Article
Endocrinology & Metabolism
Laurent Vroonen, Albert Beckers, Severine Camby, Thomas Cuny, Pablo Beckers, Marie-Lise Jaffrain-Rea, Muriel Cogne, Luciana Naves, Amandine Ferriere, Pauline Romanet, Atanaska Elenkova, Auli Karhu, Thierry Brue, Anne Barlier, Patrick Petrossians, Adrian F. Daly
Summary: AIPvar-related prolactinomas occur at a younger age and have a higher likelihood of invasion compared to unselected or DA-resistant prolactinomas. AIPvar prolactinomas also have larger tumor diameter and lower prolactin levels at diagnosis compared to unselected prolactinomas. The AIPvar group requires higher doses of dopamine agonists and shows a higher rate of tumor shrinkage (>50%) with dopamine agonist treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Uloma B. Elvis-Offiah, Suzann Duan, Juanita L. Merchant
Summary: Mutations in the MEN1 gene lead to the development of gastrinomas, which overproduce the hormone gastrin. Gastrin is a peptide hormone primarily synthesized in the gastric antrum that stimulates acid secretion. The goal of current studies is to understand how MEN1 mutations generate a mutant MENIN protein that abrogates its tumor suppressor function.
Article
Oncology
Liping He, Steeve Boulant, Megan Stanifer, Cuncai Guo, Anna Niessen, Mingyi Chen, Klaus Felix, Frank Bergmann, Oliver Strobel, Simon Schimmack
Summary: This study investigated the effect of menin and its link to PTN in pancreatic neuroendocrine neoplasms (pNEN). The results showed that menin deficiency and high PTN protein expression were associated with metastasis and shorter disease-free survival in pNEN patients. In vitro experiments further demonstrated that menin could both promote and suppress the metastasis of pNEN cells by regulating PTN expression.
Article
Biochemistry & Molecular Biology
Carmen Biancaniello, Antonia D'Argenio, Deborah Giordano, Serena Dotolo, Bernardina Scafuri, Anna Marabotti, Antonio d'Acierno, Roberto Tagliaferri, Angelo Facchiano
Summary: In this study, the effects of missense variations in the menin gene on protein structure and function were predicted using computational methods. The results provide insight into the pathological role of these variations, contributing to a better understanding of the disease mechanism.
Article
Pathology
Anna Vera D. Verschuur, Aranxa S. M. Kok, Folkert H. M. Morsink, Wendy W. J. de Leng, Medard F. M. van den Broek, Marco J. Koudijs, Johan A. Offerhaus, Gerlof D. Valk, Menno R. Vriens, Bernadette P. M. van Nesselrooij, Wenzel M. Hackeng, Lodewijk A. A. Brosens
Summary: A clinical diagnosis of multiple endocrine neoplasia type 1 (MEN1) syndrome is usually confirmed with genetic testing in the germline. This study investigated the potential of menin immunohistochemistry in parathyroid adenomas as an additional tool in the recognition and genetic diagnosis of MEN1 syndrome. Menin loss was found in 100% of patients with MEN1 and 9% of patients without MEN1, indicating the usefulness of menin immunohistochemistry in identifying MEN1-related tumors. It also showed high positive and negative predictive values for the diagnosis of MEN1.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Yadira M. Soto-Feliciano, Francisco J. Sanchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Summary: Menin interacts with oncogenic MLL1-fusion proteins, and disrupting these interactions can be a potential treatment for leukemia. The study found a molecular switch that determines the response to Menin-MLL inhibitors, involving MLL3/4-UTX chromatin-modifying complexes. By disrupting the Menin-MLL1 interaction, a tumor-suppressive program can be activated, and treatment resistance in leukemia cells can be overcome by using CDK4/6 inhibitors.
Article
Endocrinology & Metabolism
Christopher S. S. Hong, Hasan Alanya, Marcello DiStasio, Susan D. Boulware, Ryan A. Rimmer, Sacit Bulent Omay, E. Zeynep Erson-Omay
Summary: This study describes a case of pituitary adenoma arising from somatic loss of MEN1 without an underlying germline MEN1 mutation. The patient, a 23-year-old with no significant medical or family history, underwent surgical resection of a symptomatic and medically resistant prolactinoma. Whole exome sequencing revealed somatic loss of MEN1 at both alleles, indicating a double hit mechanism.
Review
Endocrinology & Metabolism
Ved Bhushan Arya, Simon J. B. Aylwin, Tony Hulse, Michal Ajzensztejn, Jennifer Kalitsi, Nicolas Kalogirou, Istvan Bodi, Nick Thomas, Tim Hampton, Ritika R. Kapoor, Charles R. Buchanan
Summary: The study focuses on young patients with prolactinomas (<20 years) and conducts a systematic review and meta-analysis. Surgical resection was necessary for patients with macroprolactinoma >20 mm. Macroprolactinoma is more common in girls, while microprolactinoma is more frequent in males with large invasive tumors.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Eva C. Coopmans, Marta Korbonits
Summary: This article provides a concise overview of the genetics of pituitary tumors and discusses the current challenges and implications of these genetic findings in clinical practice.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Koen M. A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin, H. T. Marc Timmers
Summary: Our study applied an in silico screening approach to select nine surface-exposed menin mutants from 253 disease-related MEN1 missense mutations. We found that seven of these mutants disrupt interactions with both MLL1/MLL2 and JunD complexes. Interestingly, three mutants, R52G, E255K, and E359K, predominantly reduce the interactions with MLL1 and MLL2 compared to JunD. This differential effect on interactions translates into different genomic binding patterns.
EPIGENETICS & CHROMATIN
(2022)
Article
Multidisciplinary Sciences
Danying Yi, Lijiao Zhu, Yuanling Liu, Jiahui Zeng, Jing Chang, Wencui Sun, Jiawen Teng, Yonggang Zhang, Yong Dong, Xu Pan, Yijin Chen, Ya Zhou, Mowen Lai, Qiongxiu Zhou, Jiaxin Liu, Bo Chen, Feng Ma
Summary: Overexpression of P18 has dual effects on hematopoietic differentiation, with early induction possibly severely blocking differentiation while late induction can promote the production of classic hematopoietic populations.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Cell Biology
Xue Qing David Wang, Yali Dou
Summary: A new study has found that MENIN, together with KMT2A/B methyltransferase complexes, plays an unorthodox role in repressing bivalent genes.
NATURE CELL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Lucie Coppin, Sophie Giraud, Eric Pasmant, Arnaud Lagarde, Marie-Odile North, Lauriane Le-Collen, Valerie Aubert, Gregory Mougel, Miriam Ladsous, Alyzee Louboutin, Hedia Brixi, Magalie Haissaguerre, Nicolas Scheyer, Marc Klein, Antoine Tabarin, Brigitte Delemer, Anne Barlier, Marie-Francoise Odou, Pauline Romanet
Summary: MEN1 syndrome is an autosomal dominant hereditary disorder characterized by various endocrine tumors. Research shows that mosaic MEN1 mutations do not manifest as milder phenotypes, and more systematic detection of these mutations can improve patient monitoring and genetic counseling.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Cell Biology
Anosha Kiran Ulfat, Shadab Batool, Fahad Iqbal, Naweed I. Syed
Summary: Cholinergic neuronal networks in the hippocampus play a crucial role in regulating learning and memory in mammals, and disruptions to these networks are associated with neurodegenerative diseases. This study provides direct evidence that deletion of the MEN1 gene in the CA1 region of the hippocampus leads to deficits in contextual fear conditioning in conditional knockout animals. The study also demonstrates that overexpressing MEN1 can restore this loss of function.
Article
Multidisciplinary Sciences
Jianwei Lin, Yiping Wu, Gaofei Tian, Daqi Yu, Eunjeong Yang, Wai Hei Lam, Zheng Liu, Yihang Jing, Shangyu Dang, Xiucong Bao, Jason Wing Hon Wong, Yuanliang Zhai, Xiang David Li
Summary: H3K79me2 is an important epigenetic mark involved in gene regulation, cellular differentiation, and disease progression. A nucleosome-based photoaffinity probe was used to identify menin as a reader of H3K79me2 in a nucleosomal context. Cryo-electron microscopy showed that menin interacts with the nucleosome through specific domains and recognizes the methylation mark through a p-cation interaction. In cells, menin is selectively associated with H3K79me2 on chromatin, particularly in gene bodies.
Article
Endocrinology & Metabolism
Hideyuki Okuma, Koshi Hashimoto, Takuya Ohashi, Masatomo Miharao, Isao Minami, Hajimc Izumiyama, Shigekazu Sasaki, Naoko Inoshita, Hiroshi Nishioka, Shozo Yamada, Takanobu Yoshimoto
Article
Endocrinology & Metabolism
Michiko Wada, Makoto Kita, Kaoru Kawasaki, Toru Kusakabe, Tetsuya Tagami, Noriko Satoh-Asahara, Akira Shimatsu, Koshi Hashimoto
Article
Endocrinology & Metabolism
Takuya Watanabe, Atsushi Ozawa, Sumiyasu Ishii, Takuya Tomaru, Nobuyuki Shibusawa, Tsugumichi Saito, Eijiro Yamada, Kazuhiko Horiguchi, Yasuyo Nakajima, Shunichi Matsumoto, Satoshi Yoshino, Akiko Katano-Toki, Koshi Hashimoto, Masatomo Mori, Shuichi Okada, Tetsurou Satoh, Masanobu Yamada
Article
Medicine, General & Internal
Seizaburo Masuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
Article
Medicine, General & Internal
Yujiro Nakano, Takanobu Yoshimoto, Tatsuya Fukuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Yasuhisa Fujii, Kazunori Kihara, Yoshihiro Ogawa
Article
Cell Biology
Takashi Okamura, Yasuyo Nakajima, Nobuyuki Shibusawa, Kazuhiko Horiguchi, Shunichi Matsumoto, Eijiro Yamada, Takuya Tomaru, Sumiyasu Ishii, Atsushi Ozawa, Takahiro Ishizuka, Koshi Hashimoto, Shuichi Okada, Tetsurou Satoh, Masanobu Yamada
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogawa
Article
Endocrinology & Metabolism
Koshi Hashimoto, Eijun Nishihara, Masako Matsumoto, Shunichi Matsumoto, Yasuyo Nakajima, Kazutaka Tsujimoto, Hajime Yamakage, Noriko Satoh-Asahara, Jaeduk Yoshimura Noh, Koichi Ito, Akira Miyauchi, Masatomo Mori, Masanobu Yamada, Yoshihiro Ogawa
Article
Medicine, General & Internal
Kenji Hara, Masafumi Koga, Hiroyuki Shinozaki, Mototaka Yamauchi, Tatsuhiko Suzuki, Rika Naruse, Takafumi Tsuchiya, Kohzo Takebayashi, Toshihiko Inukai, Koshi Hashimoto
Article
Multidisciplinary Sciences
Nozomi Hanzawa, Koshi Hashimoto, Xunmei Yuan, Kenichi Kawahori, Kazutaka Tsujimoto, Miho Hamaguchi, Toshiya Tanaka, Yuya Nagaoka, Hiroshi Nishina, Sumiyo Morita, Izuho Hatada, Tetsuya Yamada, Yoshihiro Ogawa
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Takahiro Fukaishi, Isao Minami, Seizaburo Masuda, Yasutaka Miyachi, Kazutaka Tsujimoto, Hajime Izumiyama, Koshi Hashimoto, Masayuki Yoshida, Sayako Takahashi, Kenichi Kashimada, Tomohiro Morio, Kenjiro Kosaki, Yoshiro Maezawa, Koutaro Yokote, Takanobu Yoshimoto, Tetsuya Yamada
Article
Endocrinology & Metabolism
Yoshihiro Niitsu, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Fuminori Satou, Motoyoshi Tsujino, Kazuki Ota, Atsushi Kudo, Minoru Tanabe, Tetsuya Yamada, Yoshihiro Ogawa
Article
Endocrinology & Metabolism
Yujiro Nakano, Koshi Hashimoto, Noriaki Ohkiba, Hideyuki Okuma, Isao Minami, Hiromitsu Takahashi, Yuji Tanaka, Takanobu Yoshimoto, Tetsuya Yamada
CASE REPORTS IN ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
JOURNAL OF DIABETES INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2018)