Journal
EMBO MOLECULAR MEDICINE
Volume 6, Issue 8, Pages 993-994Publisher
WILEY
DOI: 10.15252/emmm.201404324
Keywords
-
Categories
Funding
- NIMH NIH HHS [R01 MH091850, R01MH091850] Funding Source: Medline
- NINDS NIH HHS [R01NS081054, R01 NS081054] Funding Source: Medline
Ask authors/readers for more resources
Despite genetic evidence implicating MBD5 as the only overlapping gene between various 2q23.1 microdeletions, the function of MBD5 and its causality to 2q23.1 microdeletion syndrome, a disorder characterized by developmental delay and autistic features, has yet to be determined. In this issue of EMBO Molecular Medicine, Camarena etal generate an Mbd5 gene-trap mouse model and show for the first time that mice with reduced MBD5 expression develop behavioral abnormalities with neuronal function deficits, mimicking symptoms in 2q23.1 microdeletion syndrome, thus supporting a causal role for MBD5 haploinsufficiency in the disorder.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available