A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation

CpG and Non-CpG Oligodeoxynucleotides Directly Costimulate Mouse and Human CD4+ T Cells through a TLR9- and MyD88-Independent Mechanism

(2011) A. Landrigan et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice

(2010) Ashley M. Miller et al.   CIRCULATION RESEARCH

IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity

(2010) L. A. Zuniga et al.   JOURNAL OF IMMUNOLOGY

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Use of CpG oligonucleotides in treatment of asthma and allergic disease

(2009) David E. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides

(2009) Dennis M. Klinman et al.   Annals of the New York Academy of Sciences

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice

(2009) Guoliang Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice

(2009) Maria Pini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

T-ing up inflammation in fat

(2009) Carey N. Lumeng et al.   NATURE MEDICINE

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

(2008) Viviane Zorzanelli Rocha et al.   CIRCULATION RESEARCH

Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women

(2008) M Sumarac-Dumanovic et al.   INTERNATIONAL JOURNAL OF OBESITY

Randomized Phase II Trial of a Toll-Like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination With First-Line Taxane Plus Platinum Chemotherapy for Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Christian Manegold et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthetic oligonucleotides as modulators of inflammation

(2008) Dennis Klinman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE−/− mice through modulation of Th1/Th2 balance

(2008) Xiang Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE