Article
Cell Biology
Rong Yu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nister, Jian Zhao
Summary: Drp1 exists as a mixture of self-assembly forms in mammalian cells, and its assembly state affects its binding with MIEFs and Mff. Mff binds preferentially to higher order oligomers of Drp1, while MIEFs interact with a wider range of Drp1 assembly subunits.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Atsuhiro Tsutiya, Mitsumi Arito, Takuma Tagashira, Masaaki Sato, Kazuki Omoteyama, Toshiyuki Sato, Naoya Suematsu, Manae S. Kurokawa, Tomohiro Kato
Summary: In this study, we found that layilin localized to mitochondria and played a role in the maintenance of fragmented mitochondria in mitochondrial dynamics, which required activation of CDK1 and DRP1. Our data revealed a novel function for layilin, regulation of mitochondrial dynamics.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Yuanyuan Zhou, Ming Li, Zhenglei Wang, Xinguang Lin, Yuanyuan Xu, Shiyuan Feng, Jinfeng Miao
Summary: Excessive production of ROS leads to oxidative stress, affecting disease progression. Mitochondria are a significant source of ROS, and their dysfunction is closely associated with ROS production. S. uberis infection disrupts mitochondrial dynamics, leading to fragmentation and functional decline. The AMPK activator AICAR improves mitochondrial dysfunction induced by S. uberis infection by inhibiting Drp1 phosphorylation and translocation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Huey-Huey Chua, Mei-Hwei Chang, Ya-Hui Chen, Daw-Jen Tsuei, Yung-Ming Jeng, Po-Huang Lee, Yen-Hsuan Ni
Summary: We identified RBMY as a predictive biomarker for hepatocellular carcinoma metastasis. Provirus integration phosphorylates RBMY, leading to stabilized and translocated RBMY that promotes epithelial-mesenchymal transition and mitochondrial dysregulation in hepatocellular carcinoma, resulting in distant metastasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kaori Ishikawa, Yo Honma, Ayami Yoshimi, Shun Katada, Takaya Ishihara, Naotada Ishihara, Kazuto Nakada
Summary: Regulation of mitochondrial respiration and morphology is crucial for maintaining hematopoiesis. This study found that abnormal mitochondrial respiration or dynamics in mouse models can cause anemia, with different manifestations. When both deficits occur simultaneously, it amplifies abnormal iron metabolism and worsens anemia.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Dongjoon Kim, Hiromi Sesaki, Sayon Roy
Summary: The study found that reducing Drp1 levels can decrease diabetes-induced retinal vascular lesions, reduce the number of acellular capillaries and pericyte loss, and is associated with an increase in the expression of apoptosis-related genes.
Article
Immunology
Nanxing Yi, Yilin Mi, Xiaotong Xu, Naping Li, Baiyi Chen, Ke Yan, Kaiyun Tan, Bo Zhang, Linhua Wang, Gaoyan Kuang, Min Lu
Summary: This study found that Nodakenin can repair cartilage and reduce inflammation by regulating the mitochondrial Drp1/ROS/NLRP3 axis, suggesting its potential application in osteoarthritis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Iman F. Fergani, Luciana R. Frick
Summary: SUMOylation is a relatively novel posttranslational modification that has not been extensively studied in Schwann cells and the peripheral nervous system. It may play a role in peripheral myelination and neuropathies by affecting protein function, cellular localization, and interactions with other proteins.
Article
Endocrinology & Metabolism
Janos Steffen, Jennifer Ngo, Sheng-Ping Wang, Kevin Williams, Henning F. Kramer, George Ho, Carlos Rodriguez, Krishna Yekkala, Chidozie Amuzie, Russell Bialecki, Lisa Norquay, Andrea R. Nawrocki, Mark Erion, Alessandro Pocai, Orian S. Shirihai, Marc Liesa
Summary: Drp1 mitigates NASH by decreasing ER stress, preventing Oma1 activation, and exacerbation of ISR. The elevation in Gdf15 actions induced by NAG-Drp1si might represent an adaptive response decreasing the nutrient load to the liver when mitochondria are dysfunctional. Our study argues against blocking Drp1 in hepatocytes to combat NASH.
MOLECULAR METABOLISM
(2022)
Editorial Material
Cell Biology
Yumiko Oshima, Nicolas Verhoeven, Etienne Cartier, Mariusz Karbowski
Summary: Mitochondrial membrane dynamics, UPS activity, and mitochondrial fission play critical roles in maintaining mitochondrial function. Under acute reduction of mitochondrial translation fidelity, mosaic distribution of mitochondria was observed within a single cell, with some showing enriched population and some reduced levels of specific proteins in the intermembrane space. In the absence of PRKN activity, mosaic mitochondria formation is followed by OMM severing, IMM protein ubiquitination, and formation of mito-autophagosomes.
Article
Biochemistry & Molecular Biology
Kun-Long Zhang, Shu-Jiao Li, Xue-Yin Pu, Fei-Fei Wu, Hui Liu, Rui-Qing Wang, Bo-Zhi Liu, Ze Li, Kai-Feng Li, Nian-Song Qian, Yan-Ling Yang, Hua Yuan, Ya-Yun Wang
Summary: Mitochondria play a significant role in both inflammatory and neuropathic pain. Dynamin-related protein 1 (Drp1) is involved in the induction of mitochondrial fission and is associated with pain behavior. Overexpression of Drp1 attenuates pain hypersensitivity while down-regulation of Drp1 does not affect painful behavior.
Article
Biochemistry & Molecular Biology
Le Wang, Xin Huang, Taiqiang Dai, Jirong Xie, Qian-xin Lv, Yan Hou, Liang Kong, Yu Song, Fuwei Liu
Summary: This study investigated the impact of nano titanium surface on the mitochondrial fission-fusion dynamics of osteoblasts, revealing the crucial role of DRP1 and the significant decrease in osteogenic differentiation when DRP1 is inhibited. The findings provide insights for the design of titanium implant surface structures and highlight the importance of DRP1-regulated mitochondrial dynamics in accelerating osteogenic differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Mohamed Elbadawy, Kiwamu Tanabe, Haru Yamamoto, Yusuke Ishihara, Maria Mochizuki, Amira Abugomaa, Hideyuki Yamawaki, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki
Summary: NASH is associated with abnormal mitochondrial function, and this study found that NASH liver organoids showed enhanced metabolism and abnormal mitochondrial morphology. Treatment with the DPR1 inhibitor Mdivi-1 improved morphology and reduced fibrosis-related markers in NASH organoids. Mdivi-1 treatment in NASH model mice also reduced fatty liver and prevented fibrosis and ROS production in the liver.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Mario Alberto Burgos Aceves, Vincenzo Migliaccio, Marilena Lepretti, Gaetana Paolella, Ilaria Di Gregorio, Serena Penna, Caterina Faggio, Lilla Lionetti
Summary: The study revealed that DDE has a dose-dependent impact on cell viability and mitochondrial fusion/fission proteins, with high doses leading to decreased cell viability and increased fission/fusion ratio. Low doses of DDE stimulated cell adaption and altered mitochondrial dynamics.
Article
Pharmacology & Pharmacy
Jian Sun, Fan Yu, Tao Wang, Jianchun Bian, Zongping Liu, Hui Zou
Summary: Cadmium is an important environmental pollutant that causes damage to multiple systems of the body. This study found that cadmium damages liver cells, disrupts the structure and function of mitochondria, and increases the production of superoxide anions. It was also discovered that cadmium increases mitochondrial division and induces mitophagy through the PINK1-Parkin pathway. Mitophagy plays a protective role in early cadmium-induced liver damage.
