Meguro, Hiroshi Itoh
Summary: The COVID-19 vaccine has been reported to potentially cause or worsen diabetes. A Japanese woman who received two doses of Moderna COVID-19 vaccine was diagnosed with new-onset type 1 diabetes after eight weeks. This suggests a potential link between the vaccine and the development of diabetes.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Yoshifumi Kasuga, Tomoko Kawai, Kei Miyakoshi, Asuka Hori, Masumi Tamagawa, Keita Hasegawa, Satoru Ikenoue, Daigo Ochiai, Yoshifumi Saisho, Mariko Hida, Mamoru Tanaka, Kenichiro Hata
Summary: This study investigated DNA methylation patterns in neonates born to mothers with E-GDM, and found that there were no significant differences in DNA methylation between the E-GDM group and normal OGTT group. Neonates born to mothers with GDM diagnosed based on Japan Society of Obstetrics and Gynecology criteria may not differ in DNA methylation compared to those born to normal OGTT mothers.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Review
Pharmacology & Pharmacy
Jun Inaishi, Yoshifumi Saisho
Summary: Exenatide is a drug used for the treatment of type 2 diabetes, with two formulations available. Its long-term efficacy and safety have been demonstrated, although it did not show a significant cardiovascular risk reduction compared to other drugs in a cardiovascular outcome trial. Despite being inferior to liraglutide and semaglutide in certain comparisons, exenatide QW remains a treatment option, especially for high-risk patients.
CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Tami Tsuchiya, Yoshifumi Saisho, Jun Inaishi, Hironobu Sasaki, Midori Sato, Masaru Nishikawa, Yohei Masugi, Taketo Yamada, Hiroshi Itoh
Summary: Pancreatic cancer is associated with worsened glucose tolerance and changes in islet morphology. This study found that individuals with pancreatic cancer have an increased ratio of alpha to beta cell mass, which may contribute to the risk of worsening glucose metabolism.
Article
Endocrinology & Metabolism
Tami Tsuchiya, Yoshifumi Saisho, Jun Inaishi, Hironobu Sasaki, Midori Sato, Masaru Nishikawa, Yohei Masugi, Taketo Yamada, Hiroshi Itoh
Summary: The alpha to beta cell mass ratio is increased in patients with pancreatic cancer, which may contribute to worsened glucose metabolism. Further studies are needed to elucidate the mechanisms behind the increased alpha to beta cell mass in these patients.
Article
Endocrinology & Metabolism
Masumi Tamagawa, Yoshifumi Kasuga, Yoshifumi Saisho, Yuya Tanaka, Keita Hasegawa, Maki Oishi, Toyohide Endo, Yu Sato, Satoru Ikenoue, Mamoru Tanaka, Daigo Ochiai
Summary: Factors predicting the need for insulin therapy in early diagnosed GDM patients include pre-pregnancy BMI ≥ 25 kg/m2, a family history of diabetes, and higher fasting plasma glucose, 1 h-plasma glucose, and 2 h-plasma glucose values. Patients with these risk factors may require more careful follow-up during the perinatal period.
