Article
Endocrinology & Metabolism
Federico Gatto, Richard A. Feelders, Peter M. van Koetsveld, Fadime Dogan, Sebastian J. C. M. M. Neggers, Aart-Jan van der Lelij, Jessica Amaru, Diego Ferone, Leo J. Hofland
Summary: Cabergoline (CAB) is an off-label medical therapy for acromegaly, but it is overshadowed by first-generation somatostatin receptor ligands like octreotide (OCT). In this study, OCT was found to be slightly more effective than CAB in inhibiting growth hormone (GH) secretion in vitro. Additionally, the response to CAB treatment was shown to be better in GH/prolactin (PRL) co-secreting tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Giovanni Tulipano, Andrea Giustina
Summary: Autophagy is an important cellular process involved in degradation and recycling, regulated by various stimuli and having complex roles in tumor cells. Research on autophagy in the pituitary gland and pituitary tumors is still relatively limited, but gaining attention for its potential implications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Endocrinology & Metabolism
Xiaoxu Li, Binghao Zhao, Bo Hou, Jing Wang, Jianyu Zhu, Yong Yao, Xiaolan Lian
Summary: Ectopic thyrotropin-secreting pituitary adenoma (ectopic TSH-oma) is a rare disorder that is easily misdiagnosed in clinical work, mostly affecting middle-aged individuals but also seen in children. Achieving a timely and accurate diagnosis is challenging, requiring a combination of imaging examinations and special tests, with surgical resection leading to a satisfactory long-term outcome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Article
Endocrinology & Metabolism
Jiun-Lin Yan, Mao-Yu Chen, Yao-Liang Chen, Chi-Cheng Chuang, Peng-Wei Hsu, Kuo-Chen Wei, Chen-Nen Chang
Summary: This study evaluated the outcomes of the endoscopic transsphenoidal approach as the primary treatment for somatotroph adenomas and investigated patients with suboptimal surgical results. Factors such as tumor size, preoperative GH level, and residual tumors were found to be associated with surgical failure. Octreotide showed good outcomes for treating DGSA patients, while SRS/EXRT generated good results for patients receiving secondary treatments when remission could not be reached after 6 months of TSA operation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Bahadir Koylu, Busra Firlatan, Suleyman Nahit Sendur, Seda Hanife Oguz, Selcuk Dagdelen, Tomris Erbas
Summary: The characteristics and treatment outcomes of giant GH-secreting pituitary adenomas differ from non-giant macroadenomas. Patients with giant adenomas have higher numbers of surgeries and treatment modalities, as well as lower hormonal remission rates.
Review
Endocrinology & Metabolism
Monica R. Gadelha, Ana Carolina Gadelha, Leandro Kasuki
Summary: The treatment of acromegaly has advanced significantly in recent decades, but there are still patients who do not respond to current treatments, highlighting the need for improved treatment burden. Fortunately, there are new treatments in development that may enhance treatment efficacy and convenience.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Yamei Yang, Jie Liu, Kan Deng, Lin Lu, Huijuan Zhu, Xiaolan Lian, Xinjie Bao, Lian Duan, Yong Yao
Summary: Adolescent-onset TSH-oma patients presented with higher levels of TSH and thyroid hormones, more large tumors, and poorer treatment outcomes compared to adult cases. Early diagnosis, multidisciplinary therapy, and close follow-up are important for improving the prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jie Liu, Yamei Yang, Lian Duan, Xiaofeng Chai, Huijuan Zhu, Kan Deng, Xiaolan Lian, Yong Yao
Summary: This study evaluated the efficacy of presurgical somatostatin analogs (SSAs) treatment and long-term remission after surgery for TSH-secreting pituitary adenomas (TSHomas). The results showed that the combination of endoscopic transsphenoidal surgery and presurgical SSAs provided a higher long-term remission for TSHomas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Cristina Secosan, Andrea Pasquini, Delia Zahoi, Andrei Motoc, Diana Lungeanu, Oana Balint, Aurora Ilian, Ligia Balulescu, Dorin Grigoras, Laurentiu Pirtea
Summary: The study conducted HPV genotyping and dual-staining for p16/Ki-67 in patients undergoing LEEP for evaluating sensitivity and specificity in diagnosing CIN2+ in patients under 30 years old. The findings indicated that dual-staining p16/Ki-67 alone or in combination with HR-HPV and/or colposcopy showed higher specificity for diagnosing biopsy-confirmed CIN2+ in patients under 30 years old.
Review
Medicine, Research & Experimental
Jacobo Kerbel, Amayrani Cano-Zaragoza, Rodrigo Espinosa-Dorado, Keren-Enid Garcia de la Torre, Moises Mercado
Summary: National registries are valuable tools to investigate rare conditions like acromegaly, providing insights into epidemiology, clinical presentation, diagnosis, treatment outcomes, and mortality. While single-center studies are more homogeneous, they are often limited by small sample sizes and lack statistical power.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Neurosciences
Xuanzhi Wang, Mingwu Li, Xiaofeng Jiang, Fei Wang, Shiying Ling, Chaoshi Niu
Summary: The objective of this study was to investigate the factors influencing the prediction of the Ki-67 index in patients with pituitary adenomas (PAs). Data from 178 patients confirmed with PAs were retrospectively analyzed, and it was found that age, rich blood supply to the tumor, and erosion of the dorsum sellae bone were influencing factors for predicting the Ki-67 index. Suitable prediction models were developed and validated, providing potential for personalized treatment for PA patients.
Article
Endocrinology & Metabolism
A. Dicitore, D. Saronni, G. Gaudenzi, S. Carra, M. C. Cantone, M. O. Borghi, L. Persani, G. Vitale
Summary: This study evaluated the antitumor activity of octreotide (OCT) and pasireotide (PAS) in GH3 cell line, showing that PAS exhibited a more potent antitumor activity compared to OCT after long-term incubation, mainly modulated by a cell cycle perturbation and a relevant induction in apoptosis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Federica Mirra, Federico Donfrancesco, Tommaso Tartaglione, Pier Paolo Mattogno, Flavia Angelini, Lauretti Liverana, Marco Gessi, Anile Carmelo, Guido Rindi, Andrea Giustina, Maria Fleseriu, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: The study investigated predictors of response to Pegvisomant and Pasireotide LAR in acromegaly patients, finding that factors such as tumor extension, Ki67-Li levels, and IGF-I levels may impact treatment efficacy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)