Review
Oncology
Priyanka Sahu, Chantal Donovan, Keshav Raj Paudel, Sophie Pickles, Vrushali Chimankar, Richard Y. Kim, Jay C. Horvart, Kamal Dua, Antonio Ieni, Francesco Nucera, Helle Bielefeldt-Ohmann, Sarah Mazilli, Gaetano Caramori, J. Guy Lyons, Philip M. Hansbro
Summary: This review discusses the pathogenesis, diagnosis, and current treatment strategies for lung squamous cell carcinoma (LSCC), as well as the existing animal models for studying LSCC. LSCC is a common subtype of non-small-cell lung carcinoma (NSCLC) with low survival rates. Understanding the risk factors, genetic and epigenetic alterations, and miRNA biomarkers associated with LSCC can contribute to the development of new diagnostic and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sabrina Marcazzan, Ali Dadbin, Giulia Brachi, Elvin Blanco, Elena Maria Varoni, Giovanni Lodi, Mauro Ferrari
Summary: In this study, mouse models of OSCC lung metastasis were established through orthotopic and tail vein injection. The orthotopic model showed spontaneous lung metastases in 50% of animals, while the tail vein model had a lung metastasis rate of 60%. These results suggest that the orthotopic model using HSC-3 GFP/luciferase cells is suitable for investigating metastatic dissemination in OSCC.
Article
Multidisciplinary Sciences
Simon Mylius Rasmussen, Thomas Nielsen, Sofie Hody, Henrik Hager, Lars Peter Schousboe
Summary: This study introduces a video processing algorithm designed to identify cancer suspicious skin areas, based on remote photoplethysmography signal differences between squamous cell carcinoma and healthy skin. The research shows significant temporal signal changes in cancer areas versus healthy areas, providing valuable insights for further investigation on detailed disease boundary recognition.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Omchit Surien, Ahmad Rohi Ghazali, Siti Fathiah Masre
Summary: This study demonstrates that pterostilbene can inhibit proliferation and promote apoptosis of lung squamous cell carcinoma cells by regulating the cell cycle and upregulating the p53/p21 pathway.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Juntae Kwon, Jinmin Zhang, Boram Mok, Samuel Allsup, Chul Kim, Jeffrey Toretsky, Cecil Han
Summary: This study established a mouse model of LUSC and found that USP13 is a molecular driver of lineage plasticity in club cells and is associated with upregulation of squamous programs in lung cancer cells.
Article
Oncology
Fanglu Qin, Shenghua Lin, Kun Deng, Junqi Qin, Zhanyu Xu, Liqiang Yuan, Jiangbo Wei, Yu Sun, Tiaozhan Zheng, Shikang Li
Summary: This study identified a novel angiogenesis subtype classification in SCC and provided new insights into a hallmark of SCC progression. The angiogenesis subtype showed enrichment in angiogenesis and epithelial-mesenchymal transition, inflammatory response, and hypoxia. Patients in the angiogenesis subtype had poorer survival outcomes compared to those in the non-angiogenesis subtype.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuanwang Pan, Han Han, Kristen E. Labbe, Hua Zhang, Kwok-Kin Wong
Summary: Lung squamous cell carcinoma (LUSC) is a major subtype of non-small cell lung cancer with limited treatment options. Immunotherapy has become the new standard of care for LUSC, but targeted driver mutations are lacking. Researchers believe that improved modeling systems are needed to gain a better understanding of the biology of LUSC.
Article
Multidisciplinary Sciences
Gang Yuan, Natasha M. Flores, Simone Hausmann, Shane M. Lofgren, Vladlena Kharchenko, Maria Angulo-Ibanez, Deepanwita Sengupta, Xiaoyin Lu, Iwona Czaban, Dulat Azhibek, Silvestre Vicent, Wolfgang Fischle, Mariusz Jaremko, Bingliang Fang, Ignacio I. Wistuba, Katrin F. Chua, Jack A. Roth, John D. Minna, Ning-Yi Shao, Lukasz Jaremko, Pawel K. Mazur, Or Gozani
Summary: Amplification of the chromosomal region 8p11-12 is common in lung squamous cell carcinoma (LUSC) and the NSD3 gene in this region is identified as a key regulator of LUSC tumorigenesis. NSD3 depletion attenuates tumor growth and enhances survival in LUSC, suggesting its potential as a therapeutic target. Additionally, NSD3-dependent LUSC xenografts are sensitive to bromodomain inhibition, indicating a vulnerability of LUSC to this treatment.
Article
Oncology
Yinqiang Liu, Jin Duan, Fujun Zhang, Fanghao Liu, Xiaoyu Luo, Yunfei Shi, Youming Lei
Summary: The genomic and transcriptional levels of resectable lung squamous cell carcinoma (LUSC) were found to play a significant role in prognosis assessment. The mutational status, transcriptional levels, and changes in transcriptional levels were closely associated with prognosis.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Jin-Dong Li, Cheng-Yan Jin, Yan Zhang, Hang Guo, Guang-Lei Zhang, Chun-Guang Wang
Summary: This case report describes a patient with lung cancer who experienced histopathological transformation from squamous-cell carcinoma to large cell neuroendocrine carcinoma with a small fraction of small cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Nguyen Huu Tu, Kenji Inoue, Elyssa Chen, Bethany M. Anderson, Caroline M. Sawicki, Nicole N. Scheff, Hung D. Tran, Dong H. Kim, Robel G. Alemu, Lei Yang, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Rocco Latorre, Dane D. Jensen, Nigel W. Bunnett, Laura E. Edgington-Mitchell, Brian L. Schmidt
Summary: The study revealed the crucial role of cathepsin S in oral cancer pain, potentially offering new strategies for treating oral cancer pain. Experimental findings showed higher activity of cathepsin S in oral squamous cell carcinoma, and that its genetic deletion or inhibitor usage significantly reduced pain sensitivity. This provides a new direction for the treatment of oral cancer pain.
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Review
Oncology
Fabian Acker, Jan Stratmann, Lukas Aspacher, Ngoc Thien Thu Nguyen, Sebastian Wagner, Hubert Serve, Peter J. Wild, Martin Sebastian
Summary: KRAS is a commonly mutated oncogene, with a specific inhibitor targeting the p.G12C mutation recently approved for use in adenocarcinomas of the lung and other solid tumors. The prevalence and significance of KRAS mutations in squamous cell carcinoma of the lung remain poorly understood.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi He, Maria Jamalpour, Eric Bergquist, Robin L. Anderson, Karin Gustafsson, Michael Welsh
Summary: The passage discusses the intricate interplay between tumor cells, tumor stroma, and immune response, particularly focusing on the role of vascular barrier properties and the impact of Shb gene deletion on lung metastasis. It was found that Shb deficiency in EC promotes the recruitment of immune cells, leading to enhanced lung metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Karmele Valencia, Cristina Sainz, Cristina Bertolo, Gabriel de Biurrun, Jackeline Agorreta, Arantza Azpilikueta, Marta Larrayoz, Graziella Bosco, Carolina Zandueta, Miriam Redrado, Esther Redin, Francisco Exposito, Diego Serrano, Mirari Echepare, Daniel Ajona, Ignacio Melero, Ruben Pio, Roman Thomas, Alfonso Calvo, Luis M. Montuenga
Summary: There is a lack of adequate mouse models and cell lines for studying lung squamous cell carcinoma (LUSC). In this study, two models of transplantable LUSC cell lines were generated and characterized, revealing similar genetic and transcriptomic patterns. The immune landscape and response to immune checkpoint inhibition were also compared. Furthermore, the metastatic potential of these models showed organotropism similar to LUSC in humans. Overall, these valuable cell line tools recapitulate the complexity of the human disease.
DISEASE MODELS & MECHANISMS
(2022)
Article
Oncology
Borja Ruiz-Fernandez de Cordoba, Haritz Moreno, Karmele Valencia, Naiara Perurena, Pablo Ruedas, Thomas Walle, Alberto Pezonaga-Torres, Juan Hinojosa, Elisabet Guruceaga, Antonio Pineda-Lucena, Marta Abengozar-Muela, Denis Cochonneau, Carolina Zandueta, Susana Martinez-Canarias, Alvaro Teijeira, Daniel Ajona, Sergio Ortiz-Espinosa, Xabier Morales, Carlos Ortiz de Solorzano, Marta Santisteban, Luis Ramos-Garcia, Laura Guembe, Vratislav Strnad, Dominique Heymann, Sandra Hervas-Stubbs, Ruben Pio, Maria E. Rodriguez-Ruiz, Carlos E. de Andrea, Silvestre Vicent, Ignacio Melero, Fernando Lecanda, Rafael Martinez-Monge
Summary: Locoregional failure in breast cancer patients after surgery and irradiation is linked to a poor prognosis. The ENPP1/HP axis is exploited by tumor cells to promote local recurrence by suppressing immune cells. Blocking this axis offers new opportunities for therapeutic intervention.
Article
Education & Educational Research
Isabel Zudaire, Raquel Buil, Irantzu Uriz, Maria Napal
Summary: This study reports the implementation of an inquiry-based science project in a preschool setting, aiming to promote the development of scientific skills and conceptual knowledge among students. Through research experiments, students progressively improved their descriptions and justifications, showing great interest in conducting more research experiments.
INTERNATIONAL JOURNAL OF EARLY CHILDHOOD
(2022)
Article
Oncology
Sergio Ortiz-Espinosa, Xabier Morales, Yaiza Senent, Diego Alignani, Beatriz Tavira, Irati Macaya, Borja Ruiz, Haritz Moreno, Ana Remirez, Cristina Sainz, Alejandro Rodriguez-Pena, Alvaro Oyarbide, Mikel Ariz, Maria P. Andueza, Karmele Valencia, Alvaro Teijeira, Kai Hoehlig, Axel Vater, Barbara Rolfe, Trent M. Woodruff, Jose Maria Lopez-Picazo, Silvestre Vicent, Grazyna Kochan, David Escors, Ignacio Gil-Bazo, Jose Luis Perez-Gracia, Luis M. Montuenga, John D. Lambris, Carlos Ortiz de Solorzano, Fernando Lecanda, Daniel Ajona, Ruben Pio
Summary: This study reveals that C5a can enhance the capacity of PMN-MDSCs to promote tumor growth and metastasis by inducing the formation of NETs. The formation of NETs is dependent on the production of HMGB1 by cancer cells. Inhibiting C5a, C5aR1, or NETosis can reduce the number of circulating tumor cells and the metastatic burden in a mouse lung metastasis model. The translational relevance of these findings is supported by the stimulation of migration and NETosis in PMN-MDSCs obtained from lung cancer patients.
Review
Oncology
Ana Belen Herrera-Campos, Esteban Zamudio-Martinez, Daniel Delgado-Bellido, Monica Fernandez-Cortes, Luis M. Montuenga, F. Javier Oliver, Angel Garcia-Diaz
Summary: The tumor microenvironment (TME) characterized by low oxygen supply (hypoxia) is associated with aggressive cancer phenotypes and poor prognosis. Supplemental oxygen, or hyperoxia, has been shown to improve the efficacy of cancer therapies by reducing tumor hypoxia and promoting antitumor immunity. However, prolonged exposure to high oxygen levels can cause lung injury and inflammation, which may have negative consequences. Further studies are needed to optimize the use of hyperoxia in cancer treatment and prevent its side effects.
Article
Biotechnology & Applied Microbiology
Alejandro Rodriguez-Pena, Estibaliz Armendariz, Alvaro Oyarbide, Xabier Morales, Sergio Ortiz-Espinosa, Borja Ruiz-Fernandez de Cordoba, Denis Cochonneau, Inaki Cornago, Dominique Heymann, Josepmaria Argemi, Delia D'Avola, Bruno Sangro, Fernando Lecanda, Ruben Pio, Ivan Cortes-Dominguez, Carlos Ortiz-de-Solorzano
Summary: This paper presents a double spiral microfluidic device based on inertial separation for efficient enrichment and isolation of circulating tumor cells (CTCs). The device has a fine-tunable cut-off value and better separation results than existing technologies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Irati Garmendia, Esther Redin, Luis M. Montuenga, Alfonso Calvo
Summary: YES1, a nonreceptor tyrosine kinase, is considered as an emerging target in solid tumors. It is overexpressed in many tumor types, promoting cell proliferation and invasiveness. Novel specific inhibitors of YES1 have shown impressive antitumor effects in pre-clinical models. Inhibiting YES1 in tumors with high expression of this protein is a promising strategy against cancer.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Yaiza Senent, Beatriz Tavira, Ruben Pio, Daniel Ajona
Summary: Tumor progression is influenced by the interaction between tumor cells and their surrounding tumor microenvironment (TME), and the complement system plays a key role in this process. However, tumors can exploit the complement system to promote chronic inflammation, activate cancer-related pathways, and inhibit anti-tumor immune responses. Myeloid-derived suppressor cells are recognized as major regulators of tumor-associated complement activities.
Article
Immunology
David Reparaz, Marta Ruiz, Leyre Silva, Belen Aparicio, Josune Egea, Elizabeth Guruceaga, Daniel Ajona, Yaiza Senent, Enrique Conde, Flor Navarro, Sergio Barace, Diego Alignani, Sandra Hervas-Stubbs, Juan Jose Lasarte, Diana Llopiz, Pablo Sarobe
Summary: Vaccination using optimized strategies can increase response rates to immune checkpoint inhibitors in some tumors. In this study, the researchers analyzed the gene expression profile of immunosuppressive dendritic cells induced during vaccination and found that reducing monocyte production by gemcitabine enhanced vaccine-induced immunity and improved tumor rejection rates.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Nerea Otegui, Maeva Houry, Imanol Arozarena, Diego Serrano, Esther Redin, Francisco Exposito, Sergio Leon, Karmele Valencia, Luis Montuenga, Alfonso Calvo
Summary: Immunotherapy for NSCLC is effective for some patients, but less than half of them will benefit from it. Detection of PD-L1 in tumors is currently the only validated predictive biomarker. Genetic and metabolic alterations in tumor cells can affect the tumor microenvironment and the response to immunotherapy. Novel strategies based on these alterations may improve the efficacy of immunotherapy for lung cancer patients.
Editorial Material
Oncology
Karmele Valencia, Luis M. Montuenga, Alfonso Calvo
Summary: The influence of sex on immunotherapy response in patients with non-small cell lung cancer (NSCLC) is inconclusive. However, a recent study suggests that the existence of a 17 beta-estradiol/ER alpha/PDL1 signaling loop in NSCLC is a key factor determining the response to immunotherapy, opening up new therapeutic options.
CLINICAL CANCER RESEARCH
(2023)
